Ingunn Tho

• Petersen, Emilie Fynbo; Larsen, Bjarke Strøm; Nielsen, Rasmus Blaaholm; Pijpers, Ils; Versweyveld, Dries & Holm, René [Show all 9 contributors for this article] (2024). Co-release of paclitaxel and encequidar from amorphous solid dispersions increase oral paclitaxel bioavailability in rats. International Journal of Pharmaceutics. ISSN 0378-5173. 654. doi: 10.1016/j.ijpharm.2024.123965.
• Tzanova, Martina Martin; Larsen, Bjarke Strøm; Birolo, Rebecca; Cignolini, Sara; Tho, Ingunn & Chierotti, Michele R. [Show all 11 contributors for this article] (2024). Shifting the Focus from Dissolution to Permeation: Introducing the Meso-fluidic Chip for Permeability Assessment (MCPA). Journal of Pharmaceutical Sciences. ISSN 0022-3549. doi: 10.1016/j.xphs.2023.12.012. Full text in Research Archive
• Larsen, Bjarke Strøm; Kissi, Eric Ofosu; Parreiras Nogueira, Liebert; Genina, Natalja & Tho, Ingunn (2023). Impact of drug load and polymer molecular weight on the 3D microstructure of printed tablets. Journal of Pharmaceutical Sciences. ISSN 0022-3549. 192. doi: 10.1016/j.ejps.2023.106619. Full text in Research Archive
• Korelc, Karin; Larsen, Bjarke Strøm; Heintze, Anna-Lena; Henrik-Klemens, Åke; Karlsson, Jakob & Larsson, Anette [Show all 7 contributors for this article] (2023). Towards personalized drug delivery via semi-solid extrusion: Exploring poly(vinyl alcohol-co-vinyl acetate) copolymers for hydrochlorothiazide-loaded films. European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 192. doi: 10.1016/j.ejps.2023.106645. Full text in Research Archive
• Nielsen, Rasmus Blaaholm; Larsen, Bjarke Strøm; Holm, René; Pijpers, Ils; Snoeys, Jan & Nielsen, Ulla Gro [Show all 8 contributors for this article] (2023). Increased bioavailability of a P-gp substrate: Co-release of etoposide and zosuquidar from amorphous solid dispersions. International Journal of Pharmaceutics. ISSN 0378-5173. 642. doi: 10.1016/j.ijpharm.2023.123094. Full text in Research Archive
• Nilsson, Carl Niklas; Nezvalova-Henriksen, Katerina; Bøtker, Johan P.; Andersen, Niels Højmark; Larsen, Bjarke Strøm & Rantanen, Jukka [Show all 8 contributors for this article] (2023). Co-administration of Intravenous Drugs: Rapidly Troubleshooting the Solid Form Composition of a Precipitate in a Multi-drug Mixture Using On-Site Raman Spectroscopy. Molecular Pharmaceutics. ISSN 1543-8384. 20(6), p. 2853–2863. doi: 10.1021/acs.molpharmaceut.2c00983. Full text in Research Archive
• Korelc, Karin; Larsen, Bjarke Strøm; Gašperlin, Mirjana & Tho, Ingunn (2023). Water-soluble chitosan eases development of mucoadhesive buccal films and wafers for children. International Journal of Pharmaceutics. ISSN 0378-5173. 631. doi: 10.1016/j.ijpharm.2022.122544. Full text in Research Archive
• Meiland, Peter; Larsen, Bjarke Strøm; Knopp, Matthias Manne; Tho, Ingunn & Rades, Thomas (2022). A new method to determine drug-polymer solubility through enthalpy of melting and mixing. International Journal of Pharmaceutics. ISSN 0378-5173. 629. doi: 10.1016/j.ijpharm.2022.122391. Full text in Research Archive
• Nilsson, Niklas; Nguyen, Vivian; Nezvalova-Henriksen, Katerina & Tho, Ingunn (2022). Exploring a case of incompatibility in a complex regimen containing Plasma-Lyte 148 in the pediatric intensive care. Pediatric Anaesthesia. ISSN 1155-5645. 33(3), p. 211–218. doi: 10.1111/pan.14598.
• Nezvalova-Henriksen, Katerina; Holm, Tone Huseby; Nilsson, Niklas; Kjønniksen, Inge & Tho, Ingunn (2022). Frequently acquired drugs in neonatal intensive care and their physical compatibility. Acta Paediatrica. ISSN 0803-5253. 111(12), p. 2307–2314. doi: 10.1111/apa.16526.
