Oddmund Bakke

• Lobos, Natacha; Zulkefli, Khalisah Liyana; McAdam, Martin Berner; Vargas, Pablo; Bakke, Oddmund & Progida, Cinzia (2023). Rai14 is a novel interactor of Invariant chain that regulates macropinocytosis. Frontiers in Immunology. ISSN 1664-3224. 14, p. 1–15. doi: 10.3389/fimmu.2023.1182180. Full text in Research Archive
• Bjørnestad, Synne Arstad; Solbakken, Monica Hongrø; Jakobsen, Kjetill Sigurd; Jentoft, Sissel; Bakke, Oddmund & Progida, Cinzia (2023). Atlantic cod (Gadus morhua) MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals. Frontiers in Cell and Developmental Biology. ISSN 2296-634X. 11, p. 1–15. doi: 10.3389/fcell.2023.1050323. Full text in Research Archive
• Skjeldal, Frode Miltzow; Haugen, Linda Hofstad; Nunes De C Mateus, Duarte; Frei, Dominik Michael; Rødseth, Anna Vik & Hu, Xian [Show all 7 contributors for this article] (2021). De novo formation of early endosomes during Rab5-to-Rab7a transition. Journal of Cell Science. ISSN 0021-9533. 134(8). doi: 10.1242/jcs.254185. Full text in Research Archive Show summary

  Rab5 and Rab7a are the main determinants of early and late endosomes and are important regulators of endosomal progression. The transport from early endosomes to late endosome seems to be regulated through an endosomal maturation switch, where Rab5 is gradually exchanged by Rab7a on the same endosome. Here, we provide new insight into the mechanism of endosomal maturation, for which we have discovered a stepwise Rab5 detachment, sequentially regulated by Rab7a. The initial detachment of Rab5 is Rab7a independent and demonstrates a diffusion-like first-phase exchange between the cytosol and the endosomal membrane, and a second phase, in which Rab5 converges into specific domains that detach as a Rab5 indigenous endosome. Consequently, we show that early endosomal maturation regulated through the Rab5-to-Rab7a switch induces the formation of new fully functional Rab5-positive early endosomes. Progression through stepwise early endosomal maturation regulates the direction of transport and, concomitantly, the homeostasis of early endosomes.

• Vestre, Katharina; Persiconi, Irene; Distefano, Marita Borg; Mensali, Nadia; Guadagno, Noemi Antonella & Bretou, Marine [Show all 12 contributors for this article] (2021). Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton. Journal of Cell Science. ISSN 0021-9533. 134(18). doi: 10.1242/jcs.259221. Full text in Research Archive
• Perdreau-Dahl, Harmonie; Progida, Cinzia; Barfeld, Stefan Jörg; Guldsten, Hanne; Thiede, Bernd & Arntzen, Magnus Øverlie [Show all 10 contributors for this article] (2020). Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells. Communications Biology. ISSN 2399-3642. 3(1). doi: 10.1038/s42003-020-0851-2.
• Margiotta, Azzurra; Frei, Dominik Michael; Sendstad, Ingrid Hegnes; Janssen, Lennert; Neefjes, Jacques & Bakke, Oddmund (2020). Invariant chain regulates endosomal fusion and maturation through an interaction with the SNARE Vti1b. Journal of Cell Science. ISSN 0021-9533. 133. doi: 10.1242/jcs.244624. Full text in Research Archive
• Guadagno, Noemi Antonella; Margiotta, Azzurra; Bjørnestad, Synne Arstad; Haugen, Linda Hofstad; Kjos, Ingrid & Xiaochun, Xu [Show all 10 contributors for this article] (2020). Rab18 regulates focal adhesion dynamics by interacting with kinectin-1 at the endoplasmic reticulum . Journal of Cell Biology. ISSN 0021-9525. 219(7), p. 1–23. doi: 10.1083/JCB.201809020. Full text in Research Archive Show summary

  The members of the Rab family of small GTPases are molecular switches that regulate distinct steps in different membrane traffic pathways. In addition to this canonical function, Rabs can play a role in other processes, such as cell adhesion and motility. Here, we reveal the role of the small GTPase Rab18 as a positive regulator of directional migration in chemotaxis, and the underlying mechanism. We show that knockdown of Rab18 reduces the size of focal adhesions (FAs) and influences their dynamics. Furthermore, we found that Rab18, by directly interacting with the endoplasmic reticulum (ER)-resident protein kinectin-1, controls the anterograde kinesin-1–dependent transport of the ER required for the maturation of nascent FAs and protrusion orientation toward a chemoattractant. Altogether, our data support a model in which Rab18 regulates kinectin-1 transport toward the cell surface to form ER–FA contacts, thus promoting FA growth and cell migration during chemotaxis

• Hu, Xian; Jalal, Salma; Sheetz, Michael; Bakke, Oddmund & Margadant, Felix Martin (2020). Micro-stepping extended focus reduces photobleaching and preserves structured illumination super-resolution features. Journal of Cell Science. ISSN 0021-9533. 133, p. 1–12. doi: 10.1242/jcs.240796. Show summary

  Despite progress made in confocal microscopy, even fast systems still have insufficient temporal resolution for detailed live-cell volume imaging, such as tracking rapid movement of membrane vesicles in three-dimensional space. Depending on the shortfall, this may result in undersampling and/or motion artifacts that ultimately limit the quality of the imaging data. By sacrificing detailed information in the Z-direction, we propose a new imaging modality that involves capturing fast ‘projections’ from the field of depth and shortens imaging time by approximately an order of magnitude as compared to standard volumetric confocal imaging. With faster imaging, radiation exposure to the sample is reduced, resulting in less fluorophore photobleaching and potential photodamage. The implementation minimally requires two synchronized control signals that drive a piezo stage and trigger the camera exposure. The device generating the signals has been tested on spinning disk confocal and instant structured-illumination-microscopy (iSIM) microscopes. Our calibration images show that the approach provides highly repeatable and stable imaging conditions that enable photometric measurements of the acquired data, in both standard live imaging and super-resolution modes.

