Norwegian version of this page

SamplePrep@UiO

Before drugs and endogenous substances can be measured in biological samples, they have to be isolated from the original sample. In SamplePrep@UiO, we focus on development of new concepts for such isolation, based on microextraction. 

Image may contain: Text, Font, Line.

From left: 

Stig Pedersen-Bjergaard, Frederik Hansen, Grete Hasvold, Elisabeth Leere Øiestad, Linda Vårdal Eie, Torstein Kige Rye, Tonje Gottenberg Skaalvik, Maria Schüller, and Astrid Gjelstad.

Our Mission Is to

  • …develop microextraction (sample preparation) concepts for next generation analytical chemistry.
  • …stimulate and train young scientist in conceptual research.

Strategy

Our research group is:
  • Small, creative, effective, and with strong international recognition.
  • Focused on international dissemination and collaboration. 

Our research is:

  • Focused on development of new analytical microextraction concepts, for extraction of drugs and endogenous substances from biological fluids (such as blood).
  • Currently devoted to electromembrane extraction (EME) and liquid-phase microextraction (LPME).
  • Motivated by the expectation that next generation analytical chemistry will largely rely on microextraction technologies for sample preparation.
  • Conceptual, and balanced between
    (a) fundamental science (theoretical understanding),
    (b) applied science (technical formats, forefront pharmaceutical and biomedical applications), and
    (c) commercialization.
  • Anchored in teaching, thereby stimulating the students in direction of pharmaceutical analytical chemistry.
  • Read more about our research here.
Every single day in our research group is:
  • A day in a creative, humoristic and kind atmosphere.
  • A day with new experiments.
At the end, we hope that:
  • Our concepts are used by routine laboratories, or
  • Our concepts have inspired other scientists into conceptual research, or
  • Students trained in our group are successful outside the university.

Research News 

  • Green chemistry… Apr. 30, 2021 10:38 AM

    Next generation analytical chemist will be highly concerned about sustainability and use only green methods in their work. How green can they be?

    Read the paper...

  • Liver organoids… Apr. 30, 2021 10:35 AM

    Analytical measurements from micro-physiological systems have to be done very carefully, in order not to disturb the biochemical equilibrium in the system – this can be done using electromembrane extraction.

    Read the paper...

  • Peptides… Apr. 30, 2021 10:29 AM

    Peptides are charged substances - do they migrate across an oil membrane under influence of an electrical field? Can this principle be used in analytical chemistry?

    Read the paper...

  • Gordana Martinovic Defended Her Master Thesis Apr. 26, 2021 11:26 AM

    On April 8, Gordana Martinovic defended her master thesis entitled “ Electromembrane extraction of peptides using deep eutectic solvents as liquid membranes”. As the title implies, this work investigated the potential for using deep eutectic solvents (DES) as liquid membranes in electromembrane extraction (EME) of peptides. The project was inspired by a recent publication from our research group, where DES were successfully used as liquid membranes in EME of polar basic drugs. The present work has identified both cation-π interactions (between the DES components and cationic peptides) as well as ionic interactions (between the ionic carrier di(2-ethylhexyl)phosphate and cationic peptides) important for extraction. The results are important for future EME, and especially for development of selective EME of peptides (and potentially proteins), which will be of high priority in our future EME research.

  • World record…? Feb. 17, 2021 11:21 AM

    Extraction of very polar and water-soluble compounds is a great challenge, because they tend to stay in the aqueous sample for solubility reasons. Although extraction is supported by an electrical field in electromembrane extraction (EME), polar substances are difficult even with EME. Our job is to address such challenges, and therefore we are currently developing EME for very polar endogenous metabolites and pharmaceuticals. One example is streptomycin, an antibiotic drug. Recently, we extracted this compound successfully with EME, and as far as we know, this is the most polar substance ever extracted with EME!

    Read the paper...

  • Back to the basics... Jan. 4, 2021 1:17 PM

    Development of new applications of electromembrane extraction (EME) is highly important for the implementation of the technique. However, understanding the fundamentals is equally important; to give the concept a scientific anchor and to develop predictability. In two recent papers, we studied in more details molecular interactions and acid-base equilibria during EME. If you look into these papers, you will see that new fundamental understanding was developed directly from concepts and tools from the first chemistry course…

    Read the first paper...

    Read the second paper...

  • Collaboration with Czech scientists… Jan. 4, 2021 1:17 PM

    Foreign PhD students often visit our laboratory for a couple of months to get experience with EME/LPME and to conduct common research. Hana Bavlovic Piskackova from Charles University visited us just before COVID, did some experiments in Oslo, brought with her 96-well EME plates back to Czech Republic, and finished work with anthracyclines…

    Read the paper...

  • Testing the first commercial device for EME… Jan. 4, 2021 1:17 PM

    The Norwegian company Extraction Technologies Norway ( www.etn-eme.com) has developed commercial equipment for EME, and we were the first to test this. A unique product based on vials of conducting polymer…

  • A critical review… Jan. 4, 2021 1:17 PM

    Liquid-phase microextraction (LPME) has been around for 20 years, but still there is no use in routine laboratories. To pass that door, we need to improve the applications published in the scientific literature; use state-of-the-art instrumentation and address the hot applications…

    Read the paper...

  • Soap… Jan. 4, 2021 1:16 PM

    Detergents (soap) present in samples is a challenge in analytical chemistry, because they tend to interfere with measurements based on mass spectrometry. Most detergents are charged molecules, and therefore we tested electromembrane extraction for their fast and efficient removal…

    Read the paper...

More ...
Published Nov. 20, 2018 10:47 AM - Last modified May 4, 2021 12:37 PM