Eleonora Jonasova Parelius

• Langstad, Kristoffer; Parelius, Eleonora Jonasova; Løvold, Stian & Volgyes, David (2025). Using Monoscopic Multispectral Earth Observation Images to Predict Terrain Features With Deep Neural Networks. IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing. ISSN 1939-1404. 18, p. 21954–21966. doi: 10.1109/JSTARS.2025.3602630. Full text in Research Archive
• Langstad, Kristoffer; Volgyes, David & Parelius, Eleonora Jonasova (2024). Atmospheric corrections for Earth observation with deep learning, IGARSS 2024 - 2024 IEEE International Geoscience and Remote Sensing Symposium. IEEE (Institute of Electrical and Electronics Engineers). ISSN 9798350360325. doi: 10.1109/IGARSS53475.2024.10642799. Full text in Research Archive
• Jonasova, Eleonora Parelius (2023). A Review of Deep-Learning Methods for Change Detection in Multispectral Remote Sensing Images. Remote Sensing. doi: 10.3390/rs15082092. Full text in Research Archive Show summary

  : Remote sensing is a tool of interest for a large variety of applications. It is becomingincreasingly more useful with the growing amount of available remote sensing data. However, thelarge amount of data also leads to a need for improved automated analysis. Deep learning is anatural candidate for solving this need. Change detection in remote sensing is a rapidly evolvingarea of interest that is relevant for a number of fields. Recent years have seen a large number ofpublications and progress, even though the challenge is far from solved. This review focuses on deeplearning applied to the task of change detection in multispectral remote-sensing images. It providesan overview of open datasets designed for change detection as well as a discussion of selected modelsdeveloped for this task—including supervised, semi-supervised and unsupervised. Furthermore, thechallenges and trends in the field are reviewed, and possible future developments are considered.

• Jonasova, Eleonora Parelius; Stokke, Bjørn Torger & Prot, Victorien Emile (2022). Interrelation between swelling, mechanical constraints and reaction–diffusion processes in molecular responsive hydrogels. Soft Matter. ISSN 1744-683X. 18, p. 1510–1524. doi: 10.1039/d1sm01445e. Full text in Research Archive
• Jonasova, Eleonora Parelius & Stokke, Bjørn Torger (2020). Morpholino target molecular properties affect the swelling process of oligomorpholino-functionalized responsive hydrogels. Polymers. 12(2). doi: 10.3390/polym12020268. Full text in Research Archive Show summary

  Responsive hydrogels featuring DNA as a functional unit are attracting increasing interest due to combination of versatility and numerous applications. The possibility to use nucleic acid analogues opens for further customization of the hydrogels. In the present work, the commonly employed DNA oligonucleotides in DNA-co-acrylamide responsive hydrogels are replaced by Morpholino oligonucleotides. The uncharged backbone of this nucleic acid analogue makes it less susceptible to possible enzymatic degradation. In this work we address fundamental issues related to key processes in the hydrogel response; such as partitioning of the free oligonucleotides and the strand displacement process. The hydrogels were prepared at the end of optical fibers for interferometric size monitoring and imaged using confocal laser scanning microscopy of the fluorescently labeled free oligonucleotides to observe their apparent diffusion and accumulation within the hydrogels. Morpholino-based hydrogels’ response to Morpholino targets was compared to DNA hydrogels’ response to DNA targets of the same base-pair sequence. Non-binding targets were observed to be less depleted in Morpholino hydrogels than in DNA hydrogels, due to their electroneutrality, resulting in faster kinetics for Morpholinos. The electroneutrality, however, also led to the total swelling response of the Morpholino hydrogels being smaller than that of DNA, since their lack of charges eliminates swelling resulting from the influx of counter-ions upon oligonucleotide binding. We have shown that employing nucleic acid analogues instead of DNA in hydrogels has a profound effect on the hydrogel response.

