Joachim Mossige (Njord and RITMO, UiO): "Going with the flows of life".
Abstract: How does mammalian life evolve, from a fertilized egg to a fully developed organism? This intriguing question has baffled us for centuries, and despite of intensive research efforts over the years, it is still far from understood. Especially, we lack a good description of the critical gastrulation stage, where a spherical ball of cells starts to elongate due to collective cell migration/flows. In the ITOM-project, we set out to describe these flows and how they shape early mammalian development, and for that, we use stem cell derived embryo models (gastruloids), which we study in the lab using our home-built light-sheet microscope. To gain additional insights about the physics of flowing cells, we pair our experiments with simulations.
Ali Aslan Demir (Njord, UiO) : "From Minerals to Bone: Exploring the Calcium Phosphate Pathway in Bone Regeneration".
Abstract: The intersection between the extracellular matrix and minerals explains how our bodies have developed mineral-rich tissues such as bones. The specific focus would be Calcium Phosphate (CaP) to explain how it interacts with the environment around our bone cells. I will share how we are trying to use organ-on-a-chip technology to understand and mimic these bone growth and repair mechanisms.
Erina Prastyani (Njord, UiO): "Observation of crack orientation in two Westerly granite cores with pre-existing notches under triaxial compression and in situ 4D X-ray imaging"
Abstract: In this presentation, I'll show you my data from two Westerly granite cores with pre-existing notches, subjected to triaxial compression and monitored through in-situ 4D X-ray imaging. These advanced techniques allow for real-time observation of the evolving fracture networks within the rock, offering insights into the preparation process leading to dynamic rupture. Utilizing 3D TIFF images, I employed the global thresholding technique in Avizo software to distinguish between cracks or pores (representing light-density materials) and the surrounding rock or minerals (characterized by high-density materials). This software also enables me to obtain the statistical and geometrical properties of the segmented objects (cracks and pores), and one of those properties is the crack orientation. I aim to illustrate the dynamic evolution of crack orientation in two Westerly granite cores with pre-existing notches as they undergo deformation. Additionally, I'll explore the role of these pre-existing notches in influencing the overall orientation of the cracks.
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