Erik O Pettersen

Professor Emeritus - Biophysics and Medical Physics
Image of Erik O Pettersen
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Visiting address Sem Sælands vei 24 Fysikkbygningen 0371 Oslo
Postal address Postboks 1048 Blindern 0316 Oslo

Teaching

Supervision of students in research:

  • 38 students with completed thesis at the master level
  • 10 students with completed doctoral thesis (Dr. philos and Dr. Scient)

Higher education and employment history

  • Civil engineer at the Department for Physics, University of Trondheim, NTH, in 1972. The main subject was biophysics and the thesis was within radiation biophysics studying effects of X-rays on human cells in culture.
  • Dr. philos at the University of Oslo 1979. The title of the doctoral thesis: "Radiosensitization conferred by oxygen and hypoxic cell sensitizers on human cells cultivated in vitro".

Cooperation

Participation in International research networks:

  • December 1997- Dec 2002: Nordic Academy for Advanced Studies (NorFa): The Nordic Normoxia research Training Network. Co-ordinated by Professor Peter Ebbesen, Laboratory for Stem Cell Research, The Danish Cancer Society.
  • January 2001-January 2004: EU-Network of Excellence with 16 partners: Proposal no QLRT-1999-30579, Contract No QLRI-2000-00579: Acronym: OXNORM. Project title: Optimizing the Oxygen tension for in vitro cell work. Co-ordinated by Professor Peter Ebbesen, Laboratory for Stem Cell Research, The Danish Cancer Society.
  • February 2004- February 2007: Nordic Industrial Fund: Project number 02055: titled Transferring Oxygen Biology to Companies. Co-ordinated by Professor Peter Ebbesen, The University of Aalborg, Denmark.
  • February 2004-February 2009: EU-Integrated Project/large-scale project with 17 Partners (FP6): Proposal/Contract No 502932: Acronym EUROXY. Project title: Targeting newly discovered oxygen-sensing cascades for novel cancer treatments. Biology, equipment, drug candidates. Co-ordinated by Professor Peter Ebbesen, The University of Aalborg, Denmark.
  • EUROXY contains a program for teaching courses at the PhD level and for training of PhD-students by visiting laboratories of consortium partners. This activity is co-ordinated by Erik Pettersen at the University of Oslo.

Coordinator of international research networks:

  • February 2009-February 2014: EU-Collaborative Project/large-scale project with 22 partners (FP7): Acronym: METOXIA. Project title: Metastatic tumours facilitated by hypoxic tumour micro-environments. The kick-off Meeting was held in Oslo 18th-20th february 2009.
Tags: Life sciences