• Vestre, Katharina; Kjos, Ingrid; Guadagno, Noemi Antonella; Distefano, Marita Borg; Kohler, Felix & Fenaroli, Federico [Show all 8 contributors for this article] (2019). Rab6 regulates cell migration and invasion by recruiting Cdc42 and modulating its activity. Cellular and Molecular Life Sciences (CMLS). ISSN 1420-682X. 76(13), p. 2593–2614. doi: 10.1007/s00018-019-03057-w. Full text in Research Archive
• Mousavi, Seyed Ali; Skjeldal, Frode Miltzow; Fønhus, Marita Sporstøl; Haugen, Linda Hofstad; Eskild, Winnie & Berg, Trond [Show all 7 contributors for this article] (2019). Receptor-mediated endocytosis of VEGF-A in rat liver sinusoidal endothelial cells. BioMed Research International. ISSN 2314-6133. 2019, p. 1–12. doi: 10.1155/2019/5496197. Full text in Research Archive
• Solbakken, Monica Hongrø; Jentoft, Sissel; Reitan, Trond; Mikkelsen, Helene; Gregers, Tone Fredsvik & Bakke, Oddmund [Show all 8 contributors for this article] (2019). Disentangling the immune response and host-pathogen interactions in Francisella noatunensis infected Atlantic cod. Comparative Biochemistry and Physiology - Part D:Genomics and Proteomics. ISSN 1744-117X. 30, p. 333–346. doi: 10.1016/j.cbd.2019.04.004. Full text in Research Archive
• Mensali, Nadia; Grenov, Charlotte Amalie; Pati, Niladri Bhusan; Dillard, Pierre; Myhre, Marit Renee & Gaudernack, Gustav [Show all 10 contributors for this article] (2019). Antigen-delivery through invariant chain (CD74) boosts CD8 and CD4 T cell immunity. Oncoimmunology. ISSN 2162-4011. 8(3), p. e1558663-1–e1558663-14. doi: 10.1080/2162402X.2018.1558663. Full text in Research Archive
• Ganan, Monica; Lorentzen, Silje Benedicte; Agger, Jane Wittrup; Heyward, Catherine Anne; Bakke, Oddmund & Knutsen, Svein Halvor [Show all 10 contributors for this article] (2019). Antifungal activity of well-defined chitooligosaccharide preparations against medically relevant yeasts. PLOS ONE. ISSN 1932-6203. 14(1). doi: 10.1371/journal.pone.0210208. Full text in Research Archive Show summary

  Due to their antifungal activity, chitosan and its derivatives have potential to be used for treating yeast infections in humans. However, to be considered for use in human medicine, it is necessary to control and know the chemical composition of the compound, which is not always the case for polymeric chitosans. Here, we analyze the antifungal activity of a soluble and well-defined chito-oligosaccharide (CHOS) with an average polymerization degree (DPn) of 32 and fraction of acetylation (FA) of 0.15 (C32) on 52 medically relevant yeast strains. Minimal inhibitory concentrations (MIC) varied widely among yeast species, strains and isolates (from > 5000 to < 9.77 μg mL-1) and inhibition patterns showed a time- and dose-dependencies. The antifungal activity was predominantly fungicidal and was inversely proportional to the pH, being maximal at pH 4.5, the lowest tested pH. Furthermore, antifungal effects of CHOS fractions with varying average molecular weight indicated that those fractions with an intermediate degree of polymerization, i.e. DP 31 and 54, had the strongest inhibitory effects. Confocal imaging showed that C32 adsorbs to the cell surface, with subsequent cell disruption and accumulation of C32 in the cytoplasm. Thus, C32 has potential to be used as a therapy for fungal infections.

