Cecilie Morland

Image of Cecilie Morland
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Phone +47-22844937
Mobile phone +47-41547945
Username
Visiting address Sem Sælands vei 3 Farmasibygningen 0371 OSLO
Postal address Postboks 1068 Blindern 0316 OSLO

Scientific interests

We use a combination of in vivo and in vitro techniques to study the basic physiological mechanisms triggered in the brain in response to exercise. In particular, we study protective mechanisms of exercise in stroke. We employ animal models to mimic human disease and/or use of medications. We investigate behavioral effects of diseases, drugs, and exercise, combined with histological examinations at the light, confocal or electron microscopic level. We also use primary cell cultures and established cell lines as experimental models for mechanistic studies.

The aim is to identify new therapeutic targets for the prevention/therapy of stroke and other neurodegenerative disorders.

Teaching

FARM1110 - Pharmacology, Physiology and Cell Biology 1

FRM 3030 - Use of Drugs, Part III

FRM 5720 - Pharmaceutical Toxicology

FRM 9720 - Pharmaceutical Toxicology

Higher education and employment history

Education

PhD in Neuroscience, University of Oslo, 2012

Cand.pharm. (MScPharm) in Pharmacology, University of Oslo, 2003

Employment history

Associate Professor, School of Pharmacy, University of Oslo, 2017 - present

Associate Professor (20%), Institute for Behaviour Analysis, HiOA, 2017 - present

Associate Professor, Institute for Behaviour Analysis, HiOA, 2016-2017

Researcher (20%), Dept. of Oral Biology, University of Oslo, 2016

Post-doctor / Lab Manager, Dept. of Oral Biology, University of Oslo, 2014-2015

Course leader at the Scientist Factory (“Forskerfabrikken”), 2009-2015

Post-doctor, Dept. of Anatomy, University of Oslo, 2012-2014

Visiting Scholar McGill University, Montreal, Canada, 2013

PhD-student, CMBN and Dept. of Anatomy, University of Oslo, 2007-2012

Research Assistant, CMBN and Department of Anatomy, University of Oslo, 2004-2007

Researcher The Norwegian Defense Research Establishment, 2002-2003

 

Tags: Parkinson's disease, Mitocondria, Brain and nervous system, Physical activity and brain function

