Drug delivery to the oral cavity
Drug delivery to the oral cavity can be used both for systemic treatment as well as local treatment of diseases in the oral cavity such as ulcers, fungal or bacterial infections, cancer and dental problems as caries and periodontal infections.
Spray dried pectin microparticle.
Drug delivery for local treatment of the oral cavity is quite challenging even though the oral cavity offers easy access. This is mainly caused by the short retention time in the mouth due to the salivary flow. One way to overcome the problem with short retention time is to formulate a bioadhesive system. A bioadhesive drug delivery system may stick to the oral mucosa and thereby prolong the retention time.
The SiteDel group has for several years been working with nanoparticulate systems. The drug carrier spans from liposomes to polymer based nanoparticles.