Evolutionary history of extraintestinal virulence in Escherichia coli

CEES Extra seminar by Erick Denamur


In nature, Escherichia coli strains exhibit various lifestyles, alternating between their primary habitat, the vertebrate gut, and their secondary habitat, the soil, water and sediments. They are also responsible for both intra-and extra-intestinal diseases. The purpose of this seminar will be, using large and small-scale epidemiological studies, to show how the ecological and evolutionary forces have selected extraintestinal virulence.

Erick Denamur
UMR 722 INSERM Universités Paris Diderot et Paris Nord, «Ecologie et évolution des microorganismes». Faculté de Médecine, Site Xavier Bichat, 16 rue Henri Huchard, 75018 Paris, France. Website.

Some further readings:

Adiba, S., Nizak, C., van Baalen, M., Denamur, E., and Depaulis, F. (2010) From grazing resistance to pathogenesis: the coincidental evolution of virulence factors. PLoS One 5: e11882.

Landraud, L., Jaureguy, F., Frapy, E., Guigon, G., Gouriou, S., Carbonnelle, E. et al. (2013) Severity of Escherichia coli bacteraemia is independent of the intrinsic virulence of the strains assessed in a mouse model. Clin Microbiol Infect 19: 85-90.

Levert, M., Zamfir, O., Clermont, O., Bouvet, O., Lespinats, S., Hipeaux, M.C. et al. (2010) Molecular and evolutionary bases of within-patient genotypic and phenotypic diversity in Escherichia coli extraintestinal infections. PLoS Pathog 6: e1001125.

Tenaillon, O., Skurnik, D., Picard, B., and Denamur, E. (2010) The population genetics of commensal Escherichia coli. Nat Rev Microbiol 8: 207-217.

Touchon, M., Hoede, C., Tenaillon, O., Barbe, V., Baeriswyl, S., Bidet, P. et al. (2009) Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths. PLoS Genet 5: e1000344.

Published Feb. 27, 2013 12:39 PM - Last modified Mar. 4, 2013 10:38 AM