Nina Frederike Jeppesen Edin

Associate Professor - Biophysics and Medical Physics
Image of Nina Frederike Jeppesen Edin
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Phone +47 22855492
Mobile phone +47 92812070
Room KV330
Username
Visiting address Sem Sælands vei 24 Fysikkbygningen 0371 Oslo
Postal address Postboks 1048 Blindern 0316 Oslo

Academic Interests

My major area of interest is cellular effects of radiation and hypoxia.

This includes:

  • Low dose rate effects
  • The role of prolonged hypoxia in radiation resistance.
  • The role of TGFbeta3 in radiation response
  • Proton therapy- new ways to deliver protons and new ways to exploit the physical properties
  • Radiation induced immunogenic cell death
  • Late effects after radiotherapy, protons vs. X-rays, mechanisms and mitigation
  • Relative biological effect of radionuclides

Teaching

FYS2150 Experimental physics

FYS4720/9720 Cellular radiobiology

FYS3820 Arbeidspraksis 

Tags: Life sciences, Biomedical physics, biophysics, medical physics, Radiation physics, Radiation biophysics, Cancer, Radiation protection, Hypoxia, Low dose irradiation, Cell kinetics, Cell biology, Molecular biology, Proton therapy

Publications

  • Reaz, Fardous; Sjobak, Kyrre Ness; Malinen, Eirik; Edin, Nina Frederike Jeppesen & Adli, Erik (2022). Sharp dose profiles for high precision proton therapy using strongly focused proton beams. Scientific Reports. ISSN 2045-2322. 12(18919). doi: 10.1038/s41598-022-22677-0. Full text in Research Archive
  • Hanson, Ingunn; Pitman, Kathinka Elinor; Altanerova, Ursula; Altaner, Čestmír; Malinen, Eirik & Edin, Nina Frederike Jeppesen (2022). Low-Dose-Rate Radiation-Induced Secretion of TGF-β3 Together with an Activator in Small Extracellular Vesicles Modifies Low-Dose Hyper-Radiosensitivity through ALK1 Binding. International Journal of Molecular Sciences. ISSN 1661-6596. 23(15). doi: 10.3390/ijms23158147.
  • Hanson, Ingunn; Pitman, Kathinka Elinor; Altanerova, Ursula; Altaner, Čestmír; Malinen, Eirik & Edin, Nina Frederike Jeppesen (2022). Low-Dose-Rate Radiation-Induced Secretion of TGF-B3 Together with an Activator in Small Extracellular Vesicles Modifies Low-Dose Hyper-Radiosensitivity through ALK1 Binding. International Journal of Molecular Sciences. ISSN 1661-6596. 23(15). doi: 10.3390/%20ijms23158147.
  • Arous, Delmon; Schrunner, Stefan; Hanson, Ingunn; Edin, Nina Frederike Jeppesen & Malinen, Eirik (2022). Principal component-based image segmentation: a new approach to outline in vitro cell colonies. Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization. ISSN 2168-1163. doi: 10.1080/21681163.2022.2035822.
  • Asperud, Jonas; Arous, Delmon; Edin, Nina Frederike Jeppesen & Malinen, Eirik (2021). Spatially fractionated radiotherapy: Tumor response modelling including immunomodulation. Physics in Medicine and Biology. ISSN 0031-9155. 66(17). doi: 10.1088/1361-6560/ac176b.
  • Görgen, Andreas; Guttormsen, Magne Sveen; Larsen, Ann-Cecilie; Siem, Sunniva; Adli, Erik & Edin, Nina Frederike J [Show all 14 contributors for this article] (2021). The Oslo Cyclotron Laboratory. The European Physical Journal Plus. ISSN 2190-5444. 136, p. 1–13. doi: 10.1140/epjp/s13360-021-01150-3. Full text in Research Archive
