Cecilie Morland

Image of Cecilie Morland
Norwegian version of this page
Phone +47 22844937
Mobile phone +47 41547945
Room ZEB, rom 254
Username
Visiting address ZEB Building Sem Sælands vei 2
Postal address Postboks 1068 Blindern 0316 Oslo

Scientific interests

We use a combination of in vivo and in vitro techniques to study the basic physiological mechanisms triggered in the brain in response to exercise. In particular, we study protective mechanisms of exercise in stroke. We employ animal models to mimic human disease and/or use of medications. We investigate behavioral effects of diseases, drugs, and exercise, combined with histological examinations at the light, confocal or electron microscopic level. We also use primary cell cultures and established cell lines as experimental models for mechanistic studies.

The aim is to identify new therapeutic targets for the prevention/therapy of stroke and other neurodegenerative disorders.

Teaching

Higher education and employment history

Education

  • PhD in Neuroscience, University of Oslo, 2012
  • Cand.pharm. (MScPharm) in Pharmacology, University of Oslo, 2003

Employment history

  • Associate Professor, Department of Pharmacy, University of Oslo, 2017–present
  • Associate Professor (20%), Department of Behavioural Sciences, OsloMet, 2017–present
  • Associate Professor, Department of Behavioural Sciences, HiOA (now OsloMet), 2016–2017
  • Researcher (20%), Dept. of Oral Biology, University of Oslo, 2016
  • Post-doctor / Lab Manager, Dept. of Oral Biology, University of Oslo, 2014–2015
  • Course leader at the Scientist Factory (“Forskerfabrikken”), 2009–2015
  • Post-doctor, Dept. of Anatomy, University of Oslo, 2012–2014
  • Visiting Scholar, McGill University, Montreal, Canada, 2013
  • PhD student, CMBN and Dept. of Anatomy, University of Oslo, 2007–2012
  • Research Assistant, CMBN and Department of Anatomy, University of Oslo, 2004–2007
  • Researcher, The Norwegian Defense Research Establishment, 2002–2003
Tags: Brain and nervous system, Parkinson's disease, Physical activity and brain function, Mitocondria