Publications

  • Marzioch, Julia; Kieninger, Jochen; Weltin, Andreas; Flamm, Hubert; Aravindalochanan, Kuppusamy & Sandvik, Joe Alexander [Show all 9 contributors for this article] (2018). On-chip photodynamic therapy-monitoring cell metabolism using electrochemical microsensors. Lab on a Chip. ISSN 1473-0197. 18(22), p. 3353–3360. doi: 10.1039/C8LC00799C.
  • Mikalsen, Stine Gyland; Mikalsen, Lars Tore G; Sandvik, Joe Alexander; Aarnes, Eva-Katrine; Fenne, Siri & Flatmark, Kjersti [Show all 9 contributors for this article] (2018). Low dose-rate irradiation with [3H]-labelled valine to selectively target hypoxic cells in a human colorectal cancer xenograft model. Acta Oncologica. ISSN 0284-186X. 57(9), p. 1216–1224. doi: 10.1080/0284186X.2018.1457223.
  • Kieninger, Jochen; Tamari, Yaara; Enderle, Barbara; Jobst, Gerhard; Sandvik, Joe Alexander & Pettersen, Erik O [Show all 7 contributors for this article] (2018). Sensor access to the cellular microenvironment using the sensing cell culture flask. Biosensors. ISSN 2079-6374. 8(2), p. 1–11. doi: 10.3390/bios8020044. Full text in Research Archive
  • Mikalsen, Stine Gyland; Edin, Nina Frederike J; Sandvik, Joe Alexander & Pettersen, Erik O (2018). Separation of two sub-groups with different DNA content after treatment of T-47D breast cancer cells with low dose-rate irradiation and intermittent hypoxia. Acta Radiologica. ISSN 0284-1851. 59(1), p. 26–33. doi: 10.1177/0284185117699999.
  • Edin, Nina Frederike J; Altaner, Čestmír; Altanerova, Veronica; Ebbesen, Peter & Pettersen, Erik O (2016). Low-Dose-Rate Irradiation for 1 Hour Induces Protection Against Lethal Radiation Doses but Does Not Affect Life Span of DBA/2 Mice. Dose-Response. ISSN 1559-3258. 14(4). doi: 10.1177/1559325816673901.
  • Marzioch, Julia; Kieninger, Jochen; Sandvik, Joe Alexander; Pettersen, Erik O; Qian, Peng & Urban, Gerald (2016). Electrochemical microsensor system for cancer research on photodynamic therapy in vitro. Journal of Physics: Conference Series (JPCS). ISSN 1742-6588. 757(1). doi: 10.1088/1742-6596/757/1/012002.
  • Pettersen, Erik O; Ebbesen, Peter; Gieling, RG; Williams, KJ; Dubois, Ludwig & Lambin, Philippe [Show all 47 contributors for this article] (2015). Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium. Journal of Enzyme Inhibition and Medicinal Chemistry. ISSN 1475-6366. 30(5), p. 689–721. doi: 10.3109/14756366.2014.966704.
  • Edin, Nina Frederike J; Christoffersen, Stine; Fenne, Siri; Sandvik, Joe Alexander & Pettersen, Erik O (2015). Cell inactivation by combined low dose-rate irradiation and intermittent hypoxia. International Journal of Radiation Biology. ISSN 0955-3002. 91(4), p. 336–345. doi: 10.3109/09553002.2014.996262.
  • Larsen, Benjamin Endré; Pettersen, Erik O; Tønnesen, Hanne Hjorth & Melvik, Jan Egil (2015). Microenvironment-dependent respiration of T-47D cells cultured in alginate biostructures. Cell Proliferation. ISSN 0960-7722. 48(3), p. 318–329. doi: 10.1111/cpr.12178.
  • Larsen, Benjamin Endré; Bjørnstad, Jorunn; Pettersen, Erik O; Tønnesen, Hanne Hjorth & Melvik, Jan Egil (2015). Rheological characterization of an injectable alginate gel system. BMC Biotechnology. ISSN 1472-6750. 15:29. doi: 10.1186/s12896-015-0147-7.
  • Marzioch, Julia; Kieninger, Jochen; Sandvik, Joe Alexander; Pettersen, Erik O; Qian, Peng & Urban, Gerald (2015). Photodynamic therapy - In vitro investigation using an electrochemical microsensor system. Procedia Engineering. ISSN 1877-7058. 120, p. 468–471. doi: 10.1016/j.proeng.2015.08.671.
  • Bousquet, Paula; Sandvik, Joe Alexander; Arntzen, Magnus Øverlie; Edin, Nina Frederike J; Christoffersen, Stine & Krengel, Ute [Show all 8 contributors for this article] (2015). Hypoxia Strongly Affects Mitochondrial Ribosomal Proteins and Translocases, as Shown by Quantitative Proteomics of HeLa Cells. International Journal of Proteomics. ISSN 2090-2174. doi: 10.1155/2015/678527.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Chang, Cheng; Bergersen, Linda Hildegard & Pettersen, Erik O (2014). The roles of TGF-β3 and peroxynitrite in removal of hyper-radiosensitivity by priming irradiation. International Journal of Radiation Biology. ISSN 0955-3002. 90(7), p. 527–537. doi: 10.3109/09553002.2014.906767.