  • Grigalavicius, Mantas; Mastrangelopoulou, Maria; Berg, Kristian; Arous, Delmon; Ménard, Mathilde & Henriksen-Raabe, Tine Therese [Show all 12 contributors for this article] (2019). Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production. Nature Communications. ISSN 2041-1723. 10(1). doi: 10.1038/s41467-019-12042-7. Full text in Research Archive
  • Printzell, Lisa; Reseland, Janne Elin; Edin, Nina Frederike J & Ellingsen, Jan Eirik (2019). Effects of ionizing irradiation and interface backscatter on human mesenchymal stem cells cultured on titanium surfaces. European Journal of Oral Sciences. ISSN 0909-8836. 127(6), p. 500–507. doi: 10.1111/eos.12654. Full text in Research Archive
  • Mikalsen, Stine Gyland; Mikalsen, Lars Tore G; Sandvik, Joe Alexander; Aarnes, Eva-Katrine; Fenne, Siri & Flatmark, Kjersti [Show all 9 contributors for this article] (2018). Low dose-rate irradiation with [3H]-labelled valine to selectively target hypoxic cells in a human colorectal cancer xenograft model. Acta Oncologica. ISSN 0284-186X. 57(9), p. 1216–1224. doi: 10.1080/0284186X.2018.1457223.
  • Bousquet, Paula; Sandvik, Joe Alexander; Edin, Nina Frederike J & Krengel, Ute (2018). Hypothesis: Hypoxia induces de novo synthesis of NeuGc gangliosides in humans through CMAH domain substitute. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 495(1), p. 1562–1566. doi: 10.1016/j.bbrc.2017.11.183. Full text in Research Archive
  • Mikalsen, Stine Gyland; Edin, Nina Frederike J; Sandvik, Joe Alexander & Pettersen, Erik O (2018). Separation of two sub-groups with different DNA content after treatment of T-47D breast cancer cells with low dose-rate irradiation and intermittent hypoxia. Acta Radiologica. ISSN 0284-1851. 59(1), p. 26–33. doi: 10.1177/0284185117699999.
  • Dahle, Tordis Johnsen; Rykkelid, Anne Marit; Stokkevåg, Camilla Hanquist; Mairani, Andrea; Görgen, Andreas & Edin, Nina Frederike J [Show all 10 contributors for this article] (2017). Monte Carlo simulations of a low energy proton beamline for radiobiological experiments. Acta Oncologica. ISSN 0284-186X. 56(6), p. 779–786. doi: 10.1080/0284186X.2017.1289239.
  • Edin, Nina Frederike J; Altaner, Čestmír; Altanerova, Veronica; Ebbesen, Peter & Pettersen, Erik O (2016). Low-Dose-Rate Irradiation for 1 Hour Induces Protection Against Lethal Radiation Doses but Does Not Affect Life Span of DBA/2 Mice. Dose-Response. ISSN 1559-3258. 14(4). doi: 10.1177/1559325816673901.
  • Bousquet, Paula; Sandvik, Joe Alexander; Arntzen, Magnus Øverlie; Edin, Nina Frederike J; Christoffersen, Stine & Krengel, Ute [Show all 8 contributors for this article] (2015). Hypoxia Strongly Affects Mitochondrial Ribosomal Proteins and Translocases, as Shown by Quantitative Proteomics of HeLa Cells. International Journal of Proteomics. ISSN 2090-2174. doi: 10.1155/2015/678527.
  • Edin, Nina Frederike J; Christoffersen, Stine; Fenne, Siri; Sandvik, Joe Alexander & Pettersen, Erik O (2015). Cell inactivation by combined low dose-rate irradiation and intermittent hypoxia. International Journal of Radiation Biology. ISSN 0955-3002. 91(4), p. 336–345. doi: 10.3109/09553002.2014.996262.