• Distefano, Marita Borg; Haugen, Linda Hofstad; Wang, Yan; Perdreau-Dahl, Harmonie; Kjos, Ingrid & Jia, Da [Show all 10 contributors for this article] (2018). TBC1D5 controls the GTPase cycle of Rab7b. Journal of Cell Science. ISSN 0021-9533. 131(17), p. 1–13. doi: 10.1242/jcs.216630. Full text in Research Archive
• Nunes De C Mateus, Duarte; Marini, Elettra Sara; Progida, Cinzia & Bakke, Oddmund (2018). Rab7a modulates ER stress and ER morphology. BBA - Molecular Cell Research. ISSN 0167-4889. 1865(5), p. 781–793. doi: 10.1016/j.bbamcr.2018.02.011.
• Inderberg, Else Marit ; Mensali, Nadia; Oksvold, Morten Pedersen; Fallang, Lars Egil; Fåne, Anne & Skorstad, Gjertrud [Show all 12 contributors for this article] (2017). Human c-SRC kinase (CSK) overexpression makes T cells dummy. Cancer Immunology and Immunotherapy. ISSN 0340-7004. 67(4), p. 525–536. doi: 10.1007/s00262-017-2105-9.
• Haugen, Linda Hofstad; Skjeldal, Frode Miltzow; Bergeland, Trygve & Bakke, Oddmund (2017). Endosomal binding kinetics of Eps15 and Hrs specifically regulate the degradation of RTKs. Scientific Reports. ISSN 2045-2322. 7:17962, p. 1–13. doi: 10.1038/s41598-017-17320-2. Full text in Research Archive
• Niazy, Naima; Temme, Sebastian; Bocuk, Derya; Giesen, Carmen; Konig, Angelika & Temme, Nadine [Show all 12 contributors for this article] (2017). Misdirection of endosomal trafficking mediated by herpes simplex virus-encoded glycoprotein B. The FASEB Journal. ISSN 0892-6638. 31(4), p. 1650–1667. doi: 10.1096/fj.201600521R.
• Kjos, Ingrid; Distefano, Marita Borg; Sætre, Frank Ove; Repnik, Urska; Holland, Petter & Jones, Arwyn T [Show all 10 contributors for this article] (2017). Rab7b modulates autophagic flux by interacting with Atg4B. EMBO Reports. ISSN 1469-221X. 18(10), p. 1727–1739. doi: 10.15252/embr.201744069. Full text in Research Archive
• Margiotta, Azzurra; Progida, Cinzia; Bakke, Oddmund & Bucci, Cecilia (2017). Characterization of the role of RILP in cell migration. European journal of histochemistry. ISSN 1121-760X. doi: 10.4081/ejh.2017.2783. Full text in Research Archive
• Margiotta, Azzurra; Progida, Cinzia; Bakke, Oddmund & Bucci, Cecilia (2017). Rab7a regulates cell migration through Rac1 and vimentin. BBA - Molecular Cell Research. ISSN 0167-4889. 1864(2), p. 367–381. doi: 10.1016/j.bbamcr.2016.11.020. Full text in Research Archive
• Dukic, Aleksandra; Haugen, Linda Hofstad; Pidoux, Guillaume; Leithe, Edward; Bakke, Oddmund & Tasken, Kjetil (2017). A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells. Cellular Signalling. ISSN 0898-6568. 32, p. 1–11. doi: 10.1016/j.cellsig.2017.01.008. Full text in Research Archive
• Kucera, Ana; Bakke, Oddmund & Progida, Cinzia (2016). The multiple roles of Rab9 in the endolysosomal system. Communicative & Integrative Biology. ISSN 1942-0889. 9(4). doi: 10.1080/19420889.2016.1204498.
• Progida, Cinzia & Bakke, Oddmund (2016). Bidirectional traffic between the Golgi and the endosomes - machineries and regulation. Journal of Cell Science. ISSN 0021-9533. doi: 10.1242/jcs.185702.
• Bauer, Johannes; Bakke, Oddmund & Morth, Jens Preben (2016). Overview of the membrane-associated RING-CH (MARCH) E3 ligase family. New Biotechnology. ISSN 1871-6784. 38, p. 7–15. doi: 10.1016/j.nbt.2016.12.002.
• Kucera, Ana; Distefano, Marita Borg; Berg-Larsen, Axel; Skjeldal, Frode Miltzow; Repnik, Urska & Bakke, Oddmund [Show all 7 contributors for this article] (2016). Spatiotemporal Resolution of Rab9 and CI-MPR Dynamics in the Endocytic Pathway. Traffic: The moving front of cell biology. ISSN 1398-9219. 17(3), p. 211–229. doi: 10.1111/tra.12357.
• Øynebråten, Inger; Barois, Nicolas; Bergeland, Trygve; Kuchler, Axel Matthias; Bakke, Oddmund & Haraldsen, Guttorm (2015). Oligomerized, filamentous surface presentation of RANTES/CCL5 on vascular endothelial cells. Scientific Reports. ISSN 2045-2322. 5:9261. doi: 10.1038/srep09261. Full text in Research Archive
• Bakke, Oddmund & Progida, Cinzia (2014). Emerging regulators of endosomal dynamics during mitosis. Cell Cycle. ISSN 1538-4101. doi: 10.4161/cc.27547.
• Sand, Kine Marita Knudsen; Landsverk, Ole J. B.; Berg-Larsen, Axel; Bakke, Oddmund & Gregers, Tone Fredsvik (2014). The human-specific invariant chain isoform Iip35 modulates Iip33 trafficking and function. Immunology and Cell Biology. ISSN 0818-9641. 92(9), p. 791–798. doi: 10.1038/icb.2014.54.
• Borg, Marita Jeanett Halsen; Bakke, Oddmund & Progida, Cinzia (2014). A novel interaction between Rab7b and actomyosin reveals a dual role in intracellular transport and cell migration. Journal of Cell Science. ISSN 0021-9533. 127(22), p. 4927–4939. doi: 10.1242/jcs.155861.
• Waelchli, Sebastien; Kumari, Shraddha; Fallang, Lars-Egil; Sand, Kine Marita Knudsen; Yang, Weiwen & Landsverk, Ole J. B. [Show all 9 contributors for this article] (2014). Invariant chain as a vehicle to load antigenic peptides on human MHC class I for cytotoxic T-cell activation. European Journal of Immunology. ISSN 0014-2980. 44(3), p. 774–784. doi: 10.1002/eji.201343671.
• Berg-Larsen, Axel; Landsverk, Ole J. B.; Progida, Cinzia ; Gregers, Tone Fredsvik & Bakke, Oddmund (2013). Differential Regulation of Rab GTPase Expression in Monocyte-Derived Dendritic Cells upon Lipopolysaccharide Activation: A Correlation to Maturation-Dependent Functional Properties. PLOS ONE. ISSN 1932-6203. 8(9). doi: 10.1371/journal.pone.0073538.
• Jacobsen, Johanne Tracey; Gjerstad, Vibeke Sundvold; Skjeldal, Frode Miltzow; Andersen, Jan Terje; Abrahamsen, Greger & Bakke, Oddmund [Show all 8 contributors for this article] (2013). B-cell tolerance to the B-cell receptor variable regions. European Journal of Immunology. ISSN 0014-2980. 43(10), p. 2577–2587. doi: 10.1002/eji.201243203.
• Gregers, Tone Fredsvik; Skånland, Sigrid Strand; Waelchli, Sebastien; Bakke, Oddmund & Sandvig, Kirsten (2013). BiP Negatively Affects Ricin Transport. Toxins. ISSN 2072-6651. 5(5), p. 969–982. doi: 10.3390/toxins5050969.
• Skjeldal, Frode Miltzow; Strunze, Sten; Bergeland, Trygve; Walseng, Even; Gregers, Tone Fredsvik & Bakke, Oddmund (2012). The fusion of early endosomes induces molecular-motor-driven tubule formation and fission. Journal of Cell Science. ISSN 0021-9533. 125(8), p. 1910–1919. doi: 10.1242/jcs.092569.
• Progida, Cinzia Anita Maria; Nielsen, Morten S.; Koster, Gerbrand; Bucci, Cecilia & Bakke, Oddmund (2012). Dynamics of Rab7b-Dependent Transport of Sorting Receptors. Traffic: The moving front of cell biology. ISSN 1398-9219. 13(9), p. 1273–1285. doi: 10.1111/j.1600-0854.2012.01388.x.
• Landsverk, Ole J. B.; Ottesen, Anett Hellebø; Berg-Larsen, Axel; Appel, Silke & Bakke, Oddmund (2012). Differential regulation of MHC II and invariant chain expression during maturation of monocyte-derived dendritic cells. Journal of Leukocyte Biology. ISSN 0741-5400. 91(5), p. 729–737. doi: 10.1189/jlb.0311150.
• Bucci, Cecilia; Bakke, Oddmund & Progida, Cinzia Anita Maria (2012). Charcot-Marie-Tooth disease and intracellular traffic. Progress in Neurobiology. ISSN 0301-0082. 99(3), p. 191–225. doi: 10.1016/j.pneurobio.2012.03.003.
• Neefjes, Jacques; Paul, Petra; Jongsma, Marlieke & Bakke, Oddmund (2011). Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nature reviews. Immunology. ISSN 1474-1733. 11(12), p. 823–836. doi: 10.1038/nri3084. Show summary

  The molecular details of antigen processing and presentation by MHC class I and class II molecules have been studied extensively for almost three decades. Although the basic principles of these processes were laid out approximately 10 years ago, the recent years have revealed many details and provided new insights into their control and specificity. MHC molecules use various biochemical reactions to achieve successful presentation of antigenic fragments to the immune system. Here we present a timely evaluation of the biology of antigen presentation and a survey of issues that are considered unresolved. The continuing flow of new details into our understanding of the biology of MHC class I and class II antigen presentation builds a system involving several cell biological processes, which is discussed in this Review.

• Bucci, Cecilia; Bakke, Oddmund & Progida, Cinzia Anita Maria (2011). Rab7b and receptors trafficking. Communicative & Integrative Biology. ISSN 1942-0889. 3(5), p. 401–404. doi: 10.4161/cib.3.5.12341. Show summary

  Rab proteins are key-regulators of intracellular membrane trafficking. Rab7b is a recently identified Rab protein that may downregulate TLR4 and TLR9-mediated inflammatory responses. Rab7b, believed to have similar function as Rab7, controls however vesicular trafficking from endosomes to the TGN. It is localized to late endosomes/lysosomes as well as the TGN. Rab7b interferes with enzymes delivery to lysosomes and with the retrograde Shiga toxin transport to the Golgi. Furthermore, Rab7b depletion alters CI-MPR and TGN46 trafficking. In conclusion, Rab7b, by regulating the transport from late endosomes to the TGN, is fundamental for trafficking of several receptors, opening for a revised scenario for its influence on signaling of Toll-like Receptors (TLRs) and other receptors.

