Inger Lise Bogen

Image of Inger Lise Bogen
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Mobile phone 97041588
Username
Visiting address Oslo Universitetssykehus Lovisenberggata 6 0456 Oslo
Postal address Postboks 1068 Blindern 0316 Oslo

Research 

My research group studies the short and long term effects of drugs of abuse, their mechanism of action, toxicity, metabolism and addiction potential, as well as new therapeutic approaches to treat drug addiction. We also develop new analytical methods for novel psychoactive substances on the drug market for implementation in the forensic toxicology laboratory. We employ animal models to study behavioral effects combined with analytical methods and molecular biology techniques for determination of drug concentrations and studies of neurobiological and genetic changes. The research group has a wide network of national and international collaborators.

For more information, see OUH - Neurobiology (ous-research.no).

Research projects

Teaching

Publications

  • Harrison, Sean Philip; Siller, Richard; Tanaka, Yoshiaki; Chollet Dugarte, Maria Eugenia; de la Morena-Barrio, María Eugenia & Xiang, Yangfei [Show all 36 contributors for this article] (2023). Scalable production of tissue-like vascularized liver organoids from human PSCs. Experimental and Molecular Medicine. ISSN 1226-3613. 55, p. 2005–2024. doi: 10.1038/s12276-023-01074-1. Full text in Research Archive
  • Bogen, Inger Lise; Boix, Fernando; Andersen, Jannike Mørch; Steinsland, Synne; Nerem, Elisabeth & Mørland, Jørg Gustav (2023). Heroin metabolism in human blood and its impact for the design of an immunotherapeutic approach against heroin effects. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 133(4), p. 418–427. doi: 10.1111/bcpt.13926. Full text in Research Archive
  • Kogler, Stian; Aizenshtadt, Aleksandra; Harrison, Sean; Skottvoll, Frøydis Sved; Berg, Henriette Engen & Abadpour, Shadab [Show all 14 contributors for this article] (2022). "Organ-in-a-Column" Coupled On-line with Liquid Chromatography-Mass Spectrometry. Analytical Chemistry. ISSN 0003-2700. 94(50), p. 17677–17684. doi: 10.1021/acs.analchem.2c04530. Full text in Research Archive
  • Skottvoll, Frøydis Sved; Aizenshtadt, Aleksandra; Hansen, Frederik Andre; Amirola Martinez, Mikel; Andersen, Jannike Mørch & Bogen, Inger Lise [Show all 11 contributors for this article] (2022). Direct Electromembrane Extraction-Based Mass Spectrometry: A Tool for Studying Drug Metabolism Properties of Liver Organoids. Analysis & Sensing. ISSN 2629-2742. 2(2). doi: 10.1002/anse.202100051. Full text in Research Archive
  • Tuv, Silja Skogstad; Bergh, Marianne Skov-Skov; Andersen, Jannike Mørch; Steinsland, Synne; Vindenes, Vigdis & Baumann, Michael H. [Show all 8 contributors for this article] (2021). Comparative neuropharmacology and pharmacokinetics of methamphetamine and its thiophene analog methiopropamine in rodents. International Journal of Molecular Sciences. ISSN 1661-6596. 22(21), p. 1–16. doi: 10.3390/ijms222112002.
  • Bergh, Marianne Skov-Skov; Bogen, Inger Lise; Garibay, Nancy & Baumann, Michael H. (2021). Pharmacokinetics and pharmacodynamics of cyclopropylfentanyl in male rats. Psychopharmacology. ISSN 0033-3158. 238, p. 3629–3641. doi: 10.1007/s00213-021-05981-x. Full text in Research Archive
  • Andersen, Jannike Mørch; Bogen, Inger Lise; Karinen, Ritva Anneli; Brochmann, Gerd-Wenche; Mørland, Jørg Gustav & Vindenes, Vigdis [Show all 7 contributors for this article] (2021). Does the preparation for intravenous administration affect the composition of heroin injections? A controlled laboratory study. Addiction. ISSN 0965-2140. 116(11), p. 3104–3112. doi: 10.1111/add.15492. Full text in Research Archive
  • Bergh, Marianne Skov-Skov; Bogen, Inger Lise; Nerem, Elisabeth; Wohlfarth, Ariane; Wilson, Steven Ray Haakon & Øiestad, Åse Marit Leere (2021). Discovering the major metabolites of the three novel fentanyl analogues 3-methylcrotonylfentanyl, furanylbenzylfentanyl, and 4-fluorocyclopropylbenzylfentanyl for forensic case work. Forensic Toxicology. ISSN 1860-8965. 39, p. 167–178. doi: 10.1007/s11419-020-00560-9.
