Massimiliano Pio Di Cagno

Associate Professor - Section for Pharmaceutics and Social Pharmacy

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Email m.p.d.cagno@farmasi.uio.no

Phone +47 22856598

Mobile phone 97688378

Room 170

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Visiting address Farmasibygningen

Postal address Postboks 1068 Blindern 0316 Oslo

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With my research, me and my team work very hard to support the implementation of the 3Rs principle (Refine, Replace and Reduce) in animal testing, and promote the European Commission vision of a sustainable pharmaceutical research and drug development animal testing free within 2030. My research is based on a unique combination of in vitro and computational (in silico) methods to predict the behaviour of new drugs and drug formulations in vivo to serve biowaiver in drug discovery and pre-clinical stage of drug development. All my projects include collaboration with pharmaceutical industries and pharmaceutical stakeholders.

My ambition as researcher is to to contribute to the United Nations Sustainable Development Goals (SDGs) as follows:

	Better understanding of drug absorption mechanism empowers new and potent medicine, for the health and well-being for all
	Technologies that replace animal testing and utilize little water help to ensure availability and sustainable management of water supply for all
	The implementation of recyclable In vitro/in silico tools in pharmaceutics R&D promotes a sustainable industrialization
	A cost-effective drug development free from animal testing means affordable drugs to everyone, reducing inequality within and among countries
	Refining, Reducing and Replacing animal testing reduces the energy consumption and CO₂ emissions from pharmaceutical industries, positively affecting climate changes
	We collaborate with industrial and academic partners that share our very same sustainable vision

Please have a look at this video that describes how I see the future pharmaceutical development. Vision I share with my industrial partner Phabioc GmbH.