• Landsverk, Ole J. B.; Barois, Nicolas; Gregers, Tone Fredsvik & Bakke, Oddmund (2011). Invariant chain increases the half-life of MHC II by delaying endosomal maturation. Immunology and Cell Biology. ISSN 0818-9641. 89(5), p. 619–629. doi: 10.1038/icb.2010.143.
• Klinger, Stine C.; Glerup, Simon; Raarup, Merete K.; Mari, Muriel C.; Nyegaard, Mette & Koster, Gerbrand [Show all 14 contributors for this article] (2011). SorLA regulates the activity of lipoprotein lipase by intracellular trafficking. Journal of Cell Science. ISSN 0021-9533. 124(7), p. 1095–1105. doi: 10.1242/jcs.072538.
• Walseng, Even; Furuta, Kazuyuki; Bosch, Berta; Weih, Karis A.; Matsuki, Yohei & Bakke, Oddmund [Show all 8 contributors for this article] (2010). Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 107(47), p. 20465–20470. doi: 10.1073/pnas.1010990107.
• Husebye, Harald; Aune, Marie Hjelmseth; Stenvik, Jørgen; Samstad, Eivind Ottersen; Skjeldal, Frode Miltzow & Halaas, Øyvind [Show all 13 contributors for this article] (2010). The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes. Immunity. ISSN 1074-7613. 33(4), p. 583–596. doi: 10.1016/j.immuni.2010.09.010.
• Wegner, Catherine E Sem; Malerød, Lene; Pedersen, Nina Marie; Progida, Cinzia Anita Maria; Bakke, Oddmund & Stenmark, Harald Alfred [Show all 7 contributors for this article] (2010). Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5. Histochemistry and Cell Biology. ISSN 0948-6143. 133(1), p. 41–57. doi: 10.1007/s00418-009-0643-8. Show summary

  (Catherine Sem Wegener adresserer med Centre for Cancer Biomedicine, UiO, må meldes inn i SAP.)

• Landsverk, Helga Bjarnason; Mora-Bermúdez, Felipe; Landsverk, Ole J. B.; Hasvold, Grete; Naderi, Soheil & Bakke, Oddmund [Show all 10 contributors for this article] (2010). The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response. EMBO Reports. ISSN 1469-221X. 11(11), p. 868–875. doi: 10.1038/embor.2010.134.
• Etokebe, GE; Skjeldal, F; Nilsen, Nadra; Rodionov, Dmitrii; Knezevic, Jelena & Bulat-Kardum, Ljiljana [Show all 9 contributors for this article] (2010). Toll-Like Receptor 2 (P631H) Mutant Impairs Membrane Internalization and is a Dominant Negative Allele. Scandinavian Journal of Immunology. ISSN 0300-9475. 71(5), p. 369–381. doi: 10.1111/j.1365-3083.2010.02379.x. Full text in Research Archive
• Progida, Cinzia; Cogli, Laura; Piro, Francesco; De Luca, Azzura; Bakke, Oddmund & Bucci, Cecilia (2010). Rab7b controls trafficking from endosomes to the TGN. Journal of Cell Science. ISSN 0021-9533. 123(9), p. 1480–1491. doi: 10.1242/jcs.051474.
• Låg, Marit; Rodionov, Dmitrii; Øvrevik, Johan; Bakke, Oddmund; Schwarze, Per E & Refsnes, Magne (2010). Cadmium-induced inflammatory responses in cells relevant for lung toxicity: Expression and release of cytokines in fibroblasts, epithelial cells and macrophages. Toxicology Letters. ISSN 0378-4274. 193(3), p. 252–260. doi: 10.1016/j.toxlet.2010.01.015.
• Landsverk, OJB; Bakke, Oddmund & Gregers, TF (2009). MHC II and the Endocytic Pathway: Regulation by Invariant Chain. Scandinavian Journal of Immunology. ISSN 0300-9475. 70(3), p. 184–193. doi: 10.1111/j.1365-3083.2009.02301.x.
• Fladeby, Cathrine; Nigam, Shailly; Gupta, Shailly N.; Barois, Nicolas; Lorenzo, Petri & Simpson, Jeremy C. [Show all 8 contributors for this article] (2008). Human PARM-1 is a novel mucin-like, androgen-regulated gene exhibiting proliferative effects in prostate cancer cells. International Journal of Cancer. ISSN 0020-7136. 122(6), p. 1229–1235. doi: 10.1002/ijc.23185.
• Bergeland, Trygve; Haugen, Linda; Landsverk, Ole J.B.; Stenmark, Harald & Bakke, Oddmund (2008). Cell-cycle-dependent binding kinetics for the early endosomal tethering factor EEA1. EMBO Reports. ISSN 1469-221X. 9(2), p. 171–178. doi: 10.1038/sj.embor.7401152.
• Nilsen, Nadra; Deininger, S; Nonstad, Unni; Skjeldal, F; Husebye, Harald & Rodionov, D [Show all 12 contributors for this article] (2008). Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36. Journal of Leukocyte Biology. ISSN 0741-5400. 84, p. 280–291. doi: 10.1189/jlb.0907656.
• Walseng, Even; Bakke, Oddmund & Roche, Paul A. (2008). Major histocompatibility complex class II-peptide complexes internalize using a clathrin- and dynamin-independent endocytosis pathway. Journal of Biological Chemistry. ISSN 0021-9258. 283(21), p. 14717–14727. doi: 10.1074/jbc.M801070200.
• Steffensen, Knut Rune; Bouzga, Mariam; Skjeldal, Frode; Kåsi, Cecilie; Karahasan, Almira & Matre, Vilborg [Show all 9 contributors for this article] (2007). Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator. BMC Molecular Biology. ISSN 1471-2199. 8(1), p. 106–120.
• Nielsen, MS; Gustafsen, C; Madsen, P; Nyengaard, JR; Hermey, G & Bakke, Oddmund [Show all 11 contributors for this article] (2007). Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Molecular and Cellular Biology. ISSN 0270-7306. 27, p. 6842–6851. doi: 10.1128/MCB.00815-07.
• Bergeland, Trygve; Tewinkel, Martin & Bakke, Oddmund (2006). Precise calculation of photoactivation kinetics. Nature Methods. ISSN 1548-7091. 3(12), p. 1048–1049. Show summary

  Note i artikkelen i tidsskriftet: This article was submitted to Nature Methods by a commercial organization and has not been peer reviewed. Nature Methods takes no responsibility for the accuracy or otherwise of the information provided. Skal ikke rapporteres./tøf

• Gupta, Shailly N.; Kloster, Martine M.; Rodionov, Dimitrii G. & Bakke, Oddmund (2006). Re-routing of the invariant chain to the direct sorting pathway by introduction of an AP3-binding motif from LIMP II. European Journal of Cell Biology. ISSN 0171-9335. 85(6), p. 457–467. doi: 10.1016/j.ejcb.2006.02.001.
• Bergeland, Trygve; Tewinkel, Martin & Bakke, Oddmund (2006). Precise calculation of photoactivation kinetics. Nature Methods. ISSN 1548-7091. 3(12), p. 1048–1049. Show summary

  Measuring rapid kinetics of proteins in living cells requires the capability for fast, accurate measurements. Researchers hoping to obtain precise kinetic data from fluorescence recovery after photobleaching or photoactivation experiments need an easily controllable system for stimulation of a specific region and subsequent imaging, and the Olympus FluoView FV1000 confocal laser scanning microscope (cLSM) with SIM scanner makes this possible. We describe here how to precisely measure off rates using a cytosolic photoactivatable probe that binds endosomal membranes.