  • Edin, Nina Frederike J; Altaner, Čestmír; Altanerova, Veronica & Ebbesen, Peter (2015). TGF-Bdependent modification of radiosensitivity in reporter cells exposed to serum from whole-body low dose-rate irradiated mice. Dose-Response. ISSN 1559-3258. 13(1). doi: 10.2203/dose-response.14-015.Edin.
  • Edin, Nina Frederike J (2014). The role of interleukin-13 in the removal of hyper-radiosensitivity by priming irradiation. Journal of radiation research. ISSN 0449-3060. 55(6), p. 1066–1074. doi: 10.1093/jrr/rru053. Full text in Research Archive
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Chang, Cheng; Bergersen, Linda Hildegard & Pettersen, Erik O (2014). The roles of TGF-β3 and peroxynitrite in removal of hyper-radiosensitivity by priming irradiation. International Journal of Radiation Biology. ISSN 0955-3002. 90(7), p. 527–537. doi: 10.3109/09553002.2014.906767.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Vollan, Hilde Synnøve; Reger, Katharina; Görlach, Agnes & Pettersen, Erik O (2013). The role of nitric oxide radicals in removal of hyper-radiosensitivity by priming irradiation. Journal of radiation research. ISSN 0449-3060. 54(6), p. 1015–1028. doi: 10.1093/jrr/rrt061.
  • Chang, Cheng; Edin, Nina Frederike J; Lauritzen, Knut Husø; Aspmodal, Ida; Christoffersen, Stine & Jian, Liu [Show all 10 contributors for this article] (2012). Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. Cellular Oncology. ISSN 1570-5870. 35(3), p. 217–227. doi: 10.1007/s13402-012-0081-9.
  • Edin, Nina Frederike J; Olsen, Dag Rune; Sandvik, Joe Alexander; Malinen, Eirik & Pettersen, Erik O (2012). Low dose hyper-radiosensitivity is eliminated during exposure to cycling hypoxia but returns after reoxygenation. International Journal of Radiation Biology. ISSN 0955-3002. 88(4), p. 311–319. doi: 10.3109/09553002.2012.646046.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Olsen, Dag Rune & Pettersen, Erik O (2009). The elimination of low dose hyper-radiosensitivity by transfer of irradiated-cell conditioned medium depends on dose rate. Radiation Research. ISSN 0033-7587. 171(1), p. 22–32.
  • Edin, Nina Frederike J; Olsen, Dag Rune; Stokke, Trond; Sandvik, Joe Alexander; Ebbesen, Peter & Pettersen, Erik O (2009). Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming. International Journal of Radiation Biology. ISSN 0955-3002. 85(12), p. 1157–1165. doi: 10.3109/09553000903242107.
  • Edin, Nina Frederike J; Olsen, Dag Rune; Stokke, T & Pettersen, Erik O (2007). Recovery of low-dose hyper-radiosensitivity following a small priming dose depends on priming dose-rate. International Journal of Low Radiation. ISSN 1477-6545. 4(1), p. 69–86. doi: 10.1504/IJLR.2007.014491.
  • Pettersen, Erik O; Bjørhovde, Ingunn; Søvik, Åste; Edin, Nina Frederike J; Zachar, V & Hole, Eli Olaug [Show all 8 contributors for this article] (2007). Response of chronic hypoxic cells to low dose-rate irradiation. International Journal of Radiation Biology. ISSN 0955-3002. 83. doi: 10.1080/09553000701287791.

