Presenter: Anthony Mathelier, UiO
Title
"High-resolution modeling and mapping of TF-DNA interactions"
Abstract
Unlocking how genes are regulated is vital to understanding development, disease, and evolution. Transcription factors (TFs) are key proteins to this control as they modulate when, where, and at which intensity genes are activated or repressed. Specifically, TFs bind cis-regulatory regions at TF binding sites (TFBSs) to control transcription. Importantly, TFs do not act individually but rather cooperate to control gene expression, either forming dimers or interacting in the same cis-regulatory regions. Hence, understanding where TFs bind to the genome and cooperate is critical for decoding the cis-regulatory grammar of the genome. In this talk, I will provide an overview of our efforts towards high-resolution modeling and mapping of TF-DNA interactions through the development of our JASPAR and UniBind databases
BiLS chair
Eivind Valen