Trial lecture - time and place
26.06.2025, 10.15, ZEB building, Auditorium 3
Challenges and advantages of sustainable antimicrobial products
Conferral summary
Denne avhandlingen undersøker egenskapene til naturlige dyp-eutektiske løsemidler (NADES) som farmasøytiske hjelpestoffer, og demonstrerer hvordan de kan brukes i nye bærekraftige produkter til bruk mot blant annet sårinfeksjoner. NADES har vist lovende resultater for bruk i farmasøytiske formuleringer, kan ha bakteriedrepende effekter og bidra til å fjerne biofilm. Arbeidet viser vei for nye effektive behandlinger av kompliserte helsetilstander som kroniske sår, som er en stor utfordring i dagens helsevesen.
Main research findings
The thesis offers valuable insights into how a new type of sustainable liquid could be used as a pharmaceutical excipient to develop antibacterial products for wound and skin infections. The research suggests that some of the investigated liquids have promising qualities for pharmaceutical use and display antibacterial properties, opening up new possibilities for the treatment of for example chronic wounds.
The pharmaceutical industry is going through a change towards a more sustainable future. An important goal is to replace harmful chemicals with more environmentally friendly options. Natural deep eutectic solvents (NADES) are a new group of liquids proposed as “green” solvents. The term “green” refers to sustainable qualities such as being non-toxic to people and animals, non-polluting, and produced from renewable sources.
In this thesis, various NADES were screened and several candidates with promising pharmaceutical properties were found. Tests on biofilms revealed that NADES alone effectively killed bacteria and reduced the amount of biofilm. An antibacterial light-activated film was successfully prepared from sustainable materials using NADES, raw materials from chicken food production and a natural porphyrin. The film showed good quality and had high antibacterial properties. This work lays the foundation for the development of future NADES-based sustainable drug products.
Read more (in Norwegian)
-
Forskarar testar medisin for menneske på griseøyre (forskning.no, 4.10.21)
-
Denne filmen tek knekken på bakteriar (FAI, 11.6.25)