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  • Nattudurai, Ravikumar; Arous, Delmon; Edin, Nina Frederike Jeppesen; Pandey, Anant & Malinen, Eirik (2022). Dosimetric characterization of BaSO4 phosphors activated by Eu for proton, gamma and X-ray beams.
  • Hanson, Ingunn & Edin, Nina Frederike Jeppesen (2022). The role of TGF-β3 in modification of radiation response.
  • Hanson, Ingunn & Edin, Nina Frederike Jeppesen (2022). Shielding of the femur reduces the severity of the gastrointestinal subsyndrome of ARS and increases survival in mice.
  • Rykkelid, Anne Marit; Sørensen, Brita Singers; Horsman, Michael; Malinen, Eirik & Edin, Nina Frederike Jeppesen (2022). Effect of the Combination of Proton Radiotherapy and Immunotherapy on the MOC1/MOC2 tumor models in C57B16/Jrj mice.
  • Nattudurai, Ravikumar; Arous, Delmon; Edin, Nina Frederike Jeppesen; Pandey, Anant & Malinen, Eirik (2022). Investigation of BaSO4:Eu nanophosphors for thermoluminescence dosimetry of X-ray and proton beams. Radiotherapy and Oncology. ISSN 0167-8140. 170.
  • Edin, Nina Frederike Jeppesen (2022). Low dose radiation effects.
  • Bousquet, Paula; Sandvik, Joe Alexander; Edin, Nina Frederike Jeppesen & Krengel, Ute (2022). Corrigendum to: Hypothesis: Hypoxia induces de novo synthesis of NeuGc gangliosides in humans through CMAH domain substitute (Biochemical and Biophysical Research Communications (2018) 495(1) (1562–1566), (S0006291X17323616), (10.1016/j.bbrc.2017.11.183)). Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 587. doi: 10.1016/j.bbrc.2021.11.074.
  • Edin, Nina Frederike Jeppesen (2022). The present and future of FLASH-immunology.
  • Grigalavicius, Mantas; Mastrangelopoulou, Maria; Berg, K.; Arous, Delmon; Ménard, M. & Raabe-Henriksen, T. [Show all 12 contributors for this article] (2021). Publisher Correction: Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production (Nature Communications, (2019), 10, 1, (3986), 10.1038/s41467-019-12042-7). Nature Communications. ISSN 2041-1723. 12(1). doi: 10.1038/s41467-021-27175-x.
  • Hanson, Ingunn; Pitman, Kathinka Elinor; Thiede, Bernd; Cai, Yiqing & Edin, Nina Frederike Jeppesen (2021). Proteomic Analysis of Low Dose-Rate Primed Cells and Extracellular Exosomes.
  • Nattudurai, Ravikumar; Arous, Delmon; Edin, Nina Frederike Jeppesen & Malinen, Eirik (2021). Estimating linear energy transfer in proton beams using alanine/EPR dosimetry.
  • Edin, Nina Frederike Jeppesen (2021). Proton radiobiology studies at Oslo Cyclotron Laboratory.
  • Nattudurai, Ravikumar; Arous, Delmon; Edin, Nina Frederike Jeppesen & Malinen, Eirik (2021). Alanine dosimeters for determining linear energy transfer in proton beams. Radiotherapy and Oncology. ISSN 0167-8140. 161, p. 229–229.
  • Edin, Nina Frederike Jeppesen (2020). Increased immunogenic calreticulin signaling at the distal end of the proton Bragg peak .
  • Zlygosteva, Olga; Malinen, Eirik & Edin, Nina Frederike J (2020). PROCCA: a new convergence environment.
  • Hanson, Ingunn; Edin, Nina Frederike J; Thiede, Bernd & Altanerova, Ursula (2020). Communication of radioprotective efects by TGF-β3.
  • Hanson, Ingunn; Altanerova, Ursula; Thiede, Bernd & Edin, Nina Frederike J (2020). Radioprotector TGF-β3 is secreted in exosomes and activated by LDR priming.
  • Edin, Nina Frederike J (2019). The role of TGF-beta3 in radioresistance.
  • Edin, Nina Frederike J; Rykkelid, Anne Marit; Görgen, Andreas; Baker, Agnes; Siem, Sunniva & Ytre-Hauge, Kristian [Show all 7 contributors for this article] (2019). Very high yield of double strand breaks found at the distal end of the proton Bragg peak. Radiotherapy and Oncology. ISSN 0167-8140. 133, p. 594–594.
  • Rykkelid, Anne Marit; Tormodsrud, Vera; Siem, Sunniva; Görgen, Andreas; Ytre-Hauge, Kristian & Malinen, Eirik [Show all 7 contributors for this article] (2019). Very high RBE values found at the distal end of the proton Bragg peak.
