New article from multiple PharmaTox-affiliated researchers!

Multiple PharmaTox-affiliated researchers have contributed to a paper now available as a preprint on bioRxiv! The preprint presents a novel multi-omics protocol to study early human brain development and neuropharmacological effects. Explore their searchable tool here!

Overview of the work presented in the preprint now available on bioRxiv. Illustration: Samara *et al.* (2022).

Lead by Prof. Ragnhild Eskeland and Dr. Robert Lyle, multiple PharmaTox-affiliated researchers have developed a novel protocol to better understand early human brain development. Using both transcriptomic and epigenomic data at four timepoints during the development of human embryonic stem cells into mature telencephalic-like neurons (see illustration), they comprehensively charted earl human neuronal differentiation. You can explore early neuronal development and the effect of medications in their searchable interactive gene analysis tool here!

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Athina Samara, Mari Spildrejorde, Ankush Sharma, Martin Falck, Magnus Leithaug, Stefania Modafferi, Pål Marius Bjørnstad, Ganesh Acharya, Kristina Gervin, Robert Lyle, Ragnhild Eskeland. A multi-omics approach to visualize early neuronal differentiation in 4D. bioRxiv 2022.02.01.478732; doi: https://doi.org/10.1101/2022.02.01.478732

Published Feb. 4, 2022 6:03 PM - Last modified Feb. 4, 2022 6:08 PM