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Biophysics and medical physics (BMP)

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BMP – where physics meets medicine, biology and chemistry.

Biophysics and medical physics is a broad field where basic physical theories and methods are used to explore medical and biological questions.

Student working in the cell laboratory

About the group

Our research activity falls in the cross-section between Physics, Medicine, Chemistry and Biology, and

  • includes fundamental research as well as applied research
  • is theoretically and experimentally challenging
  • is centered around the activity at the Cell-laboratory, the cyclotron (OCL), and the EPR-laboratory
  • has strong connections to the medical community in the Oslo region
  • collaborates with research and medical institutions nationally and internationally

The research activities span from experimental research to imaging, simulations and modelling.

overview over experimental activities

 

The effects of ionizing radiation is a common factor in most of our research.  We want to understand the basic nature of the interactions between ionizing radiation and biological matter to become better equipped to utilize ionizing radiation in cancer treatment, and to better understand the effects of exposure to low dose/dose rate ionizing radiation. Our research converge in the aim to improve radiotherapy, alone or in combination with immunotherapy or other drugs, for better cancer treatment with less side effects.

The BMF group is involved in research of the effects of ionizing radiation on all levels; molecular, cellular, preclinical and clinical, with most focus on first three levels. We have a strong focus on dosimetry and combine experimental activities with simulations and modelling.

From molecular science to clinic

​Research projects

ProGRID- Proton GRID irradiation to improve anti-tumor immune response.

In ProGRID, we investigate: 1) whether protons are more efficient than photons in inducing immunogenic responses in two syngeneic mouse oral cancer cell lines. 2) The effect of combination of proton/photon radiation with immune checkpoint inhibitors. 3) Whether spatial fractionation (GRID) of radiation can improve the immune system's ability to eradicate local and metastatic cancer by sparing intra-tumor immune cells, in addition to sparing normal tissues.

PROCCA-PROtons Contra Cancer.

PROCCA is a highly interdisciplinary convergence environment funded by UIO: Life science led by BMF. In PROCCA, we investigate the mechanisms leading to normal tissue side effects in head and neck cancer patients after proton and X-ray irradiation; from physical energy deposition patterns, though cellular effects, to physical effects in mice and humans, as well as psychological effects in human cancer survivors. More information here.

The effect of TGF-β3 on radiation response.

We have discovered an unexpected permanent change to a more radioresistant phenotype in low dose-rate irradiated as well as hypoxic cells involving secretion of TGF-β3. Other factors we have found to be involved in its activation and action are nitric oxide, peroxynitrite and interleukin 13. For cells in vitro, the radioresistance was mainly induced for low doses eliminating so-called low dose hyper-radiosensitivity. In animal models, pre-irradiation with low dose rate protected against lethal doses. We have recently published a paper in which we elucidate the underlying mechanisms involved in TGF-β3 secretion in extracellular vesicles, its activation and receptor binding. We are also investigating the in vivo mechanisms of radiation protection by TGF-β3, which we have reason to believe are related to fibrosis mitigation.

NanoDos- synthesis of nano-phosphors and spin-trapping nano-crystals as energy independent dosimeters for radiotherapy beams.

NanoDos is a collaboration with University of Delhi, funded by the Norwegian Research council and the Indian Ministry of Science and Technology. In Nanodos, we develop cost-effective energy-independent radiation dosimeters based on thermoluminescence nano-phosphors and spin-trapping nano-crystals for accurate dose determination of proton, carbon and photon beams used in radiotherapy. A special focus is on development of dosimeters, which can discriminate between different energies and/or LET levels.

PRISMAP-the European medical isotope program: Production of high purity isotopes by mass separation.

We are a partner in the EU H2020-INFRAIA funded project PRISMAP. Our role is to establish a method for measuring the relative biological effects (RBE) of different radionuclides produced in the project.

 

Industrial collaborations

Diatec Monoclonals. In 2018-2022, we were partner in MEDPROT led by Diatec Monoclonals, which was a user-driven research based innovation project (BIA) funded by the Research Council of Norway with the aim to establish new production technologies enabling competitive process development and manufacturing for protein-based pharmaceuticals, including radiopharmaceuticals. The collaboration with Diatec Monoclonals will continue with an industrial PhD project.

Kongsberg Beam Technology

 

The Cell laboratory

The Cell laboratory is completely equipped for culturing mammalian cells and has instruments for measuring and controlling the oxygen level in the cells' microenvironment. 

We have an X-ray facility for cell irradiations at BMF. For proton irradiation, we have established a cell laboratory and cell irradiation set-up at Oslo Cyclotron Laboratory (OCL).

We use a number of molecular biological methods (e.g. western blotting, transfection, flow cytometry, PCR etc.) as well as advanced microscopy equipment (e.g. confocal microscopy).

For more details the the cell-laboratory webpage

The EPR-laboratory

Electron Paramagnetic Resonance (EPR/ESR) spectroscopy is a unique technique for identifying radicals and other paramagnetic substances. At the EPR-laboratory, we employ advanced experimental techniques (EPR-, ENDOR-, EIE spectroscopy). 

For more details the the EPR-laboratory webpage

 

 

Academic programmes and courses

Our masterstudents are part of the Master program in Physics, with the programme option Biological and Medical Physics.

The bachelor course FYS3700 (Biophysics and Medical Physics) is taught in the fall and can also be part of the master curriculum (FYS4700)  

Master courses / phd courses  - given by, or in close collaboration with, the BMF group:

FYS4711   /    FYS9711 Radiation and dosimetry fall
FYS4720  /  FYS9720    Cellular radiobiology fall
FYS4730  /  FYS9730 Medical radiation physics for radiotherapy spring
FYS4740  /  FYS9740 MR-theory and medical diagnostics spring
FYS4250  /  FYS9250 Biomedical instrumentation

spring

FYS4762  /  FYS9762   Medical imaging with ionising radiation fall

      

     

     

     

     

     

     

    Tags: biophysics, medical physics, biomedical physics, radiation physics, radiation biophysics, medical physicist, EPR, ESR, ENDOR, magnetic resonance, free radicals, dosimetri, hypoxi, cancer, radiation protection, low dose irradiation, cell kinetics, cell and molecular biology
    Published Nov. 10, 2010 3:28 PM - Last modified Oct. 14, 2022 10:09 AM