Yvette Dehnes

• Gjelstad, Astrid; Holden, Geir; Gundersen, Per Ole Mobråten; Dehnes, Yvette; Tvedte, Magnus & Levernæs, Maren [Show all 8 contributors for this article] (2026). Positive Doping Test Linked to Crumb Rubber From Artificial Football Pitch: Case Report. Drug Testing and Analysis. ISSN 1942-7603. doi: 10.1002/dta.70067. Full text in Research Archive
• Hostrup, Morten; Moesgaard, Lukas; Fischer, Mads; Wickham, Kate Aiko; Pleshardt, Mads & Andersen, Andreas Breenfeldt [Show all 13 contributors for this article] (2025). Clenbuterol induces lean mass and muscle protein accretion, but attenuates cardiorespiratory fitness and desensitizes muscle β<inf>2</inf>-adrenergic signalling. Journal of Physiology. ISSN 0022-3751. 603(19), p. 5529–5545. doi: 10.1113/JP289023. Full text in Research Archive
• Faiss, Raphael; Krumm, Bastien; Cubel, Claes; Klaris, Magnus Bak; Bækken, Lasse Vestli & Dehnes, Yvette [Show all 12 contributors for this article] (2025). Endocrine and androgenic response to altitude training in professional cyclists. Journal of Physiology. ISSN 0022-3751. doi: 10.1113/JP289303. Full text in Research Archive Show summary

  This study investigated endocrine and steroidal blood markers in 31 male elite cyclists monitored over 7 weeks, including a 3 week altitude training camp either at 2050 m (n = 19) or 3000 m (n = 12). Serum samples were analysed for steroidal [e.g. testosterone (T)] and endocrine [i.e. insulin-like growth factor-1 (IGF-1) and N-terminal propeptide type III procollagen (P-III-NP)] variables. Total haemoglobin mass (Hbmass) and plasma volume (PV) were measured by CO-rebreathing. After 21 days at altitude, T increased at 2050 m (from 5.2 ± 2.6 to 8.3 ± 2.7 ng mL−1, P < 0.001) but not at 3000 m. IGF-1 was elevated (by 16%, P = 0.003, and 11%, P = 0.01 at 2050 and 3000 m, respectively) only after returning to near sea-level. P-III-NP decreased by 20% (P = 0.01) at 2050 m but increased by 25% (P < 0.001) at 3000 m. After altitude, Hbmass increased by 3.7% (+40 g, P < 0.001) at 2050 m, and by 3.5% (+34 g, P < 0.001) at 3000 m. Conversely, PV had decreased by 5.7% (−216 mL, P = 0.002) at 2050 m, and by 12.2% (−460 mL, P < 0.001) at 3000 m. In both groups pooled, Hbmass correlated with both T levels (r = 0.38, P = 0.003) and IGF-1 values (r = −0.25, P = 0.04). In conclusion, a higher hypoxic dose at 3000 m (vs. 2050 m) did not result in a larger relative increase in Hbmass. Steroidal and endocrine variations were observed during the altitude sojourn with differences depending on the altitude level. The amplitude of haematological and training adaptations may be linked to changes in T and IGF-1 after 3 weeks at 2050 m.

• Mrsa, Ago; Matijevic, Marijana; Dehnes, Yvette; Halvorsen, Trine Grønhaug & Reubsaet, Leon (2025). Comparative Evaluation of Smart Sampling for hCG Determination: A New Potential Direction in Protein Biomarker Analysis From Dried Microsamples. Drug Testing and Analysis. ISSN 1942-7603. 17(12), p. 2390–2398. doi: 10.1002/dta.3948. Full text in Research Archive Show summary