  • Kieninger, Jochen; Aravindalochanan, Kuppusamy; Sandvik, Joe Alexander; Pettersen, Erik O & Urban, Gerald (2014). Pericellular oxygen monitoring with integrated sensor chips for reproducible cell culture experiments. Cell Proliferation. ISSN 0960-7722. 47(2), p. 180–188. doi: 10.1111/j.1365-2184.2013.12089.x.
  • Larsen, Benjamin Endré; Sandvik, Joe Alexander; Karlsen, Jan; Pettersen, Erik O & Melvik, Jan Egil (2013). Oxygen consumption in T-47D cells immobilized in alginate. Cell Proliferation. ISSN 0960-7722. 46(4), p. 469–481. doi: 10.1111/cpr.12041.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Vollan, Hilde Synnøve; Reger, Katharina; Görlach, Agnes & Pettersen, Erik O (2013). The role of nitric oxide radicals in removal of hyper-radiosensitivity by priming irradiation. Journal of radiation research. ISSN 0449-3060. 54(6), p. 1015–1028. doi: 10.1093/jrr/rrt061.
  • Pettersen, Erik O (2012). Cell cycle alterations by hypoxic microenvironment. In Kopacek, Juraj & Pastorekova, Silvia (Ed.), Tumour Hypoxia: Molecular Mechanisms and Clinical Implications. Peter Lang Publishing Group. ISSN 978-3-631-63991-7. p. 195–216.
  • Chang, Cheng; Edin, Nina Frederike J; Lauritzen, Knut Husø; Aspmodal, Ida; Christoffersen, Stine & Jian, Liu [Show all 10 contributors for this article] (2012). Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. Cellular Oncology. ISSN 1570-5870. 35(3), p. 217–227. doi: 10.1007/s13402-012-0081-9.
  • Edin, Nina Frederike J; Olsen, Dag Rune; Sandvik, Joe Alexander; Malinen, Eirik & Pettersen, Erik O (2012). Low dose hyper-radiosensitivity is eliminated during exposure to cycling hypoxia but returns after reoxygenation. International Journal of Radiation Biology. ISSN 0955-3002. 88(4), p. 311–319. doi: 10.3109/09553002.2012.646046.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Olsen, Dag Rune & Pettersen, Erik O (2009). The elimination of low dose hyper-radiosensitivity by transfer of irradiated-cell conditioned medium depends on dose rate. Radiation Research. ISSN 0033-7587. 171(1), p. 22–32.
  • Ebbesen, Peter; Pettersen, Erik O; Gorr, Thomas A.; Jobst, Gerhard; Williams, Kaye J. & Kieninger, Jochen [Show all 21 contributors for this article] (2009). Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies. Journal of Enzyme Inhibition and Medicinal Chemistry. ISSN 1475-6366. 24 , p. 1–39. doi: 10.1080/14756360902784425.
  • Edin, Nina Frederike J; Olsen, Dag Rune; Stokke, Trond; Sandvik, Joe Alexander; Ebbesen, Peter & Pettersen, Erik O (2009). Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming. International Journal of Radiation Biology. ISSN 0955-3002. 85(12), p. 1157–1165. doi: 10.3109/09553000903242107.
  • Hanisch, PH; Furre, Torbjørn; Olsen, Dag Rune & Pettersen, Erik O (2007). Radiobiological responses for two cell lines following continuous low dose-rate (CLDR) and pulsed dose rate (PDR) brachytherapy. Acta Oncologica. ISSN 0284-186X. 46, p. 602–611. doi: 10.1080/02841860600978981.
  • Pettersen, Erik O; Bjørhovde, Ingunn; Søvik, Åste; Edin, Nina Frederike J; Zachar, V & Hole, Eli Olaug [Show all 8 contributors for this article] (2007). Response of chronic hypoxic cells to low dose-rate irradiation. International Journal of Radiation Biology. ISSN 0955-3002. 83. doi: 10.1080/09553000701287791.
  • Edin, Nina Frederike J; Olsen, Dag Rune; Stokke, T & Pettersen, Erik O (2007). Recovery of low-dose hyper-radiosensitivity following a small priming dose depends on priming dose-rate. International Journal of Low Radiation. ISSN 1477-6545. 4(1), p. 69–86. doi: 10.1504/IJLR.2007.014491.
  • Pettersen, Erik O; Larsen, LH; Ramsing, NB & Ebbesen, P (2005). Pericellular oxygen depletion during ordinary tissue culturing, measured with oxygen microsensors. Cell Proliferation. ISSN 0960-7722. 38, p. 257–267.