• Nilsson, Niklas; Storesund, Ingebjørg; Tho, Ingunn & Nezvalova-Henriksen, Katerina (2022). Co-administration of drugs with parenteral nutrition in the neonatal intensive care unit—physical compatibility between three components. European Journal of Pediatrics. ISSN 0340-6199. 181, p. 2685–2693. doi: 10.1007/s00431-022-04466-z. Full text in Research Archive
• Govender, Rydvikha; Kissi, Eric Ofosu; Larsson, Anette & Tho, Ingunn (2021). Polymers in Pharmaceutical Additive Manufacturing: A Balancing Act Between Printability and Product Performance. Advanced Drug Delivery Reviews. ISSN 0169-409X. 177. doi: 10.1016/j.addr.2021.113923.
• Kissi, Eric Ofosu; Nilsson, Robin; Nogueira, Liebert Parreiras; Larsson, Anette & Tho, Ingunn (2021). Influence of Drug Load on the Printability and Solid-State Properties of 3D-Printed Naproxen-Based Amorphous Solid Dispersion. Molecules. ISSN 1431-5157. 26(15). doi: 10.3390/molecules26154492. Full text in Research Archive
• Gulin-Sarfraz, Tina; Kalantzopoulos, Georgios N.; Pettersen, Marit Kvalvåg; Åsli, Anette Wold; Tho, Ingunn & Axelsson, Lars Torsten [Show all 7 contributors for this article] (2021). Inorganic Nanocarriers for Encapsulation of Natural Antimicrobial Compounds for Potential Food Packaging Application: A Comparative Study. Nanomaterials. ISSN 2079-4991. 11(2). doi: 10.3390/nano11020379. Full text in Research Archive Show summary

  Design and development of novel inorganic nanocarriers for encapsulation of natural antimicrobial substances for food packaging applications have received great interest during the last years. Natural nanoclays are the most investigated nanocarriers and recently interest has also grown in the synthetically produced porous silica particles. However, these different carrier matrices have not been compared in terms of their loading capability and subsequent release. In this study, the feasibility of porous silica particles (with different pore structures and/or surface functionalities) and commercially available nanoclays were evaluated as encapsulation matrices. Two well-studied antimicrobial substances, thymol and curcumin, were chosen as volatile and non-volatile model compounds, respectively. The encapsulation efficiency, and the subsequent dispersibility and release, of these substances differed significantly among the nanocarriers. Encapsulation of the volatile compound highly depends on the inner surface area, i.e., the protective pore environment, and an optimal nanocarrier can protect the encapsulated thymol from volatilization. For the non-volatile compound, only the release rate and dispersibility are affected by the pore structure. Further, water-activated release of the volatile compound was demonstrated and exhibited good antimicrobial efficacy in the vapor phase against Staphylococcus aureus. This comparative study can provide a base for selecting the right nanocarrier aimed at a specific food packaging application. No nanocarrier can be considered as a universally applicable one.

• Alopaeus, Julia Fredrika; Göbel, Anja; Breitkreutz, Jörg; Sande, Sverre Arne & Tho, Ingunn (2020). Investigation of hydroxypropyl-β-cyclodextrin inclusion complexation of two poorly soluble model drugs and their taste-sensation - Effect of electrolytes, freeze-drying and incorporation into oral film formulations. Journal of Drug Delivery Science and Technology. ISSN 1773-2247. 61. doi: 10.1016/j.jddst.2020.102245.
• Tzanova, Martina; Hagesæther, Ellen & Tho, Ingunn (2020). Solid lipid nanoparticle-loaded mucoadhesive buccal films – Critical quality attributes and in vitro safety & efficacy . International Journal of Pharmaceutics. ISSN 0378-5173. 592. doi: 10.1016/j.ijpharm.2020.120100. Full text in Research Archive
• Liu, JingWen; Rades, Thomas; Tho, Ingunn & Kissi, Eric Ofosu (2020). Functionalised calcium carbonate as a coformer to stabilize amorphous drugs by mechanochemical activation. European journal of pharmaceutics and biopharmaceutics. ISSN 0939-6411. 155, p. 22–28. doi: 10.1016/j.ejpb.2020.07.029.
• Hagesæther, Ellen; Adamczak, Malgorzata Iwona; Hiorth, Marianne & Tho, Ingunn (2020). Characterization of Bioadhesion, Mucin‐interactions and Mucosal Permeability of Pharmaceutical Nano‐ and Microsystems. In Peltonen, Leena (Eds.), Characterization of Pharmaceutical Nano and Microsystems. John Wiley & Sons. ISSN 9781119414018. p. 171–205. doi: https:/doi.org/10.1002/9781119414018.ch5.
• Nezvalova-henriksen, Katerina; Nilsson, Niklas; Holvik, Camilla Tomine; Staven Berge, Vigdis & Tho, Ingunn (2020). Y-site physical compatibility of numeta g13e with drugs frequently used at neonatal intensive care. Pharmaceutics. ISSN 1999-4923. 12(7). doi: 10.3390/pharmaceutics12070677. Full text in Research Archive
• Brustugun, Jørgen; Notaker, Nikolai; Paetz, Lasse Holtan; Tho, Ingunn & Bjerknes, Kathrin (2020). Adjusting the dose in paediatric care by dispersing fragments of four different aspirin tablets. Acta Paediatrica. ISSN 0803-5253. 109(11), p. 2394–2401. doi: 10.1111/apa.15216.
