Jack Christopher Leo

Image of Jack Christopher Leo
Norwegian version of this page
Mobile phone +47-22859027
Room 3521
Username
Visiting address Kristine Bonnevies hus (Blindernveien 31)
Postal address Postboks 1066 Blindern 0316 OSLO

Research interests:

Bacterial adhesion: The binding of bacteria to surfaces is a major challeng in medical and industrial settings. I am interested in a particular class of molecules, called autotransporters, that mediate the attachment of bacteria to host tissues. I work on two aspects of these molecules: how they bind to their receptors and how they are transported to the surface of the bacteria.

Biological nanoparticle formation: Under certain conditions, bacteria are able to reduce heavy metal ions into metallic nanoparticles at the cell surface. These nanoparticles have unusual electronic, magnetic and catalytic properties that are of interest in industry (electronics, chemical catalysts). I aim to find out how the bacteria form these nanoparticles and which biochemical pathways are involved.

Tags: Bacteria, autotransporter, adhesion

Publications

Bacterial adhesion:

Mühlenkamp MC, Hallström T, Autenrieth IB, Bohn E, Linke D, Rinker J, Riesbeck K, Singh B, Leo JC, Hammerschmidt S, Zipfel PF, Schütz MS (2016): Vitronectin binds to a specific stretch within the head region of Yersinia adhesin A and thereby modulates Yersinia enterocolitica host interaction. J Innate Immun. 9(1):33-51. doi: 10.1159/000449200

Leo JC, Oberhettinger P, Yoshimoto S, Udatha DBRKG, Morth JP, Schütz M, Hori K, Linke D (2016): The secretion of the intimin passenger domain is driven by protein folding. J Biol Chem. 291(38):20096-112, doi: 10.1074/jbc.M116.731497. 

Chauhan N, Wrobel A, Skurnik M, Leo JC (2016): Yersinia adhesins: an arsenal for infection. Proteomics Clin Appl. 10(9-10):949-963, doi: 10.1002/prca.201600012.

Leo JC, Oberhettinger P, Schütz M, Linke D (2015): The inverse autotransporter family: Intimin, Invasin and related proteins. Int J Med Microbiol., 305(2): 276-82.

Mühlenkamp M, Oberhettinger P, Leo JC, Linke D, Schütz M (2015): Yersinia adhesin A (YadA) – beauty and beast. Int J Med Microbiol., 305(2): 252-8.

Oberhettinger P, Leo JC, Linke D, Autenrieth IB, Schütz M (2015): The inverse autotransporter Intimin exports its passenger domain via a hairpin intermediate. J Biol Chem., 290(3): 1837-49.

Leo JC, Oberhettinger P, Chaubey M, Schütz M, Kühner D, Götz F, Autenrieth IB, Coles M, Linke D (2015): The Intimin periplasmic domain mediates dimerisation and binding to peptidoglycan. Mol Microbiol., 95(1): 80-100. 

Leo JC, Grin I, Linke D (2012): Type V secretion: mechanism(s) of autotransport through the bacterial outer membrane. Philos Trans R Soc Lond B Biol Sci., 367(1592): 1088-1101.

 

Nanoparticles:

Shen X, Bonde JS, Kamra T, Bülow L, Leo JC, Linke D, Ye L (2014): Bacterial imprinting at Pickering emulsion interfaces. Angew Chem Int Ed Engl., 53(40):10687-90.

  • Chauhan, Nandini; Wrobel, Agnieszka; Skurnik, Mikael & Leo, Jack Christopher (2016). Yersinia adhesins: An arsenal for infection. PROTEOMICS - Clinical Applications.  ISSN 1862-8354.  10(9-10), s 949- 963 . doi: 10.1002/prca.201600012
  • Michalik, Marcin; Djahanshiri, Bardya; Leo, Jack Christoffer & Linke, Dirk (2016). Reverse Vaccinology: The Pathway from Genomes and Epitope Predictions to Tailored Recombinant Vaccines, In Sunil Thomas (ed.),  Vaccine Design Methods and Protocols: Volume 1: Vaccines for Human Diseases.  Springer.  ISBN 978-1-4939-3385-3.  Chapter 4.  s 87 - 106

View all works in Cristin

Published Apr. 8, 2015 1:05 PM - Last modified Feb. 6, 2017 12:00 PM