  ABSTRACT Since the early 20th century, sampling biological matrices like blood on paper (dried blood spots [DBS]) has been vital in clinical analysis. While DBS microsampling is convenient for small molecules, extensive sample preparation can make LC‐MS protein analysis impractical because of the time‐consuming steps, especially for low‐abundance proteins. Smart sampling, introduced in 2018, simplifies this by integrating sample preparation directly on the sampler. The work presented in this paper aims to compare a newly validated smart sampling method with two other methods: an in‐house method based on immunocapture on magnetic beads and a commercial method that uses electrochemiluminescence immunoassay (ECLIA). The performance of the three hCG methods was compared using 21 single‐blind serum samples. Linear regression analysis revealed strong correlations (all R 2  > 0.91) between the actual sample concentrations and the results obtained from all three methods. Immunocapture with magnetic beads showed the strongest linear correlation ( R 2  = 0.974). To assess agreement between the methods, Bland–Altman analysis was conducted. The comparison between smart sampling and magnetic beads showed an average bias of −5.2, with no significant trend in variation across the sample concentration range of 0.5–75 ng/mL. The smart sampling and ECLIA comparison revealed a bias of 0.4 ± 4 ng/mL, indicating even better agreement and consistent results. This paper presents the first‐ever comparison of a smart sampling method with existing methods. The results highlight smart sampling as a promising new approach for bioanalysis and boost the technique as a viable alternative in protein biomarker analysis from complex matrices using LC‐MS.

• Johannsen, Christina; Nguyen, Anna Kha Tu; Shabani, Sasha; Oulie, Inger; Dørum, Siri & Dehnes, Yvette [Show all 8 contributors for this article] (2025). Development of smart samplers and their comparison to dried serum spots for the analysis of growth hormone releasing hormone analogs using LC[sbnd]HRMS/MS. Advances in Sample Preparation. 15. doi: 10.1016/j.sampre.2025.100190. Full text in Research Archive
• Levernæs, Maren Christin Stillesby; Solheim, Sara Amalie; Broderstad, Lillian; Zandy, Essa; Mørkeberg, Jakob & Dehnes, Yvette (2024). Detection of doping substances in paired dried blood spots and urine samples collected during doping controls in Danish fitness centers. Drug Testing and Analysis. ISSN 1942-7603. doi: 10.1002/dta.3660. Full text in Research Archive
• Equey, Tristan; Sletten, Camilla Johanne; Dehnes, Yvette; D`Onofrio, Guiseppe; Brugnara, Carlo & Baume, Norbert [Show all 7 contributors for this article] (2021). Standardization of reticulocyte counts in the athlete biological passport: A practical update. International Journal of Laboratory Hematology (IJLH). ISSN 1751-5521. 44(1), p. 112–117. doi: 10.1111/ijlh.13732. Full text in Research Archive
• Solheim, Sara Amalie; Levernæs, Maren Christin Stillesby; Mørkeberg, Jakob; Juul, Anders; Upners, Emmie N. & Nordsborg, Nikolai Baastrup [Show all 7 contributors for this article] (2021). Stability and detectability of testosterone esters in dried blood spots after intramuscular injections. Drug Testing and Analysis. ISSN 1942-7603. doi: 10.1002/dta.3030. Full text in Research Archive
• Solheim, Sara Amalie; Ringsted, Thomas Kamm; Nordsborg, Nikolai B.; Dehnes, Yvette; Levernæs, Maren Christin Stillesby & Mørkeberg, Jakob (2021). No pain, just gain: Painless, easy, and fast dried blood spot collection from fingertip and upper arm in doping control. Drug Testing and Analysis. ISSN 1942-7603. 13(10), p. 1783–1790. doi: 10.1002/dta.3135. Full text in Research Archive
• Solheim, Sara Amalie; Mørkeberg, Jakob; Dehnes, Yvette; Hullstein, Ingunn Riise; Juul, Anders & Upners, Emmie N. [Show all 7 contributors for this article] (2020). Changes in blood parameters after intramuscular testosterone ester injections – Implications for anti-doping. Drug Testing and Analysis. ISSN 1942-7603. 12(8), p. 1019–1030. doi: 10.1002/dta.2803. Full text in Research Archive
• Jessen, Søren; Becker, Victoria; Rzeppa, Sebastian; Backer, Vibeke; Bengtsen, Kasper Høtoft & Hullstein, Ingunn Riise [Show all 8 contributors for this article] (2020). Pharmacokinetics of salmeterol and its main metabolite α‐hydroxysalmeterol after acute and chronic dry powder inhalation in exercising endurance‐trained men: Implications for doping control. Drug Testing and Analysis. ISSN 1942-7603. doi: 10.1002/dta.2978. Full text in Research Archive Show summary

