Determination of tryptamine analogs in whole blood by 96-well electromembrane extraction and UHPLC-MS/MS

A high-throughput method with electromembrane extraction and UHPLC-MS/MS was developed for the simultaneous determination of 20 tryptamine analogs in whole blood. Tryptamines are psychoactive substances, and may not be discovered in routine toxicology screening due to the diversity in structural analogs.  We here present a single-step green sample preparation procedure which solves this issue. 

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