In her thesis, Linda investigated both electromembrane extraction (EME) and 96-well LPME for extraction of drugs of abuse. The experimental work represent a major step forward for both EME and LPME. Thus, EME of compounds with very weakly basic properties has been characterised and discussed very comprehensively, as well as EME of basic substances in a large polarity window. Additionally, the clean-up properties of EME was investigated in details, and EME was found very efficient for removal of blood phospholipids. The EME experiments have contributed with new fundamental understanding, which can be applied also for other substances than drugs of abuse. The LPME part of the work has developed and validated methods for drugs of abuse, with strong potential for routine use. The EME and LPME experiments were conducted with the same set of substances. Therefore the thesis gives a unique understanding of differences and similarities of the two different extraction principles, based on electrokinetic migration and passive diffusion, respectively.
