Christian Magnus Page

Bilde av Christian Magnus Page
English version of this page
Mobiltelefon +47 99574451
Rom 822
Brukernavn
Besøksadresse Moltke Moes vei 35 Niels Henrik Abels hus 0851 Oslo
Postadresse Postboks 1053 Blindern 0316 Oslo

Academic interests

My research interested is focused around modeling of chronic disease risk and reproductive biology. I am interested in using statistical models to understand the heterogeneity in human disease risk, and how to assessing the contribution from genetics and environment, both separately and in conjunction. This includes using models for family relationships and geographical models to estimate disease risk in different family constellations and different parts of the country. 

A large part of my research has also been focused on methodology when studying reproductive biology and pregnancy health, including how to assess safety of medication use during pregnancy. This includes how to draw causal inference in from large population wide registry and genetic studies of pregnant woman and assess later outcomes in the children depending on maternal use of medication etc. 

Courses taught

  • MF9380 (Guest lecture) 
  • NORBIS: Large genetic studies in biobanks: from registries screening, to interpretation of GWAS and beyond (Guest lecture) 

Background

I have a bachelor’s degree in mathematical biology from NTNU (2010) and a master’s degree in statistics from the same university (2012). I defended my PhD in genetic epidemiology at the medical faculty (UiO) in 2016, and have had different post-doc and research positions in genetic epidemiology and statistical genetics since then. 

Positions held

For a full CV, see my ORCID

  • 2015-2020 Post-doc Oslo Centre for Biostatistics and Epidemiology 
  • 2015 -> d.d. Researcher at Norwegian Institute of Public Health 
  • 2019 mar-dec -> Visiting scientist at Columbia School of Public Health, New York

Partners

Emneord: genetisk epidemiologi, beregnings epidemiologi, Statistisk genetikk, Befolkningsgenetikk, Statistikk og biostatistikk

