Vilde Bruhn Kinneberg

• Voje, Kjetil L.; Saulsbury, James Gabriel; Starrfelt, Jostein; Latorre, Daniel Varajão; Rojas, Alexis & Kinneberg, Vilde Bruhn [Vis alle 10 forfattere av denne artikkelen] (2023). Measurement theory and paleobiology. Trends in Ecology & Evolution. ISSN 0169-5347. 38, s. 1165–1176. doi: 10.1016/j.tree.2023.08.005. Fulltekst i vitenarkiv
• Kinneberg, Vilde Bruhn; Lü, Dabao Sun; Peris, David; Ravinet, Mark & Skrede, Inger (2023). Introgression between highly divergent fungal sister species. Journal of Evolutionary Biology. ISSN 1010-061X. 36(8), s. 1133–1149. doi: 10.1111/jeb.14190. Fulltekst i vitenarkiv
• Peris, David; Lü, Dabao Sun; Kinneberg, Vilde Bruhn; Methlie, Ine-Susanne Hopland; Stapnes Dahl, Malin & Y. James, Timothy [Vis alle 8 forfattere av denne artikkelen] (2022). Large-scale fungal strain sequencing unravels the molecular diversity in mating loci maintained by long-term balancing selection. PLoS Genetics. ISSN 1553-7390. 18(3). doi: 10.1371/journal.pgen.1010097. Fulltekst i vitenarkiv Vis sammendrag

  Balancing selection, an evolutionary force that retains genetic diversity, has been detected in multiple genes and organisms, such as the sexual mating loci in fungi. However, to quantify the strength of balancing selection and define the mating-related genes require a large number of strains. In tetrapolar basidiomycete fungi, sexual type is determined by two unlinked loci, MATA and MATB. Genes in both loci define mating type identity, control successful mating and completion of the life cycle. These loci are usually highly diverse. Previous studies have speculated, based on culture crosses, that species of the non-model genus Trichaptum (Hymenochaetales, Basidiomycota) possess a tetrapolar mating system, with multiple alleles. Here, we sequenced a hundred and eighty strains of three Trichaptum species. We characterized the chromosomal location of MATA and MATB, the molecular structure of MAT regions and their allelic richness. The sequencing effort was sufficient to molecularly characterize multiple MAT alleles segregating before the speciation event of Trichaptum species. Analyses suggested that long-term balancing selection has generated trans-species polymorphisms. Mating sequences were classified in different allelic classes based on an amino acid identity (AAI) threshold supported by phylogenetics. 17,550 mating types were predicted based on the allelic classes. In vitro crosses allowed us to support the degree of allelic divergence needed for successful mating. Even with the high amount of divergence, key amino acids in functional domains are conserved. We conclude that the genetic diversity of mating loci in Trichaptum is due to long-term balancing selection, with limited recombination and duplication activity. The large number of sequenced strains highlighted the importance of sequencing multiple individuals from different species to detect the mating-related genes, the mechanisms generating diversity and the evolutionary forces maintaining them.

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• Peris Navarro, David; Lü, Dabao Sun; Kinneberg, Vilde Bruhn; Methlie, Ine-Susanne Hopland; James, Timothy & Kauserud, Håvard [Vis alle 7 forfattere av denne artikkelen] (2022). Ancient mating alleles maintained by balancing selection in basidiomycete fungi.
• Kinneberg, Vilde Bruhn; Lü, Dabao Sun; Peris, David; Ravinet, Mark & Skrede, Inger (2022). Ancient introgression between highly divergent fungal sister species.
• Peris, David; Lü, Dabao Sun; Kinneberg, Vilde Bruhn; Methlie, Ine-Susanne Hopland; Dahl, Malin Stapnes & James, Timothy Y. [Vis alle 8 forfattere av denne artikkelen] (2022). Long-term balancing selection in a white-root fungi.
• Kinneberg, Vilde Bruhn (2022). Ancient introgression between highly divergent fungal sister species.

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