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Centre for Bioinformatics

DNA

The Centre for Bioinformatics constitutes the hub of bioinformatics and computational biology. Our competence spans from precision medicine through all aspects of genomics, regardless of species and populations, through to protein structure.

 

News

  • Network with over a million human genomes becomes available for research Nov. 18, 2022 3:23 PM

    In the long term, this could have a major impact on personalized medicine.

  • Bacterial genes in the faeces can reveal early colorectal cancer Nov. 18, 2022 1:12 PM

    Scientists are now analysing all the genes in the intestinal content of thousands of people. The aim is to reveal the early phase of colorectal cancer by looking at the microbiota in the bowel.

  • New group leader at the Centre for Bioinformatics May 20, 2022 9:18 AM

    The centre for Bioinformatics is delighted to announce that Dr. Trine Rounge has started as a new group leader at the centre from May 2022. Rounge group aims to unravel the molecular mechanisms that can detect and explain cancer progression at an early stage.

  • MoDLE: High-performance stochastic modeling of DNA loop extrusion interactions Apr. 28, 2022 9:21 PM

    "MoDLE is a computational tool for fast, stochastic modeling of molecular contacts from DNA loop extrusion capable of simulating realistic contact patterns genome wide in a few minutes. MoDLE accurately simulates contact maps in concordance with existing molecular dynamics approaches and with Micro-C data, and does so orders of magnitude faster than existing approaches. MoDLE's speed opens up for exploratory and predictive modeling of 3D genome structure in a wide range of settings", says Jonas Paulsen, professor at the Department of Biosciences.

Sven Furberg Seminars in Bioinformatics and Statistical Genomics

No upcoming events.

The latest publications from the Centre

Axcrona K, Aas K, Axcrona U, Skotheim RI (2022)
Re: Spatially Resolved Clonal Copy Number Alterations in Benign and Malignant Tissue
Eur Urol (in press)
DOI 10.1016/j.eururo.2022.11.013, PubMed 36464529

Rossini R, Kumar V, Mathelier A, Rognes T, Paulsen J (2022)
MoDLE: high-performance stochastic modeling of DNA loop extrusion interactions
Genome Biol, 23 (1), 247
DOI 10.1186/s13059-022-02815-7, PubMed 36451166

van der Meer D, Gurholt TP, Sønderby IE, Shadrin AA, Hindley G, Rahman Z, de Lange AG, Frei O, Leinhard OD, Linge J, Simon R, Beck D, Westlye LT, Halvorsen S, Dale AM, Karlsen TH, Kaufmann T, Andreassen OA (2022)
The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition
Commun Biol, 5 (1), 1271
DOI 10.1038/s42003-022-04237-4, PubMed 36402844

Software developed at the centre

  • CARMA

    Software for extraction of DNA copy number motifs in cancer

  • Chimeraviz

    Chimeraviz manages data from fusion gene finders and provides useful visualization tools.

  • CompAIRR

    Comparison of Adaptive Immune Receptor Repertoires

  • Genomic HyperBrowser

    Statistical methodology and computing power to handle a variety of biological inquires on genomic datasets

  • HoCoRT

    Host contamination removal tool

  • immuneML

    immuneML: an ecosystem for machine learning analysis of adaptive immune receptor repertoires

  • KAGE

    Kmer-based Alignment-free Graph Genotyper

  • MoDLE

    MoDLE: High-performance stochastic modeling of DNA loop extrusion interactions

  • ScaR

    ScaR — a tool for sensitive detection of known fusion transcripts: establishing prevalence of fusions in testicular germ cell tumors

  • Swarm

    Highly-scalable and high-resolution amplicon clustering

  • VSEARCH

    A versatile open source tool for metagenomics

Collaborations

ELIXIR Norway

ELIXIR Norway is the Norwegian national node of ELIXIR, the pan-European infrastructure for biological information, supporting life science research and its translation to medicine, environment, the bioindustries and society. This organization is a virtual organization where the Center of Bioinformatics hosts the regional Oslo node. It participates to the national help-desk user support, and in that activity also collaborates and coordinates closely with the Helse Sør-Øst-funded Bioinformatics Core facility.

Partners and collaborating organizational units

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