Publikasjoner

  • Hernaez Camba, Alvaro; Rogne, Tormod; Skåra, Karoline Hansen; Håberg, Siri Eldevik; Page, Christian Magnus & Fraser, Abigail [Vis alle 9 forfattere av denne artikkelen] (2021). Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study. Human Reproduction. ISSN 0268-1161. 36(12), s. 3141–3151. doi: 10.1093/humrep/deab224.
  • Haftorn, Kristine Løkås; Lee, Yunsung; Denault, William Robert Paul; Page, Christian Magnus; Nustad, Haakon Egdetveit & Lyle, Robert [Vis alle 17 forfattere av denne artikkelen] (2021). An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies. Clinical Epigenetics. ISSN 1868-7075. 13. doi: 10.1186/s13148-021-01055-z. Fulltekst i vitenarkiv
  • Caramaschi, Doretta; Jungius, James; Page, Christian M.; Novakovic, Boris; Saffery, Richard & Halliday, Jane [Vis alle 13 forfattere av denne artikkelen] (2021). Association of medically assisted reproduction with offspring cord blood DNA methylation across cohorts. Human Reproduction. ISSN 0268-1161. 36(8), s. 2403–2413. doi: 10.1093/humrep/deab137. Fulltekst i vitenarkiv
  • Mygland, Line; Mahmuda, Shoshy; Strand, Martin Frank; Olsen, Petter Angell; Aizenshtadt, Aleksandra & Lund, Kaja [Vis alle 21 forfattere av denne artikkelen] (2021). Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines. iScience. ISSN 2589-0042. 24(7). doi: 10.1016/j.isci.2021.102807. Fulltekst i vitenarkiv
  • Sharp, Gemma C.; Alfano, Rossella; Ghantous, Akram; Urquiza, Jose; Rifas-Shiman, Sheryl L. & Page, Christian [Vis alle 46 forfattere av denne artikkelen] (2021). Paternal body mass index and offspring DNA methylation: findings from the PACE consortium. International Journal of Epidemiology. ISSN 0300-5771. 50(4), s. 1297–1315. doi: 10.1093/ije/dyaa267. Fulltekst i vitenarkiv
  • Sammallahti, Sara; Hidalgo, Andrea P. Cortes; Tuominen, Samuli; Malmberg, Anni; Mulder, Rosa H. & Brunst, Kelly J. [Vis alle 51 forfattere av denne artikkelen] (2021). Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation. Molecular Psychiatry. ISSN 1359-4184. 26, s. 1832–1845. doi: 10.1038/s41380-020-00976-0.
  • Vehmeijer, Florianne O.; Küpers, Leanne K; Sharp, Gemma C.; Salas, Lucas A.; Lent, Samantha & Jima, Dereje D. [Vis alle 85 forfattere av denne artikkelen] (2020). DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies. Genome Medicine. ISSN 1756-994X. 12(105), s. 1–15. doi: 10.1186/s13073-020-00810-w. Fulltekst i vitenarkiv
  • Lee, Yunsung; Jacobsen, Kristine Løkås; Denault, William Robert Paul; Nustad, Haakon Egdetveit; Page, Christian & Lyle, Robert [Vis alle 19 forfattere av denne artikkelen] (2020). Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array. BMC Genomics. ISSN 1471-2164. 21(1). doi: 10.1186/s12864-020-07168-8. Fulltekst i vitenarkiv
  • Merid, Simon Kebede; Novoloaca, Alexei; Sharp, Gemma C.; Küpers, Leanne K.; Tho, Alvin T. & Roy, Ritu [Vis alle 50 forfattere av denne artikkelen] (2020). Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age. Genome Medicine. ISSN 1756-994X. 12. doi: 10.1186/s13073-020-0716-9. Fulltekst i vitenarkiv
  • Page, Christian; Djordjilovic, Vera; Nøst, Therese Haugdahl; Ghiasvand, Reza; Sandanger, Torkjel M & Frigessi Di Rattalma, Arnoldo [Vis alle 8 forfattere av denne artikkelen] (2020). Lifetime ultraviolet radiation exposure and DNA methylation in blood leukocytes: The Norwegian Women and Cancer Study. Scientific Reports. ISSN 2045-2322. 10, s. 1–8. doi: 10.1038/s41598-020-61430-3. Fulltekst i vitenarkiv
  • Bucher-Johannessen, Cecilie; Page, Christian Magnus; Haugen, Trine B.; Wojewodzic, Marcin; Fosså, Sophie Dorothea & Grotmol, Tom [Vis alle 8 forfattere av denne artikkelen] (2019). Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome. Clinical Epigenetics. ISSN 1868-7075. 11:179, s. 1–13. doi: 10.1186/s13148-019-0764-4. Fulltekst i vitenarkiv
  • Kazmi, Nabila; Sharp, Gemma C.; Reese, Sarah E.; Vehmeijer, Florianne O.; Lahti, Jari & Page, Christian Magnus [Vis alle 43 forfattere av denne artikkelen] (2019). Hypertensive disorders of pregnancy and DNA methylation in newborns: Findings from the pregnancy and childhood epigenetics consortium. Hypertension. ISSN 0194-911X. 74(2), s. 375–383. doi: 10.1161/HYPERTENSIONAHA.119.12634. Fulltekst i vitenarkiv
