Disputation: Frederik André Hansen

Doctoral candidate Frederik André Hansen at the Department of Pharmacy, Faculty of Mathematics and Natural Sciences, is defending the thesis "Electromembrane extraction of polar pharmaceutical bases and endogenous metabolites" for the degree of Philosophiae Doctor.

illustration photo

The PhD defence will be fully digital and streamed directly using Zoom. The host of the session will moderate the technicalities while the chair of the defence will moderate the disputation.

Ex auditorio questions: the chair of the defence will invite the audience to ask ex auditorio questions either written or oral. This can be requested by clicking 'Participants -> Raise hand'.

Trial lecture: Drug analysis in wastewater to define the size and habits of a population

Main research findings

Biological samples such as blood and urine are extensively used for measuring different chemicals in the human (or animal) body, for example pharmaceutical drugs, drugs-of-abuse, or different metabolites. In addition to the substances of interest, these samples however contain thousands of other compounds, commonly called matrix components, which may interfere with the measurements. Clean up of the samples is therefore mandatory prior to analysis. One option is the do an extraction, in which substances of interest are removed from the blood or urine and transferred into a clean solution for further analysis. Extractions are however difficult to get efficient and selective when the substances of interest have similar properties to the matrix components. Many matrix components are for example highly water-soluble. In the present work, extraction systems for water-soluble substances based on voltage-assisted transport across a thin oil membrane have therefore been developed and studied. Designing the oil membrane to provide desirable chemical interactions was found to be the best strategy to ensure high extraction efficiency, and for controlling the broadness of selectivity. The work has demonstrated the principal feasibility of this technique, and will serve as foundational bricks that future developments may be built upon.

Read more (in Norwegian)

Published Aug. 18, 2021 10:00 AM - Last modified Feb. 3, 2022 8:34 AM