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• Høgsbjerg, Kristine Wiborg; Thomsen, Mette Skovhus; Boye, Kristian; Jensen, Ingelise; Bekke, Susanne Nørring & Lorenzen, Ebbe Laugaard [Show all 24 contributors for this article] (2026). Radiotherapy quality assurance in the Danish breast cancer Group RT Natural trial. Clinical and Translational Radiation Oncology. 59. doi: 10.1016/j.ctro.2026.101190. Full text in Research Archive Show summary

  Purpose/Objective Partial breast irradiation (PBI) is standard for selected relatively low-risk breast cancer patients, aiming to minimise late effects while maintaining local control. The Danish Breast Cancer Group (DBCG) RT Natural trial investigated whether PBI could be safely omitted in selected patients. Here, we report the radiotherapy quality assurance in the trial, evaluating target coverage and doses to organs of interest against protocol criteria. Material/Methods Eligible patients were women ≥ 60 years with T ≤ 20 mm, unilateral, unifocal, node-negative, hormone receptor–positive, HER2-normal, non-lobular invasive breast cancer. Patients were randomised 1:1 to PBI (40 Gy in 15 fractions) versus no radiotherapy. Treatment plans for all patients treated with PBI were prospectively collected in a centralised DICOM-RT database and evaluated for protocol compliance. Results Data from the 238 patients receiving PBI were analysed. Dose coverage was high, with median V95% of 100% for the tumour bed and CTVp_PBI and 98% for the PTVp_PBI. Only 1% had a CTVp_PBI V95% below the intended 95%, whereas 22% had a PTVp_PBI V95% <95%. No patients exceeded 110% of the prescribed dose. Dose conformity was good with median whole-breast V40Gy of 21%. Ipsilateral median mean lung dose was 1.52 Gy, and median mean heart dose 0.25 Gy left / 0.12 Gy right with no violation of dose guidance. Respiratory gating did not significantly affect lung or heart doses. Conclusion PBI in the DBCG RT Natural trial provided robust target coverage with minimal high-dose volumes, and maintained low cardiac and pulmonary doses, consistent with protocol planning objectives.

• Svestad, Jørund Graadal; Mikalsen, Stine Gyland; Heydari, Mojgan; Francke, Regine Hjort; Hervani, Maziar & Hellebust, Taran Annette Paulsen (2025). Setup Accuracy and Efficiency of Real-Time Video Assistance for Surface-Guided Positioning in Radiation Therapy of Right-Sided Locoregional Breast Cancer. Advances in Radiation Oncology. ISSN 2452-1094. 10(9). doi: 10.1016/j.adro.2025.101829. Full text in Research Archive
• Mikalsen, Stine Gyland; Skjøtskift, Torleiv; Flote, Vidar Gordon; Hämäläinen, Niklas Petteri; Heydari, Mojgan & Rydén-Eilertsen, Karsten (2023). Extensive clinical testing of Deep Learning Segmentation models for thorax and breast cancer radiotherapy planning. Acta Oncologica. ISSN 0284-186X. 62(10), p. 1184–1193. doi: 10.1080/0284186X.2023.2270152. Full text in Research Archive
• Svestad, Jørund Graadal; Mojgan, Heydari; Mikalsen, Stine Gyland; Flote, Vidar Gordon; Nordby, Fredrik & Hellebust, Taran Annette Paulsen (2022). Surface-guided positioning eliminates the need for skin markers in radiotherapy of right sided breast cancer: A single center randomized crossover trial. Radiotherapy and Oncology. ISSN 0167-8140. 177, p. 46–52. doi: 10.1016/j.radonc.2022.10.017. Full text in Research Archive
• Mikalsen, Stine Gyland; Mikalsen, Lars Tore G; Sandvik, Joe Alexander; Aarnes, Eva-Katrine; Fenne, Siri & Flatmark, Kjersti [Show all 9 contributors for this article] (2018). Low dose-rate irradiation with [3H]-labelled valine to selectively target hypoxic cells in a human colorectal cancer xenograft model. Acta Oncologica. ISSN 0284-186X. 57(9), p. 1216–1224. doi: 10.1080/0284186X.2018.1457223. Full text in Research Archive
• Mikalsen, Stine Gyland; Edin, Nina Frederike J; Sandvik, Joe Alexander & Pettersen, Erik O (2018). Separation of two sub-groups with different DNA content after treatment of T-47D breast cancer cells with low dose-rate irradiation and intermittent hypoxia. Acta Radiologica. ISSN 0284-1851. 59(1), p. 26–33. doi: 10.1177/0284185117699999. Full text in Research Archive
• Bousquet, Paula; Sandvik, Joe Alexander; Arntzen, Magnus Øverlie; Edin, Nina Frederike J; Christoffersen, Stine & Krengel, Ute [Show all 8 contributors for this article] (2015). Hypoxia Strongly Affects Mitochondrial Ribosomal Proteins and Translocases, as Shown by Quantitative Proteomics of HeLa Cells. International Journal of Proteomics. ISSN 2090-2174. doi: 10.1155/2015/678527. Full text in Research Archive
• Edin, Nina Frederike J; Christoffersen, Stine; Fenne, Siri; Sandvik, Joe Alexander & Pettersen, Erik O (2015). Cell inactivation by combined low dose-rate irradiation and intermittent hypoxia. International Journal of Radiation Biology. ISSN 0955-3002. 91(4), p. 336–345. doi: 10.3109/09553002.2014.996262. Full text in Research Archive
• Chang, Cheng; Edin, Nina Frederike J; Lauritzen, Knut Husø; Aspmodal, Ida; Christoffersen, Stine & Jian, Liu [Show all 10 contributors for this article] (2012). Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. Cellular Oncology. ISSN 1570-5870. 35(3), p. 217–227. doi: 10.1007/s13402-012-0081-9. Full text in Research Archive

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• Christoffersen, Stine; Sandvik, Joe Alexander; Pettersen, Erik O & Edin, Nina Frederike J (2012). Cell respiration, hypoxia and low dose rate radiation. Full text in Research Archive
• Mikalsen, Stine Gyland (2019). Selective targeting of hypoxic T-47D and HT29 cancer cells by internal ultra-low dose-rate (3H)-labelled valine irradiation: in vitro and in vivo studies. Universitetet i Oslo. Full text in Research Archive

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