• Jonasova, Eleonora Parelius; Bjørkøy, Astrid & Stokke, Bjørn Torger (2020). Toehold length of target ssDNA affects its reaction-diffusion behavior in DNA-responsive DNA-co-acrylamide hydrogels. Biomacromolecules. ISSN 1525-7797. 21(5), p. 1687–1699. doi: 10.1021/acs.biomac.9b01515. Full text in Research Archive Show summary

  In the present study, we expand on the understanding of hydrogels with embedded deoxyribonucleic acid (DNA) cross-links, from the overall swelling to characterization of processes that precede the swelling. The hydrogels respond to target DNA strands because of a toehold-mediated strand displacement reaction in which the target strand binds to and opens the dsDNA cross-link. The spatiotemporal evolution of the diffusing target ssDNA was determined using confocal laser scanning microscopy (CLSM). The concentration profiles revealed diverse partitioning of the target DNA inside the hydrogel as compared with the immersing solution: excluding a nonbinding DNA, while accumulating a binding target. The data show that a longer toehold results in faster cross-link opening but reduced diffusion of the target, thus resulting in only a moderate increase in the overall swelling rate. The parameters obtained by fitting the data using a reaction-diffusion model were discussed in view of the molecular parameters of the target ssDNA and hydrogels.

• Jonasova, Eleonora Parelius & Stokke, Bjørn Torger (2016). Bioresponsive DNA-co-polymer hydrogels for fabrication of sensors. Current Opinion in Colloid & Interface Science. ISSN 1359-0294. 26, p. 1–8. doi: 10.1016/j.cocis.2016.07.001. Full text in Research Archive
• Jonasova, Eleonora Parelius; Bjørkøy, Astrid & Stokke, Bjørn Torger (2016). Recovering fluorophore concentration profiles from confocal images near lateral refractive index step changes. Journal of Biomedical Optics. ISSN 1083-3668. 21(12). doi: 10.1117/1.JBO.21.12.126014. Full text in Research Archive Show summary

  Optical aberrations due to refractive index mismatches occur in various types of microscopy due to refractive differences between the sample and the immersion fluid or within the sample. We study the effects of lateral refractive index differences by fluorescence confocal laser scanning microscopy due to glass or polydimethylsiloxane cuboids and glass cylinders immersed in aqueous fluorescent solution, thereby mimicking realistic imaging situations in the proximity of these materials. The reduction in fluorescence intensity near the embedded objects was found to depend on the geometry and the refractive index difference between the object and the surrounding solution. The observed fluorescence intensity gradients do not reflect the fluorophore concentration in the solution. It is suggested to apply a Gaussian fit or smoothing to the observed fluorescence intensity gradient and use this as a basis to recover the fluorophore concentration in the proximity of the refractive index step change. The method requires that the reference and sample objects have the same geometry and refractive index. The best results were obtained when the sample objects were also used for reference since small differences such as uneven surfaces will result in a different extent of aberration.

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• Zurzul, Natasa; Jonasova, Eleonora Parelius & Stokke, Bjørn Torger (2017). Development of sensors based on molecule responsive hydrogels with an interferometric readout. Full text in Research Archive
• Jonasova, Eleonora Parelius; Bjørkøy, Astrid & Stokke, Bjørn Torger (2016). Effect of target molecule binding properties on DNA-responsive hydrogel swelling. Full text in Research Archive
• Jonasova, Eleonora Parelius; Bjørkøy, Astrid & Stokke, Bjørn Torger (2016). Studying processes leading to swelling of DNA-responsive hydrogels. Full text in Research Archive
• Jonasova, Eleonora Parelius; Bjørkøy, Astrid & Stokke, Bjørn Torger (2015). Challenges encountered in quantitative confocal laser scanning microscopy of samples containing embedded objects of differing refractive index. Full text in Research Archive
• Jonasova, Eleonora Parelius & Stokke, Bjørn Torger (2015). Understanding DNA responsive hydrogels. Full text in Research Archive
• Stokke, Bjørn Torger; Psonka-Antonczyk, Katarzyna Maria; Brede, Gaute; Ribe, Jonas Myren & Jonasova, Eleonora (2014). Biomarker characterization aided by nanoscale approaches. Full text in Research Archive

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