Disputation: Magnus Saed Restan
Doctoral candidate Magnus Saed Restan at the Department of Pharmacy, Faculty of Mathematics and Natural Sciences, is defending the thesis "Electromembrane extraction - enhanced theoretical understanding and new applications" for the degree of Philosophiae Doctor.
The PhD defence will be fully digital and streamed directly using Zoom. The host of the session will moderate the technicalities while the chair of the defence will moderate the disputation.
Ex auditorio questions: the chair of the defence will invite the audience to ask ex auditorio questions either written or oral. This can be requested by clicking 'Participants -> Raise hand'.
Mass spectrometry: untargeted and targeted analysis
Main research findings
In the field of bioanalysis, drug molecules and endogenous compounds can be determined and quantified from biological samples such as blood and urine. However, the complexity of such biological samples makes selective determination of target compounds challenging. Therefore, a sample preparation step is often implemented to extract and separate target compounds from the rest of the sample before analysis. The work in this thesis has been focused on the further development of the sample preparation technique Electromembrane Extraction (EME). In EME, an electrical field is applied across an organic solvent immobilized within a porous membrane, which is used to selectively and rapidly separate target compounds based on their electrical charge and polarity. Even though previous work has demonstrated the high functionality and versatility of EME, more work is deemed necessary in order to move EME from an academic setting over to routine laboratories and analytical industries. This present work has contributed to this pursuit by increasing the theoretical knowledge of EME related to pH conditions and its effects on the selective extraction of non-polar basic analytes. Additionally, the EME concept was tuned towards sample purification of unwanted matrix components, thereby increasing the sample preparation possibilities of EME.
Eitt steg nærmare legemiddelsjekk ved kjøkkenbordet (Titan 10. mars 2020, in Norwegian)