Publications

  • Morland, Cecilie & Nordengen, Kaja (2022). N-Acetyl-Aspartyl-Glutamate in Brain Health and Disease. International Journal of Molecular Sciences. ISSN 1661-6596. 23(3). doi: 10.3390/ijms23031268.
  • Kildal, Emilie; Stadskleiv, Kristine; Boysen, Elin Sundby; Øderud, Tone; Dahl, Inger-Lise & Seeberg, Trine Margrethe [Show all 9 contributors for this article] (2021). Increased heart rate functions as a signal of acute distress in non-communicating persons with intellectual disability. Scientific Reports. ISSN 2045-2322. 11(1). doi: 10.1038/s41598-021-86023-6.
  • Lambertus, Marvin; Øverberg, Linda Thøring; Andersson, Krister Andreas; Hjelden, Malin Sørli; Hadzic, Alena & Haugen, Øyvind Pernell [Show all 10 contributors for this article] (2020). L‐lactate induces neurogenesis in the mouse ventricular‐subventricular zone via the lactate receptor HCA1. Acta Physiologica. ISSN 1748-1708. doi: 10.1111/apha.13587. Full text in Research Archive
  • Cunnane, Stephen C.; Trushina, Eugenia; Morland, Cecilie; Prigione, Alessandro; Casadesus, Gemma & Andrews, Zane B [Show all 27 contributors for this article] (2020). Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nature Reviews Drug Discovery. ISSN 1474-1776. 19, p. 609–633. doi: 10.1038/s41573-020-0072-x. Full text in Research Archive
  • Hadzic, Alena; Nguyen, Teresa Dang; Hosoyamada, Makoto; Tomioka, Naoko H.; Bergersen, Linda Hildegard & Storm-Mathisen, Jon [Show all 7 contributors for this article] (2020). The Lactate Receptor HCA1 Is Present in the Choroid Plexus, the Tela Choroidea, and the Neuroepithelial Lining of the Dorsal Part of the Third Ventricle. International Journal of Molecular Sciences. ISSN 1661-6596. 21(18). doi: 10.3390/ijms21186457. Full text in Research Archive
  • Nordengen, Kaja; Morland, Cecilie; Slusher, B.S. & Gundersen, Vidar (2019). Dendritic localization and exocytosis of NAAG in the rat hippocampus. Cerebral Cortex. ISSN 1047-3211. doi: 10.1093/cercor/bhz176. Full text in Research Archive
  • Bækkerud, Fredrik Hjulstad; Salerno, Simona; Ceriotti, Paola; Morland, Cecilie; Storm-Mathisen, Jon & Bergersen, Linda Hildegard [Show all 9 contributors for this article] (2019). High intensity interval training ameliorates mitochondrial dysfunction in the left ventricle of mice with type 2 diabetes. Cardiovascular Toxicology. ISSN 1530-7905. 19(5), p. 422–431. doi: 10.1007/s12012-019-09514-z. Full text in Research Archive
  • Geiseler, Samuel & Morland, Cecilie (2018). The janus face of VEGF in stroke. International Journal of Molecular Sciences. ISSN 1661-6596. 19:1362(5), p. 1–20. doi: 10.3390/ijms19051362. Full text in Research Archive
  • Morland, Cecilie; Frøland, Anne-Sofie; Nguyen, Mi Mong Tran; Storm-Mathisen, Jon; Gundersen, Vidar & Rise, Frode (2018). Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia. Biochemical Journal. ISSN 0264-6021. 475(4), p. 749–758. doi: 10.1042/BCJ20170814.
  • Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv & Gille, Andreas [Show all 21 contributors for this article] (2017). Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. Nature Communications. ISSN 2041-1723. 8. doi: 10.1038/ncomms15557. Full text in Research Archive
  • Morland, Cecilie; Pettersen, Mi Nguyen & Hassel, Bjørnar (2016). Hyperosmolar sodium chloride is toxic to cultured neurons and causes reduction of glucose metabolism and ATP levels, an increase in glutamate uptake, and a reduction in cytosolic calcium. Neurotoxicology. ISSN 0161-813X. 54, p. 34–43. doi: 10.1016/j.neuro.2016.03.005.