  • Skottvoll, Frøydis Sved; Hansen, Frederik; Harrison, Sean; Boger, Ida Caroline Sneis; Mrsa, Ago & Restan, Magnus Saed [Show all 14 contributors for this article] (2021). Electromembrane extraction and mass spectrometry for liver organoid drug metabolism studies. Analytical Chemistry. ISSN 0003-2700. 93, p. 3576–3585. doi: 10.1021/acs.analchem.0c05082. Full text in Research Archive
  • Harrison, Sean; Siller, Richard; Tanaka, Yoshiaki; Xiang, Yangfei; Patterson, Benjamin & Kempf, Henning [Show all 29 contributors for this article] (2020). Scalable production of tissue-like vascularised liver organoids from human PSCs. bioRxiv. ISSN 2692-8205. doi: 10.1101/2020.12.02.406835.
  • Bergh, Marianne Skov-Skov; Øiestad, Åse Marit Leere; Baumann, Michael H & Bogen, Inger Lise (2020). Selectivity and sensitivity of urine fentanyl test strips to detect fentanyl analogues in illicit drugs. International journal of drug policy. ISSN 0955-3959. 90(103065). doi: 10.1016/j.drugpo.2020.103065.
  • Kongstorp, Mette; Bogen, Inger Lise; Stiris, Tom & Andersen, Jannike Mørch (2020). Prenatal exposure to methadone or buprenorphine impairs cognitive performance in young adult rats. Drug and Alcohol Dependence. ISSN 0376-8716. 212(108008), p. 1–9. doi: 10.1016/j.drugalcdep.2020.108008. Full text in Research Archive
  • Kongstorp, Mette; Bogen, Inger Lise; Steinsland, Synne; Nerem, Elisabeth; Salih, Triske Woshyar & Stiris, Tom [Show all 7 contributors for this article] (2020). Prenatal exposure to methadone or buprenorphine alters µ-opioid receptor binding and downstream signaling in the rat brain. International Journal of Developmental Neuroscience. ISSN 0736-5748. 80(5), p. 443–453. doi: 10.1002/jdn.10043. Full text in Research Archive
  • Kongstorp, Mette; Bogen, Inger Lise; Stiris, Tom & Andersen, Jannike Mørch (2019). High accumulation of methadone compared with buprenorphine in fetal rat brain after maternal exposure. Journal of Pharmacology and Experimental Therapeutics. ISSN 0022-3565. 371(1), p. 130–137. doi: 10.1124/jpet.119.259531.
  • Bergh, Marianne Skov-Skov; Bogen, Inger Lise; Garibay, Nancy & Baumann, Michael H (2019). Evidence for nonlinear accumulation of the ultrapotent fentanyl analog, carfentanil, after systemic administration to male rats. Neuropharmacology. ISSN 0028-3908. 158. doi: 10.1016/j.neuropharm.2019.04.002.
