Research Interests
Our main scientific interest is the comprehension of molecular mechanisms underlying the intracellular trafficking and the interplay between membrane transport and cytoskeleton dynamics. We are especially interested in the Rab family of small GTPases, which are master regulators of intracellular transport but can also regulate other cellular processes, including cytoskeleton remodeling. In order to unravel the fundamental mechanisms that control the spatio-temporal regulation of intracellular transport and cytoskeleton dynamics, we use molecular and cell biology methods combined with state-of-the-art imaging techniques.
Teaching
Collaborations
University of Oslo, Norway
Oslo University Hospital, Norway
Technical University of Denmark, Denmark
Institute Curie, France
University of Salento, Italy
Leiden University, The Netherlands
University of California Berkeley, USA
Tags:
Cell biology,
molecular biology,
membrane trafficking,
Cancer,
Life Science
Selected publications
Lobos Patorniti N, Zulkefli KL, McAdam ME, Vargas P, Bakke O, Progida C. Rai14 is a novel interactor of Invariant chain that regulates macropinocytosis Front Immunol. 2023 Jul 21;14:1182180. doi: 10.3389/fimmu.2023.1182180
Bjørnestad SA, Solbakken MH, Jakobsen KS, Jentoft S, Bakke O, Progida C. Atlantic cod (Gadus morhua) MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals. Front Cell Dev Biol. 2023 Jan 25 doi: 10.3389/fcell.2023.1050323
Guadagno NA, Progida C. Probing the ER-Focal Adhesion Link During Cell Migration. Methods Mol Biol. 2023;2608:39-50. doi: 10.1007/978-1-0716-2887-4_3.
Bjørnestad SA, Guadagno NA, Kjos I, Progida C. Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration. iScience. 2022 Apr 14;25(5):104250. doi: 10.1016/j.isci.2022.104250.
Vestre K, Persiconi I, Distefano MB, Mensali N, Guadagno NA, Bretou M, Wälchli S, Arnold-Schrauf C, Bakke O, Dalod M, Lennon-Dumenil AM, Progida C. Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton. J Cell Sci. 2021 Sep 15;134(18):jcs259221. doi: 10.1242/jcs.259221.
Vinje JB, Guadagno NA, Progida C, Sikorski P. Analysis of Actin and Focal Adhesion Organisation in U2OS Cells on Polymer Nanostructures. Nanoscale Res Lett. 2021 Sep 15;16(1):143. doi: 10.1186/s11671-021-03598-9.
Guadagno NA, Margiotta A, Bjørnestad SA, Haugen LH, Kjos I, Xu X, Hu X, Bakke O, Margadant F, Progida C. Rab18 regulates focal adhesion dynamics by interacting with kinectin-1 at the endoplasmic reticulum. J Cell Biol 6 July 2020; 219 (7): e201809020. doi: https://doi.org/10.1083/jcb.20180902
Sneeggen M, Guadagno NA, Progida C. Intracellular Transport in Cancer Metabolic Reprogramming. Front Cell Dev Biol. 2020 Oct 30;8:597608. doi: 10.3389/fcell.2020.597608.
Perdreau-Dahl H, Progida C, Barfeld SJ, Guldsten H, Thiede B, Arntzen M, Bakke O, Mills IG, Krauss S, Morth JP. Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells. Commun Biol. 2020 Mar 13;3(1):123. doi: 10.1038/s42003-020-0851-2.
Progida C .Multiple Roles of Rab GTPases at the Golgi. In The Golgi Apparatus and Centriole: Functions, Interactions and Role in Disease, (ed. M. Kloc), pp. 95-123. Cham: Springer International Publishing. 2019;67:95-123. doi: 10.1007/978-3-030-23173-6_6.
Guadagno NA, Progida C. Rab GTPases: Switching to Human Diseases. Cells. 2019 Aug 16;8(8). pii: E909. doi: 10.3390/cells8080909.
Vestre K, Kjos I, Guadagno NA, Borg Distefano M, Kohler F, Fenaroli F, Bakke O, Progida C. Rab6 regulates cell migration and invasion by recruiting Cdc42 and modulating its activity. Cell. Mol. Life Sci. (2019). Jul;76(13):2593-2614. doi: 10.1007/s00018-019-03057-w.
