Title: Spatiotemporal Modelling of Brain Changes Predicted by Sleep Quality
Abstract: Poor sleep is associated with multiple age-related neurodegenerative and neuropsychiatric conditions. In addition, the structure of different brain regions (volume, thickness) is well known to change across the lifespan. It is therefore of interest to understand how sleep relates to brain structure across the lifespan. In this talk I will present results from a recent study which investigated the longitudinal relationship between sleep and hippocampus volume of 3,105 adults using data from major European brain studies. Next, I will discuss statistical challenges in an ongoing work, aiming to discover brain regions (clusters) affected by sleep quality. Key topics include modelling of longitudinal trajectories with generalised additive mixed models, modelling of spatial correlations within clusters, cluster search, control of false discovery rates, and replication with independent data.
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