Massimiliano Pio Di Cagno

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Phone +47 22856598
Mobile phone 97688378
Room 170
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Visiting address Farmasibygningen
Postal address Postboks 1068 Blindern 0316 Oslo

With my research, me and my team work very hard to support the implementation of the 3Rs principle (Refine, Replace and Reduce) in animal testing, and promote the European Commission vision of a sustainable pharmaceutical research and drug development animal testing free within 2030. My research is based on a unique combination of in vitro and computational (in silico) methods to predict the behaviour of new drugs and drug formulations in vivo to serve biowaiver in drug discovery and pre-clinical stage of drug development. All my projects include collaboration with pharmaceutical industries and pharmaceutical stakeholders.

My ambition as researcher is to to contribute to the United Nations Sustainable Development Goals (SDGs) as follows:

Better understanding of drug absorption mechanism empowers new and potent medicine, for the health and well-being for all

Technologies that replace animal testing and utilize little water help to ensure availability and sustainable management of water supply for all

The implementation of recyclable In vitro/in silico tools in pharmaceutics R&D promotes a sustainable industrialization

A cost-effective drug development free from animal testing means affordable drugs to everyone, reducing inequality within and among countries

Refining, Reducing and Replacing animal testing reduces the energy consumption and CO2 emissions from pharmaceutical industries, positively affecting climate changes

We collaborate with industrial and academic partners that share our very same sustainable vision

 

Tags: Pharmaceutics

Publications

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  • Di Cagno, Massimiliano Pio (2020). In vitro artificial permeability assays: a guide for users.
  • Di Cagno, Massimiliano Pio & Stein, Paul C (2019). Studying the effect of solubilizing agents on drug diffusion through the unstirred water layer (UWL) by localized spectroscopy .
  • Wu, Iren Yeeling; Nikolaisen, Trygg Einar; Skalko-Basnet, Natasa & Di Cagno, Massimiliano Pio (2018). Tonicity environmental changes do affect drug release from large unilamellar vesicles.
  • Wu, Iren Yeeling; Nikolaisen, Trygg Einar; Skalko-Basnet, Natasa & Di Cagno, Massimiliano Pio (2017). Influence of the environmental tonicity perturbations on the release of two fluorescent markers from large unilamellar vesicles (LUVs).
  • Wu, Iren Yeeling; Skalko-Basnet, Natasa & Di Cagno, Massimiliano Pio (2017). Influence of the environmental tonicity perturbations on the release of two fluorescent markers from large unilamellar vesicles (LUVs).
  • Stelzl, Dominik; Nielsen, Thorbjørn Terndrup; Hansen, Terkel & Di Cagno, Massimiliano Pio (2016). β-CD-dextran for efficient sequestration of cholesterol from phospholipid bilayers: Mechanistic and safe-toxicity investigations .
  • Di Cagno, Massimiliano Pio (2015). PermeapadTM: an innovative tool for passive drug permeabilities investigation.
  • Di Cagno, Massimiliano Pio (2015). Biomimetic Barrier PermeapadTM: an innovative tool for passive drug permeabilities investigation.
  • Di Cagno, Massimiliano Pio (2014). β-cyclodextrin-dextran polymers for the solubilization of poorly soluble drugs.
  • Di Cagno, Massimiliano Pio (2013). True supersaturation states induced by polymeric micelles and liposomes: the mechanistic explanation of drug permeability enhancements.
  • Di Cagno, Massimiliano Pio (2012). Study on the host-guest interaction between different β-cyclodextrin derivatives and model drug ibuprofen.
  • Di Cagno, Massimiliano Pio (2012). Antioxidant micelles as optimal tools for delivery of unstable pharmaceutical entities.
  • Di Cagno, Massimiliano Pio (2012). Preformulation of poorly soluble and Instable cytotoxic compounds: A comparison of three approaches for oral and i.v. administration.
  • Di Cagno, Massimiliano Pio (2011). New 3-hydroxyquinolinone derivatives with promising anticancer activity: the challenge of water media.
  • Di Cagno, Massimiliano Pio (2010). Host-guest Interaction between different commercial types of β-cyclodextrin and ibuprofen, Drug Transport and Delivery.
  • Di Cagno, Massimiliano Pio (2010). Liposomes as vehicle do increase water solubility of new quinolones derivatives with promising anticancer activity.

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Published Mar. 1, 2019 10:10 AM - Last modified Oct. 13, 2022 10:58 AM