• Brustugun, Jørgen; Aas, Elisabeth Birkedal; Tho, Ingunn & Bjerknes, Kathrin (2020). Comparing Two Methods of Tablet Manipulation to Adjust the Warfarin Dose in Paediatric Care. Pharmaceutics. ISSN 1999-4923. 12(4), p. 1–13. doi: 10.3390/pharmaceutics12040375. Full text in Research Archive
• Alopaeus, Julia Fredrika; Hellfritzsch, Marie; Gutowski, Tobias; Scherließ, Regina; Almeida, Andreia F & Sarmento, Bruno [Show all 8 contributors for this article] (2019). Mucoadhesive buccal films based on a graft co-polymer – A mucin-retentive hydrogel scaffold . European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 142:105142, p. 1–15. doi: 10.1016/j.ejps.2019.105142. Full text in Research Archive
• Nilsson, Niklas; Nezvalova-Henriksen, Katerina & Tho, Ingunn (2019). Emulsion Stability of Different Intravenous Propofol Formulations in Simulated Co-Administration with Remifentanil Hydrochloride. Pharmaceutical Technology in Hospital Pharmacy (PTHP). ISSN 2365-2411. 4(2), p. 77–87. doi: 10.1515/pthp-2019-0014. Full text in Research Archive
• Brustugun, Jørgen; Notaker, Nikolai; Paetz, Lasse Holtan; Tho, Ingunn & Bjerknes, Kathrin (2019). Adjusting the dose in paediatric care: dispersing four different aspirin tablets and taking a proportion. European Journal of Hospital Pharmacy (EJHP). ISSN 2047-9956. doi: 10.1136/ejhpharm-2019-001903. Full text in Research Archive
• Adrover, Alessandra; Paolicelli, Patrizia; Petralito, Stefania; Di Muzio, Laura; Trilli, Jordan & Cesa, Stefania [Show all 8 contributors for this article] (2019). Gellan Gum/Laponite Beads for the Modified Release of Drugs: Experimental and Modeling Study of Gastrointestinal Release . Pharmaceutics. ISSN 1999-4923. 11(4). doi: 10.3390/pharmaceutics11040187. Full text in Research Archive
• Alopaeus, Julia Fredrika; Hagesæther, Ellen & Tho, Ingunn (2019). Micellisation Mechanism and Behaviour of Soluplus®–Furosemide Micelles: Preformulation Studies of an Oral Nanocarrier-Based System. Pharmaceuticals. ISSN 1424-8247. 12(1). doi: 10.3390/ph12010015. Full text in Research Archive
• Adrover, Alessandra; Varani, Gabriele; Paolicelli, Patrizia; Petralito, Stefania; Di Muzio, Laura & Casadei, Maria Antonietta [Show all 7 contributors for this article] (2018). Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin Films. Pharmaceutics. ISSN 1999-4923. 10(4). doi: 10.3390/pharmaceutics10040222. Full text in Research Archive
• Roque, Luis; Duarte, Noelia; Bronze, Maria Rosario; Garcia, Catarina; Alopaeus, Julia Fredrika & Molpeceres, Jesus [Show all 10 contributors for this article] (2018). Development of a bioadhesive nanoformulation with Glycyrrhiza glabra L. extract against Candida albicans . Biofouling (Print). ISSN 0892-7014. 34(8), p. 880–892. doi: 10.1080/08927014.2018.1514391.
• Roque, Luis; Alopaeus, Julia Fredrika; Reis, Cláudia; Rijo, Patricia; Molpeceres, Jesus & Hagesæther, Ellen [Show all 8 contributors for this article] (2018). Mucoadhesive assessment of different antifungal nanoformulations. Bioinspiration & Biomimetics. ISSN 1748-3182. 13(5). doi: 10.1088/1748-3190/aad488.
• Staven, Vigdis; Wang, Siri; Grønlie, Ingrid & Tho, Ingunn (2018). Physical stability of an all-in-one parenteral nutrition admixture for preterm infants upon mixing with micronutrients and drugs. European Journal of Hospital Pharmacy (EJHP). ISSN 2047-9956. 27, p. 36–42. doi: 10.1136/ejhpharm-2018-001562. Full text in Research Archive
• Roque, Luis; Castro, Pedro; Molpeceres, Jesus; Viana, Ana S.; Roberto, Amilcar & Reis, Cláudia [Show all 10 contributors for this article] (2018). Bioadhesive polymeric nanoparticles as strategy to improve the treatment of yeast infections in oral cavity: in-vitro and ex-vivo studies. European Polymer Journal. ISSN 0014-3057. 104, p. 19–31. doi: 10.1016/j.eurpolymj.2018.04.032.