  • Bergh, Marianne Skov-Skov; Bogen, Inger Lise; Wohlfarth, Ariane; Wilson, Steven Ray Haakon & Øiestad, Åse Marit Leere (2019). Distinguishing Between Cyclopropylfentanyl and Crotonylfentanyl by Methods Commonly Available in the Forensic Laboratory. Therapeutic Drug Monitoring. ISSN 0163-4356. 41(4), p. 519–527. doi: 10.1097/FTD.0000000000000617. Full text in Research Archive
  • Kvello, Anne Marte Sjursen; Andersen, Jannike Mørch; Boix, Fernando; Mørland, Jørg & Bogen, Inger Lise (2019). The role of 6-acetylmorphine in heroin-induced reward and locomotor sensitization in mice. Addiction Biology. ISSN 1355-6215. p. 1–10. doi: 10.1111/adb.12727. Full text in Research Archive
  • Avvisati, Riccardo; Bogen, Inger Lise; Andersen, Jannike Mørch; Vindenes, Vigdis; Mørland, Jørg & Badiani, Aldo [Show all 7 contributors for this article] (2019). The active heroin metabolite 6-acetylmorphine has robust reinforcing effects as assessed by self-administration in the rat. Neuropharmacology. ISSN 0028-3908. 150, p. 192–199. doi: 10.1016/j.neuropharm.2018.12.023.
  • Kvello, Anne Marte Sjursen; Andersen, Jannike Mørch; Øiestad, Elisabeth Leere; Steinsland, Synne; Aase, Audun & Mørland, Jørg [Show all 7 contributors for this article] (2019). A monoclonal antibody against 6-acetylmorphine protects female mice offspring from adverse behavioral effects induced by prenatal heroin exposure. Journal of Pharmacology and Experimental Therapeutics. ISSN 0022-3565. 368(1), p. 106–115. doi: 10.1124/jpet.118.251504. Full text in Research Archive
  • Bergh, Marianne Skov-Skov; Bogen, Inger Lise; Wilson, Steven Ray Haakon & Øiestad, Åse Marit Leere (2018). Addressing the Fentanyl Analogue Epidemic by Multiplex UHPLC-MS/MS Analysis of Whole Blood. Therapeutic Drug Monitoring. ISSN 0163-4356. 40(6), p. 738–748. doi: 10.1097/FTD.0000000000000564.
  • Bergh, Marianne Skov-Skov; Bogen, Inger Lise; Andersen, Jannike Mørch; Øiestad, Åse Marit Leere & Berg, Thomas (2017). Determination of adrenaline, noradrenaline and corticosterone in rodent blood by ion pair reversed phase UHPLC–MS/MS. Journal of chromatography. B. ISSN 1570-0232. 1072, p. 161–172. doi: 10.1016/j.jchromb.2017.11.016.
  • Vevelstad, Merete; Øiestad, Elisabeth Leere; Nerem, Elisabeth; Arnestad, Marianne & Bogen, Inger Lise (2017). Studies on para-methoxymethamphetamine (PMMA) metabolite pattern and influence of CYP2D6 genetics in human liver microsomes and authentic samples from fatal PMMA intoxications. Drug Metabolism And Disposition. ISSN 0090-9556. 45(12), p. 1326–1335. doi: 10.1124/dmd.117.077263.
  • Berntsen, Hanne Friis; Bogen, Inger Lise; Wigestrand, Mattis B; Fonnum, Frode; Walaas, S. Ivar & Moldes-Anaya, Angel (2017). The fungal neurotoxin penitrem A induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations. Toxicology. ISSN 0300-483X. 392, p. 64–70. doi: 10.1016/j.tox.2017.10.008.
  • Berntsen, Hanne Friis; Fonnum, Frode; Walaas, S. Ivar & Bogen, Inger Lise (2016). Low-chlorinated non-dioxin-like polychlorinated biphenyls present in blood and breast milk induce higher levels of reactive oxygen species in neutrophil granulocytes than high-chlorinated congeners. Basic & Clinical Pharmacology & Toxicology. ISSN 1742-7835. 119(6), p. 588–597. doi: 10.1111/bcpt.12620.
  • Bergh, Marianne Skov-Skov; Bogen, Inger Lise; Lundanes, Elsa & Øiestad, Åse Marit Leere (2016). Validated methods for determination of neurotransmitters and metabolites in rodent brain tissue and extracellular fluid by reversed phase UHPLC-MS/MS. Journal of chromatography. B. ISSN 1570-0232. 1028, p. 120–129. doi: 10.1016/j.jchromb.2016.06.011.
