Harald Stranger Mjønes

• Mjønes, Harald Stranger; Havik, Mona; Seferi, Gezime & Morland, Cecilie (2026). High-intensity interval exercise affects neurogenesis and angiogenesis differently in diabetic and non-diabetic mice. Frontiers in Neuroscience. ISSN 1662-4548. 20, p. 1–12. doi: 10.3389/fnins.2026.1927709. Full text in Research Archive
• Seferi, Gezime; Mjønes, Harald Stranger; Havik, Mona; Reiersen, Herman; Dalen, Knut Tomas & Nordengen, Kaja [Show all 7 contributors for this article] (2024). Distribution of lipid droplets in hippocampal neurons and microglia: impact of diabetes and exercise. Life Science Alliance (LSA). 7(10). doi: 10.26508/lsa.202302239. Full text in Research Archive Show summary

  Neuroinflammation, aging, and neurodegenerative disorders are associated with excessive accumulation of neutral lipids in lipid droplets (LDs) in microglia. Type 2 diabetes mellitus (T2DM) may cause neuroinflammation and is a risk factor for neurodegenerative disorders. Here, we show that hippocampal pyramidal neurons contain smaller, more abundant LDs than their neighboring microglia. The density of LDs varied between pyramidal cells in adjacent subregions, with CA3 neurons containing more LDs than CA1 neurons. Within the CA3 region, a gradual increase in the LD content along the pyramidal layer from the hilus toward CA2 was observed. Interestingly, the high neuronal LD content correlated with less ramified microglial morphotypes. Using the db/db model of T2DM, we demonstrated that diabetes increased the number of LDs per microglial cell without affecting the neuronal LD density. High-intensity interval exercise induced smaller changes in the number of LDs in microglia but was not sufficient to counteract the diabetes-induced changes in LD accumulation. The changes observed in response to T2DM may contribute to the cerebral effects of T2DM and provide a mechanistic link between T2DM and neurodegenerative disorders.

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