Tags: Pharmaceutics

Tzanova, Martina Martin; Larsen, Bjarke Strøm; Birolo, Rebecca; Cignolini, Sara; Tho, Ingunn & Chierotti, Michele R. [Show all 11 contributors for this article] (2024). Shifting the Focus from Dissolution to Permeation: Introducing the Meso-fluidic Chip for Permeability Assessment (MCPA). Journal of Pharmaceutical Sciences. ISSN 0022-3549. doi: 10.1016/j.xphs.2023.12.012. Full text in Research Archive
Tzanova, Martina Martin; Nguyen, Lisa; Moretti, Federica; Grassi, Mario; Magnano, Greta Camilla & Voinovich, Dario [Show all 9 contributors for this article] (2023). Interpreting permeability as a function of free drug fraction: The case studies of cyclodextrins and liposomes. European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 189. doi: 10.1016/j.ejps.2023.106559. Full text in Research Archive
Sallustio, Valentina; Ferruggia, Giovanna; Di Cagno, Massimiliano Pio; Tzanova, Martina Martin; Marto, Joana & Ribeiro, Helena [Show all 13 contributors for this article] (2023). Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract. Gels. ISSN 2310-2861. 9(5). doi: 10.3390/gels9050362. Full text in Research Archive
jacobsen, Ann-Christin; Visentin, Sonja; Butnarasu, Cosmin; Stein, Paul C & Di Cagno, Massimiliano Pio (2023). Commercially Available Cell-Free Permeability Tests for Industrial Drug Development: Increased Sustainability through Reduction of In Vivo Studies. Pharmaceutics. ISSN 1999-4923. 15(2). doi: 10.3390/pharmaceutics15020592. Full text in Research Archive
Magnano, Greta Camilla; Sut, Stefania; Dall'Acqua, Stefano; Di Cagno, Massimiliano Pio; Lee, Luke & Lee, Ming [Show all 10 contributors for this article] (2022). Validation and testing of a new artificial biomimetic barrier for estimation of transdermal drug absorption. International Journal of Pharmaceutics. ISSN 0378-5173. 628. doi: 10.1016/j.ijpharm.2022.122266.
Corazza, Elisa; Di Cagno, Massimiliano Pio; Bauer-Brandl, Annette; Abruzzo, Angela; Cerchiara, Teresa & Bigucci, Federica [Show all 7 contributors for this article] (2022). Drug delivery to the brain: In situ gelling formulation enhances carbamazepine diffusion through nasal mucosa models with mucin. European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 179. doi: 10.1016/j.ejps.2022.106294. Full text in Research Archive
Tzanova, Martina Martin; Moretti, Federica; Grassi, Gabriele; Stein, Paul; Hiorth, Marianne & Abrami, Michela [Show all 8 contributors for this article] (2022). Modelling drug diffusion through unstirred water layers allows real-time quantification of free/loaded drug fractions and release kinetics from colloidal-based formulations. European journal of pharmaceutics and biopharmaceutics. ISSN 0939-6411. 178, p. 168–178. doi: 10.1016/j.ejpb.2022.08.009. Full text in Research Archive
Corazza, Elisa; Abruzzo, Angela; Giordani, Barbara; Cerchiara, Teresa; Bigucci, Federica & Vitali, Beatrice [Show all 8 contributors for this article] (2022). Human Lactobacillus Biosurfactants as Natural Excipients for Nasal Drug Delivery of Hydrocortisone. Pharmaceutics. ISSN 1999-4923. 14(3). doi: 10.3390/pharmaceutics14030524. Full text in Research Archive
Tzanova, Martina Martin; Randelov, Elizabeta; Stein, Paul C.; Hiorth, Marianne & Di Cagno, Massimiliano Pio (2021). Towards a better mechanistic comprehension of drug permeation and absorption: Introducing the diffusion-partitioning interplay. International Journal of Pharmaceutics. ISSN 0378-5173. 608. doi: 10.1016/j.ijpharm.2021.121116. Full text in Research Archive
Abruzzo, Angela; Parolin, Carola; Corazza, Elisa; Giordani, Barbara; Di Cagno, Massimiliano Pio & Cerchiara, Teresa [Show all 9 contributors for this article] (2021). Influence of Lactobacillus Biosurfactants on Skin Permeation of Hydrocortisone. Pharmaceutics. ISSN 1999-4923. 13(6). doi: 10.3390/pharmaceutics13060820.
Falavigna, Margherita; Stein, Paul C.; Flaten, Gøril Eide & Di Cagno, Massimiliano Pio (2020). Impact of mucin on drug diffusion: Development of a straightforward in vitro method for the determination of drug diffusivity in the presence of mucin. Pharmaceutics. ISSN 1999-4923. 12:168(2), p. 1–13. doi: 10.3390/pharmaceutics12020168. Full text in Research Archive
Wu, Iren Yeeling; Bala, Sonali; Skalko-Basnet, Natasa & Di Cagno, Massimiliano Pio (2019). Interpreting non-linear drug diffusion data: Utilizing Korsmeyer-Peppas model to study drug release from liposomes . European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 138. doi: 10.1016/j.ejps.2019.105026. Full text in Research Archive
Di Cagno, Massimiliano Pio & Stein, Paul C (2019). Studying the effect of solubilizing agents on drug diffusion through the unstirred water layer (UWL) by localized spectroscopy. European journal of pharmaceutics and biopharmaceutics. ISSN 0939-6411. 139, p. 205–212. doi: 10.1016/j.ejpb.2019.04.005. Full text in Research Archive
