Trial lecture - time and place
13.05.2025, 10.15, Helga Engs hus, auditorium 1
Solubility improvement of the BCS class II drugs beyond amorphous solid dispersions: recent advances
Conferral summary
3D-printing gir nye muligheter for å skreddersy legemidler til den enkelte pasient – raskt og kostnadseffektivt, samt å produsere legemidler i sin amorfe glass-form for å øke biotilgjengelighet og gi et høyere opptak I kroppen. I denne avhandling er det utviklet en termodynamisk metode og en programvare for å forutsi om et legemiddel og et hjelpestoff kan smeltes sammen til et amorft glass under smeltebasert 3D-printing. Arbeidet bringer oss et skritt nærmere persontilpassede tabletter laget med 3D-printing samt gir ny kunnskap om farmasøytiske glass-formuleringer.
Main research findings
3D printing is changing how we produce pharmaceuticals. Using this technology, we can create personalized tablets tailored to individual patients – quickly and cost-effectively. This could be a big step toward delivering optimized treatment to a diverse patient population.
In my research, I explored how to 3D print tablets using a common drug, prednisolone, and a water-soluble polymer, called HPMC. The goal was to prepare the drug in a stable glass-like form – meaning not crystalline – to help it dissolve better in the body after the tablet is taken.
To achieve this, I developed a method to predict whether the drug and polymer could be melted and mixed into this amorphous glass form. This led to the creation of a software tool, the Glass Solution Companion App, which helps researchers doing the complex thermodynamic equations necessary to predict the possibility of getting a pharmaceutical glass.
The printed tablets showed overall good quality, and the drug was mostly present in its desired glass form. While small amounts of crystals remained in the tablets, the results are promising. This work brings us a step closer to producing high-quality tablets through 3D printing – and to advancing the science behind pharmaceutical glasses for improved drug delivery.
Read more (in Norwegian)
- Å utvikle legemiddel kan gå mykje raskare med desse utrekningane (forskning.no, 24.3.23)
- 3D-utskrift kan gje kvar pasient spesialtilpassa tablettar (forskning.no, 15.1.24)
- Forskarar lanserer ny app for raskare utvikling av legemiddel (forskning.no, 7.11.24)