  • Morland, Cecilie; Lauritzen, Knut Husø; Puchades, Maja Amedjkouh; Holm-Hansen, Signe; Andersson, Krister & Gjedde, Albert [Show all 9 contributors for this article] (2015). The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain. Journal of Neuroscience Research. ISSN 0360-4012. 93(7), p. 1045–1055. doi: 10.1002/jnr.23593.
  • Lauritzen, Knut Husø; Morland, Cecilie; Puchades, Maja Amedjkouh; Holm-Hansen, Signe; Hagelin, Else Marie Valbjørn & Lauritzen, Fredrik [Show all 10 contributors for this article] (2014). Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism. Cereb Cortex. Cerebral Cortex. ISSN 1047-3211. p. 2784–2795. doi: 10.1093/cercor/bht136.
  • Lauritzen, Knut Husø; Morland, Cecilie; Puchades, Maja Amedjkouh; Holm-Hansen, Signe; Hagelin, Else Marie Valbjørn & Lauritzen, Fredrik [Show all 10 contributors for this article] (2013). Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism. Cerebral Cortex. ISSN 1047-3211. doi: 10.1093/cercor/bht136.
  • Morland, Cecilie; Nordengen, Kaja; Larsson, Max; Prolo, Laura M.; Farzampour, Zoya & Reimer, Richard J. [Show all 7 contributors for this article] (2013). Vesicular uptake and exocytosis of L-aspartate is independent of sialin. The FASEB Journal. ISSN 0892-6638. 27(3), p. 1264–1274. doi: 10.1096/fj.12-206300.
  • Berg, L K; Larsson, M; Morland, Cecilie & Gundersen, Vidar (2013). PRE- AND POSTSYNAPTIC LOCALIZATION OF NMDA RECEPTOR SUBUNITS AT HIPPOCAMPAL MOSSY FIBRE SYNAPSES. Neuroscience. ISSN 0306-4522. 230, p. 139–150. doi: 10.1016/j.neuroscience.2012.10.061.
  • Morland, Cecilie; Nordengen, Kaja & Gundersen, Vidar (2012). Valproate causes reduction of the excitatory amino acid aspartate in nerve terminals. Neuroscience Letters. ISSN 0304-3940. 527(2), p. 100–104. doi: 10.1016/j.neulet.2012.08.042.
  • Larsson, Max; Sawada, Keisuke; Morland, Cecilie; Hiasa, Miki; Ormel, Lasse & Moriyama, Yoshinori [Show all 7 contributors for this article] (2012). Functional and Anatomical Identification of a Vesicular Transporter Mediating Neuronal ATP Release. Cerebral Cortex. ISSN 1047-3211. 22(5), p. 1203–1214. doi: 10.1093/cercor/bhr203.
  • Bergersen, Linda Hildegard; Morland, Cecilie; Ormel, Lasse; Rinholm, Johanne Egge; Larsson, Max David & Wold, Johan Fredrik Hustad [Show all 13 contributors for this article] (2012). Immunogold Detection of L-glutamate and D-serine in Small Synaptic-Like Microvesicles in Adult Hippocampal Astrocytes. Cerebral Cortex. ISSN 1047-3211. 22(7), p. 1690–1697. doi: 10.1093/cercor/bhr254.
  • Larsson, Max; Morland, Cecilie; Poblete-Naredo, Irais; Biber, Jürg; Danbolt, Niels Christian & Gundersen, Vidar (2011). The Sodium-Dependent Inorganic Phosphate Transporter SLC34Al (NaPi-IIa) Is Not Localized in the Mouse Brain: A Case of Tissue-Specific Antigenic Cross-Reactivity. Journal of Histochemistry and Cytochemistry. ISSN 0022-1554. 59(9), p. 807–812. doi: 10.1369/0022155411411713.
  • Holten, Aleksander Talgøy; Morland, Cecilie; Nordengen, Kaja & Gundersen, Vidar (2008). Vesicular Release of L- and D-Aspartate from Hippocampal Nerve Terminals: Immunogold Evidence. Open Neuroscience Journal. ISSN 1874-0820. 2, p. 51–58. doi: 10.2174/1874082000802010051.
  • Morland, Cecilie; Henjum, Solveig; Iversen, Evy Grini; Skrede, Knut Kristian & Hassel, Bjørnar (2007). Evidence for a higher glycolytic than oxidative metabolic activity in white matter of rat brain. Neurochemistry International. ISSN 0197-0186. 50(5), p. 703–709.
  • Morland, Cecilie; Boldingh, Karen A; Iversen, Evy Grini & Hassel, Bjørnar (2004). Valproate is neuroprotective against malonate toxicity in rat striatum: an association with augmentation of high-affinity glutamate uptake. Journal of Cerebral Blood Flow and Metabolism. ISSN 0271-678X. 24(11), p. 1226–1234.