  • Kvello, Anne Marte Sjursen; Andersen, Jannike Mørch; Øiestad, Elisabeth Leere; Mørland, Jørg & Bogen, Inger Lise (2016). Pharmacological Effects of a Monoclonal Antibody against 6-Monoacetylmorphine upon Heroin-Induced Locomotor Activity and Pharmacokinetics in Mice. Journal of Pharmacology and Experimental Therapeutics. ISSN 0022-3565. 358(2), p. 181–189. doi: 10.1124/jpet.116.233510.
  • Vevelstad, Merete; Øiestad, Elisabeth Leere; Bremer, Sara; Bogen, Inger Lise; Zackrisson, Anna-Lena & Arnestad, Marianne (2016). Is toxicity of PMMA (paramethoxymethamphetamine) associated with cytochrome P450 pharmacogenetics? Forensic Science International. ISSN 0379-0738. 261, p. 137–147. doi: 10.1016/j.forsciint.2016.02.027.
  • Viluksela, Matti; Heikkinen, Päivi; van der Ven, Leo T.M.; Rendel, Filip; Roos, Robert & Esteban, Javier [Show all 29 contributors for this article] (2014). Toxicological profile of ultrapure 2,2′,3,4,4′,5,5′- heptachlorbiphenyl (PCB 180) in adult rats. PLOS ONE. ISSN 1932-6203. 9:e0104639(8). doi: 10.1371/journal.pone.0104639.
  • Breivik, Torbjørn; Bogen, Inger Lise; Haug, Kristin Huse; Fonnum, Frode; Opstad, Per Kristian & Eide, Dag Markus (2014). Effects of long-term exposure of 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") on neuronal transmitter transport, brain immuno-regulatory systems and progression of experimental periodontitis in rats. Neurochemistry International. ISSN 0197-0186. 72, p. 30–36. doi: 10.1016/j.neuint.2014.04.002.
  • Bogen, Inger Lise; Boix, Fernando; Nerem, Elisabeth; Mørland, Jørg & Andersen, Jannike Mørch (2014). A monoclonal antibody specific for 6-monoacetylmorphine reduces acute heroin effects in mice. Journal of Pharmacology and Experimental Therapeutics. ISSN 0022-3565. 349(3), p. 568–576. doi: 10.1124/jpet.113.212035.
  • Berntsen, H F; Wigestrand, Mattis Brænne; Bogen, Inger Lise; Fonnum, Frode; Walaas, S. Ivar & Moldes-Anaya, Angel (2013). Mechanisms of penitrem-induced cerebellar granule neuron death in vitro: Possible involvement of GABA(A) receptors and oxidative processes. Neurotoxicology. ISSN 0161-813X. 35, p. 129–136. doi: 10.1016/j.neuro.2013.01.004.
  • Dervola, Kine-Susann Noren; Roberg, Bjørg Åse; Wøien, Grete; Bogen, Inger Lise; Sandvik, Torbjørn & Sagvolden, Terje [Show all 9 contributors for this article] (2012). Marine omega-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behavior and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD. Behavioral and Brain Functions. ISSN 1744-9081. 8(56). doi: 10.1186/1744-9081-8-56. Full text in Research Archive
  • Wendt, Anna; Speidel, Dina; Danielsson, Anders; Esguerra, Jonathan L S; Bogen, Inger Lise & Walaas, S. Ivar [Show all 8 contributors for this article] (2012). Synapsins I and II Are Not Required for Insulin Secretion from Mouse Pancreatic beta-cells. Endocrinology. ISSN 0013-7227. 153(5), p. 2112–2119. doi: 10.1210/en.2011-1702.
  • Bogen, Inger Lise; Jensen, Vidar; Hvalby, Øyvind Christian & Walaas, S. Ivar (2011). Glutamatergic neurotransmission in the synapsin I and II double knock-out mouse. Seminars in Cell and Developmental Biology. ISSN 1084-9521. 22(4), p. 400–407. doi: 10.1016/j.semcdb.2011.07.004.
  • Bogen, Inger Lise; Jensen, Vidar; Hvalby, Øyvind Christian & Walaas, S. Ivar (2009). Synapsin-dependent development of glutamatergic vesicles and presynaptic plasticity in postnatal mouse brain. Neuroscience. ISSN 0306-4522. 158(1), p. 231–241. doi: 10.1016/j.neuroscience.2008.05.055.