• Tovsen, Marianne Lilletvedt; Tho, Ingunn & Tønnesen, Hanne Hjorth (2018). Viscosity reduction of isotonic solutions of the photosensitizer TPCS2a by cyclodextrin complexation. Drug Development and Industrial Pharmacy. ISSN 0363-9045. 44(2), p. 261–265. doi: 10.1080/03639045.2017.1386210.
• Andersen, Toril; Mishchenko, Ekaterina; Flaten, Gøril Eide; Sollid, Johanna U Ericson; Mattsson, Sofia & Tho, Ingunn [Show all 7 contributors for this article] (2017). Chitosan-based nanomedicine to fight genital Candida infections: Chitosomes. Marine Drugs. ISSN 1660-3397. 15:64(3), p. 1–12. doi: 10.3390/md15030064. Full text in Research Archive Show summary

  Vaginal infections are associated with high recurrence, which is often due to a lack of efficient treatment of complex vaginal infections comprised of several types of pathogens, especially fungi and bacteria. Chitosan, a mucoadhesive polymer with known antifungal effect, could offer a great improvement in vaginal therapy; the chitosan-based nanosystem could both provide antifungal effects and simultaneously deliver antibacterial drugs. We prepared chitosan-containing liposomes, chitosomes, where chitosan is both embedded in liposomes and surface-available as a coating layer. For antimicrobial activity, we entrapped metronidazole as a model drug. To prove that mucoadhesivness alone is not sufficient for successful delivery, we used Carbopol-containing liposomes as a control. All vesicles were characterized for their size, zeta potential, entrapment efficiency, and in vitro drug release. Chitosan-containing liposomes were able to assure the prolonged release of metronidazole. Their antifungal activity was evaluated in a C. albicans model; chitosan-containing liposomes exhibited a potent ability to inhibit the growth of C. albicans. The presence of chitosan was crucial for the system’s antifungal activity. The antifungal efficacy of chitosomes combined with antibacterial potential of the entrapped metronidazole could offer improved efficacy in the treatment of mixed/complex vaginal infections.

• Staven, Vigdis; Iqbal, Herra; Wang, Siri; Grønlie, Ingrid & Tho, Ingunn (2016). Physical compatibility of total parenteral nutrition and drugs in Y-site administration to children from neonates to adolescents. Journal of Pharmacy and Pharmacology (JPP). ISSN 0022-3573. 69(4), p. 448–462. doi: 10.1111/jphp.12647.
• Hagen, Eirik; Sandberg Løding, Fredrik; Mattsson, Sofia & Tho, Ingunn (2016). Use of interactive mixtures to obtain mini-tablets with high dose homogeneity for paediatric drug delivery. Journal of Drug Delivery Science and Technology. ISSN 1773-2247. 34, p. 51–59. doi: 10.1016/j.jddst.2016.03.006.
• Staven, Vigdis; Wang, Siri; Grønlie, Ingrid & Tho, Ingunn (2016). Development and evaluation of a test program for Y-site compatibility testing of total parenteral nutrition and intravenous drugs. Nutrition Journal. ISSN 1475-2891. 15. doi: 10.1186/s12937-016-0149-x. Full text in Research Archive Show summary

  Background: There is no standardized procedure or consensus to which tests should be performed to judge compatibility/ incompatibility of intravenous drugs. The purpose of this study was to establish and evaluate a test program of methods suitable for detection of physical incompatibility in Y-site administration of total parenteral nutrition (TPN) and drugs. Methods: Eight frequently used methods (dynamic light scattering, laser diffraction, light obscuration, turbidimetry, zeta potential, light microscopy, pH-measurements and visual examination using Tyndall beams), were scrutinized to elucidate strengths and weaknesses for compatibility testing. The responses of the methods were tested with samples containing precipitation of calcium phosphate and with heat destabilized TPN emulsions. A selection of drugs (acyclovir, ampicillin, ondansetron and paracetamol) was mixed with 3-in-1 TPN admixtures (Olimel® N5E, Kabiven® and SmofKabiven®) to assess compatibility (i.e. potential precipitates and emulsion stability). The obtained compatibility data was interpreted according to theory and compared to existing compatibility literature to further check the validity of the methods. Results: Light obscuration together with turbidimetry, visual inspection and pH-measurements were able to capture signs of precipitations. For the analysis of emulsion stability, light obscuration and estimation of percent droplets above 5 μm (PFAT5) seemed to be the most sensitive method; however laser diffraction and monitoring changes in pH might be a useful support. Samples should always be compared to unmixed controls to reveal changes induced by the mixing. General acceptance criteria are difficult to define, although some limits are suggested based on current experience. The experimental compatibility data was supported by scattered reports in literature, further confirming the suitability of the test program. However, conflicting data are common, which complicates the comparison to existing literature. Conclusions: Testing of these complex blends should be based on a combination of several methods and accompanied by theoretical considerations.

