Precision medicine

Precision medicine is a paradigmatic change to leverage molecular information in diagnostics and therapy. The change is taking place now. Our aim is to develop algorithms and tools, as well as contributing to implement and facilitate uptake of this approach.

Principal Investigator:  Eivind Hovig

Recent publications 

Roadmap for a precision-medicine initiative in the Nordic region.
Njølstad PR, Andreassen OA, Brunak S, Børglum AD, Dillner J, Esko T, Franks PW, Freimer N, Groop L, Heimer H, Hougaard DM, Hovig E, Hveem K, Jalanko A, Kaprio J, Knudsen GP, Melbye M, Metspalu A, Mortensen PB, Palmgren J, Palotie A, Reed W, Stefánsson H, Stitziel NO, Sullivan PF, Thorsteinsdóttir U, Vaudel M, Vuorio E, Werge T, Stoltenberg C, Stefánsson K. Nat Genet. 2019 Apr 15. doi: 10.1038/s41588-019-0391-1. PMID: 30988515

2. Integrative genomic analysis of peritoneal malignant mesothelioma: understanding a case with extraordinary chemotherapy response. Lund-Andersen C, Nakken S, Nygård S, Fromm B, Aasheim LB, Davidson B, Julsrud L, Abrahamsen TW, Kristensen AT, Dybdahl B, Larsen SG, Hovig E, Flatmark K. Cold Spring Harb Mol Case Stud. 2019 Apr 1;5(2). pii: a003566. 


3. Causes for Frequent Pathogenic BRCA1 Variants Include Low Penetrance in Fertile Ages, Recurrent De-Novo Mutations and Genetic Drift. Møller P, Dominguez-Valentin M, Rødland EA, Hovig E. Cancers (Basel). 2019 Jan 23;11(2). pii: E132.  PMID: 30678073 

4. Ancient genomes from Iceland reveal the making of a human population. Ebenesersdóttir SS, Sandoval-Velasco M, Gunnarsdóttir ED, Jagadeesan A, Guðmundsdóttir VB, Thordardóttir EL, Einarsdóttir MS, Moore KHS, Sigurðsson Á, Magnúsdóttir DN, Jónsson H, Snorradóttir S, Hovig E, Møller P, Kockum I, Olsson T, Alfredsson L, Hansen TF, Werge T, Cavalleri GL, Gilbert E, Lalueza-Fox C, Walser JW 3rd, Kristjánsdóttir S, Gopalakrishnan S, Árnadóttir L, Magnússon ÓÞ, Gilbert MTP, Stefánsson K, Helgason A.
Science. 2018 Jun 1;360(6392):1028-1032. PMID: 29853688

5. Sample-Index Misassignment Impacts Tumour Exome Sequencing.
Vodák D, Lorenz S, Nakken S, Aasheim LB, Holte H, Bai B, Myklebost O, Meza-Zepeda LA, Hovig E. Sci Rep. 2018 Mar 28;8(1):5307.  PMID: 29593270 

Collaborations

Several of the groups collaborate with various research group at Oslo University Hospital and elsewhere towards various disease and questions in precision medicine
 

Published Apr. 2, 2019 2:55 PM - Last modified May 16, 2019 12:08 PM