Wu, Iren Yeeling; Nikolaisen, Trygg Einar; Skalko-Basnet, Natasa & Di Cagno, Massimiliano Pio (2019). The hypotonic environmental changes affect liposomal formulations for nose-to-brain targeted drug delivery . Journal of Pharmaceutical Sciences. ISSN 0022-3549. 108(8), p. 2570–2579. doi: 10.1016/j.xphs.2019.03.006. Full text in Research Archive
Di Cagno, Massimiliano Pio; Clarelli, Fabrizio; Våbenø, Jon; Lesley, Christina; Rahman , Sokar Darsim & Cauzzo, Jennifer [Show all 9 contributors for this article] (2018). Experimental Determination of Drug Diffusion Coefficients in Unstirred Aqueous Environments by Temporally Resolved Concentration Measurements. Molecular Pharmaceutics. ISSN 1543-8384. 15(4), p. 1488–1494. doi: 10.1021/acs.molpharmaceut.7b01053.
Wu, Iren Yeeling; Skalko-Basnet, Natasa & Di Cagno, Massimiliano Pio (2017). Influence of the environmental tonicity perturbations on the release of model compounds from large unilamellar vesicles (LUVs): A mechanistic investigation. Colloids and Surfaces B: Biointerfaces. ISSN 0927-7765. 157, p. 65–71. doi: 10.1016/j.colsurfb.2017.05.062.
Falavigna, Margherita; Skalko-Basnet, Natasa; Cavallari, Cristina; Pini, Andrea; Luppi, Barbara & Di Cagno, Massimiliano Pio (2017). Novel in situ gel-forming solid dosage form (gfSDF) prepared by the simple syringe-based moulding: A screening study. European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 105, p. 11–18. doi: 10.1016/j.ejps.2017.05.008. Full text in Research Archive
Di Cagno, Massimiliano Pio (2017). The potential of cyclodextrins as novel active pharmaceutical ingredients: A short overview. Molecules. ISSN 1431-5157. 22(1), p. 1–14. doi: 10.3390/molecules22010001. Full text in Research Archive
Stelzl, Dominik; Nielsen, Thorbjørn Terndrup; Hansen, Terkel & Di Cagno, Massimiliano Pio (2015). β-CD-dextran polymer for efficient sequestration of cholesterol from phospholipid bilayers: Mechanistic and safe-toxicity investigations. International Journal of Pharmaceutics. ISSN 0378-5173. 496(2), p. 896–902. doi: 10.1016/j.ijpharm.2015.10.041.
Bibi, Hanady A.; Di Cagno, Massimiliano Pio; Holm, Rene & Bauer-Brandl, Annette (2015). Permeapad™ for investigation of passive drug permeability: The effect of surfactants, co-solvents and simulated intestinal fluids (FaSSIF and FeSSIF). International Journal of Pharmaceutics. ISSN 0378-5173. 493(1-2), p. 192–197. doi: 10.1016/j.ijpharm.2015.07.028.
Di Cagno, Massimiliano Pio; Bibi, Hanady A. & Bauer-Brandl, Annette (2015). New biomimetic barrier Permeapad™ for efficient investigation of passive permeability of drugs. European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 73, p. 29–34. doi: 10.1016/j.ejps.2015.03.019.
Cerchiara, Teresa; Abruzzo, Angela; Di Cagno, Massimiliano Pio; Bigucci, Federica; Bauer-Brandl, Annette & Parolin, C [Show all 9 contributors for this article] (2015). Chitosan based micro- and nanoparticles for colon-targeted delivery of vancomycin prepared by alternative processing methods. European journal of pharmaceutics and biopharmaceutics. ISSN 0939-6411. 92, p. 112–119.
Di Cagno, Massimiliano Pio; Nielsen, Thorbjørn Terndrup; Larsen, Kim Lambertsen; Kuntsche, Judith & Bauer-Brandl, Annette (2014). b-Cyclodextrin-dextran polymers for the solubilization of poorly soluble drugs. International Journal of Pharmaceutics. ISSN 0378-5173. 468, p. 258–263. doi: 10.1016/j.ijpharm.2014.04.029.
Di Cagno, Massimiliano Pio & Luppi, Barbara (2013). Drug ‘‘supersaturation’’ states induced by polymeric micelles and liposomes: A mechanistic investigation into permeability enhancements. European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 48, p. 775–780. doi: 10.1016/j.ejps.2013.01.006.
Di Cagno, Massimiliano Pio; Stein, Paul C; Styskala, Jakub; Hlavac, Jan; Skalko-Basnet, Natasa & Bauer-Brandl, Annette (2012). Overcoming instability and low solubility of new cytostatic compounds: A comparison of two approaches. European journal of pharmaceutics and biopharmaceutics. ISSN 0939-6411. 80, p. 657–662. doi: 10.1016/j.ejpb.2011.11.016.
Di Cagno, Massimiliano; Styskala, Jakub; Hlavac, Jan; Brandl, Martin; Bauer-Brandl, Annette & Skalko-Basnet, Natasa (2011). Liposomal solubilization of new 3-hydroxy-quinolinone derivatives with promising anticancer activity: a screening method to identify maximum incorporation capacity. Journal of liposome research. ISSN 0898-2104. 21(4), p. 272–278. doi: 10.3109/08982104.2010.550265.
Di Cagno, Massimiliano; Stein, Paul C; Skalko-Basnet, Natasa; Brandl, Martin & Bauer-Brandl, Annette (2011). Solubilization of ibuprofen with beta-cyclodextrin derivatives: Energetic and structural studies. Journal of Pharmaceutical and Biomedical Analysis. ISSN 0731-7085. 55(3), p. 446–451. doi: 10.1016/j.jpba.2011.02.022.
Stein, Paul C; Di Cagno, Massimiliano Pio & Bauer-Brandl, Annette (2011). A Novel Method for the Investigation of Liquid/Liquid Distribution Coefficients and Interface Permeabilities Applied to the Water-Octanol-Drug System. Pharmaceutical Research. ISSN 0724-8741. 28(2), p. 2140–2146. doi: 10.1007/s11095-011-0441-6.