• Andersen, Toril; Bleher, Stefan; Flaten, Gøril Eide; Tho, Ingunn; Mattsson, Sofia & Skalko-Basnet, Natasa (2015). Chitosan in Mucoadhesive Drug Delivery: Focus on Local Vaginal Therapy. Marine Drugs. ISSN 1660-3397. 13(1), p. 222–236. doi: 10.3390/md13010222. Full text in Research Archive Show summary

  Mucoadhesive drug therapy destined for localized drug treatment is gaining increasing importance in today’s drug development. Chitosan, due to its known biodegradability, bioadhesiveness and excellent safety profile offers means to improve mucosal drug therapy. We have used chitosan as mucoadhesive polymer to develop liposomes able to ensure prolonged residence time at vaginal site. Two types of mucoadhesive liposomes, namely the chitosan-coated liposomes and chitosan-containing liposomes, where chitosan is both embedded and surface-available, were made of soy phosphatidylcholine with entrapped fluorescence markers of two molecular weights, FITC-dextran 4000 and 20,000, respectively. Both liposomal types were characterized for their size distribution, zeta potential, entrapment efficiency and the in vitro release profile, and compared to plain liposomes. The proof of chitosan being both surface-available as well as embedded into the liposomes in the chitosan-containing liposomes was found. The capability of the surface-available chitosan to interact with the model porcine mucin was confirmed for both chitosan-containing and chitosan-coated liposomes implying potential mucoadhesive behavior. Chitosan-containing liposomes were shown to be superior in respect to the simplicity of preparation, FITC-dextran load, mucoadhesiveness and in vitro

• Staven, Vigdis; Waaseth, Marit; Wang, Siri; Grønlie, Ingrid & Tho, Ingunn (2014). Utilization of the Tyndall effect for enhanced visual detection of particles in compatibility testing of intravenous fluids: Validity and reliability. PDA journal of pharmaceutical science and technology. ISSN 1079-7440. 69(2), p. 270–283. doi: 10.5731/pdajpst.2015.01020.
• Hiorth, Marianne ; Nilsen, Susanne & Tho, Ingunn (2014). Bioadhesive Mini-Tablets for Vaginal Drug Delivery. Pharmaceutics. ISSN 1999-4923. 6(3), p. 494–511. doi: 10.3390/pharmaceutics6030494. Full text in Research Archive
• Vanic, Zeljka; Planinsek, Odon; Skalko-Basnet, Natasa & Tho, Ingunn (2014). Tablets of pre-liposomes govern in situ formation of liposomes: Concept and potential of the novel drug delivery system. European journal of pharmaceutics and biopharmaceutics. ISSN 0939-6411. 88(2), p. 443–454. doi: 10.1016/j.ejpb.2014.06.003.
• Jøraholmen, May Wenche; Vanić, Željka; Tho, Ingunn & Škalko-Basnet, Nataša (2014). Chitosan-coated liposomes for topical vaginal therapy: Assuring localized drug effect. International Journal of Pharmaceutics. ISSN 0378-5173. 472(1-2), p. 94–101. doi: 10.1016/j.ijpharm.2014.06.016. Full text in Research Archive
• Hiorth, Marianne ; Liereng, Linda; Reinertsen Selmer, Reidun & Tho, Ingunn (2013). Formulation of bioadhesive hexylaminolevulinate pellets intended for photodynamic therapy in the treatment of cervical cancer. International Journal of Pharmaceutics. ISSN 0378-5173. 441(1-2), p. 544–554. doi: 10.1016/j.ijpharm.2012.10.046.
• Andersen, Toril; Vanic, Zeljka; Flaten, Gøril Eide; Mattsson, S.; Tho, Ingunn & Skalko-Basnet, Natasa (2013). Pectosomes and Chitosomes as Delivery Systems for Metronidazole: The One-Pot Preparation Method. Pharmaceutics. ISSN 1999-4923. 5, p. 445–456. doi: 10.3390/pharmaceutics5030445. Full text in Research Archive
• Tho, Ingunn & Bauer-Brandl, Annette (2012). Chemometrics (PCA)in Pharmaceutics: Tablet Development, Manufacturing and Quality Assurance. In Sanguansat, Parinya (Eds.), Principal component analysis - multidisciplinary applications. IntechOpen. ISSN 9789535101291. p. 43–58. doi: 10.5772/37185.