  • Bogen, Inger Lise; Haug, Kristin Huse; Roberg, Bjørg Åse; Fonnum, Frode & Walaas, S. Ivar (2009). The importance of synapsin I and II for neurotransmitter levels and vesicular storage in cholinergic, glutamatergic and GABAergic nerve terminals. Neurochemistry International. ISSN 0197-0186. 55(1-3), p. 13–21. doi: 10.1016/j.neuint.2009.02.006.
  • Bogen, IL; Risa, Øystein; Risa, O; Haug, KH; Sonnewald, Ursula & Fonnum, F [Show all 7 contributors for this article] (2008). Distinct changes in neuronal and astrocytic amino acid neurotransmitter metabolism in mice with reduced numbers of synaptic vesicles. Journal of Neurochemistry. ISSN 0022-3042. 105(6), p. 2524–2534. doi: 10.1111/j.1471-4159.2008.05344.x.
  • Bogen, Inger Lise; Boulland, Jean-Luc; Mariussen, Espen; Wright, Marianne; Fonnum, Frode & Kao, H.T [Show all 7 contributors for this article] (2006). Absence of synapsin I and II is accompanied by decreases in vesicular transport of specific neurotransmitters. Journal of Neurochemistry. ISSN 0022-3042. 96, p. 1458–1466. doi: 10.1111/j.1471-4159.2005.03636.
  • Hallberg, Olof Ehlers; Bogen, Inger Lise; Reistad, Trine; Haug, Kristin Huse; Wright, Marianne & Fonnum, Frode (2006). Differential development of vesicular glutamate transporters in brain: An in vitro study of cerebellar granule cells. Neurochemistry International. ISSN 0197-0186. p. 579–585. doi: 10.1016/j.neuint.2005.12.027.
  • Gundersen, Yngvar; Vaagenes, Per; Thrane, Ingjerd; Bogen, Inger Lise; Haug, Kristin Huse & Reistad, Trine (2005). Response of circulating immune cells to major gunshot injury, haemorrhage, and acute surgery. Injury. ISSN 0020-1383. 36(8), p. 949–955. doi: 10.1016/j.injury.2004.09.021. Full text in Research Archive
  • Haug, Kristin Huse; Bogen, Inger Lise; Osmundsen, Harald; Walaas, Sven Ivar & Fonnum, Frode (2005). Effects on cholinergic markers in rat brain and blood after short and prolonged administration of Donepezil. Neurochemical Research. ISSN 0364-3190. 30(12), p. 1511–1520.
  • Gylterud, Simen; Bogen, Inger Lise; Walaas, Sven Ivar; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2005). Ultrastructural quantification of glutamate receptors at excitatory synapses in hippocampus of synapsin I+II double knock-out mice. Neuroscience. ISSN 0306-4522. 136, p. 769–777.
  • Myhre, Oddvar; Sterri, Sigrun Hanne; Bogen, Inger Lise & Fonnum, Frode (2004). Erk1/2 phosphorylation and reactive oxygen species formation via nitric oxide and Akt-1/Raf-1 crosstalk in cultured rat cerebellar granule cells exposed to the organic solvent 1,2,4-trimethylcyclohexane. Toxicological Sciences. ISSN 1096-6080. 80(2), p. 296–303. doi: 10.1093/toxsci/kfh166.
  • Bogen, Inger Lise; Haug, Kristin Huse; Myhre, Oddvar & Fonnum, Frode (2003). Short- and long-term effects of MDMA ("ecstasy") on synaptosomal and vesicular uptake of neurotransmitters in vitro and ex vivo. Neurochemistry International. ISSN 0197-0186. 43(4-5), p. 393–400. doi: 10.1016/S0197-0186(03)00027-5.

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  • Kogler, Stian; Aizenshtadt, Aleksandra; Harrison, Sean Philip; Sullivan, Gareth John; Lundanes, Elsa & Bogen, Inger Lise [Show all 9 contributors for this article] (2023). Organ-in-a-column – automated on-line incubation, sampling, and LC-MS analysis for measurement of drug metabolites.
