Frederik Andre Hansen

Postdoctoral Fellow - Section for Pharmaceutical Chemistry
Image of Frederik Andre Hansen
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Room 217
Username
Visiting address Sem Sælands vei 3 Farmasibygningen 0371 OSLO
Postal address Postboks 1068 Blindern 0316 Oslo
Other affiliations Department of Education (Student)

Research

Sample preparation techniques for highly polar substances are still in the modern-day field of analytical chemistry seriously limited compared to what is available for apolar substances. Electromembrane extraction (EME) is a technique that since its establishment in 2006 have gained much attention and shown great potential for selective extraction of apolar and moderately polar substances. We are now taking the first steps towards developing EME systems for extraction of the highly polar class of substances.

The research is very conceptual and include the following activities: 

  • Development of stable and robust systems for electromembrane extraction of highly polar drugs and endogenous metabolites. 
  • Understand on a fundamental level the mechanisms of successful (and unsuccessful) transfer of highly polar substances across a supported liquid membrane (SLM) under the influence of an electric field.
  • Characterization of matrix effects in EME of highly polar substances, and development of strategies to overcome such matrix effects. 

Teaching

Teaching students of pharmacy at UiO on bachelor and master level. Courses include:

Academic background

  • Master of Pharmaceutical Sciences, University of Copenhagen, Denmark (2018)

Awards

  • PharmaSchool H.C. Ørsted medal as top graduate from School of Pharmaceutical Sciences, University of Copenhagen, Denmark (2018).

ORCID

https://orcid.org/0000-0002-1666-0447

 

 

Tags: Analytical chemistry, Sample preparation, Drug analysis, Electromembrane extraction

Publications

  • Eie, Linda Vårdal; Pedersen-Bjergaard, Stig & Hansen, Frederik Andre (2022). Electromembrane extraction of polar substances – Status and perspectives. Journal of Pharmaceutical and Biomedical Analysis. ISSN 0731-7085. 207. doi: 10.1016/j.jpba.2021.114407.
  • Rye, Torstein Kige; Martinovic, Gordana; Eie, Linda Vårdal; Hansen, Frederik Andre; Halvorsen, Trine Grønhaug & Pedersen-Bjergaard, Stig (2021). Electromembrane extraction of peptides using deep eutectic solvents as liquid membrane. Analytica Chimica Acta. ISSN 0003-2670. 1175. doi: 10.1016/j.aca.2021.338717.
  • Hansen, Frederik Andre; Tirandaz, Shima & Pedersen-Bjergaard, Stig (2021). Selectivity and efficiency of electromembrane extraction of polar bases with different liquid membranes—Link to analyte properties. Journal of Separation Science. ISSN 1615-9306. 44(13), p. 2631–2641. doi: 10.1002/jssc.202100167.
  • Skottvoll, Frøydis Sved; Hansen, Frederik; Harrison, Sean; Boger, Ida Caroline Sneis; Mrsa, Ago & Restan, Magnus Saed [Show all 14 contributors for this article] (2021). Electromembrane extraction and mass spectrometry for liver organoid drug metabolism studies. Analytical Chemistry. ISSN 0003-2700. 93, p. 3576–3585. doi: 10.1021/acs.analchem.0c05082. Full text in Research Archive
  • Eie, Linda Vårdal; Rye, Torstein Kige; Hansen, Frederik; Halvorsen, Trine Grønhaug & Pedersen-Bjergaard, Stig (2021). Electromembrane extraction of peptides and amino acids – status and perspectives. Bioanalysis. ISSN 1757-6180. 13(4), p. 277–289. doi: 10.4155/bio-2020-0285.
  • Hansen, Frederik & Pedersen-Bjergaard, Stig (2021). Electromembrane extraction of streptomycin from biological fluids. Journal of Chromatography A. ISSN 0021-9673. 1639. doi: 10.1016/j.chroma.2021.461915.
  • Hansen, Frederik; Santigosa-Murillo, Elia; Payan, Maria Ramos; Munoz, Maria; Øiestad, Elisabeth Leere & Pedersen-Bjergaard, Stig (2020). Electromembrane extraction using deep eutectic solvents as the liquid membrane. Analytica Chimica Acta. ISSN 0003-2670. 1143, p. 109–116. doi: 10.1016/j.aca.2020.11.044.
  • Drobnjak, Milena; Hansen, Frederik; Øiestad, Elisabeth Leere; Løvli, Trond; Trones, Roger & Martinsen, Ørjan Grøttem [Show all 7 contributors for this article] (2020). Electromembrane extraction with vials of conducting polymer. LC GC North America. ISSN 1527-5949. 38, p. 435–439.
  • Hansen, Frederik; Øiestad, Elisabeth Leere & Pedersen-Bjergaard, Stig (2020). Bioanalysis of pharmaceuticals using liquid-phase microextraction combined with liquid chromatography–mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. ISSN 0731-7085. 189, p. 1–12. doi: 10.1016/j.jpba.2020.113446.
  • Hansen, Frederik; Jensen, Henrik & Pedersen-Bjergaard, Stig (2020). Electromembrane extraction using sacrificial electrodes. Analytical Chemistry. ISSN 0003-2700. 92(7), p. 5595–5603. doi: 10.1021/acs.analchem.0c00626.
  • Hansen, Frederik; Jaghl, Mohamad Fadi; Øiestad, Elisabeth Leere; Jensen, Henrik; Pedersen-Bjergaard, Stig & Huang, Chuixiu (2020). Impact of ion balance in electromembrane extraction. Analytica Chimica Acta. ISSN 0003-2670. 1124, p. 129–136. doi: 10.1016/j.aca.2020.05.039.
  • Hansen, Frederik; Kuban, Pavel; Øiestad, Elisabeth Leere & Pedersen-Bjergaard, Stig (2020). Electromembrane extraction of highly polar bases from biological samples – Deeper insight into bis(2-ethylhexyl) phosphate as ionic carrier. Analytica Chimica Acta. ISSN 0003-2670. 1115, p. 23–32. doi: 10.1016/j.aca.2020.04.027.
  • Hansen, Frederik & Pedersen-Bjergaard, Stig (2019). Emerging extraction strategies in analytical chemistry. Analytical Chemistry. ISSN 0003-2700. 92(1), p. 2–15. doi: 10.1021/acs.analchem.9b04677.

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  • Skottvoll, Frøydis Sved; Harrison, Sean; Hansen, Frederik; Pedersen-Bjergaard, Stig; Sullivan, Gareth & Bogen, Inger Lise [Show all 8 contributors for this article] (2020). Liver mini-organ analyses using liquid chromatography mass spectrometry.

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Published Nov. 16, 2018 11:23 AM - Last modified Apr. 26, 2021 2:59 PM

Research groups