• Martins, Susana; Tho, Ingunn; Reimold, Isolde; Fricker, Gert; Souto, Eliana & Ferreira, Domingos C. [Show all 7 contributors for this article] (2012). Brain delivery of camptothecin by means of solid lipid nanoparticles: Formulation design, in vitro and in vivo studies. International Journal of Pharmaceutics. ISSN 0378-5173. 439(1-2), p. 49–62. doi: 10.1016/j.ijpharm.2012.09.054.
• Tho, Ingunn; Picker-Freyer, Katharina M.; Salbu, Linda & Bauer-Brandl, Annette (2012). On the Drug-Loading Capacity of Pectin Powder for Direct Compression. AAPS PharmSciTech. ISSN 1530-9932. 13(2), p. 601–604. doi: 10.1208/s12249-012-9785-4.
• Salbu, Linda; Picker-Freyer, Katharina M.; Schmid, Wolfgang; Bauer-Brandl, Annette & Tho, Ingunn (2012). Use of 3-D modelling in early development phase of pectin tablets. Journal on Excipients and Food Chemicals. ISSN 2150-2668. 3, p. 5–16. Full text in Research Archive
• Martins, Susana; Tho, Ingunn; Souto, Eliana; Ferreira, Domingos C. & Brandl, Martin (2012). Multivariate design for the evaluation of lipid and surfactant composition effect for optimisation of lipid nanoparticles. European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 45(5), p. 613–623. doi: 10.1016/j.ejps.2011.12.015.
• Basnet, Purusotam; Hussain, Haider; Tho, Ingunn & Skalko-Basnet, Natasa (2012). Liposomal delivery system enhances anti-inflammatory properties of curcumin. Journal of Pharmaceutical Sciences. ISSN 0022-3549. 101(2), p. 598–609. doi: 10.1002/jps.22785.
• Salbu, Linda; Bauer-Brandl, Annette ; Alderborn, Göran & Tho, Ingunn (2012). Effect of degree of methoxylation and particle size on compression properties and compactibility of pectin powders. Pharmaceutical development and technology (Print). ISSN 1083-7450. 17, p. 333–343. doi: 10.3109/10837450.2010535831.
• Tho, Ingunn & Bauer-Brandl, Annette (2011). Quality by design (QbD) approaches for the compression step of tableting. Expert Opinion on Drug Delivery. ISSN 1742-5247. 8(12), p. 1631–1644. doi: 10.1517/17425247.2011.633506.
• Cavalcanti, Leide Passos; Tho, Ingunn; Konovalov, Oleg; Fossheim, Sigrid L & Brandl, Martin (2011). Compressibility study of quaternary phospholipid blend monolayers. Colloids and Surfaces B: Biointerfaces. ISSN 0927-7765. 85(2), p. 153–160. doi: 10.1016/j.colsurfb.2011.02.015.
• Martins, Susana; Tho, Ingunn; Ferreira, D.C; Souto, Eliana B & Brandl, Martin (2011). Physicochemical properties of lipid nanoparticles: Effect of lipid and surfactant composition. Drug Development and Industrial Pharmacy. ISSN 0363-9045. 37(7), p. 815–824. doi: 10.3109/03639045.2010.545414.
• Kanzer, Johanna; Tho, Ingunn; Flaten, Gøril Eide; Mägerlein, Markus; Hölig, Peter & Fricker, Gert [Show all 7 contributors for this article] (2010). In-vitro permeability screening of melt extrudate formulations containing poorly water-soluble drug compounds using the phospholipid vesicle-based barrier. Journal of Pharmacy and Pharmacology (JPP). ISSN 0022-3573. 62(11), p. 1591–1598. doi: 10.1111/j.2042-7158.2010.01172.x.
• Salbu, Linda; Bauer-Brandl, Annette & Tho, Ingunn (2010). Direct Compression Behavior of Low- and High-Methoxylated Pectins. AAPS PharmSciTech. ISSN 1530-9932. 11(1), p. 18–26. doi: 10.1208/s12249-009-9349-4.
• Haware, Rahul; Bauer-Brandl, Annette & Tho, Ingunn (2010). Comparative evaluation of the powder and compression properties of various grades and brands of microcrystalline cellulose by multivariate methods. Pharmaceutical development and technology (Print). ISSN 1083-7450. 15(4), p. 394–404. doi: 10.3109/10837450903262041.
• Tho, Ingunn; Liepold, Bernd; Rosenberg, Jürg; Maegerlein, Markus; Brandl, Martin & Fricker, Gert (2010). Formation of nano/micro-dispersions with improved dissolution properties upon dispersion of ritonavir melt extrudate in aqueous media. European Journal of Pharmaceutical Sciences. ISSN 0928-0987. 40(1), p. 25–32. doi: 10.1016/j.ejps.2010.02.003.
• Haware, Rahul; Tho, Ingunn & Bauer-Brandl, Annette (2010). Evaluation of a rapid approximation method for the elastic recovery of tablets. Powder Technology. ISSN 0032-5910. 202(1-3), p. 71–77. doi: 10.1016/j.powtec.2010.04.012.
