Bent Wilhelm Schoultz

• Kristian, Alexandr; Riss, Patrick; Qu, Hong; Milde, Mona; Schoultz, Bent Wilhelm; Engebråten, Olav; Mælandsmo, Gunhild & Malinen, Eirik (2014). Positron emission tomography and pharmacokinetics of 2-[18F]-fluoroethyl choline for metabolic studies in breast cancer xenografts. Acta Oncologica.  ISSN 0284-186X.  53(8), s 1086- 1092 . doi: 10.3109/0284186X.2014.934398
• Schoultz, Bent Wilhelm; Hjornevik, Trine; Reed, Brian Jeffrey; Marton, Janos; Coello, Christopher; Willoch, Frode & Henriksen, Gjermund (2014). Synthesis and evaluation of three structurally related <sup>18</sup>F- labeled orvinols of different intrinsic activities: 6-O-[<sup>18</sup>F] fluoroethyl-diprenorphine ([<sup>18</sup>F]FDPN), 6-O-[<sup>18</sup>F] fluoroethyl-buprenorphine ([<sup>18</sup>F]FBPN), and 6-O-[<sup>18</sup>F] fluoroethyl-phenethyl-orvinol ([<sup>18</sup>F]FPEO). Journal of Medicinal Chemistry.  ISSN 0022-2623.  57(12), s 5464- 5469 . doi: 10.1021/jm500503k
• Galante, Eva; Schoultz, Bent Wilhelm; Koepp, Matthias & Arstad, Erik (2013). Chelator-Accelerated One-Pot 'Click' Labeling of Small Molecule Tracers with 2-[F-18]Fluoroethyl Azide. Molecules.  ISSN 1420-3049.  18(5), s 5335- 5347 . doi: 10.3390/molecules18055335
• Schoultz, Bent Wilhelm; Reed, Brian Jeffrey; Marton, Janos; Willoch, Frode & Henriksen, Gjermund (2013). A Fully Automated Radiosynthesis of [F-18]Fluoroethyl-Diprenorphine on a Single Module by Use of SPE Cartridges for Preparation of High Quality 2-[F-18]Fluoroethyl Tosylate. Molecules.  ISSN 1420-3049.  18(6), s 7271- 7278 . doi: 10.3390/molecules18067271
• Hjornevik, Trine; Schoultz, Bent Wilhelm; Marton, Janos; Gjerstad, Johannes; Drzezga, Alexander; Henriksen, Gjermund & Willoch, Frode (2010). Spinal long-term potentiation is associated with reduced opioid neurotransmission in the rat brain. Clinical Physiology and Functional Imaging.  ISSN 1475-0961.  30(4), s 285- 293 . doi: 10.1111/j.1475-097X.2010.00939.x Vis sammendrag

  Introduction: Neuronal events leading to development of long‐term potentiation (LTP) in the nociceptive pathways may be a cellular mechanism underlying hyperalgesia. In the present study, we examine if induction of spinal LTP may be associated with functional changes in the supraspinal opioidergic system. The opioid receptors (ORs) play a key role in nociceptive processing and controlling the descending modulatory system to the spinal cord. Methods: Spinal LTP was induced by electrical high‐frequency stimulation (HFS) conditioning applied to the sciatic nerve, and the excitability at spinal level was verified by spinal field potential recordings. To study supraspinal changes in opioid neurotransmission following the same HFS conditioning, we used small animal positron emission tomography (PET) and [11C]Phenethyl‐Orvinol ([11C]PEO). All rats included in the PET study were scanned at baseline and 150 min after HFS, and specific binding was calculated with a reference tissue model. Results: A clear C‐fibre LTP, i.e. increased C‐fibre response and reduced C‐fibre threshold, was observed 150 min after HFS conditioning (t‐test, P<0·05, n = 6). Moreover, increased OR binding, relative to baseline, was observed after the same type of HFS conditioning ipsilaterally in the amygdala, hippocampus, somatosensory cortex and superior colliculus, and bilaterally in the nucleus accumbens, caudate putamen and hypothalamus (paired t‐test, HFS>baseline, P<0·05, n = 8). Conclusions: HFS conditioning of the sciatic nerve resulted in both spinal LTP and functional changes in supraspinal opioidergic signalling. Our findings suggest that induction of spinal LTP may be associated with reduced opioid neurotransmission in brain regions involved in pain modulation and affective‐emotional responses.

