Maria Perona Fjeldstad

• Yamamoto, Kei; Fischer-Holzhausen, Sophie; Fjeldstad, Maria & Maleckar, Molly (2022). Ordinary Differential Equation-based Modeling of Cells in Human Cartilage. In McCabe, Kimberly (Eds.), Computational Physiology: Simula Summer School 2021 − Student Reports. Springer Nature. p. 25–39. Full text in Research Archive Show summary

  Chondrocytes produce the extracellular cartilage matrix required for smooth joint mobility. As cartilage is not vascularised, and chondrocytes are not innervated by the nervous system, chondrocytes are therefore generally considered non-excitable. However, chondrocytes do express a range of ion channels, ion pumps, and receptors involved in cell homeostasis and cartilage maintenance. Dysfunction in these ion channels and pumps has been linked to degenerative disorders such as arthritis. Because the electrophysiological properties of chondrocytes are difficult to measure experimentally, mathematical modelling can instead be used to investigate the regulation of ionic currents. Such models can provide insight into the finely tuned parameters underlying fluctuations in membrane potential and cell behaviour in healthy and pathological conditions. Here, we introduce an open-source, intuitive, and extendable mathematical model of chondrocyte electrophysiology, implementing key proteins involved in regulating the membrane potential. Because of the inherent biological variability of cells and their physiological ranges of ionic concentrations, we describe a population of models that provides a robust computational representation of the biological data. This permits parameter variability in a manner mimicking biological variation, and we present a selection of parameter sets that suitably represent experimental data. Our mathematical model can be used to efficiently investigate the ionic currents underlying chondrocyte behaviour.

• Fischer-Holzhausen, Sophie; Yamamoto, Kei; Fjeldstad, Maria Perona & Maleckar, Mary Margot Catherine (2021). Probing the Putative Role of KATP Channels and Biological Variability in a Mathematical Model of Chondrocyte Electrophysiology. Bioelectricity. ISSN 2576-3105. 3(4), p. 272–281. doi: 10.1089/bioe.2021.0034. Full text in Research Archive

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• Olsen, Elise; Fjeldstad, Maria; Thon, Sarah; Haug, Nicolai; Lepperød, Mikkel & Sugar, Jørgen [Show all 8 contributors for this article] (2025). Oscillatory Rhythms in the Hippocampus and Entorhinal Cortex During Social Recognition. Full text in Research Archive
• Thon, Sarah Kriebel; Olsen, Elise Reppe; Fjeldstad, Maria Perona; Schøyen, Vemund Sigmundson; Lepperød, Mikkel Elle & Christensen, Ane Charlotte [Show all 8 contributors for this article] (2024). Social and spatial codes in the hippocampus. Full text in Research Archive
• Olsen, Elise Reppe; Fjeldstad, Maria Perona; Thon, Sarah Kriebel; Schøyen, Vemund Sigmundson; Lepperød, Mikkel Elle & Sugar, Jørgen Afseth [Show all 8 contributors for this article] (2024). Exploring social and spatial coding in the lateral and medial entorhinal cortex. Full text in Research Archive
• Fjeldstad, Maria Perona; Lepperød, Mikkel Elle; Schøyen, Vemund Sigmundson; Christensen, Ane Charlotte; Grødem, Sverre & Fyhn, Marianne [Show all 7 contributors for this article] (2024). Theta modulation of grid cells in the medial entorhinal cortex in a novel environment task. Full text in Research Archive
• Thon, Sarah Kriebel; Christensen, Ane Charlotte; Fjeldstad, Maria P; Schøyen, Vemund Sigmundson; Olsen, Elise Reppe & Lepperød, Mikkel Elle [Show all 8 contributors for this article] (2022). Social and spatial codes in hippocampus CA2 and entorhinal cortex. Full text in Research Archive

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