Trial lecture - time and place
27.11.2024, 10.15, Helga Engs hus, Auditorium 2
AI in drug discovery and design: state of the art and future perspective
Conferral summary
Kronisk inflammasjon er opphavet til mange alvorlige sykdommer det ikke finnes noen kur mot, blant annet kronisk smerte. Studier viser at bestemte omega-3 fettsyrer effektivt bidrar til å avslutte inflammasjonstilstander. Dette phd-prosjektet har bidratt med ny kunnskap om hvordan disse molekylene kan fremstilles, og deres effekter i musemodeller av kronisk smerte har blitt studert. Resultater presentert i studier viser at hanmus, men ikke hunmus fikk forbedret smertetilstand.
Main research findings
The resolution of inflammation is an active process, strictly regulated by specific signalling molecules termed specialized pro-resolving mediators (SPMs). The SPMs are hydroxylated polyunsaturated fatty acids, endogenously biosynthesized in our bodies. They express their biological effects by potent binding to G-protein coupled receptors found in the cell membranes. Considering the beneficial biological effects promoted by the SPMs, a deeper understanding and knowledge in the field of resolution biology is of growing interest.
Presented in this thesis, the first stereoselective total synthesis of one SPM is reported, enabling extensive biological evaluations and receptor activation studies. In addition, several analogs mimicking the SPMs were designed and synthesized, providing valuable insights into the activation profile of the receptors involved in promoting the biological effects. Furthermore, a study investigating pain-relief effects of the synthesized compounds revealed potent effects in male mice, but no pain-relief in female mice.
All organic chemistry experiments were conducted at the Department of Pharmacy, University of Oslo, in the LIPCHEM-group. The biological evaluations and receptor studies were performed by our collaborators in the Dalli group at Queen Mary University of London and in the Ji group at Duke University.
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