• Johnsen, Ingvild Bjellmo; Nguyen, Thank Thuy Thi; Ringdal, Monika; Tryggestad, AM; Bakke, Oddmund & Lien, Egil [Show all 8 contributors for this article] (2006). Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. EMBO Journal. ISSN 0261-4189. 26(25), p. 3335–3346.
• Barois, Nicolas & Bakke, Oddmund (2005). AP-4 as a component of the clathrin coat machinery: A morphological study. Biochemical Journal. ISSN 0264-6021. 385(2), p. 503–510. Show summary

  The four members of the adaptor protein family are heterotetrameric cytosolic complexes involved in the intracellular trafficking of cargo proteins between different organelles. They interact with motifs present in the cytoplasmic tail of their specific cargo proteins at different intracellular locations. While AP-1, AP-2 and AP-3 have been investigated extensively, very few studies have focused on fourth member, AP-4. In the present study, we report on the intracellular localisation of AP-4 in MDCK and MelJuSo cell lines after immunogold labelling of ultrathin cryosections. We find that AP-4 is localised mainly in the Golgi complex, as well as on endosomes and transport vesicles. Interestingly, and for the first time, we show that AP-4 is localised with the clathrin coat machinery in the Golgi complex and in the endocytic pathway. Furthermore, we find that AP-4 is localised with CI-MPR, but not with TfR, LAMP-2 or Ii. The difference in morphology between CI-MPR/AP-4 positive vesicles and CI-MPR/AP-1 positive vesicles raises the possibility that AP-4 acts at a place different from that of AP-1 in the intracellular trafficking pathway of CI-MPR.

• Barois, Nicolas & Bakke, Oddmund (2005). AP-4 as a component of the clathrin coat machinery: A morphological study. Biochemical Journal. ISSN 0264-6021. 385(2), p. 503–510. Show summary

  The four members of the adaptor protein family are heterotetrameric cytosolic complexes involved in the intracellular trafficking of cargo proteins between different organelles. They interact with motifs present in the cytoplasmic tail of their specific cargo proteins at different intracellular locations. While AP-1, AP-2 and AP-3 have been investigated extensively, very few studies have focused on fourth member, AP-4. In the present study, we report on the intracellular localisation of AP-4 in MDCK and MelJuSo cell lines after immunogold labelling of ultrathin cryosections. We find that AP-4 is localised mainly in the Golgi complex, as well as on endosomes and transport vesicles. Interestingly, and for the first time, we show that AP-4 is localised with the clathrin coat machinery in the Golgi complex and in the endocytic pathway. Furthermore, we find that AP-4 is localised with CI-MPR, but not with TfR, LAMP-2 or Ii. The difference in morphology between CI-MPR/AP-4 positive vesicles and CI-MPR/AP-1 positive vesicles raises the possibility that AP-4 acts at a place different from that of AP-1 in the intracellular trafficking pathway of CI-MPR.

• Lawton, Anna P.; Prigozy, TI; Brossay, L; Pei, B; Khurana, Archana & Martin, David M. A. [Show all 13 contributors for this article] (2005). The mouse CD1d cytoplasmic tail mediates CD1d trafficking and antigen presentation by adaptor protein 3-dependent and -independent mechanisms. Journal of Immunology. ISSN 0022-1767. 174(6), p. 3179–3186.
• Øynebråten, Inger; Barois, Nicolas; Hagelsteen, Kathrine; Johansen, Finn Eirik; Bakke, Oddmund & Haraldsen, Guttorm (2005). Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase A and diacylglycerol. Journal of Immunology. ISSN 0022-1767. 175(8), p. 5358–5369. Show summary

  We have recently shown that several proinflammatory chemokines can be stored in secretory granules of endothelial cells (ECs). Subsequent regulated exocytosis of such chemokines may then enable rapid recruitment of leukocytes to inflammatory sites. Although IL-8/CXCL8 and eotaxin-3/CCL26 are sorted to the rod-shaped Weibel-Palade body (WPB), we found that GROalpha/CXCL1 and MCP-1/CCL2 reside in small granules that, similarly to the WPB, respond to secretagogue stimuli. In the present study, we report that GROalpha and MCP-1 colocalized in 50- to 100-nm granules, which occur throughout the cytoplasm and at the cell cortex. Immunofluorescence confocal microscopy revealed no colocalization with multimerin or tissue plasminogen activator, i.e., proteins that are released from small granules of ECs by regulated exocytosis. Moreover, the GROalpha/MCP-1-containing granules were Rab27-negative, contrasting the Rab27-positive, WPB. The secretagogues PMA, histamine, and forskolin triggered distinct dose and time-dependent responses of GROalpha release. Furthermore, GROalpha release was more sensitive than IL-8 release to inhibitors and activators of PKA and PKC but not to an activator of Epac, a cAMP-regulated GTPase exchange factor, indicating that GROalpha release is regulated by molecular adaptors different from those regulating exocytosis of the WPB. On the basis of these findings, we designated the GROalpha/MCP-1-containing compartment the type 2 granule of regulated secretion in ECs, considering the WPB the type 1 compartment. In conclusion, we propose that the GROalpha/MCP-1-containing type 2 granule shows preferential responsiveness to important mediators of EC activation, pointing to the existence of selective agonists that would allow differential release of selected chemokines.

• Øynebråten, Inger; Barois, Nicolas; Hagelsteen, Kathrine; Johansen, Finn Eirik; Bakke, Oddmund & Haraldsen, Guttorm (2005). Characterization of a novel chemokine-containing storage granule in endothelial cells: evidence for preferential exocytosis mediated by protein kinase A and diacylglycerol. Journal of Immunology. ISSN 0022-1767. 175(8), p. 5358–5369. Show summary

  We have recently shown that several proinflammatory chemokines can be stored in secretory granules of endothelial cells (ECs). Subsequent regulated exocytosis of such chemokines may then enable rapid recruitment of leukocytes to inflammatory sites. Although IL-8/CXCL8 and eotaxin-3/CCL26 are sorted to the rod-shaped Weibel-Palade body (WPB), we found that GROalpha/CXCL1 and MCP-1/CCL2 reside in small granules that, similarly to the WPB, respond to secretagogue stimuli. In the present study, we report that GROalpha and MCP-1 colocalized in 50- to 100-nm granules, which occur throughout the cytoplasm and at the cell cortex. Immunofluorescence confocal microscopy revealed no colocalization with multimerin or tissue plasminogen activator, i.e., proteins that are released from small granules of ECs by regulated exocytosis. Moreover, the GROalpha/MCP-1-containing granules were Rab27-negative, contrasting the Rab27-positive, WPB. The secretagogues PMA, histamine, and forskolin triggered distinct dose and time-dependent responses of GROalpha release. Furthermore, GROalpha release was more sensitive than IL-8 release to inhibitors and activators of PKA and PKC but not to an activator of Epac, a cAMP-regulated GTPase exchange factor, indicating that GROalpha release is regulated by molecular adaptors different from those regulating exocytosis of the WPB. On the basis of these findings, we designated the GROalpha/MCP-1-containing compartment the type 2 granule of regulated secretion in ECs, considering the WPB the type 1 compartment. In conclusion, we propose that the GROalpha/MCP-1-containing type 2 granule shows preferential responsiveness to important mediators of EC activation, pointing to the existence of selective agonists that would allow differential release of selected chemokines.

