Anne Marit Rykkelid

• Rykkelid, Anne Marit; Skeie, Hilde Solesvik; Tormodsrud, Vera Helene; Siem, Sunniva; Malinen, Eirik & Edin, Nina Frederike Jeppesen (2026). Cell survival and DNA damage along the distal edge of the proton Bragg peak. International Journal of Radiation Biology. ISSN 0955-3002. p. 1–10. doi: 10.1080/09553002.2026.2666062. Full text in Research Archive
• Rykkelid, Anne Marit; Sinha, Priyanshu Manojkumar; Folefac, Charlemagne Asonganyi; Horsman, Michael R.; Sørensen, Brita Singers & Søland, Tine Merete [Show all 9 contributors for this article] (2024). Combination of proton- or X-irradiation with anti-PDL1 immunotherapy in two murine oral cancers. Scientific Reports. 14(1). doi: 10.1038/s41598-024-62272-z. Full text in Research Archive Show summary

  Combining radiation therapy with immunotherapy is a strategy to improve both treatments. The purpose of this study was to compare responses for two syngeneic head and neck cancer (HNC) tumor models in mice following X-ray or proton irradiation with or without immune checkpoint inhibition (ICI). MOC1 (immunogenic) and MOC2 (less immunogenic) tumors were inoculated in the right hind leg of each mouse (C57BL/6J, n = 398). Mice were injected with anti-PDL1 (10 mg/kg, twice weekly for 2 weeks), and tumors were treated with single-dose irradiation (5–30 Gy) with X-rays or protons. MOC2 tumors grew faster and were more radioresistant than MOC1 tumors, and all mice with MOC2 tumors developed metastases. Irradiation reduced the tumor volume in a dose-dependent manner. ICI alone reduced the tumor volume for MOC1 with 20% compared to controls, while no reduction was seen for MOC2. For MOC1, there was a clear treatment synergy when combining irradiation with ICI for radiation doses above 5 Gy and there was a tendency for X-rays being slightly more biologically effective compared to protons. For MOC2, there was a tendency of protons being more effective than X-rays, but both radiation types showed a small synergy when combined with ICI. Although the responses and magnitudes of the therapeutic effect varied, the optimal radiation dose for maximal synergy appeared to be in the order of 10–15 Gy, regardless of tumor model.

• Dahle, Tordis Johnsen; Rykkelid, Anne Marit; Stokkevåg, Camilla Hanquist; Mairani, Andrea; Görgen, Andreas & Edin, Nina Frederike J [Show all 10 contributors for this article] (2017). Monte Carlo simulations of a low energy proton beamline for radiobiological experiments. Acta Oncologica. ISSN 0284-186X. 56(6), p. 779–786. doi: 10.1080/0284186X.2017.1289239. Full text in Research Archive

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• Rykkelid, Anne Marit; Sinha, Priyanshu Manojkumar; Folefac, Charlemagne Asonganyi; Horsman, Michael R.; Sørensen, Brita Singers & Søland, Tine Merete [Show all 9 contributors for this article] (2024). Correction to: Combination of proton- or X-irradiation with anti-PDL1 immunotherapy in two murine oral cancers (Scientific Reports, (2024), 14, 1, (11569), 10.1038/s41598-024-62272-z). Scientific Reports. 14(1). doi: 10.1038/s41598-024-66148-0. Full text in Research Archive
• Rykkelid, Anne Marit; sinha, Priyanshu; Folefac, Charlemagne; Horsman, Michael; Sørensen, Brita Singers & Søland, Tine Merete [Show all 9 contributors for this article] (2023). Synergistic effects of combining proton- or X-irradiation with anti-PDL1 immunotherapy in two murine oral cancers. Full text in Research Archive
• Rykkelid, Anne Marit; sinha, Priyanshu; Folefac, Charlemagne; Horsman, Michael; Sørensen, Brita Singers & Søland, Tine Merete [Show all 9 contributors for this article] (2023). Synergistic effects of combining proton- or X-irradiation with anti-PDL1 immunotherapy in two murine oral cancers. Full text in Research Archive
• Rykkelid, Anne Marit; Sørensen, Brita Singers; Horsman, Michael; Malinen, Eirik & Edin, Nina Frederike Jeppesen (2022). Effect of the Combination of Proton Radiotherapy and Immunotherapy on the MOC1/MOC2 tumor models in C57B16/Jrj mice. Full text in Research Archive
• Edin, Nina Frederike J; Rykkelid, Anne Marit; Görgen, Andreas; Baker, Agnes; Siem, Sunniva & Ytre-Hauge, Kristian [Show all 7 contributors for this article] (2019). Very high yield of double strand breaks found at the distal end of the proton Bragg peak. Radiotherapy and Oncology. ISSN 0167-8140. 133, p. 594–594. Full text in Research Archive
• Rykkelid, Anne Marit; Tormodsrud, Vera; Siem, Sunniva; Görgen, Andreas; Ytre-Hauge, Kristian & Malinen, Eirik [Show all 7 contributors for this article] (2019). Very high RBE values found at the distal end of the proton Bragg peak. Full text in Research Archive
• Rykkelid, Anne Marit; Siem, Sunniva; Ytre-Hauge, Kristian; Malinen, Eirik & Edin, Nina Frederike J (2018). Very high relative biological effectiveness found at the distal end of the proton Bragg peak. Radiotherapy and Oncology. ISSN 0167-8140. 127, p. 1259–1259. Full text in Research Archive

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