his talk discusses a nonparametric inference framework for occupation time curves derived from wearable device data. Such curves provide the total time a subject maintains activity above a given level as a function of that level. Taking advantage of the monotonicity and smoothness properties of these curves, we develop a likelihood ratio approach to construct confidence bands for mean occupation time curves. An extension to fitting concurrent functional regression models is also developed. Application to wearable device data from an ongoing study of an experimental gene therapy for mitochondrial DNA depletion syndrome will be discussed. Based on joint work with Hsin-Wen Chang (Academia Sinica).
Structural equation models are simultaneous equation regression models, whose variables are latent, and measured via a confirmatory factor model (that is, with measurement error and repeated measurements). When the functional form of the simultaneous equation system is unknown, it has previously been observed in simulations that factor scores inputted into non-parametric regression methods approximate the true functional form. Factor scores estimate the latent variables (per person), and several types exist. We provide a theoretical (though population-based) analysis of this procedure, and provide assumptions under which it is theoretically justified in using Bartlett factor scores, which are simple linear transformations of the data. In simulations, we compare this suggestion to an already available though understudied non-linear and computationally heavy procedure, and observe that the simple Bartlett approach appears to work better.