Summer Research Highlights: Recent Contributions from Our Group

1. Impact of Prior SARS-CoV-2 Infection on COVID-19 Vaccine Effectiveness in Children and Adolescents in Norway and Italy
   Authors: Elisa Barbieri, Nhung T.H. Trinh, Costanza Di Chiara, Giovanni Corrao, Riccardo Boracchini, Ester Rosa, Cecilia Liberati, Daniele Donà, Angela Lupattelli, Carlo Giaquinto, Anna Cantarutti
   This retrospective matched cohort study analyzed the effectiveness of mRNA COVID-19 vaccines among children and adolescents, focusing on the role of hybrid immunity. Our findings revealed enhanced protection against reinfection in vaccinated individuals with prior SARS-CoV-2 infection, highlighting the importance of vaccination strategies within this demographic.

2. Advancing Health Equity in Europe: Explore, Tailor, Implement, and Evaluate (ETIE) - A Framework of Diversity and Fairness in Pharmacoepidemiologic Research
   Authors: Enriqueta Vallejo-Yagüe, Sieta T de Vries, Daniel La Parra-Casado, Helga Gardarsdottir, Maria Luisa Faquetti..... Hedvig Nordeng.
   In this work, we introduced a comprehensive framework aimed at promoting diversity and equity in pharmacoepidemiological research. This operational guide emphasizes the necessity of addressing various diversity domains to ensure that health research equitably benefits all populations, ultimately fostering health equity across Europe.

3. Longitudinal Methods Versus Multiple Imputation to Infer Missing Maternal Data in Registry-Based Pregnancy Studies
   Authors: Takamasa Sakai, Hedvig Nordeng, Marleen M.H.J. van Gelder
   Our study compared the performance of longitudinal methods against multiple imputation techniques for inferring missing maternal data in registry-based pregnancy studies. Findings indicate that longitudinal methods substantially outperform multiple imputation, suggesting their applicability in enhancing the quality and validity of maternal health research.

These publications epitomize the dedication and productivity of our research team as we continue to address pressing health issues. We take pride in our contributions and are committed to improving health outcomes through our research efforts.

Additional Publications:

• Trajectories of Selective Serotonin Reuptake Inhibitor Use in Pregnancy and Perinatal Outcomes: A Longitudinal Register Study
  Authors: Guro Pauck Bernhardsen, Maiju Pesonen, Leea Keski-Nisula, Hedvig Nordeng, Soili M Lehto

• Beware of Counter-Intuitive Levels of False Discoveries in Datasets with Strong Intra-Correlations
  Authors: Chakravarthi Kanduri, Maria Mamica, Emilie Willoch Olstad, Manuela Zucknick, Jingyi Jessica Li, Geir Kjetil Sandve

• Methods of Estimating Prevalence of Multiple Sclerosis in Six European Healthcare Data Sources: A Contribution from the ConcePTION Project
  Authors: Marie Beslay, Anna-Belle Beau, Davide Messina, Justine Benevent, Elisa Ballardini... Hedvig Nordeng, et al.

• Identifying Multiple Sclerosis in Women of Childbearing Age in Six European Countries: A Contribution from the ConcePTION Project
  Authors: Marie Beslay, Yvonne Geissbühler, Anna-Belle Beau, Davide Messina, Justine Benevent... Hedvig Nordeng, et al.

• Clinical Course, Outcomes, and Risk Factors of Myocarditis and Pericarditis Following Administration of mRNA-1273 Vaccination: A Protocol for a Federated Real-World Evidence Vaccine Safety Study
  Authors: Laura C Zwiers, Diederick E Grobbee, Rob Schneijdenberg, Corine Baljé, Samantha St Laurent... Anteneh A Desalegn, Angela Lupattelli, et al.

• Clusters of Post-Acute COVID-19 Symptoms: A Latent Class Analysis Across 9 Databases and 7 Countries
  Authors: Kim López-Güell, Martí Català, Daniel Dedman, Talita Duarte-Salles, Raivo Kolde... Hedvig Nordeng... Nhung TH Trinh, et al.

• Identifying Maternal Conditions Leading to Gabapentinoid Prescriptions in Pregnancy Using Electronic Health Records from Six European Countries: A Contribution from the IMI ConcePTION Project
  Authors: Anna-Belle Beau, Olga Paoletti, Justine Bénévent, Marie Beslay, Xavier Moisset... Hedvig Nordeng, et al.

• Predicting Drug Transfer Into Human Milk With the Simcyp Simulator: A Contribution From the ConcePTION Project
  Authors: Julia Macente, Nina Nauwelaerts, Justine Marine Badée, Rodolfo Hernandes Bonan, Miao-Chan Huang... Hedvig Nordeng, et al.

• Maternal Hormonal Contraceptive Use and Childhood Central Nervous System Tumor Risk in a Large Scandinavian Cohort
  Authors: Caroline H Hemmingsen, Susanne K Kjaer, Sarah Hjorth, Ulrika Nörby, Anton Pottegård... Hedvig Nordeng, et al.

• Evidence-Based Clinical Practice Guidelines for Prevention, Screening, and Treatment of Peripartum Depression
  Authors: Sandra Nakić Radoš, Ana Ganho-Ávila, Maria F Rodriguez-Muñoz, Rena Bina, Sarah Kittel-Schneider... Angela Lupattelli, et al.