• Schoultz, Bent Wilhelm; Hjornevik, Trine; Willoch, Frode; Marton, J; Noda, A.; Murakami, Y; Miyoshi, S.; Nishimura, S.; Årstad, Erik; Drzezga, A; Matsunari, I. & Henriksen, Gjermund (2010). Evaluation of the kappa-opioid receptor-selective tracer [C-11]GR103545 in awake rhesus macaques. European Journal of Nuclear Medicine and Molecular Imaging.  ISSN 1619-7070.  37(6), s 1174- 1180 . doi: 10.1007/s00259-010-1384-6
• Marton, J; Schoultz, Bent Wilhelm; Hjornevik, Trine; Drzezga, A; Yousefi, BH; Wester, HJ; Willoch, F & Henriksen, Gjermund (2009). Synthesis and Evaluation of a Full-Agonist Orvinol for PET-Imaging of Opioid Receptors: [C-11]PEO. Journal of Medicinal Chemistry.  ISSN 0022-2623.  52(18), s 5586- 5589 . doi: 10.1021/jm900892x

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• Spilhaug, Mona M.; Riss, Patrick & Schoultz, Bent Wilhelm (2017). Determination of partitioning coefficients and protein binding using high performance liquid chromatography: Towards in vitro pharmacology in radiotracer development.
• Kristian, Alexandr; Riss, Patrick; Qu, Hong; Milde, Mona; Schoultz, Bent Wilhelm; Engebråten, Olav; Mælandsmo, Gunhild & Malinen, Eirik (2014). Pharmacokinetic modeling of dynamic 18F‐Choline PET reflects choline metabolism in breast carcinoma xenografts.
• Reed, Brian Jeffrey; Schoultz, Bent Wilhelm; Coello, Christopher; Hjornevik, Trine; Lindblom, Ina Sandberg; Henriksen, G & Willoch, Frode (2012). Longitudinal Measurement of Opioid Receptor Occupancy from Sustained Release Naltrexone: Comparison of Agonist, Partial Agonist and Antagonist Opioid Receptor Radiotracers in Rats. European Journal of Nuclear Medicine and Molecular Imaging.  ISSN 1619-7070.  39, s S266- S266
• Schoultz, Bent Wilhelm & Görbitz, Carl Henrik (2012). Automated radiosynthesis of tracers for use in positron emission tomography.
• Hjornevik, Trine; Schoultz, Bent Wilhelm; Gjerstad, Johannes; Henriksen, Gjermund & Willoch, Frode (2009). C-fibre LTP is associated with dynamic changes in opioid neurotransmission in the brain. Journal of Cerebral Blood Flow and Metabolism.  ISSN 0271-678X.  29, s S369- S370
• Hjornevik, Trine; Schoultz, Bent Wilhelm; Gjerstad, Johannes; Henriksen, Gjermund & Willoch, Frode (2009). C-fibre LTP is associated with dynamic changes in opioid neurotransmission in the brain.
• Hjornevik, Trine; Schoultz, Bent Wilhelm; Marton, Janos; Gjerstad, Johannes; Drzezga, Alexander; Henriksen, Gjermund & Willoch, Frode (2009). Spinal LTP is associated with reduced opioid neurotransmission in the rat brain.
• Hjørnevik, Trine; Qu, Hong; Gjerstad, Johannes; Jacobsen, Line; Schoultz, Bent Wilhelm; Henriksen, Gjermund; Bjaalie, Jan G. & Willoch, Frode (2007). 18F FDG PET Measurement of long-term potentiation in rat brain.

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