Advanced focusing systems for proton therapy

In the SHARP-project, we are working on making the future of radiation therapy for cancer as precise as possible. To do this, we are creating a new method for focusing the beam delivering the radiation dose, applying new technology developed for advanced particle accelerators. In this master, you can work on solving the challenges for applying this to proton therapy.

Active plasma lens at CLEAR

Active plasma lens at CLEAR

The SHARP project [1] is studying how we can use new technology under development for advanced particle accelerators such as plasma wakefield accelerators to make radiation therapy for cancer even more precise. The method we are developing is that we use an active plasma lens (see picture above) to first enlarge the beam, enabling it to then be efficiently focused with a large convergence angle. Effectively, the particles will simultaneously converge towards the target from many different directions. Using an active plasma lens makes the focusing system significantly more compact than what would otherwise be possible, as illustrated below.

Beamsize through the final focusing system, with different alternatives for APL strength.
Beamsize through the final focusing system, with different alternatives for APL strength. From [2].

The task of one or more master students in this project is to look for answers to one or more of the following questions:

  1. How can this style of particle beam optics be integrated with the experimental beamline at the Oslo proton therapy center?
  2. The beam from the proton therapy center is accelerated with a cyclotron, which delivers long beam pulses. How can an active plasma lens, which is a discharge device, be adapted to this time structure?
  3. In a treatment facility with this style of final focus beam optics, what would be the treatment possibilities?

The work will include both computer simulations of beam optics and radiation transport Monte-Carlo, and potentially also experimental work at the CERN CLEAR VHEE (200 MeV electrons) accelerator [3], where we have an active plasma lens [4-6].

[1] https://www.mn.uio.no/fysikk/english/research/projects/sharp-particle-accelerator-precision-focus-system-medical-applications/
[2] https://arxiv.org/abs/2602.19712
[3] https://clear.cern/
[4] https://www.sciencedirect.com/science/article/pii/S0168900218300809
[5] https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.121.194801
[6] https://journals.aps.org/prab/abstract/10.1103/PhysRevAccelBeams.24.121306

 

 

 

Tags: particle accelerators, proton therapy, advanced accelerators, plasma accelerators, final focus system, active plasma lens, beam optics
Published Apr. 9, 2026 10:14 AM - Last modified May 18, 2026 10:23 AM

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