Guest lectures and seminars - Page 13
We have developed a pump-less recirculation Organ-on-Chip (rOoC) platform that generates a directional gravity-driven flow. This platform can be adapted to various flow conditions and enables the study of endothelial lining, blood vessel sprouting, circulation of immune cells, pathogens or other particles, and incorporation of 3D cell models like organoids. Additionally, we have developed a computational model to predict shear stress and mass transport within the rOoC, allowing for customization of the platform for various use-cases.
The rOoC platform is very versatile and can be used to model for instance drug-induced liver-injury (DILI) that mimics the complex interaction between resident human stem cell-derived liver organoids (3D-HLO) and circulating immune cells. Moreover, we show the functional crosstalk between 3D-HLOs and human pancreatic islets to model the onset of type-2 diabetes.
Markus Spitzweck (Universität Osnabrück) will present the talk «Representation categories and motives».
This seminar will consist of two separate presentations, each about 15-minute long.
1) Magnetic Quincke Rollers with tunable single particle dynamics and collective states
2) Electrically controllable ferrofluids
We further discuss the generalization of these results to compact operators in L2, and explain how they can be used to both describe the out-performance of smooth spline approximations of solutions to differential equations when compared to classical finite element methods, and to solve the outlier-problem in isogeometric analysis.
This talk is based on work done in collaboration with Michael Floater, Carla Manni and Hendrik Speleers.