  As of 2020, use of beta2‐agonist salmeterol is restricted by the World Anti‐Doping Agency (WADA) and is only permitted by inhalation at therapeutic doses not exceeding 200 μg in 24 h. In contrast to beta2‐agonists salbutamol and formoterol, WADA has not established a urine threshold for salmeterol despite its muscle hypertrophic actions observed in animals. Herein, we investigated plasma (0–4 h) and urine (0–24 h) concentrations (by ultra‐high‐performance liquid chromatography–tandem mass spectrometry [UHPLC–MS/MS]) of salmeterol and α‐hydroxysalmeterol after dry powder inhalation at supratherapeutic (400 μg) and high therapeutic (200 μg) doses, and after seven consecutive days of therapeutic inhalation (200 μg × day−1) in 11 healthy endurance‐trained men. During each trial, participants inhaled salmeterol before 1½ h moderate‐intensity cycling. Mean ± SD maximum urine concentrations of salmeterol unadjusted for specific gravity reached 4.0 ± 1.6, 2.1 ± 1.5, and 2.2 ± 1.1 ng × ml−1 for 400 μg, 200 μg, and seven consecutive days of 200 μg, respectively, with corresponding maximum urine concentrations of α‐hydroxysalmeterol being 11.6 ± 6.1, 5.7 ± 4.6, and 6.5 ± 2.6 ng × ml−1. Within the relevant window for doping control (first 6 h post‐inhalation), the present data (119 samples), along with 64 biobank urine samples, showed that a combined salmeterol and α‐hydroxysalmeterol urine threshold with equal cut‐offs of 3.3 ng × ml−1 was superior to a salmeterol‐only threshold to discriminate therapeutic (200 μg) from supratherapeutic use (400 μg) with a sensitivity of 24% with 0% false positives when applying the WADA technical document (TD2019DL.v2) method of specific gravity adjustment. Thus, a combination of urine salmeterol and α‐hydroxysalmeterol concentrations may be suitable for discriminating between therapeutic and supratherapeutic prohibited inhalation of salmeterol.