Publications

  • Geiseler, Samuel & Morland, Cecilie (2018). The janus face of VEGF in stroke. International Journal of Molecular Sciences.  ISSN 1422-0067.  19:1362(5), s 1- 20 . doi: 10.3390/ijms19051362 Full text in Research Archive.
  • Morland, Cecilie; Frøland, Anne-Sofie; Nguyen, Mi Mong Tran; Storm-Mathisen, Jon; Gundersen, Vidar; Rise, Frode & Hassel, Bjørnar (2018). Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia. Biochemical Journal.  ISSN 0264-6021.  475(4), s 749- 758 . doi: 10.1042/BCJ20170814
  • Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv; Gille, Andreas; Rinholm, Johanne Egge; Palibrk, Vuk; Diget, Elisabeth Holm; Kennedy, Lauritz Hagen; Stølen, Tomas; Hennestad, Eivind; Moldestad, Olve; Cai, Yiqing; Puchades, Maja Amedjkouh; Offermanns, Stefan; Vervaeke, Koen Gerard Alois; Bjørås, Magnar; Wisløff, Ulrik; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2017). Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. Nature Communications.  ISSN 2041-1723.  8 . doi: 10.1038/ncomms15557 Full text in Research Archive. Show summary
  • Morland, Cecilie; Pettersen, Mi Nguyen & Hassel, Bjørnar (2016). Hyperosmolar sodium chloride is toxic to cultured neurons and causes reduction of glucose metabolism and ATP levels, an increase in glutamate uptake, and a reduction in cytosolic calcium. Neurotoxicology.  ISSN 0161-813X.  54, s 34- 43 . doi: 10.1016/j.neuro.2016.03.005
  • Morland, Cecilie; Lauritzen, Knut Husø; Puchades, Maja Amedjkouh; Holm-Hansen, Signe; Andersson, Krister; Gjedde, Albert; Attramadal, Håvard; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2015). The lactate receptor, G-protein-coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain. Journal of Neuroscience Research.  ISSN 0360-4012.  93(7), s 1045- 1055 . doi: 10.1002/jnr.23593
  • Lauritzen, Knut Husø; Morland, Cecilie; Puchades, Maja Amedjkouh; Holm-Hansen, Signe; Hagelin, Else Marie Valbjørn; Lauritzen, Fredrik; Attramadal, Håvard; Storm-Mathisen, Jon; Gjedde, Albert & Bergersen, Linda Hildegard (2014). Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism. Cereb Cortex. Cerebral Cortex.  ISSN 1047-3211.  s 2784- 2795 . doi: 10.1093/cercor/bht136
  • Berg, L K; Larsson, M; Morland, Cecilie & Gundersen, Vidar (2013). PRE- AND POSTSYNAPTIC LOCALIZATION OF NMDA RECEPTOR SUBUNITS AT HIPPOCAMPAL MOSSY FIBRE SYNAPSES. Neuroscience.  ISSN 0306-4522.  230, s 139- 150 . doi: 10.1016/j.neuroscience.2012.10.061
  • Lauritzen, Knut Husø; Morland, Cecilie; Puchades, Maja Amedjkouh; Holm-Hansen, Signe; Hagelin, Else Marie Valbjørn; Lauritzen, Fredrik; Attramadal, Håvard; Storm-Mathisen, Jon; Gjedde, Albert & Bergersen, Linda Hildegard (2013). Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism. Cerebral Cortex.  ISSN 1047-3211. . doi: 10.1093/cercor/bht136 Show summary
  • Morland, Cecilie; Nordengen, Kaja; Larsson, Max; Prolo, Laura M.; Farzampour, Zoya; Reimer, Richard J. & Gundersen, Vidar (2013). Vesicular uptake and exocytosis of L-aspartate is independent of sialin. The FASEB Journal.  ISSN 0892-6638.  27(3), s 1264- 1274 . doi: 10.1096/fj.12-206300
  • Bergersen, Linda Hildegard; Morland, Cecilie; Ormel, Lasse; Rinholm, Johanne Egge; Larsson, Max David; Wold, Johan Fredrik Hustad; Røe, Åsmund Treu; Stranna, Andrea; Santello, M; Bouvier, David; Ottersen, Ole Petter; Volterra, Andrea & Gundersen, Vidar (2012). Immunogold Detection of L-glutamate and D-serine in Small Synaptic-Like Microvesicles in Adult Hippocampal Astrocytes. Cerebral Cortex.  ISSN 1047-3211.  22(7), s 1690- 1697 . doi: 10.1093/cercor/bhr254
  • Larsson, Max; Sawada, Keisuke; Morland, Cecilie; Hiasa, Miki; Ormel, Lasse; Moriyama, Yoshinori & Gundersen, Vidar (2012). Functional and Anatomical Identification of a Vesicular Transporter Mediating Neuronal ATP Release. Cerebral Cortex.  ISSN 1047-3211.  22(5), s 1203- 1214 . doi: 10.1093/cercor/bhr203
  • Morland, Cecilie; Nordengen, Kaja & Gundersen, Vidar (2012). Valproate causes reduction of the excitatory amino acid aspartate in nerve terminals. Neuroscience Letters.  ISSN 0304-3940.  527(2), s 100- 104 . doi: 10.1016/j.neulet.2012.08.042
  • Larsson, Max; Morland, Cecilie; Poblete-Naredo, Irais; Biber, Jürg; Danbolt, Niels Christian & Gundersen, Vidar (2011). The Sodium-Dependent Inorganic Phosphate Transporter SLC34Al (NaPi-IIa) Is Not Localized in the Mouse Brain: A Case of Tissue-Specific Antigenic Cross-Reactivity. Journal of Histochemistry and Cytochemistry.  ISSN 0022-1554.  59(9), s 807- 812 . doi: 10.1369/0022155411411713
  • Holten, Aleksander Talgøy; Morland, Cecilie; Nordengen, Kaja & Gundersen, Vidar (2008). Vesicular Release of L- and D-Aspartate from Hippocampal Nerve Terminals: Immunogold Evidence. Open Neuroscience Journal.  ISSN 1874-0820.  2, s 51- 58 . doi: 10.2174/1874082000802010051
  • Morland, Cecilie; Henjum, Solveig; Iversen, Evy Grini; Skrede, Knut Kristian & Hassel, Bjørnar (2007). Evidence for a higher glycolytic than oxidative metabolic activity in white matter of rat brain. Neurochemistry International.  ISSN 0197-0186.  50(5), s 703- 709
  • Morland, Cecilie; Boldingh, Karen A; Iversen, Evy Grini & Hassel, Bjørnar (2004). Valproate is neuroprotective against malonate toxicity in rat striatum: an association with augmentation of high-affinity glutamate uptake. Journal of Cerebral Blood Flow and Metabolism.  ISSN 0271-678X.  24(11), s 1226- 1234