• Dahle, Øyvind; Bakke, Oddmund & Gabrielsen, Odd Stokke (2004). c-Myb associates with PML in nuclear bodies in hematopoietic cells. Experimental Cell Research. ISSN 0014-4827. 297, p. 118–126.
• Øynebråten, Inger; Oynebraten, Inger; Bakke, Oddmund; Brandtzæg, Per; Johansen, Finn Erik & Haraldsen, Guttorm (2004). Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments. Blood. ISSN 0006-4971. 104(2), p. 314–320. Show summary

  The neutrophil-attracting chemokine interleukin 8 (IL-8) is stored in the Weibel-Palade body (WPB) of endothelial cells (ECs) from which it can be rapidly released after exposure to the secretagogues histamine or thrombin. In this manner, IL-8 may enable rapid recruitment of leukocytes to inflammatory sites. To explore the possible storage of EC-derived chemokines that may attract other subsets of leukocytes, we examined the intracellular localization and secretagogue responsiveness of growth-related oncogene alpha (GROalpha), monocyte chemoattractant protein-1 (MCP-1), eotaxin-3, interferon-gamma-inducible protein 10 (IP-10), and regulated on activation, normal T-cell expressed and secreted (RANTES). While eotaxin-3, GROalpha, and MCP-1 were rapidly released from ECs, the release of the T-cell attractors RANTES and IP-10 was not sensitive to the secretagogues. Moreover, of the 3 former chemokines, only eotaxin-3 was stored in WPBs. GROalpha and MCP-1 resided mainly in smaller vesicles compatible with sorting to a different, histamine-responsive compartment, which has been described in ECs although not reported to contain chemokines. In conclusion, we propose that rapid release of chemokines is restricted to those primarily recruiting leukocytes of the innate immune system, and that their storage in ECs is not restricted to the WPB compartment.

• Dahle, Øyvind; Bakke, Oddmund & Gabrielsen, Odd Stokke (2004). c-Myb associates with PML in nuclear bodies in hematopoietic cells. Experimental Cell Research. ISSN 0014-4827. 297(1), p. 118–126. Show summary

  The c-Myb transcription factor plays a central role in the regulation of cell growth and differentiation of hematopoietic cells. Being the product of a proto-oncogene, one would expect c-Myb function to be modulated by signal transduction pathways, but our knowledge on such regulation of c-Myb is rather limited. Recently, we and others showed that c-Myb is subjected to sumoylation and that this posttranslational modification has considerable effect on c-Myb's activity. Interestingly, many proteins subjected to SUMO-1 conjugation associate with the promyelocytic leukemia (PML) protein and localize to PML nuclear bodies (PML NBs). Although the precise molecular function of PML NBs still remains to be defined, they seem to play a role in regulation of gene expression and are linked to specific cellular signaling. We show here that c-Myb localizes to PML NBs and that c-Myb interacts with PML as judged by immunofluorescence microcopy and co-immunoprecipitation experiments. Enforced expression of PML IV was shown to enhance c-Myb-dependent reporter activation. Our results imply a role for PML and possibly other components of PML NBs in regulating c-Myb's activity. This novel link between c-Myb and PML, two gene products being implicated in leukemic disorders, suggests that previously unknown mechanisms for regulating c-Myb's activity involving PML may exist.

• Gregers, Tone F.; Nordeng, Tommy W. & Bakke, Oddmund (2003). Antigen Presentation by MHC Class II Molecules. In Gorvel, Jean-Pierre (Eds.), Intracellular Pathogens in Membrane Interactions and Vacuole Biogenesis. Eurekah.com and Kluwer Academic / Plenum Publishers.. ISSN 0-306-47833-1. p. 251–278.
• Gregers, Tone F.; Nordeng, Tommy W.; Birkeland, Hanne C. G.; Sandlie, Inger & Bakke, Oddmund (2003). THE CYTOPLASMIC TAIL OF INVARIANT CHAIN MODULATES ANTIGEN PROCESSING AND PRESENTATION. European Journal of Immunology. ISSN 0014-2980. 33(2), p. 277–286.
• Bakke, Oddmund; Fleckenstein, Burkhard; Gregers, Tone F.; Roepstorff, Peter; Sandlie, Inger & Vartdal, Frode (2003). MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs:implications for T cell activation. International Immunology. ISSN 0953-8178. 15(11), p. 1291–1299.
• Bakke, Oddmund; Elewaut, D; Lawton, AP; Nagarajan, NA; Maverakis, E & Khurana, A [Show all 11 contributors for this article] (2003). The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 198(8), p. 1133–1146.
• Bakke, Oddmund & Barrett, Jeannie (2003). Firing up B cells. ELSO Gazette. 2(15). Show summary

  B cells have to gear-up their secretory protein production before they can devote themselves to producing the antibodies that fight infections. A new proteomics study documents the endoplasmic reticulum protein reinforcements that are recruited to this task.

• Gregers, Tone; Nordeng, Tommy W.; Birkeland, Hanne; Sandlie, Inger & Bakke, Oddmund (2003). The cytoplasmic tail of invariant chain modulates antigen processing and presentation. European Journal of Immunology. ISSN 0014-2980. 198(8), p. 1133–1146. Show summary

  The MHC class II-associated invariant chain (Ii) has several important functions in antigen presentation. In this study, we have examined the effect of Iip33 expression on endocytic transport and antigen presentation. We find that degradation of both endocytosed antigen and Ii itself is delayed in cells expressing high levels of Ii, whereas a mutant Ii with an altered charge distribution in the cytoplasmic tail was unable to exert this effect. Furthermore, the Ii mutant did not enhance the presentation of an Ii-dependent MHC class II-restricted epitope to the same extent as the wild type. In a parallel study, we investigated the effect of charge in the cytoplasmic tail of Ii. We find that due to exposed negative charges, it promotes endosome fusion events, and we suggest that this causes endosomal retention (Nordeng et al., Mol. Biol. Cell 2002). Together, the data reveal an additional property of the Iip33 cytoplasmic tail that contributes to the modulation of antigen processing and presentation.

• Elewaut, Dirk; Lawton, Anna P.; Nagarajan, Niranjana A.; Maverakis, Emanual; Khurana, Archana & Höning, Stefan [Show all 10 contributors for this article] (2003). The Adaptor Protein AP-3 Is Required for CD1d-Mediated Antigen Presentation of Glycosphingolipids and Development of V14i NKT Cells. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 198(8), p. 1133–1146. Show summary

  Relatively little is known about the pathway leading to the presentation of glycolipids by CD1 molecules. Here we show that the adaptor protein complex 3 (AP-3) is required for the efficient presentation of glycolipid antigens that require internalization and processing. AP-3 interacts with mouse CD1d, and cells from mice deficient for AP-3 have increased cell surface levels of CD1d and decreased expression in late endosomes. Spleen cells from AP-3-deficient mice have a reduced ability to present glycolipids to natural killer T (NKT) cells. Furthermore, AP-3-deficient mice have a significantly reduced NKT cell population, although this is not caused by self-tolerance that might result from increased CD1d surface levels. These data suggest that the generation of the endogenous ligand that selects NKT cells may also be AP-3 dependent. However, the function of MHC class II-reactive CD4+ T lymphocytes is not altered by AP-3 deficiency. Consistent with this divergence from the class II pathway, NKT cell development and antigen presentation by CD1d are not reduced by invariant chain deficiency. These data demonstrate that the AP-3 requirement is a particular attribute of the CD1d pathway in mice and that, although MHC class II molecules and CD1d are both found in late endosomes or lysosomes, different pathways mediate their intracellular trafficking.