View all works in Cristin

  • Arous, Delmon; Pettersen, Erik O; Malinen, Eirik & Hellebust, Taran Paulsen (2018). Radiobiological plan evaluation in brachytherapy using two different cell survival models. Radiotherapy and Oncology. ISSN 0167-8140. 127, p. 1233–1233.
  • Arous, Delmon; Pettersen, Erik O; Malinen, Eirik & Hellebust, Taran Paulsen (2017). Radiotherapy cell survival curves for cervical cancer: Linear quadratic vs universal survival.
  • Rykkelid, Anne Marit; Siem, Sunniva; Görgen, Andreas; Ytre-Hauge, Kristian; Brondz, Efim & Sandvik, Joe Alexander [Show all 9 contributors for this article] (2017). A high-resolution proton irradiator for in vitro studies of relative biological effectiveness.
  • Pettersen, Erik O (2017). Noen sammenhenger mellom stråling og kreft: Og litt om Radon-problematikk på godt og vondt .
  • Hole, Eli Olaug; Edin, Nina Frederike J; Malinen, Eirik; Pettersen, Erik O & Sagstuen, Einar (2017). Biophysics and medical physics at UiO: Research and education. An incomplete overview.
  • Pettersen, Erik O (2015). EKKO; Abels tårn, Radonproblematikk. [Radio]. NRK P2.
  • Bousquet, Paula; Abshiru, Nebiyu; Sandvik, Joe Alexander; Pettersen, Erik O; Thiede, Bernd & Woods, Robert [Show all 8 contributors for this article] (2014). Anti-tumor antibodies and hypoxia.
  • Pettersen, Erik O (2014). The METOXIA project ends this summer: What was it all about? Who participated? Any results pointing forwards? .
  • Pettersen, Erik O (2014). Fysikk og kreft .
  • Pettersen, Erik O (2014). Stråling: Et naturprodukt med konsekvenser innen medisin og energi. Men hvordan virker stråling på oss?
  • Bousquet, Paula; Abshiru, Nebiyu; Johansen, Rune Forstrøm; Bjørås, Magnar; Sandvik, Joe Alexander & Pettersen, Erik O [Show all 10 contributors for this article] (2013). A structural and functional study of anti-ganglioside antibodies. International Journal of Molecular Medicine. ISSN 1107-3756. 32, p. S42–S42.
  • Pettersen, Erik O (2013). Further development within the METOXIA-project period as guided by the CR-UK proposed programme. Coordinator's view.
  • Pettersen, Erik O (2013). A brief summing up of the data produced so far by Cyprotex Discovery Ltd on compounds DTC-24a, Xanti-15a, DH348, NKP60, DH307, DH338 and Acetazolamide.
  • Pettersen, Erik O (2013). A short résumé of to what extent METOXIA reached its goals; planning round-up of the METOXIA project.
  • Pettersen, Erik O (2013). Summing up of METOXIA patenting and possibility for development of a hypoxia-specific drug.
  • Edin, Nina Frederike J; Pettersen, Erik O; Sandvik, Joe Alexander; Bergersen, Linda Hildegard; Chang, Cheng & Vollan, Hilde Synnøve [Show all 9 contributors for this article] (2012). The role of TGFb3 and induced nitric oxide synthase activity in connection with induced resistance against low dose hyper-radiosensitivity.
  • Christoffersen, Stine; Sandvik, Joe Alexander; Pettersen, Erik O & Edin, Nina Frederike J (2012). Cell respiration, hypoxia and low dose rate radiation.
  • Pettersen, Erik O & Ebbesen, Peter (2012). The scientific frame-work for this course and hypoxia and acidosis in human physiology and diseases.
  • Pettersen, Erik O (2012). Hypoxia within METOXIA; possible follow-up?
  • Larsen, B E; Pettersen, Erik O; Karlsen, J. & Melvik, Jan Egil (2012). Oxygen consumption in T-47D cells immobilized in alginate. Journal of Tissue Engineering and Regenerative Medicine. ISSN 1932-6254. 6(Supp. 1), p. 275–275.
