Intestinal drug delivery
Intestinal drug delivery may be very useful if there exist an absorption window where conditions for absorption of the drug is superior over other parts of the gastrointestinal tract. In addition intestinal drug delivery is very important for treatment of local diseases of the intestinal tract itself especially in the colon.
MCC pellets coated with a combination of alginate and chitosan.
Colon drug delivery is though quite difficult to obtain. The formulation must withstand the harsh environment as well as the variable transit time in the stomach. In addiiton the shift in pH when going from the stomach to the small intestine is also challenging. Numerous approaches have been tried to obtain colon drug delivery such as a pH dependant approach and a time dependant approach. In addition, a promising approach is to rely on bipolymers that will be degraded enzymatically when entering the colon.
The group has been working with the topic of intestinal drug delivery as well as colon drug delivery for several years.