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Di Cagno, Massimiliano Pio (2023). Quantification of free/loaded drug fractions and release kinetics from colloidal-based formulations.
Di Cagno, Massimiliano Pio (2022). Permeapad® an in vitro tool for predicting biopharmaceutical drug performance.
Di Cagno, Massimiliano Pio (2021). Permeapad® an in vitro tool for predicting biopharmaceutical drug performance.
Di Cagno, Massimiliano Pio (2020). In vitro artificial permeability assays: a guide for users.
Di Cagno, Massimiliano Pio & Stein, Paul C (2019). Studying the effect of solubilizing agents on drug diffusion through the unstirred water layer (UWL) by localized spectroscopy .
Wu, Iren Yeeling; Nikolaisen, Trygg Einar; Skalko-Basnet, Natasa & Di Cagno, Massimiliano Pio (2018). Tonicity environmental changes do affect drug release from large unilamellar vesicles.
Wu, Iren Yeeling; Nikolaisen, Trygg Einar; Skalko-Basnet, Natasa & Di Cagno, Massimiliano Pio (2017). Influence of the environmental tonicity perturbations on the release of two fluorescent markers from large unilamellar vesicles (LUVs).
Wu, Iren Yeeling; Skalko-Basnet, Natasa & Di Cagno, Massimiliano Pio (2017). Influence of the environmental tonicity perturbations on the release of two fluorescent markers from large unilamellar vesicles (LUVs).
Stelzl, Dominik; Nielsen, Thorbjørn Terndrup; Hansen, Terkel & Di Cagno, Massimiliano Pio (2016). β-CD-dextran for efficient sequestration of cholesterol from phospholipid bilayers: Mechanistic and safe-toxicity investigations .
Scaglione, Silvia & Di Cagno, Massimiliano Pio (2015). Concepts and Models for Drug Permeability Studies. In Bruno, Sarmento (Eds.), Concepts and Models for Drug Permeability Studies. Cell and Tissue based In Vitro Culture Models. Elsevier. ISSN 9780081000946. p. 613–626. doi: https:/doi.org/10.1016/B978-0-443-15510-9.00005-0.
Di Cagno, Massimiliano Pio (2015). PermeapadTM: an innovative tool for passive drug permeabilities investigation.
Di Cagno, Massimiliano Pio (2015). Biomimetic Barrier PermeapadTM: an innovative tool for passive drug permeabilities investigation.
Di Cagno, Massimiliano Pio (2014). β-cyclodextrin-dextran polymers for the solubilization of poorly soluble drugs.
Di Cagno, Massimiliano Pio (2013). True supersaturation states induced by polymeric micelles and liposomes: the mechanistic explanation of drug permeability enhancements.
Di Cagno, Massimiliano Pio (2012). Study on the host-guest interaction between different β-cyclodextrin derivatives and model drug ibuprofen.
Di Cagno, Massimiliano Pio (2012). Antioxidant micelles as optimal tools for delivery of unstable pharmaceutical entities.
Di Cagno, Massimiliano Pio (2012). Preformulation of poorly soluble and Instable cytotoxic compounds: A comparison of three approaches for oral and i.v. administration.
Di Cagno, Massimiliano Pio (2011). New 3-hydroxyquinolinone derivatives with promising anticancer activity: the challenge of water media.
Di Cagno, Massimiliano Pio (2010). Host-guest Interaction between different commercial types of β-cyclodextrin and ibuprofen, Drug Transport and Delivery.
Di Cagno, Massimiliano Pio (2010). Liposomes as vehicle do increase water solubility of new quinolones derivatives with promising anticancer activity.

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Published Mar. 1, 2019 10:10 AM - Last modified Aug. 15, 2023 9:43 AM

Research groups

Site-specific Drug Delivery (SiteDel)