Borg Distefano M, Haugen LH, Wang Y, Perdreau-Dahl H, Kjos I, Jia D, Morth JP, Neefjes J, Bakke O, Progida C. TBC1D5 controls the GTPase cycle of Rab7b. J Cell Sci. 2018 Sep 3;131(17). pii: jcs.216630. doi: 10.1242/jcs.216630.
Kjos I, Vestre K, Guadagno NA, Borg Distefano M, Progida C. Rab and Arf proteins at the crossroad between membrane transport and cytoskeleton dynamics. Biochim Biophys Acta. 2018 Jul 17;1865(10):1397-1409. doi: 10.1016/j.bbamcr.2018.07.009.
Mateus D, Marini ES, Progida C, Bakke O. Rab7a modulates ER stress and ER morphology. Biochim Biophys Acta. 2018 May;1865(5):781-793. doi: 10.1016/j.bbamcr.2018.02.011.
Balasundaram SV, Hess J, Durling MB, Moody SC, Thorbek L, Progida C, LaButti K, Aerts A, Barry K, Grigoriev IV, Boddy L, Högberg N, Kauserud H, Eastwood DC, Skrede I. The fungus that came in from the cold: dry rot's pre-adapted ability to invade buildings. ISME J. 2018 Mar;12(3):791-801. doi: 10.1038/s41396-017-0006-8.
Inderberg EM, Mensali N, Oksvold MP, Fallang LE, Fåne A, Skorstad G, Stenvik GE, Progida C, Bakke O, Kvalheim G, Myklebust JH, Wälchli S. Human c-SRC kinase (CSK) overexpression makes T cells dummy. Cancer Immunol Immunother. 2018 Apr;67(4):525-536. doi: 10.1007/s00262-017-2105-9.
Kjos I, Borg Distefano M, Sætre F, Repnik U, Holland P, Jones AT, Engedal N, Simonsen A, Bakke O, Progida C. Rab7b modulates autophagic flux by interacting with Atg4B. EMBO Rep. 2017 Oct;18(10):1727-1739. doi: 10.15252/embr.201744069.
Margiotta A, Progida C, Bakke O, Bucci C. Characterization of the role of RILP in cell migration. Eur J Histochem. 2017 May 31;61(2):2783. doi: 10.4081/ejh.2017.2783.
Repnik U, Distefano MB, Speth MT, Ng MYW, Progida C, Hoflack B, Gruenberg J, Griffiths G. LLOMe does not release cysteine cathepsins to the cytosol but inactivates them in transiently permeabilized lysosomes. J Cell Sci. 2017 Jul 28. pii: jcs.204529. doi: 10.1242/jcs.204529.
Margiotta A, Progida C, Bakke O, Bucci C. Rab7a regulates cell migration through Rac1 and vimentin. Biochim Biophys Acta. 2017 Feb;1864(2):367-381. doi: 10.1016/j.bbamcr.2016.11.020. Epub 2016 Nov 23.
Progida C, Bakke O. Bidirectional traffic between the Golgi and the endosomes - machineries and regulation. J Cell Sci. 2016 Nov 1;129(21):3971-3982.
Kucera A, Bakke O, Progida C. The multiple roles of Rab9 in the endolysosomal system. Commun Integr Biol. 2016 Jul 22;9(4):e1204498. doi: 10.1080/19420889.2016.1204498
Kucera A, Distefano MB, Berg-Larsen A, Skjeldal F, Repnik U, Bakke O, Progida C. Spatio-temporal resolution of Rab9 and CI-MPR dynamics in the endocytic pathway. Traffic. 2016 Mar; 17(3):211-29. doi: 10.1111/tra.12357
Borg Distefano M, Kjos I, Bakke O, Progida C. Rab7b at the intersection of intracellular trafficking and cell migration. Commun Integr Biol. 2015 Aug 27;8(6):e1023492. doi: 10.1080/19420889.2015.1023492.
Borg M, Bakke O, Progida C. A novel interaction between Rab7b and actomyosin reveals a dual role in intracellular transport and cell migration. J Cell Sci. 2014 Nov 15;127(22):4927-39. .