• Barrett, Jeannie & Bakke, Oddmund (2003). Firing up B cells. http://www.the-elso-gazette.org/. Show summary

  B cells have to gear-up their secretory protein production before they can devote themselves to producing the antibodies that fight infections. A new proteomics study documents the endoplasmic reticulum protein reinforcements that are recruited to this task.

• Rodionov, Dmitrii G.; Honing, Stefan; Silye, A.; Kongsvik, Thomas Lasker; Figura, Kurt von & Bakke, Oddmund (2002). Structural requirements for interactions between leucine-sorting signals and clathrin-associated adaptor protein complex AP3. Journal of Biological Chemistry. ISSN 0021-9258. p. 47436–47443. Show summary

  Cytoplasmic tails of LIMPII and the invariant chain contain similar leucine-based sorting signals, but the invariant chain interacts only with AP1 and AP2, whereas LIMPII interacts strongly with AP3. In a series of in vitro experiments, we investigated the effect of residues upstream of the leucine pairs and demonstrated that these residues determine adapter binding, and certain residues favor interactions with AP3. Furthermore, constructs that interacted stronger with AP3 interacted weakly with AP1 and vice versa. Exchanging residues upstream of the leucine-based signal in LIMPII with those of the invariant chain reduced LIMPII binding to AP3 in vitro, and in vivo the corresponding LIMPII mutant was rerouted via the plasma membrane like the invariant chain. These preferential interactions of different leucine signals with different AP complexes may thus be the determining step sorting proteins from the trans-Golgi network to their final destinations. Proteins that interact with AP3 are sorted directly to endosomes/lysosomes, whereas proteins that interact with AP1 are sorted via a different route. At the same time, constructs that exhibited specificity for either AP1 or AP3 might still interact with AP2, suggesting that AP2 may recognize a wider variety of leucine signals. This is consistent with the suggested role of AP2 in internalization of proteins containing general leucine-based signals, including proteins that have been missorted to the plasma membrane

• Nordeng, Tommy W.; Gregers, Tone F.; Kongsvik, Thomas Lasker; Meresse, S.; Gorvel, Jean-Pierre & Jourdan, F. [Show all 8 contributors for this article] (2002). The cytoplasmic tail of invariant chain regulates endosome fusion and morphology. Molecular Biology of the Cell. ISSN 1059-1524. p. 1846–1856. Show summary

  The major histocompatibility complex class II associated invariant chain (Ii) has been shown to inhibit endocytic transport and to increase the size of endosomes. We have recently found that this property has a significant impact on antigen processing and presentation. Here, we show in a cell-free endosome fusion assay that expression of Ii can increase fusion after phosphatidylinositol 3-kinase activity is blocked by wortmannin. In live cells wortmannin was also not able to block formation of the Ii-induced enlarged endosomes. The effects of Ii on endosomal transport and morphology depend on elements within the cytoplasmic tail. Data from mutagenesis analysis and nuclear magnetic resonance-based structure calculations of the Ii cytoplasmic tail demonstrate that free negative charges that are not involved in internal salt bridges are essential for both interactions between the tails and for the formation of enlarged endosomes. This correlation indicates that it is interactions between the Ii cytoplasmic tails that are involved in endosome fusion. The combined data from live cells, cell-free assays, and molecular dynamic simulations suggest that Ii molecules on different vesicles can promote endosome docking and fusion and thereby control endosomal traffic of membrane proteins and endosomal content.

• Kongsvik, Thomas Lasker; Honing, Stefan; Bakke, Oddmund & Rodionov, Dmitrii G. (2002). Mechanism of interaction between leucine-based sorting signals from the invariant chain and clathrin-associated adaptor protein complexes AP1 and AP2. Journal of Biological Chemistry. ISSN 0021-9258. p. 16484–16488. Show summary

  The cytoplasmic tail of the invariant chain contains two leucine-based sorting signals, and each of those seems sufficient to route the invariant chain to its intracellular destination in either normal or polarized cells. It is believed that the intracellular routing of the invariant chain is mediated by its interactions with the clathrin-associated adaptor protein complexes AP1 and AP2. We () have previously demonstrated the in vitro interactions between the cytoplasmic tail of the invariant chain and AP1/AP2 complexes. These interactions were specific and depended on the critical leucine residues in the invariant chain's sorting signals. In the present study, we decided to investigate the molecular mechanism of these interactions. To this end, we constructed a set of glutathione S-transferase fusion proteins that contained the intact cytoplasmic tail of the invariant chain and its various mutants to define residues important for its interactions with AP1 and AP-2. Our results demonstrated the importance of several residues other than the critical leucine residues for such interactions. A strong correlation between in vitro binding of AP2 to the invariant chain and in vivo internalization of the invariant chain was observed, confirming the primary role of AP2 in recognition of endocytic signals. In addition, we demonstrated different requirements for AP1 and AP2 binding to cytoplasmic tail of the invariant chain, which may reflect that the different sorting pathways mediated by AP1 and AP2 involve their recognition of the primary structure of the sorting signal.

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• Hu, Xian; Margadant, Felix Martin & Bakke, Oddmund (2021). International Patent: Microscope apparatus. WO2021160723A1. . Show summary

  A microscope apparatus (10) comprises: an imaging volume with orthogonal X, Y and Z axes; a camera (211) having a focal plane; a light source (110, 120) for illumination of the imaging volume; and a Z-stage movement system (131, 132) for relative movement of the imaging volume and the focal plane in the Z axis. Images of microscopic biological objects S are obtained using the microscope apparatus (10) via a method comprising: using the camera (211) to obtain an image in a single exposure whilst using the Z-stage movement system (131, 132) for relative movement of the imaging volume and the focal plane; wherein the Z axis movement is a step-wise movement in which there are multiple resting steps providing periods of no relative motion in between multiple periods of relative motion; and wherein during the periods of relative motion the light source is controlled to reduce the illumination of the imaging volume.