  • Skottvoll, Frøydis Sved; Aizenshtadt, Aleksandra; Harrison, Sean; Krauss, Stefan Johannes Karl; Sullivan, Gareth & Bogen, Inger Lise [Show all 9 contributors for this article] (2022). Organ-in-a-column - On-line incubation and LC-MS-analysis for drug metabolism studies.
  • Boger, Ida Caroline Sneis; Nerem, Elisabeth; Skottvoll, Frøydis Sved; Harrison, Sean; Sullivan, Gareth & Lundanes, Elsa [Show all 8 contributors for this article] (2020). Determination of liver organoid-induced drug metabolites using liquid chromatography-mass spectrometry (LC-MS)”.
  • Kongstorp, Mette; Andersen, Jannike Mørch; Bogen, Inger Lise & Stiris, Tom (2019). Prenatal exposure to opioid maintenance treatment (OMT) reduces cognitive performance in young adult rats.
  • Mrša, Ago; Boger, Ida Caroline Sneis; Nerem, Elisabeth; Skottvoll, Frøydis Sved; Harrison, Sean & Lundanes, Elsa [Show all 9 contributors for this article] (2019). Studying organoid drug metabolism using UHPLC/nanoLC-MS.
  • Skottvoll, Frøydis Sved; Boger, Ida Caroline Sneis; Harrison, Sean; Nerem, Elisabeth; Bogen, Inger Lise & Sullivan, Gareth [Show all 7 contributors for this article] (2019). LC-MS approaches to liver organoid analyses.
  • Kongstorp, Mette; Andersen, Jannike Mørch & Bogen, Inger Lise (2018). Prenatal exposure to opioid maintenance treatment (OMT) reduced cognitive performance in young adult rats.
  • Kongstorp, Mette; Andersen, Jannike Mørch & Bogen, Inger Lise (2018). The effect on neonatal rat offspring born to dams exposed to methadone or buprenorphine during pregnancy.
  • Kongstorp, Mette; Andersen, Jannike Mørch & Bogen, Inger Lise (2017). Neurobiological development in rat pups exposed to methadone or buprenorphine during gestation.
  • Bogen, Inger Lise; Boix, Fernando; Nerem, Elisabeth; Mørland, Jørg & Andersen, Jannike Mørch (2013). Prekliniske studier av en heroin-vaksine.
  • Bogen, Inger Lise; Boix, Fernando; Nerem, Elisabeth; Mørland, Jørg & Andersen, Jannike Mørch (2013). Preklinisk studie av en passiv heroinvaksine.
  • Bogen, Inger Lise; Andersen, Jannike Mørch; Boix, Fernando; Nerem, Elisabeth; Normann, Per Trygve & Mørland, Jørg (2012). Heroin abuse and addiction: Heroin metabolism as a key player and possible target for new pharmacotherapy.
  • Bergh, Marianne Skov-Skov; Øiestad, Åse Marit Leere; Bogen, Inger Lise & Wilson, Steven Ray Haakon (2020). Fentanyl Analogs: Development of Bioanalytical Methods for Forensic Case Work and Studies of Metabolism and Pharmacodynamic Effects. Matematisk Naturvitenskapelig fakultet, Universitetet i Oslo. ISSN 1501-7710. 2020(2287).
  • Boger, Ida Caroline Sneis; Wilson, Steven Ray Haakon; Skottvoll, Frøydis Sved; Lundanes, Elsa & Bogen, Inger Lise (2020). Determination of liver organoid- and spheroid induced drug metabolites using liquid chromatography-mass spectrometry. Universitetet i Oslo.
  • Vevelstad, Merete; Vege, Åshild; Arnestad, Marianne; Bogen, Inger Lise & Øiestad, Elisabeth Leere (2018). Para-methoxymethamphetamine (PMMA): A study of risk factors for fatal intoxication with emphasis on metabolite pattern and CYP genetics. Universitetet i Oslo. ISSN 978-82-8377-282-1.

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Published Aug. 18, 2022 7:25 AM - Last modified Oct. 19, 2023 2:33 PM