  • Czamara, Darina; Eraslan, Gökçen; Page, Christian Magnus; Lahti, Jari; Lahti-Pulkkinen, Marius & Hämäläinen, Esa [Vis alle 34 forfattere av denne artikkelen] (2019). Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nature Communications. ISSN 2041-1723. 10:2548, s. 1–18. doi: 10.1038/s41467-019-10461-0. Fulltekst i vitenarkiv
  • Wikenius, Ellen; Myhre, Anne Margrethe; Page, Christian Magnus; Moe, Vibeke; Smith, Lars & Heiervang, Einar [Vis alle 8 forfattere av denne artikkelen] (2019). Prenatal maternal depressive symptoms and infant DNA methylation: a longitudinal epigenome-wide study. Nordic Journal of Psychiatry. ISSN 0803-9488. 73(4-5), s. 257–263. doi: 10.1080/08039488.2019.1613446.
  • Djordjilovic, Vera; Page, Christian Magnus; Gran, Jon Michael; Nøst, Therese Haugdahl; Sandanger, Torkjel M & Veierød, Marit Bragelien [Vis alle 7 forfattere av denne artikkelen] (2019). Global test for high-dimensional mediation: Testing groups of potential mediators. Statistics in Medicine. ISSN 0277-6715. 38(18), s. 3346–3360. doi: 10.1002/sim.8199. Fulltekst i vitenarkiv
  • Küpers, Leanne K.; Monnereau, Claire; Sharp, Gemma C.; Yousefi, Paul; Salas, Lucas A. & Ghantous, Akram [Vis alle 127 forfattere av denne artikkelen] (2019). Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. Nature Communications. ISSN 2041-1723. 10:1893, s. 1–11. doi: 10.1038/s41467-019-09671-3. Fulltekst i vitenarkiv
  • Magnus, Maria Christine; Karlstad, Øystein; Parr, Christine Louise; Page, Christian; Nafstad, Per & Magnus, Per [Vis alle 10 forfattere av denne artikkelen] (2019). Maternal history of miscarriages and measures of fertility in relation to childhood asthma. Thorax. ISSN 0040-6376. 74(2), s. 106–113. doi: 10.1136/thoraxjnl-2018-211886. Fulltekst i vitenarkiv
  • Magnus, Maria Christine; Miliku, Kozeta; Bauer, Anna; Engel, Stephanie M.; Felix, Janine F. & Jaddoe, Vincent W.V. [Vis alle 18 forfattere av denne artikkelen] (2018). Vitamin D and risk of pregnancy-related hypertensive disorders: Mendelian randomization study. Obstetrical and Gynecological Survey. ISSN 0029-7828. 73(11), s. 617–619. doi: 10.1097/01.ogx.0000549828.61856.d0.
  • Reese, Sarah E; Xu, Cheng-Jian; Den Dekker, Herman T; Lee, Mi Kyeong; Sikdar, Sinjini & Ruiz-Arenas, Carlos [Vis alle 52 forfattere av denne artikkelen] (2018). Epigenome-wide meta-analysis of DNA methylation and childhood asthma. Journal of Allergy and Clinical Immunology. ISSN 0091-6749. 143(6), s. 2062–2074. doi: 10.1016/j.jaci.2018.11.043. Fulltekst i vitenarkiv
  • Kvaløy, Kirsti; Page, Christian & Holmen, Turid Lingaas (2018). Epigenome-wide methylation differences in a group of lean and obese women – A HUNT Study. Scientific Reports. ISSN 2045-2322. 8. doi: 10.1038/s41598-018-34003-8. Fulltekst i vitenarkiv
  • Page, Christian; Vos, Linda; Rounge, Trine Ballestad; Harbo, Hanne Flinstad & Kulle, Bettina (2018). Assessing genome-wide significance for the detection of differentially methylated regions. Statistical Applications in Genetics and Molecular Biology. ISSN 1544-6115. 17(6). doi: 10.1515/sagmb-2017-0050. Fulltekst i vitenarkiv
  • LeBlanc, Marissa; Nustad, Haakon Egdetveit; Zucknick, Manuela & Page, Christian (2018). Quality control for Illumina 450K methylation data in the absence of iDat files using correlation structure in pedigrees and repeated measures. BMC Genetics. ISSN 1471-2156. 19. doi: 10.1186/s12863-018-0636-5. Fulltekst i vitenarkiv
  • Nustad, Haakon Egdetveit; Almeida, Marci; Canty, AJ; LeBlanc, Marissa; Page, Christian & Melton, Philip E. (2018). Epigenetics, heritability and longitudinal analysis. BMC Genetics. ISSN 1471-2156. 19, s. 99–108. doi: 10.1186/s12863-018-0648-1. Fulltekst i vitenarkiv
  • Nustad, Haakon Egdetveit; Page, Christian; Reiner, Andrew Henry; Zucknick, Manuela & LeBlanc, Marissa (2018). A Bayesian mixed modeling approach for estimating heritability. BMC Proceedings. ISSN 1753-6561. 12, s. 117–122. doi: 10.1186/s12919-018-0131-z. Fulltekst i vitenarkiv