• Solheim, Sara Amalie; Jessen, S.; Mørkeberg, Jakob; Thevis, Mario; Dehnes, Yvette & Eibye, Kasper [Show all 8 contributors for this article] (2020). Single-dose administration of clenbuterol is detectable in dried blood spots. Drug Testing and Analysis. ISSN 1942-7603. 12(9), p. 1366–1372. doi: 10.1002/dta.2872. Full text in Research Archive
• Bejder, Jacob; Andersen, Andreas Breenfeldt; Bonne, Thomas Christian; Piil, Jacob Feder; Hagen, Linn Camilla Hauan & Dehnes, Yvette [Show all 9 contributors for this article] (2020). Tramadol Does Not Improve Performance or Impair Motor Function in Trained Cyclists. Medicine & Science in Sports & Exercise. ISSN 0195-9131. 52(5), p. 1169–1175. doi: 10.1249/MSS.0000000000002217. Full text in Research Archive
• Solheim, Sara Amalie; Mørkeberg, Jakob; Juul, Anders; Freiesleben, Stine Yde; Upners, Emmie N. & Dehnes, Yvette [Show all 7 contributors for this article] (2020). An Intramuscular Injection of Mixed Testosterone Esters Does Not Acutely Enhance Strength and Power in Recreationally Active Young Men. Frontiers in Physiology. 11. doi: 10.3389/fphys.2020.563620. Full text in Research Archive
• Krug, Oliver; Thomas, Andreas; Malerød-Fjeld, Helle; Dehnes, Yvette; Laussmann, Tim & Feldmann, Ingo [Show all 8 contributors for this article] (2018). Analysis of new growth promoting black market products. Growth Hormone & IGF Research. ISSN 1096-6374. 41, p. 1–6. doi: 10.1016/j.ghir.2018.05.001. Full text in Research Archive
• Krogh, Nanna; Rzeppa, Sebastian; Dyreborg, Anders; Dehnes, Yvette; Hemmersbach, Peter J & Backer, Vibeke [Show all 7 contributors for this article] (2017). Terbutaline accumulates in blood and urine after daily therapeutic inhalation. Medicine & Science in Sports & Exercise. ISSN 0195-9131. 49(6), p. 1236–1243. doi: 10.1249/MSS.0000000000001199. Full text in Research Archive
• Pitarch-Motellón, Jorge; Roig-Navarro, Antoni Francesc; Sancho, Juan Vicente; Ibáñez, Maria; Fabregat-Cabello, Neus & Pozo, Oscar J. [Show all 15 contributors for this article] (2017). Evaluation of uncertainty sources in the determination of testosterone in urine by calibration-based and isotope dilution quantification using ultra high performance liquid chromatography tandem mass spectrometry. Journal of Chromatography A. ISSN 0021-9673. 1508, p. 73–80. doi: 10.1016/j.chroma.2017.05.072. Full text in Research Archive
• Hullstein, Ingunn; Malerød-Fjeld, Helle; Dehnes, Yvette & Hemmersbach, Peter J (2015). Black market products confiscated in Norway 2011-2014 compared to analytical findings in urine samples. Drug Testing and Analysis. ISSN 1942-7603. 7(11-12), p. 1025–1029. doi: 10.1002/dta.1900. Full text in Research Archive
• Dehnes, Yvette; Shan, Jufang; Beuming, Thijs; Shi, Lei; Weinstein, Harel & Javitch, Jonathan A. (2014). Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation. Neurochemistry International. ISSN 0197-0186. 73(1), p. 4–15. doi: 10.1016/j.neuint.2014.02.003. Full text in Research Archive
• Martinov, Vladimir Nikolkaev; Dehnes, Yvette; Holmseth, Silvia; Shimamoto, Keiko; Danbolt, Niels Christian & Valen, Guro (2014). A novel glutamate transport blocker, LL-TBOA, attenuates ischemic injury in the isolated, perfused rat heart despite low transporter levels. European Journal of Cardio-Thoracic Surgery. ISSN 1010-7940. 45(4), p. 710–716. doi: 10.1093/ejcts/ezt487. Full text in Research Archive
• Dehnes, Yvette; Myrvold, Linda; Strøm, H.; Ericsson, M & Hemmersbach, Peter J (2014). MAIIA EPO SeLect - a rapid screening kit for the detection of recombinant EPO analogues in doping control: Inter-laboratory prevalidation and normative study of athlete urine and plasma samples. Drug Testing and Analysis. ISSN 1942-7603. 6(11-12), p. 1144–1150. doi: 10.1002/dta.1752. Full text in Research Archive
• Dehnes, Yvette; Shalina, Alexandra & Myrvold, Linda (2013). Detection of recombinanat EPO in blood and urine samples with EPO WGA MAIIIEF and SAR-PAGE after microdose injections. Drug Testing and Analysis. ISSN 1942-7603. doi: 10.1002/dta.1579. Full text in Research Archive
• Holmseth, Silvia; Dehnes, Yvette; Huang, YHH; Follin-Arbelet, Virginie; Verket, Nina Julie & Mylonakou, Maria-Niki [Show all 12 contributors for this article] (2012). The Density of EAAC1 (EAAT3) Glutamate Transporters Expressed by Neurons in the Mammalian CNS. Journal of Neuroscience. ISSN 0270-6474. 32(17), p. 6000–6013. doi: 10.1523/JNEUROSCI.5347-11.2012. Full text in Research Archive
• Dehnes, Yvette & Hemmersbach, Peter J (2011). Effect of single doses of methoxypolyethylene glycol-epoetin beta (CERA, Mircera) and epoetin delta (Dynepo) on isoelectric erythropoietin profiles and haematological parameters. Drug Testing and Analysis. ISSN 1942-7603. 3(5), p. 291–299. doi: 10.1002/dta.270. Full text in Research Archive
• Lönnberg, Maria; Dehnes, Yvette; Drevin, Malin; Garle, Mats; Lamon, Séverine & Leuenberger, Nicolas [Show all 8 contributors for this article] (2010). Rapid affinity purification of erythropoietin from biological samples using disposable monoliths. Journal of Chromatography A. ISSN 0021-9673. 1217(45), p. 7031–7037. doi: 10.1016/j.chroma.2010.09.034. Full text in Research Archive
• Dehnes, Yvette; Lamon, Séverine & Lönnberg, Maria (2010). Erythropoietin (EPO) immunoaffinity columns-A powerful tool for purifying EPO and its recombinant analogues. Journal of Pharmaceutical and Biomedical Analysis. ISSN 0731-7085. 53(4), p. 1028–1032. doi: 10.1016/j.jpba.2010.06.017. Full text in Research Archive
• Furness, DN; Dehnes, Yvette; Akhtar, Aisha Qureshi; Rossi, DJ; Hamann, M & Grutle, Nina J. [Show all 14 contributors for this article] (2008). A QUANTITATIVE ASSESSMENT OF GLUTAMATE UPTAKE INTO HIPPOCAMPAL SYNAPTIC TERMINALS AND ASTROCYTES: NEW INSIGHTS INTO A NEURONAL ROLE FOR EXCITATORY AMINO ACID TRANSPORTER 2 (EAAT2). Neuroscience. ISSN 0306-4522. 157(1), p. 80–94. doi: 10.1016/j.neuroscience.2008.08.043. Full text in Research Archive