  • Pettersen, Erik O (2012). Further development within the METOXIA-project period as guided by the CR-UK proposed programme.
  • Pettersen, Erik O (2012). Further development within the METOXIA-project period with respect to sensor development and 3D in vitro models.
  • Pettersen, Erik O (2012). METOXIA: Tumour micro-environment for new specific cancer treatment. Public Service Review: European Union. ISSN 1472-3395. 23, p. 222–223.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Chang, Cheng; Vollan, Hilde Synnøve; Reger, Katharina & Görlach, Agnes [Show all 8 contributors for this article] (2011). Molecular mechanisms for induction of sustained elimination of low dose hyper-radiosensitivity.
  • Pettersen, Erik O (2011). A short resume of to what extent METOXIA in its first two years reached its goals; an outline of where there are pressing problems for the project as a whole.
  • Pettersen, Erik O (2011). Some background and data for the METOXIA CAIX-inhibitor project.
  • Pettersen, Erik O (2011). METOXIA-prosjektets tematikk og fagområde ved Fysisk Institutt.
  • Pettersen, Erik O (2011). Inven2 a/s and MetaSignal Therapeutics Inc and agreements.
  • Pettersen, Erik O (2011). METOXIA - Hvordan bygge et storskala samarbeidkonsortium innen kreftforskning med et budsjett på over 15 millioner Euro.
  • Pettersen, Erik O (2011). Patent situation and strategy to follow-up the PCT-application on our patented CA-IX inhibitors.
  • Pettersen, Erik O (2011). Hva er vitenskapelige fakta om lavdosebestråling, radon og kreftutvikling.
  • Pettersen, Erik O (2010). Presentation of the METOXIA program.
  • Kieninger, Jochen; Sandvik, Joe Alexander; Pettersen, Erik O; Jobst, Gerhard; Aravindalochanan, Kuppusamy & Urban, Gerald A (2010). Monitoring of peri-cellular oxygen levels in tumor cell cultures by amperometric oxygen sensor array.
  • Pettersen, Erik O (2010). Introductory remarks concerning patenting in METOXIA and the scientific basis of the 2 patents so far in question.
  • Pettersen, Erik O (2010). To what extent has METOXIA in its first year reached its goals? Pressing problems for the project as a whole.
  • Pettersen, Erik O (2010). Patent situation and strategy to demonstrate therapeutic and diagnostic proof-of-principle.
  • Pettersen, Erik O (2010). METOXIA: The translation of new knowledge into cancer detection and treatment processes. Public Service Review: European Union. ISSN 1472-3395. 20, p. 188–189.
  • Pettersen, Erik O (2009). Introduction and overview of purpose of meeting – project status.
  • Pettersen, Erik O (2009). Introduction and overview of purpose of meeting – and project status.
  • Pettersen, Erik O (2009). Implementing our plans. Our five year plan, and our stated goals for 2009 including the deliverables. The recommendation of the three-sub group meetings held in 2009. Decisions we must take during the present meeting. How did we get under way?
  • Pettersen, Erik O (2009). The goals and structure of the METOXIA project and the project organisation.
  • Pettersen, Erik O (2009). Noen poenger om hypoksiens relevans for cellesyklus, kreftutvikling og strålefølsomhet.
  • Pettersen, Erik O (2009). Plans for collaboration between clinicians and with pre-clinicians within METOXIA.
  • Pettersen, Erik O (2009). Noen tanker om hypoksiens relevans for cellesyklus og strålefølsomhet.
  • Pettersen, Erik O (2009). Hypoxic cell cycle and replication.
  • Aravindalochanan, K; Kieninger, Jochen; Sandvik, Joe Alexander; Pettersen, Erik O & Urban, Gerald A (2009). Optimising a nitric oxide sensing technique for hypoxic tumor cell cultures.