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  • Geiseler, Samuel; Hadzic, Alena; Sajedi, Ghazal; Forbord, Karl Martin Frøseth & Morland, Cecilie (2020). Lactate injections are neuroprotective in stroke via HCAR1 .
  • Lindgren, Pia Elise Øchslie & Morland, Cecilie (2019). Forstå meg! Erfaringer fra bachelorprosjektet.
  • Morland, Cecilie (2019). Forstå meg! -Bruk av pulsmåling som supplerende kommunikasjon hos personer med svært begrensede kommunikajsonsevner.
  • Lambertus, Marvin & Morland, Cecilie (2019). The role of Lactate Receptor HCAR1 in Subventricular Zone Neurogenesis.
  • Lambertus, Marvin; Seferi, Gezime; Øverberg, Linda Thøring & Morland, Cecilie (2019). Lactate receptor HCAR1 in cerebral insulin resistance and neurogenesis.
  • Morland, Cecilie (2018). Sliten i kroppen, klar i toppen. Blir man smartere av å trene?
  • Morland, Cecilie (2018). Sliten i kroppen – Klar i toppen Blir man smartere av å trene? .
  • Lambertus, Marvin; Sørli, Malin; Haugen, Øyvind Pernell; Andersson, Krister Andreas & Morland, Cecilie (2018). The effects of HCAR1 activation on the release of growth factors from pia mater fibroblasts.
  • Øverberg, Linda Thøring; Andersson, Krister Andreas; Lambertus, Marvin; Hadzic, Alena; Haugen, Øyvind Pernell & Storm-Mathisen, Jon [Show all 8 contributors for this article] (2018). Adult neurogenesis: A regulatory role of lactate through the lactate receptor HCAR1? .
  • Morland, Cecilie (2017). Blir man smartere av å trene?
  • Andersson, Krister; Morland, Cecilie; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv & Gille, Andreas [Show all 21 contributors for this article] (2017). Exercise benefits brain through the lactate receptor HCAR1, increasing VEGF and capillary density in hippocampus and cortex.
  • Andersson, Krister; Morland, Cecilie; Haugen, Øyvind Pernell; Bergersen, Linda Hildegard & Storm-Mathisen, Jon (2017). Physical exercise promotes brain angiogenesis through a lactate receptor.
  • Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv & Gille, Andreas [Show all 18 contributors for this article] (2016). A novel mechanism for cerebral angiogenesis via lactate receptor HCAR1 at pial vessels.
  • Morland, Cecilie (2016). A novel mechansim for exercise-induced angiogenesis in the brain.
  • Hadzic, Alena; Andersson, Krister; Haugen, Øyvind Pernell; Storm-Mathisen, Jon; Stølen, Tomas & Wisløff, Ulrik [Show all 8 contributors for this article] (2016). Lactate receptor HCAR1 mediates synaptic plasticity.
  • Moretti, Laura; Stølen, Tomas; Wisløff, Ulrik; Storm-Mathisen, Jon; Bergersen, Linda Hildegard & Morland, Cecilie (2016). Effects of intrinsic fitness level on mitochondria during exercise .
  • Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv & Gille, Andreas [Show all 18 contributors for this article] (2016). Exercise induces cerebral angiogenesis via lactate receptor HCAR1 at pial vessels.
  • Narvesen, Cecilie; Boldingh, Karen A; Iversen, Evy Grini; Taubøll, Erik & Hassel, Bjørnar (2003). Valproate may be neuroprotective through various mechanisms. Nevrodagene 2003..
  • Nguyen, Teresa Dang; Morland, Cecilie & Hadzic, Alena (2020). The lactate receptor HCAR1 at the brain-cerebrospinal fluid interface and its role in stroke. Universitetsforlaget.
  • Brox, Camilla; Morland, Cecilie & Geiseler, Samuel (2020). Lactate receptor HCAR1 in the protection against neuroinflammation in stroke . Universitetsforlaget.
  • Phan, Kimberly Dungdung; Geiseler, Samuel & Morland, Cecilie (2020). The lactate receptor HCAR1 in the regulation of neurogenesis and angiogenesis during stroke. Universitetsforlaget.
  • Karl Martin Frøseth, Forbord & Morland, Cecilie (2019). HCAR1-dependent Effect of Therapeutic Lactate in Post-Stroke Pathophysiology in Mice. DUO UiO.
  • Sajedi, Ghazal & Morland, Cecilie (2019). Effekter av laktat via laktatreseptor HCAR1 ved iskemisk hjerneslag. DUO, UiO.
  • Sørli, Malin & Morland, Cecilie (2018). HCAR1-dependent intracellular signaling in fibroblasts. DUO UiO.

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Published Sep. 18, 2017 10:40 AM - Last modified Nov. 16, 2020 10:34 AM