• Kanzer, Johanna; Hupfeld, Stefan; Vasskog, Terje; Tho, Ingunn; Hoelig, Peter & Maegerlein, Markus [Show all 8 contributors for this article] (2010). In situ formation of nanoparticles upon dispersion of melt extrudate formulations in aqueous medium assessed by asymmetrical flow field-flow fractionation. Journal of Pharmaceutical and Biomedical Analysis. ISSN 0731-7085. 53(3), p. 359–365. doi: 10.1016/j.jpba.2010.04.012.
• Klevan, Ingvild; Nordstroem, Josefina; Tho, Ingunn & Alderborn, Goran (2010). A statistical approach to evaluate the potential use of compression parameters for classification of pharmaceutical powder materials. European journal of pharmaceutics and biopharmaceutics. ISSN 0939-6411. 75(3), p. 425–435. doi: 10.1016/j.ejpb.2010.04.006.
• Haware, Rahul; Tho, Ingunn & Bauer-Brandl, Annette (2009). Multivariate analysis of relationships between material properties, process parameters and tablet tensile strength for alpha-lactose monohydrates. European journal of pharmaceutics and biopharmaceutics. ISSN 0939-6411. 73(3), p. 424–431. doi: 10.1016/j.ejpb.2009.08.005.
• Haware, Rahul; Tho, Ingunn & Bauer-Brandl, Annette (2009). Application of multivariate methods to compression behavior evaluation of directly compressible materials. European journal of pharmaceutics and biopharmaceutics. ISSN 0939-6411. 72(1), p. 148–155. doi: 10.1016/j.ejpb.2008.11.008.

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• Alopaeus, Julia Fredrika & Tho, Ingunn (2019). The micellisation mechanism of Soluplus: effect of temperature, concentration and disperse media.
• Valen, Håkon; Blomqvist, Brianna; Dragland, Inger Sofie; Tho, Ingunn; Bruzell, Ellen Merete & Tønnesen, Hanne Hjorth (2018). Antibacterial and anti-adhesive Properties of Pluronic F127 solutions in the abscence and presence of photoactivation.
• Valen, Håkon; Dragland, Inger Sofie; Blomqvist, Brianna; Tho, Ingunn; Bruzell, Ellen Merete & Tønnesen, Hanne Hjorth (2018). Antibacterial and anti-adhesive properties of Pluronic® F127 solutions in the absence or presence of photoactivation.
• Alopaeus, Julia Fredrika; Nguyen, Lina Mai; Pohjavirta, Jennie; Hagesæther, Ellen; Tønnesen, Hanne Hjorth & Tho, Ingunn (2018). Evaluation of concentration-dependent self-assembling structures of Soluplus and their properties in oral drug delivery.
• Roque, Luis; Castro, P; Fonte, P; Hagesæther, Ellen; Molpeceres, J & Rijo, P [Show all 8 contributors for this article] (2018). Mucoadhesive assessment of different antifungal nanoformulations .
• Roque, Luis; Castro, P; Tho, Ingunn; Hagesæther, Ellen; Molpeceres, J & Rijo, P [Show all 7 contributors for this article] (2018). Mucoadhesive assessment of different antifungal nanoformulations for the Treatment of Yeast Infections in oral mucosa .
• Tho, Ingunn (2016). Nano-particulate drug delivery to various targets.
• Blomqvist, Brianna; Kvam, Ketil; Dragland, Inger Sofie; Tho, Ingunn; Bruzell, Ellen Merete & Hjorth Tønnesen, Hanne (2015). Evaluation of Material Suitability for Nanoparticle-Based Coatings and Further Antimicrobial Treatment .
• Alopaeus, Julia Fredrika; Tønnesen, Hanne Hjorth & Tho, Ingunn (2015). The influence of drug-cyclodextrin inclusion complexes on properties of hydroxypropyl cellulose based orodispersible films.
• Louis, Betoko; Skalko-Basnet, Natasa & Tho, Ingunn (2015). Orodispersible films containing inclusion complexes of HP-β-CD furosemide for taste-masking.
• Tho, Ingunn; Vanic, Zeljka & Skalko-Basnet, Natasa (2015). Compaction of pre-liposomal tablets that governing in situ formation of liposomes.
• Tho, Ingunn & Skalko-Basnet, Natasa (2015). Cell-based in vitro models for vaginal permeability studies. In Bruno, Sarmento (Eds.), Concepts and Models for Drug Permeability Studies. Cell and Tissue based In Vitro Culture Models. Elsevier. ISSN 9780081000946. p. 115–128. doi: 10.1016/B978-0-08-100094-6.00008-0.
• Tho, Ingunn (2015). Kvinner og legemidler. Norsk Farmaceutisk Tidsskrift. ISSN 0029-1935. 4.