• Distefano, Marita Borg; Kjos, Ingrid; Bakke, Oddmund & Progida, Cinzia (2015). Rab7b at the intersection of intracellular trafficking and cell migration. Communicative & Integrative Biology. ISSN 1942-0889. 8(6). doi: 10.1080/19420889.2015.1023492.
• Perdreau, Harmonie; Guldsten, Hanne; Progida, Cinzia; Thiede, Bernd; Bakke, Oddmund & Morth, Jens Preben (2014). Molecular and Structural Characterization of Sjögren syndrome/scleroderma autoantigen 1 (SSSCA1).
• Müller, Elisabeth; Stavna, A.; Jahnsen, Frode Lars; Bakke, Oddmund & Corthay, Alexandre (2013). Using Live Imaging to Investigate the Mechanisms Underlying Tumor Cell Killing by Macrophages. Scandinavian Journal of Immunology. ISSN 0300-9475. 77(4), p. 275–276.
• Wälchli, Sebastien; Landsverk, Ole J. B.; Fallang, Lars-Egil; Olweus, Johanna; Bakke, Oddmund & Gregers, Tone Fredsvik (2012). Invariant chain as a tool to load antigenic peptides on MHC class I. Molecular Immunology. ISSN 0161-5890. 51(1), p. 16–16. doi: 10.1016/j.molimm.2012.02.039.
• Sand, Kine Marita Knudsen; Landsverk, Ole J. B.; Bakke, Oddmund & Gregers, Tone Fredsvik (2012). Intracellular trafficking of the human invariant chain isoforms, Iip33 and Iip35. Molecular Immunology. ISSN 0161-5890. 51(1), p. 30–30. doi: 10.1016/j.molimm.2012.02.081.
• Berg-Larsen, Axel; Landsverk, Ole J. B.; Gregers, Tone Fredsvik & Bakke, Oddmund (2012). Rab GTPases are differentially regulated during DC maturation. Molecular Immunology. ISSN 0161-5890. 51(1), p. 8–8. doi: 10.1016/j.molimm.2012.02.016.
• Kucera, Ana; Bakke, Oddmund & Gregers, Tone Fredsvik (2012). Direct targeting of invariant chain to the MHC II loading compartment. Molecular Immunology. ISSN 0161-5890. 51(1), p. 20–21. doi: 10.1016/j.molimm.2012.02.054.
• Landsverk, Ole J. B.; Gregers, Tone Fredsvik & Bakke, Oddmund (2012). Differential regulation of MHC II and invariant chain expression during maturation of monocyte derived dendritic cells and how invariant chain increases the half-life of MHC II by delaying endosomal maturation. Molecular Immunology. ISSN 0161-5890. 51(1), p. 7–7. doi: 10.1016/j.molimm.2012.02.012.
• Bakke, Oddmund & Andersson, K. Kristoffer (2012). Åpent seminar: Fra imaging show til celler og proteinsrukturer. NBS-nytt. ISSN 0801-3535. 1, p. 22–22. Full text in Research Archive Show summary

  Fra imaging show til celler og proteinstrukturer Oddmund Bakke og K. Kristoffer Andersson, IMBV, Univ. Oslo. I anledning universitetets 200 års jubileum og Mat Nat Fakultetets 150 års jubileum i 2011 vi i oppdrag å fylle en dag med cellebiologi/strukturbiologi og lage en kortfilm med moderne mikroskopi som tema. Den 12. oktober ble et slikt møte arrangert i det høyteknologiske auditoriet i det nye IT bygget, Ole-Johan Dahls hus. Første del av programmet spente fra undervisning i cellebiologi til autofagi og det nyeste innen mikroskopi. Ikke minst var det stor spenning knyttet til premieren på kortfilmen ”Evolution”. http://www.mn.uio.no/imbv/english/about/news-and-events/events/imbvday/index.html From Imaging Show to Cells Join the Imaging Show and listen to international top scientists explain our understanding of the structure of the smallest living unit in the body: The cell. On October 12 2011, Department of Molecular Biosciences arranges the IMBV Day. Time and place: Oct 12, 2011 09:00 AM - 04:15 PM, Auditorium Simula, Ole-Johan Dahls hus Image Our understanding of life has advanced tremendously during the last 20 years. Today we can determine the structure of molecules, alone and in complex with other molecules, and we can build detailed models of the functions of cells. Aided by advanced microscopy and data technology we can even make movies inside living cells, directly observing single molecules and cell constituents. On this day, leading local and international experts in cell biology and protein crystallography will explain cellular molecules and structures and our current understanding of living organisms. Through sound and pictures we will experience a 3D and 4D imaging show of cells, filmed using microscopic laser technology.

• Bakke, Oddmund & Andersson, K. Kristoffer (2011). Åpent seminar: Fra imaging show til celler og proteinsrukturer.
• Kucera, Ana; Bakke, Oddmund & Gregers, Tone Fredsvik (2011). Direct Targeting of Invariant Chain to the MHC II Loading Compartment. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 362–362.
• Berg-Larsen, Axel; Landsverk, Ole J. B.; Gregers, Tone Fredsvik & Bakke, Oddmund (2011). Rab GTPases are Differentially Regulated Duringe DC Maturation. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 361–361.
• Sundvold-Gjerstad, Vibeke; Kristiansen, Tone Fredsvik; Granum, Stine; Berge, Tone; Koster, Gerbrand & Skjeldal, Frode Miltzow [Show all 9 contributors for this article] (2011). T cell Specific Adapter Protein (TSAd) Relocates the Tec Family Protein Tyrosine Kinase Itk from the Plasma Membrane to the Perinuclear Area. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 359–359.
• Sand, Kine Marita Knudsen; Bakke, Oddmund & Gregers, Tone Fredsvik (2011). The Role of li p35 in MHC Class II Antigen Presentation. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 358–358.
• Kucera, Ana; Bakke, Oddmund & Gregers, Tone Fredsvik (2011). The Role of Inhibitory NKR-P1 Receptors in the Gut. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 362–363.
• Landsverk, Helga Bjarnason; Mora-Bermúdez, Felipe; Landsverk, Ole J. B.; Hasvold, Grete; Naderi, Soheil & Bakke, Oddmund [Show all 10 contributors for this article] (2010). The protein phosphatase 1 regulator PNUTS is a novel component of the DNA damage response.
• Doving, KB; Skjeldal, Frode Miltzow; Sandvig, Kirsten; Bakke, Oddmund; Heikkinen, I & Larsen, HK [Show all 7 contributors for this article] (2009). Fish Chemosenses; Olfaction, Taste, and Ligand-Specific Endocytosis. Chemical Senses. ISSN 0379-864X. 34(3), p. E13–E13.
• Landsverk, Helga Bjarnason; Mora-Bermudez, Felipe; Landsverk, Ole J. B.; Hasvold, Grete; Naderi, Soheil & Bakke, Oddmund [Show all 10 contributors for this article] (2009). PP1 nuclear targeting subunit (PNUTS/p99/R111/CAT53) is an integral part of the G2 DNA damage checkpoint.
• Nilsen, Nadra; Deininger, Susanne; Nonstad, Unni; Skjeldal, Frode; Husebye, Harald & Rodionov, Dmitrii [Show all 11 contributors for this article] (2008). Toll-like receptor 2 signaling occurs preferentially at the plasma membrane, independent of internalization, and is facilitated by both CD36 and CD14.
• Hol, Johanna; Wik, Jonas Aakre; La Cour Poulsen, Lars & Bakke, Oddmund (2016). Glucose and Vascular Inflammation. Thesis for the degree of Master of Science in Molecular Biosciences, University of Oslo. Universitetet i Oslo.

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