  • Rykkelid, Anne Marit; Siem, Sunniva; Ytre-Hauge, Kristian; Malinen, Eirik & Edin, Nina Frederike J (2018). Very high relative biological effectiveness found at the distal end of the proton Bragg peak. Radiotherapy and Oncology. ISSN 0167-8140. 127, p. 1259–1259.
  • Rykkelid, Anne Marit; Siem, Sunniva; Görgen, Andreas; Ytre-Hauge, Kristian; Brondz, Efim & Sandvik, Joe Alexander [Show all 9 contributors for this article] (2017). A high-resolution proton irradiator for in vitro studies of relative biological effectiveness.
  • Hole, Eli Olaug; Edin, Nina Frederike J; Malinen, Eirik; Pettersen, Erik O & Sagstuen, Einar (2017). Biophysics and medical physics at UiO: Research and education. An incomplete overview.
  • Dahle, Tordis Johnsen; Rykkelid, Anne Marit; Stokkevåg, Camilla Hanquist; Görgen, Andreas; Edin, Nina Frederike J & Malinen, Eirik [Show all 7 contributors for this article] (2017). Monte Carlo simulations of a low-energy proton beam and estimation of LET distributions. Radiotherapy and Oncology. ISSN 0167-8140. 123, p. 179–180.
  • Frettem, Åshild Kvammen; Edin, Nina Frederike J; Galtung, Hilde & Søland, Tine Merete (2016). Tumour associated Aquaporin-3 and hypoxia in an oral squamous cell carcinoma cell line .
  • Edin, Nina Frederike J; altaner, cestmir; Altanerova, Veronica & Ebbesen, Peter (2014). TGF-3 IN PROTECTION AGAINST RADIATION DAMAGE.
  • Edin, Nina Frederike J (2014). Induction of protection against radiation damage.
  • Christoffersen, Stine; Sandvik, Joe Alexander; Pettersen, Erik O & Edin, Nina Frederike J (2012). Cell respiration, hypoxia and low dose rate radiation.
  • Edin, Nina Frederike J (2012). Cycling hypoxia and inverse radiomodifying effects of oxygen at ultra-low radiation doses.
  • Edin, Nina Frederike J; Pettersen, Erik O; Sandvik, Joe Alexander; Bergersen, Linda Hildegard; Chang, Cheng & Vollan, Hilde Synnøve [Show all 9 contributors for this article] (2012). The role of TGFb3 and induced nitric oxide synthase activity in connection with induced resistance against low dose hyper-radiosensitivity.
  • Edin, Nina Frederike J (2012). Hvor farlig er radioaktiv stråling?
  • Edin, Nina Frederike J & Ebbesen, Peter (2012). Effect of small doses whole-body γ-radiation given at low dose-rate to mice with normal micro-flora.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Chang, Cheng; Vollan, Hilde Synnøve; Reger, Katharina & Görlach, Agnes [Show all 8 contributors for this article] (2011). Molecular mechanisms for induction of sustained elimination of low dose hyper-radiosensitivity.
  • Edin, Nina Frederike J (2011). The mechanism by which reoxygenation and low dose-rate radiation turn off hyper-radiosensitivity.
  • Edin, Nina Frederike J (2011). Low dose-rate gamma irradiation can protect against subsequent high dose-rate irradiation .
  • Edin, Nina Frederike J (2011). Molecular mechanisms for induction of sustained elimination of low dose hyper-radiosensitivity.
  • Edin, Nina Frederike J; Olsen, Dag Rune; Sandvik, Joe Alexander; Stokke, Trond & Pettersen, Erik O (2008). Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Olsen, Dag Rune & Pettersen, Erik O (2007). LOW DOSE HYPER-RADIOSENSITIVITY IN T-47D CELLS.
  • Edin, Nina Frederike J; Olsen, Dag Rune & Pettersen, Erik O (2006). Lav-dosis hypersensitivitet hos T-47D brystkræftceller.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Olsen, Dag Rune & Pettersen, Erik O (2006). Intracellular signalling through medium transfer and low dose hyper-radiosensitivity.
  • Edin, Nina Frederike J; Olsen, Dag Rune & Pettersen, Erik O (2005). Recovery of low-dose HRS following a small priming dose depends on priming dose rate.
  • Edin, Nina Frederike J (2008). Elimination of low dose hyper-radiosensitivity in T-47D cells. Then significance of dose-rate and oxygen level. Det matematisk naturvitenskapelige fakultet.

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Published Nov. 4, 2010 12:13 PM - Last modified Apr. 27, 2022 9:11 AM

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