Alexandra Vallet: Biomechanical approach to brain ageing


Registration Link: 

Abstract: Frailty is a multi-system dysregulation leading to a loss of physiological reserve known to predict dementia. However, its link with neurodegenerative alterations of the central nervous system (CNS) is not well understood at present. We investigated the association between the biomechanical response of the CNS and frailty in older adults suspected of normal pressure hydrocephalus (NPH) presenting markers of multiple comorbid neurodegenerative pathologies, including pathologies of Alzheimer’s Disease. The biomechanical response of the CNS was characterized from phase contrast magnetic resonance imaging and intracranial pressure monitoring during a lumbar infusion test. Frailty was assessed with an index of health deficit accumulation. We found a significant association between the CNS biomechanical response and frailty, with an effect size comparable to that between frailty and age, the latter being the strongest known risk factor of frailty. The CNS biomechanical characterization may help to understand how frailty is related to neurodegeneration and detect the shift from normal to pathological brain ageing.

This talk is part of the Mechanics Lunch Seminar series. That means 20min talks plus discussion in an informal setting.

Important: Due to the limited available space during the Corona situation, we require you to register to attend this event. Please find the registration link in the description above. If there is demand, we can arrange online participation on short notice. If there is any problem with the registration or you have questions regarding the seminar please contact Timo Koch (timokoch at

We kindly remind everyone of the UiO guidelines for corona prevention . During the seminar keep at least 1m distance to each other and follow the usual guidelines.

Published Oct. 16, 2020 3:27 PM - Last modified Oct. 16, 2020 3:38 PM