  • Magnus, Maria Christine; Miliku, Kozeta; Bauer, Anna; Engel, Stephanie M.; Felix, Janine F. & Jaddoe, Vincent W.V. [Vis alle 18 forfattere av denne artikkelen] (2018). Vitamin D and risk of pregnancy related hypertensive disorders: Mendelian randomisation study. BMJ (Clinical Research Edition). ISSN 0959-8138. 361. doi: 10.1136/bmj.k2167. Fulltekst i vitenarkiv
  • Størdal, Ketil; McArdle, Harry J.; Hayes, Helen; Tapia, German; Viken, Marte K & Lund-Blix, Nicolai Andre [Vis alle 17 forfattere av denne artikkelen] (2018). Prenatal iron exposure and childhood type 1 diabetes. Scientific Reports. ISSN 2045-2322. 8. doi: 10.1038/s41598-018-27391-4. Fulltekst i vitenarkiv
  • Parr, Christine Louise; Magnus, Maria Christine; Karlstad, Øystein; Holvik, Kristin; Lund-Blix, Nicolai Andre & Haugen, Margaretha [Vis alle 12 forfattere av denne artikkelen] (2018). Vitamin A and D intake in pregnancy, infant supplementation, and asthma development: The Norwegian Mother and Child Cohort. American Journal of Clinical Nutrition. ISSN 0002-9165. 107(5), s. 789–798. doi: 10.1093/ajcn/nqy016. Fulltekst i vitenarkiv
  • Veierød, Marit Bragelien; Page, Christian; Aaserud, Stein; Bassarova, Assia Vassileva; Jacobsen, Kari Dolven & Helsing, Per [Vis alle 7 forfattere av denne artikkelen] (2018). Melanoma staging: Varying precision and terminal digit clustering in Breslow thickness data is evident in a population-based study. Journal of American Academy of Dermatology. ISSN 0190-9622. 79(1), s. 118–125.e1. doi: 10.1016/j.jaad.2018.03.023. Fulltekst i vitenarkiv
  • Sharp, Gemma C.; Arathimos, Ryan; Reese, Sarah E.; Page, Christian; Felix, Janine F. & Küpers, Leanne K. [Vis alle 24 forfattere av denne artikkelen] (2018). Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts. Epigenomics. ISSN 1750-1911. 10(1), s. 27–42. doi: 10.2217/epi-2017-0095.
  • Winsvold, Bendik K S; Palta, P; Eising, Else; Page, Christian; Van Den Maagdenberg, Arn M.J.M. & Palotie, Aarno [Vis alle 7 forfattere av denne artikkelen] (2018). Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study. Cephalalgia. ISSN 0333-1024. 38(2), s. 312–322. doi: 10.1177/0333102417690111. Fulltekst i vitenarkiv
  • Magnus, Maria Christine; Wright, Rosalind J.; Røysamb, Espen; Parr, Christine Louise; Karlstad, Øystein & Page, Christian [Vis alle 10 forfattere av denne artikkelen] (2018). Association of Maternal Psychosocial Stress with Increased Risk of Asthma Development in Offspring. American Journal of Epidemiology. ISSN 0002-9262. 187(6), s. 1199–1209. doi: 10.1093/aje/kwx366.
  • Felix, Janine F.; Joubert, Bonnie R.; Baccarelli, Andrea A.; Sharp, Gemma C.; Almqvist, Catarina & Annesi-Maesano, Isabella [Vis alle 58 forfattere av denne artikkelen] (2017). Cohort profile: Pregnancy and childhood epigenetics (PACE) consortium. International Journal of Epidemiology. ISSN 0300-5771. 47(1), s. 22–23u. doi: 10.1093/ije/dyx190. Fulltekst i vitenarkiv
  • Sharp, Gemma C; Salas, Lucas A; Monnereau, Claire; Allard, Catherine; Yousefi, Paul & Everson, Todd M. [Vis alle 85 forfattere av denne artikkelen] (2017). Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. Human Molecular Genetics. ISSN 0964-6906. 26(20), s. 4067–4085. doi: 10.1093/hmg/ddx290. Fulltekst i vitenarkiv
  • Brix, Maiken Kirkegaard; Westman, Eric; Simmons, Andrew; Ringstad, Geir; Eide, Per Kristian & Wagner-Larsen, Kari Strøno [Vis alle 9 forfattere av denne artikkelen] (2017). The Evans' Index revisited: New cut-off levels for use in radiological assessment of ventricular enlargement in the elderly. European Journal of Radiology. ISSN 0720-048X. 95, s. 28–32. doi: 10.1016/j.ejrad.2017.07.013.
  • Valeri, Linda; Reese, Sarah L; Zhao, Shanshan; Page, Christian; Nystad, Wenche & Coull, Brent A [Vis alle 7 forfattere av denne artikkelen] (2017). Misclassified exposure in epigenetic mediation analyses. Does DNA methylation mediate effects of smoking on birthweight? Epigenomics. ISSN 1750-1911. 9(3), s. 253–265. doi: 10.2217/epi-2016-0145.