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• Danbolt, Niels Christian; Holmseth, Silvia; Dehnes, Yvette; Huang, Y.; Follin-Arbelet, Virginie & Grutle, N [Show all 11 contributors for this article] (2011). QUANTIFICATION AND LOCALIZATION OF THE EAAC1 GLUTAMATE TRANSPORTER IN BRAIN. Glia. ISSN 0894-1491. 59, p. S66–S66. Full text in Research Archive
• Danbolt, Niels Christian; Attwell, D; Bergles, D; Dehnes, Yvette; Furness, DN & Gundersen, Vidar [Show all 12 contributors for this article] (2006). Glutamate transporters around synapses. Journal of Neurochemistry. ISSN 0022-3042. 96, p. 87–87. Full text in Research Archive
• Holmseth, Silvia; Dehnes, Yvette; Bjørnsen, Lars Petter B.W.; Furness, David N; Bergles, Dwight & Danbolt, Niels Christian (2004). The determination of the concentrations of the glutamate transporter EAAT3 (EAAC) in brain tissue and unexpected cross-reactivities of antibodies directed to EAAT3. Full text in Research Archive
• Danbolt, Niels Christian; Attwell, David; Dehnes, Yvette; Furness, David N; Gundersen, Vidar & Hamann, Martine [Show all 10 contributors for this article] (2004). Cellular distribution and function of glutamate transporters. Full text in Research Archive
• Danbolt, Niels Christian; Bjomsen, LP; Dehnes, Yvette; Furness, DN; Holmseth, Silvia & Lehre, Knut Petter Dæhlin [Show all 10 contributors for this article] (2003). Synaptic distribution of glutamate transporters. Journal of Neurochemistry. ISSN 0022-3042. 87, p. 43–43. Full text in Research Archive
• Bjørnsen, Lars Petter B.W.; Holmseth, Silvia; Dehnes, Yvette; Lehre, Knut Petter Dæhlin; Kanzler, A & Mylonakou, Maria-Niki [Show all 7 contributors for this article] (2003). The concentration of glutamate transporter 3 in rat brain and kidney. Journal of Neurochemistry. ISSN 0022-3042. 87, p. 114–114. Full text in Research Archive

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