Stephen Hladky: Extravascular routes for fluid movement in normal fluid homeostasis and hydrocephalus

Stephen Hladky presents work in collaboration with Margery A. Barrand (both Department of Pharmacology, University of Cambridge).

Abstract: Extravascular fluxes of marker substances and some wastes are sufficiently fast that there is almost certain to be a component of flow augmenting their diffusion in the parenchyma. There have been two major proposals for how this flow is produced and where it is important. The evidence for the classical and glymphatic hypotheses will be reviewed. Extravascular, and in particular perivascular, routes for fluid movement out of the parenchyma to lymphatics may be important in the development of hydrocephalus.