• Tho, Ingunn (2015). Dosage forms today and in the future.
• Vanic, Zeljka; Skalko-Basnet, Natasa & Tho, Ingunn (2015). In situ liposomes from novel pre-liposome tablets for vaginal drug delivery.
• Staven, Vigdis; Waaseth, Marit; Wang, Siri; Grønlie, Ingrid & Tho, Ingunn (2014). Visual examination for compatibility testing of parenterals: experiences with two different light sources.
• Tho, Ingunn & Bauer-Brandl, Annette (2013). Principal component analysis as a useful tool in tableting.
• Jøraholmen, May Wenche; Vanic, Zeljka; Tho, Ingunn & Skalko-Basnet, Natasa (2013). Chitosan-coating as a mean to prolong vaginal residence time: Liposomes with clotrimazole.
• Tho, Ingunn (2012). New dosage forms for children: Mini-tablets.
• Tho, Ingunn (2012). Nye legemiddelformer for barn – er minitabletter løsningen?
• Andersen, Toril; Vanic, Zeljka; Tho, Ingunn & Skalko-Basnet, Natasa (2012). mucoadhesive lipsoomes for vaginal therapy: Chitosan vs pectin.
• Jøraholmen, May Wenche; Vanic, Zeljka; Tho, Ingunn & Skalko-Basnet, Natasa (2012). Vaginal penetration of chitosan-coated liposomes with clotrimazole: The effect of vesicle size.
• Vanic, Zeljka; Duvnjak, Marieta; Skalko-Basnet, Natasa & Tho, Ingunn (2012). Tableting of spray-dried liposomes - concept and possibilities.
• Meland, H-G; Pflaumer, H; Skalko-Basnet, Natasa & Tho, Ingunn (2012). Choice of polymer matrix for development of bioadhesive mini-tablets for vaginal delivery of metronidazole.
• Tho, Ingunn (2012). Smeltetabletter - brukervennlige og kjappe. [Internet]. Podkast.
• Tho, Ingunn (2012). Formulering av bedre legemidler til barn. Norsk Farmaceutisk Tidsskrift. ISSN 0029-1935.
• Tho, Ingunn (2012). Smeltetabletter – fordeler og ulemper. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 132, p. 424–425. doi: 10.4045/tidsskr.10.1464.
• Staven, Vigdis; Aasarød, Kristin; Grønlie, Ingrid & Tho, Ingunn (2011). Innledende Studie av Kompatibilitet mellom Legemidler og en Standard Trekammer-TPN-Pose til Pediatriske Pasienter.
• Tho, Ingunn; Aasarød, Kristin; Staven, Vigdis; Fjellaksel, Richard & Grønlie, Ingrid (2011). Compatibility of Y-site Administration of Medications with a Standard 3-in-1 Parenteral Nutriton Admixture for Paediatrics.
• Tho, Ingunn; Aasarød, Kristin; Staven, Vigdis; Fjellaksel, Richard & Grønlie, Ingrid (2011). Compatibility of Y-site Administration of Medications with a Standard 3-in-1 Parenteral Nutrition Admixture for Paediatrics.
• Solum, Skjalg Nyheim; Klevan, Ingvild; Tho, Ingunn & Bauer-Brandl, Annette (2010). Assessing tablet hardness by indentation in a texture analyzer - possibilities and challenges.
• Basnet, Purusotam; Tho, Ingunn & Skalko-Basnet, Natasa (2010). Curcumin: Liposomal delivery system enhances anti-inflammatory property.
• Basnet, Purusotam; Tho, Ingunn & Skalko-Basnet, Natasa (2010). Curcumin, a wonder drug of 21st century: liposomal delivery system targeting vaginal inflammation.
• Pistone, Sara; Tho, Ingunn; Fini, Adamo & Skalko-Basnet, Natasa (2010). Vescicle-based mucoadhesive hydrogels for vaginal delivery of metronidazole.
• Salbu, Linda; Bauer-Brandl, Annette; Alderborn, Göran & Tho, Ingunn (2010). Fragmentation propensity of pectin during compression.
• Staven, Vigdis & Tho, Ingunn (2016). Y-site compatibility testing of intravenous drugs and total parenteral nutrition. Establishment of a test program and study of mixtures relevant for children. UiT Norges arktiske universitet. ISSN 978-82-7589-492-0.
• Salbu, Linda & Tho, Ingunn (2011). Compressibility and compactibility of pectin powders: A study of their potential as direct compression excipients in tablets. UiT Norges arktiske universitet. ISSN 978-82-7589-311-4.
• Kanzer, Johanna; Brandl, Martin; Tho, Ingunn & Fricker, Gert (2010). Biopharmaceutical Characterisation of poorly water-soluble drugs in solid dispersions. University of Tromsoe.

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