De Luca M, Cogli L, Progida C, Nisi V, Pascolutti R, Sigismund S, Di Fiore PP, Bucci C. RILP regulates vacuolar ATPase through interaction with the V1G1 subunit. J Cell Sci. 2014 Jun 15;127(Pt 12):2697-708.
Bakke O, Progida C. Emerging regulators of endosomal dynamics during mitosis. Cell Cycle. 2014 Feb 1;13(3):349-50. .
Berg-Larsen A, Landsverk OJ, Progida C, Gregers TF, Bakke O. Differential regulation of Rab GTPase expression in monocyte-derived dendritic cells upon lipopolysaccharide activation: a correlation to maturation-dependent functional properties. PLoS One. 2013 Sep 5;8(9):e73538. .
Cogli L, Progida C, Bramato R, Bucci C. Vimentin phosphorylation and assembly are regulated by the small GTPase Rab7a. Biochim Biophys Acta. 2013 Jun;1833(6):1283-93.
Cogli L, Progida C, Thomas CL, Spencer-Dene B, Donno C, Schiavo G, Bucci C. Charcot-Marie-Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin. Acta Neuropathol. 2013 Feb;125(2):257-72.
Progida C, Nielsen MS, Koster G, Bucci C, Bakke O. Dynamics of Rab7b-dependent transport of sorting receptors. Traffic. 2012 Sep;13(9):1273-85.
Bucci C, Bakke O, Progida C. Charcot-Marie-Tooth disease and intracellular traffic. Prog Neurobiol. 2012 Dec;99(3):191-225.
Sonawane A, Santos JC, Mishra BB, Jena P, Progida C, Sorensen OE, Gallo R, Appelberg R, Griffiths G. Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages. Cell Microbiol. 2011 Oct;13(10):1601-17.
Bucci C, Bakke O, Progida C. Rab7b and receptors trafficking. Commun Integr Biol. 2010 Sep;3(5):401-4.
Cogli L, Progida C, Lecci R, Bramato R, Krüttgen A, Bucci C. CMT2B-associated Rab7 mutants inhibit neurite outgrowth. Acta Neuropathol. 2010 Oct;120(4):491-501.
Progida C, Cogli L, Piro F, De Luca A, Bakke O, Bucci C. Rab7b controls trafficking from endosomes to the TGN. J Cell Sci. 2010 May 1;123(Pt 9):1480-91.
Wegner CS, Malerød L, Pedersen NM, Progida C, Bakke O, Stenmark H, Brech A. Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5. Histochem Cell Biol. 2010 Jan;133(1):41-55.
Talà A, Progida C, De Stefano M, Cogli L, Spinosa MR, Bucci C, Alifano P. The HrpB-HrpA two-partner secretion system is essential for intracellular survival of Neisseria meningitidis. Cell Microbiol. 2008 Dec;10(12):2461-82.
De Luca A, Progida C, Spinosa MR, Alifano P, Bucci C. Characterization of the Rab7K157N mutant protein associated with Charcot-Marie-Tooth type 2B. Biochem Biophys Res Commun. 2008 Jul 25;372(2):283-7.
Spinosa MR, Progida C, De Luca A, Colucci AM, Alifano P, Bucci C. Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease. J Neurosci. 2008 Feb 13;28(7):1640-8.
Progida C, Malerød L, Stuffers S, Brech A, Bucci C, Stenmark H. RILP is required for the proper morphology and function of late endosomes. J Cell Sci. 2007 Nov 1;120(Pt 21):3729-37.
Spinosa MR, Progida C, Talà A, Cogli L, Alifano P, Bucci C. The Neisseria meningitidis capsule is important for intracellular survival in human cells. Infect Immun. 2007 Jul;75(7):3594-603.
Progida C, Spinosa MR, De Luca A, Bucci C. RILP interacts with the VPS22 component of the ESCRT-II complex. Biochem Biophys Res Commun. 2006 Sep 8;347(4):1074-9.
Monaco C, Talà A, Spinosa MR, Progida C, De Nitto E, Gaballo A, Bruni CB, Bucci C, Alifano P. Identification of a meningococcal L-glutamate ABC transporter operon essential for growth in low-sodium environments. Infect Immun. 2006 Mar;74(3):1725-40.
Published
Nov. 4, 2010 2:46 PM
- Last modified
Aug. 8, 2023 9:27 AM
