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Trial lecture - time and place
05.06.2025, 10.15. Geologibygningen, aud. 1
Microsampling for omics analysis - analytical challenges and potential implications
Conferral summary
Blodprøver er sentrale i diagnostikk og antidoping, men tradisjonelle metoder krever ofte venøs prøvetaking og omfattende laboratoriearbeid. Denne doktoravhandlingen omhandler utvikling og optimalisering av «smart samplers», der prøvematerialet er funksjonalisert for å fange målstoffer direkte under prøvetakingen. Resultatene viser at teknologien kan forenkle og forbedre blodanalyser, gjøre prosessen mer bærekraftig og åpne for hjemmebasert prøvetaking.
Main research findings
Most blood tests today require venous blood draws, which can be invasive and require skilled healthcare personnel. This PhD thesis explores an alternative: smart samplers. Simple devices that not only collect blood through a finger prick but also immediately start preparing it for analysis.
What makes smart samplers unique is that their surfaces are functionalized with antibodies that can selectively capture key molecules for diagnostics and doping control directly during sampling. By combining collection and preparation into one easy-to-use tool, smart samplers reduce the need for complicated laboratory processing. Some of the developed smart samplers in this thesis are even based on paper, making them more environmentally friendly and cost-effective. Their simplicity allows for blood sampling at home without professional assistance, with samples sent directly to the lab by mail.
Compared to traditional methods, smart samplers demonstrated faster processing, improved reproducibility at low concentrations, and simpler handling. This technology has the potential to make blood testing quicker, greener, and more accessible, paving the way for new solutions in clinical diagnostics, therapeutic drug monitoring, and anti-doping analysis.