Audun Kvalvaag: Clathrin mediates bidirectional membrane transfer during T cell activation

Abstract: T cell activation is initiated upon T cell receptor (TCR) binding to cognate peptide-MHC complexes on the surface of antigen presenting cells (APCs). This initiates the formation of the immunological synapse – a specialized hub for bidirectional membrane transfer between T cells and APCs which is essential for processes such as downregulation of triggered TCR and T cell-mediated stimulation of B cells. Here, I will present some recent advancements in our understanding of how this is regulated.

This talk is part of the Mechanics Lunch Seminar series. Bring-your-own-lunch and lots of questions. Hybrid format via Zoom possible on demand (contact timokoch at

Published Apr. 19, 2022 4:12 PM - Last modified Apr. 27, 2022 9:55 AM