A tutorial on clever optimization of EME methods

In this tutorial, we show how response surface methodology (RSM) can transform the optimization of electromembrane extraction (EME) from a trial-and-error exercise into a systematic and highly efficient process. We guide readers through every step of the workflow, from selecting the most relevant EME parameters and designing experiments, to building, evaluating, and interpreting statistical models. Supported by practical case studies, the tutorial highlights how RSM can reveal parameter interactions, identify optimal extraction conditions, and accelerate the development of robust, efficient, and greener EME methods…

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