  • Gruzieva, Olena; Xu, Cheng-Jian; Breton, Carrie V; Annesi-Maesano, Isabella; Anto, Josep M & Auffray, Charles [Vis alle 36 forfattere av denne artikkelen] (2017). Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure. Environmental Health Perspectives. ISSN 0091-6765. 125(1), s. 104–110. doi: 10.1289/EHP36. Fulltekst i vitenarkiv
  • Rounge, Trine Ballestad; Page, Christian; Lepistö, Maija; Ellonen, Pekka; Andreassen, Bettina Kulle & Weiderpass, Elisabete (2016). Genome-wide DNA methylation in saliva and body size of adolescent girls. Epigenomics. ISSN 1750-1911. 8(11), s. 1495–1505. doi: 10.2217/epi-2016-0045. Fulltekst i vitenarkiv
  • Wikenius, Ellen; Moe, Vibeke; Malde, Marian Kjellevold; Smith, Lars; Lyle, Robert & Waagbø, Rune [Vis alle 8 forfattere av denne artikkelen] (2016). The association between hair cortisol and self-reported symptoms of depression in pregnant women. PLOS ONE. ISSN 1932-6203. 11(9). doi: 10.1371/journal.pone.0161804.
  • Bohlin, Jon; Håberg, Siri Eldevik; Magnus, Per; Reese, Sarah E; Gjessing, Håkon K. & Magnus, Maria Christine [Vis alle 10 forfattere av denne artikkelen] (2016). Prediction of gestational age based on genome-wide differentially methylated regions. Genome Biology. ISSN 1465-6906. 17(207). doi: 10.1186/s13059-016-1063-4. Fulltekst i vitenarkiv
  • Gervin, Kristina; Page, Christian; Aass, Hans Christian; Jansen, Michelle A; Fjeldstad, Heidi & Andreassen, Bettina Kulle [Vis alle 17 forfattere av denne artikkelen] (2016). Cell type specific DNA methylation in cord blood: a 450K-reference data set and cell count-based validation of estimated cell type composition. Epigenetics. ISSN 1559-2294. 11(9), s. 690–698. doi: 10.1080/15592294.2016.1214782.
  • Suderman, Matthew; Stene, Lars Christian; Bohlin, Jon; Page, Christian; Holvik, Kristin & Parr, Christine Louise [Vis alle 13 forfattere av denne artikkelen] (2016). 25-Hydroxyvitamin D in pregnancy and genome wide cord blood DNA methylation in two pregnancy cohorts (MoBa and ALSPAC). Journal of Steroid Biochemistry and Molecular Biology. ISSN 0960-0760. 159, s. 102–109. doi: 10.1016/j.jsbmb.2016.03.005. Fulltekst i vitenarkiv
  • Berge, Tone; Leikfoss, Ingvild Sørum; Brorson, Ina Skaara; Bos, Steffan Daniel; Page, Christian & Gustavsen, Marte Wendel [Vis alle 13 forfattere av denne artikkelen] (2016). The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by Vitamin D in CD4+ T cells. Genes and Immunity. ISSN 1466-4879. 17(2), s. 118–127. doi: 10.1038/gene.2015.61.
  • Page, Christian; Baranzini, Sergio E.; Mevik, Bjørn-Helge; Bos, Steffan Daniel; Harbo, Hanne Flinstad & Kulle, Bettina (2015). Assessing the Power of Exome Chips. PLOS ONE. ISSN 1932-6203. 10(10). doi: 10.1371/journal.pone.0139642. Fulltekst i vitenarkiv
  • Bos, Steffan Daniel; Page, Christian; Kulle, Bettina; Elboudwarej, Emon; Gustavsen, Marte Wendel & Briggs, Farren [Vis alle 12 forfattere av denne artikkelen] (2015). Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis. PLOS ONE. ISSN 1932-6203. 10(3). doi: 10.1371/journal.pone.0117403.
  • Gustavsen, Marte Wendel; Page, Christian; Moen, Stine Marit; Bjølgerud, Anja; Berg-Hansen, Pål & Nygaard, Gro Owren [Vis alle 10 forfattere av denne artikkelen] (2014). Environmental exposures and the risk of multiple sclerosis investigated in a Norwegian case-control study. BMC Neurology. ISSN 1471-2377. 14(1). doi: 10.1186/s12883-014-0196-x. Fulltekst i vitenarkiv

Se alle arbeider i Cristin

  • Parr, Christine Louise; Page, Christian; Holvik, Kristin; Sandanger, Torkjel M; Nøst, Therese Haugdahl & Magnus, Maria Christine [Vis alle 13 forfattere av denne artikkelen] (2017). Pregnancy fatty acid status and newborn DNA methylation: the MoBa pregnancy cohort.
  • Kvaløy, Kirsti; Page, Christian & Holmen, Turid Lingaas (2017). Epigenome-wide methylation differences in a group of lean and obese women - A HUNT Study.
  • Kvaløy, Kirsti; Page, Christian & Holmen, Turid Lingaas (2017). Epigenetiske forskjeller knyttet til fedme blant kvinner – en HUNT studie .

Se alle arbeider i Cristin

Publisert 3. juni 2020 15:25 - Sist endret 25. juni 2020 12:55