  • Pettersen, Erik O (2008). Krever mer av norske forskere. [Newspaper]. Dagsavisen.
  • Pettersen, Erik O (2008). Strålefølsomhet for humane celler: Aspekter relatert til hypoksi, respirasjon og hypersensitivitet.
  • Pettersen, Erik O (2008). Fulfilling Promises.
  • Pettersen, Erik O (2008). Forskere ved Universitetet i Oslo vil drepe kreftceller ved å stråle dem fra innsiden av kroppen. [Radio]. NRK P2, Programmet Verdt å vite.
  • Pettersen, Erik O (2008). Dreper de aller verste kreftcellene. [Newspaper]. Østlendingen.
  • Pettersen, Erik O (2008). Svært lav stråling dreper resistente kreftceller. [Newspaper]. Apollon, Forskningsmagasin fra Universitetet i Oslo, 4/2008.
  • Pettersen, Erik O (2008). Dreper dødelige kreftceller; Norsk kreftfunn. [Newspaper]. Verdens Gang.
  • Pettersen, Erik O (2008). Skal ta knekken på de tøffeste kreftcellene. [Newspaper]. ABC Nyheter.
  • Edin, Nina Frederike J; Olsen, Dag Rune; Sandvik, Joe Alexander; Stokke, Trond & Pettersen, Erik O (2008). Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming.
  • Pettersen, Erik O (2008). EU-søknadsprosess fra start til kontrakt-samarbeid mellom ulike institusjoner.
  • Pettersen, Erik O (2008). Cancer Hypoxia in Retrospect.
  • Pettersen, Erik O (2008). Cancer and Treatment.
  • Pettersen, Erik O (2008). Gjennomslag i EUs rammeprogram - METOXIA, et samarbeidsprosjekt mellom universitet, sykehus og industri.
  • Larsen, Benjamin Endre; Pettersen, Erik O; Karlsen, Jan; Sandvik, Joe Alexander & Melvik, Jan Egil (2008). Oksygenmetabolisme hos celler dyrket i alginat.
  • Larsen, Benjamin Endre; Pettersen, Erik O; Karlsen, Jan; Sandvik, Joe Alexander & Melvik, Jan Egil (2008). Oxygen Metabolism in Cells Cultured in Alginate Matrices.
  • Pettersen, Erik O (2008). Internasjonalisering sett med forskerblikk.
  • Kieninger, Jochen; Dannenberg, Arne; Aravindalochanan, Kuppusamy; Jobst, Gerhard; Pettersen, Erik O & Urban, Gerald A (2007). Amperometric oxygen sensor array with novel chronoamperometric protocols for hypoxic tumor cell cultures.
  • Pettersen, Erik O (2007). Definitions of hypoxia in normal and pathological situations.
  • Pettersen, Erik O (2007). Consortium answering the FP7 call: Health: Translating the hypoxic tumour microenvironment.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Olsen, Dag Rune & Pettersen, Erik O (2007). LOW DOSE HYPER-RADIOSENSITIVITY IN T-47D CELLS.
  • Pettersen, Erik O (2007). Noen aspekter ved hypoksi, respirasjon og strålefølsomhet.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Olsen, Dag Rune & Pettersen, Erik O (2006). Intracellular signalling through medium transfer and low dose hyper-radiosensitivity.
  • Pettersen, Erik O (2006). 7th framework program.
  • Edin, Nina Frederike J; Olsen, Dag Rune & Pettersen, Erik O (2006). Lav-dosis hypersensitivitet hos T-47D brystkræftceller.
  • Pettersen, Erik O (2006). Extreme hypoxia at work.
  • Pettersen, Erik O (2006). WP2 at 24 months: Effects of low oxygen and mild radiation on cell cycling and survival.
  • Pettersen, Erik O (2006). Development of methodology for characterization and definition of appropriate in vitro oxygenation for cancer research.
  • Pettersen, Erik O (2006). An integrated project growing out of EUROXY.

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Published Nov. 4, 2010 12:30 PM - Last modified Oct. 24, 2013 4:19 PM

Projects

No ongoing projects