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  • Lambertus, Marvin; Sørli, Malin; Haugen, Øyvind Pernell; Andersson, Krister Andreas & Morland, Cecilie (2018). The effects of HCAR1 activation on the release of growth factors from pia mater fibroblasts.
  • Morland, Cecilie (2018). Sliten i kroppen – Klar i toppen Blir man smartere av å trene?.
  • Morland, Cecilie (2018). Sliten i kroppen, klar i toppen. Blir man smartere av å trene?.
  • Øverberg, Linda Thøring; Andersson, Krister Andreas; Lambertus, Marvin; Hadzic, Alena; Haugen, Øyvind Pernell; Storm-Mathisen, Jon; Bergersen, Linda Hildegard & Morland, Cecilie (2018). Adult neurogenesis: A regulatory role of lactate through the lactate receptor HCAR1?.
  • Andersson, Krister; Morland, Cecilie; Haugen, Øyvind Pernell; Bergersen, Linda Hildegard & Storm-Mathisen, Jon (2017). Physical exercise promotes brain angiogenesis through a lactate receptor. Show summary
  • Andersson, Krister; Morland, Cecilie; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv; Gille, Andreas; Rinholm, Johanne Egge; Palibrk, Vuk; Diget, Elisabeth Holm; Kennedy, Lauritz Hagen; Stølen, Tomas; Hennestad, Eivind; Moldestad, Olve; Cai, Yiqing; Puchades, Maja; Offermanns, Stefan; Vervaeke, Koen; Bjørås, Magnar; Wisløff, Ulrik; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2017). Exercise benefits brain through the lactate receptor HCAR1, increasing VEGF and capillary density in hippocampus and cortex. Show summary
  • Morland, Cecilie (2017). Blir man smartere av å trene?.
  • Hadzic, Alena; Andersson, Krister; Haugen, Øyvind Pernell; Storm-Mathisen, Jon; Stølen, Tomas; Wisløff, Ulrik; Bergersen, Linda Hildegard & Morland, Cecilie (2016). Lactate receptor HCAR1 mediates synaptic plasticity.
  • Moretti, Laura; Stølen, Tomas; Wisløff, Ulrik; Storm-Mathisen, Jon; Bergersen, Linda Hildegard & Morland, Cecilie (2016). Effects of intrinsic fitness level on mitochondria during exercise.
  • Morland, Cecilie (2016). A novel mechansim for exercise-induced angiogenesis in the brain.
  • Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv; Gille, Andreas; Rinholm, Johanne Egge; Diget, Elisabeth Holm; Kennedy, Lauritz Hagen; Stølen, Tomas; Hennestad, Eivind; Cai, Yiqing; Puchades, Maja Amedjkouh; Offermanns, Stefan; Vervaeke, Koen Gerard Alois; Wisløff, Ulrik; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2016). A novel mechanism for cerebral angiogenesis via lactate receptor HCAR1 at pial vessels.
  • Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv; Gille, Andreas; Rinholm, Johanne Egge; Elisabeth, Holm Diget; Kennedy, Lauritz Hagen; Stølen, Tomas; Hennestad, Eivind; Cai, Yiqing; Puchades, Maja Amedjkouh; Offermanns, Stefan; Vervaeke, Koen Gerard Alois; Wisløff, Ulrik; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2016). Exercise induces cerebral angiogenesis via lactate receptor HCAR1 at pial vessels.
  • Narvesen, Cecilie; Boldingh, Karen A; Iversen, Evy Grini; Taubøll, Erik & Hassel, Bjørnar (2003). Valproate may be neuroprotective through various mechanisms. Nevrodagene 2003..  (16), s 91

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Published Sep. 18, 2017 10:40 AM - Last modified Jan. 11, 2018 9:08 PM