Nina Frederike J Edin

• Grigalavicius, Mantas; Mastrangelopoulou, Maria; Berg, Kristian; Arous, Delmon; Ménard, Mathilde; Henriksen-Raabe, Tine Therese; Brondz, Efim; Siem, Sunniva; Görgen, Andreas; Edin, Nina Frederike J; Malinen, Eirik & Theodossiou, Theodossis (2019). Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production. Nature Communications.  ISSN 2041-1723.  10(1) . doi: 10.1038/s41467-019-12042-7
• Printzell, Lisa; Reseland, Janne Elin; Edin, Nina Frederike J & Ellingsen, Jan Eirik (2019). Effects of ionizing irradiation and interface backscatter on human mesenchymal stem cells cultured on titanium surfaces. European Journal of Oral Sciences.  ISSN 0909-8836. . doi: 10.1111/eos.12654
• Bousquet, Paula; Sandvik, Joe Alexander; Edin, Nina Frederike J & Krengel, Ute (2018). Hypothesis: Hypoxia induces de novo synthesis of NeuGc gangliosides in humans through CMAH domain substitute. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  495(1), s 1562- 1566 . doi: 10.1016/j.bbrc.2017.11.183 Fulltekst i vitenarkiv.
• Mikalsen, Stine Gyland; Edin, Nina Frederike J; Sandvik, Joe Alexander & Pettersen, Erik O (2018). Separation of two sub-groups with different DNA content after treatment of T-47D breast cancer cells with low dose-rate irradiation and intermittent hypoxia. Acta Radiologica.  ISSN 0284-1851.  59(1), s 26- 33 . doi: 10.1177/0284185117699999
• Mikalsen, Stine Gyland; Mikalsen, Lars Tore G; Sandvik, Joe Alexander; Aarnes, Eva-Katrine; Fenne, Siri; Flatmark, Kjersti; Lyng, Heidi; Edin, Nina Frederike J & Pettersen, Erik O (2018). Low dose-rate irradiation with [3H]-labelled valine to selectively target hypoxic cells in a human colorectal cancer xenograft model. Acta Oncologica.  ISSN 0284-186X.  57(9), s 1216- 1224 . doi: 10.1080/0284186X.2018.1457223
• Dahle, Tordis Johnsen; Rykkelid, Anne Marit; Stokkevåg, Camilla Hanquist; Mairani, Andrea; Görgen, Andreas; Edin, Nina Frederike J; Rørvik, Eivind; Fjæra, Lars Fredrik; Malinen, Eirik & Ytre-Hauge, Kristian (2017). Monte Carlo simulations of a low energy proton beamline for radiobiological experiments. Acta Oncologica.  ISSN 0284-186X.  56(6), s 779- 786 . doi: 10.1080/0284186X.2017.1289239
• Edin, Nina Frederike J; Altaner, Čestmír; Altanerova, Veronica; Ebbesen, Peter & Pettersen, Erik O (2016). Low-Dose-Rate Irradiation for 1 Hour Induces Protection Against Lethal Radiation Doses but Does Not Affect Life Span of DBA/2 Mice. Dose-Response.  ISSN 1559-3258.  14(4) . doi: 10.1177/1559325816673901
• Edin, Nina Frederike J; Altaner, Čestmír; Altanerova, Veronica & Ebbesen, Peter (2015). TGF-Bdependent modification of radiosensitivity in reporter cells exposed to serum from whole-body low dose-rate irradiated mice. Dose-Response.  ISSN 1559-3258.  13(1) . doi: 10.2203/dose-response.14-015.Edin
• Edin, Nina Frederike J; Christoffersen, Stine; Fenne, Siri; Sandvik, Joe Alexander & Pettersen, Erik O (2015). Cell inactivation by combined low dose-rate irradiation and intermittent hypoxia. International Journal of Radiation Biology.  ISSN 0955-3002.  91(4), s 336- 345 . doi: 10.3109/09553002.2014.996262
• Edin, Nina Frederike J (2014). The role of interleukin-13 in the removal of hyper-radiosensitivity by priming irradiation. Journal of radiation research.  ISSN 0449-3060.  55(6), s 1066- 1074 . doi: 10.1093/jrr/rru053 Fulltekst i vitenarkiv.
• Edin, Nina Frederike J; Sandvik, Joe Alexander; Chang, Cheng; Bergersen, Linda Hildegard & Pettersen, Erik O (2014). The roles of TGF-β3 and peroxynitrite in removal of hyper-radiosensitivity by priming irradiation. International Journal of Radiation Biology.  ISSN 0955-3002.  90(7), s 527- 537 . doi: 10.3109/09553002.2014.906767
• Edin, Nina Frederike J; Sandvik, Joe Alexander; Vollan, Hilde Synnøve; Reger, Katharina; Görlach, Agnes & Pettersen, Erik O (2013). The role of nitric oxide radicals in removal of hyper-radiosensitivity by priming irradiation. Journal of radiation research.  ISSN 0449-3060.  54(6), s 1015- 1028 . doi: 10.1093/jrr/rrt061
• Chang, Cheng; Edin, Nina Frederike J; Lauritzen, Knut Husø; Aspmodal, Ida; Christoffersen, Stine; Jian, Liu; Rasmussen, Lene Juel; Pettersen, Erik O; Gao, Xiaoqun & Bergersen, Linda Hildegard (2012). Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. Cellular Oncology.  ISSN 1570-5870.  35(3), s 217- 227 . doi: 10.1007/s13402-012-0081-9
• Edin, Nina Frederike J; Olsen, Dag Rune; Sandvik, Joe Alexander; Malinen, Eirik & Pettersen, Erik O (2012). Low dose hyper-radiosensitivity is eliminated during exposure to cycling hypoxia but returns after reoxygenation. International Journal of Radiation Biology.  ISSN 0955-3002.  88(4), s 311- 319 . doi: 10.3109/09553002.2012.646046
• Edin, Nina Frederike J; Olsen, Dag Rune; Stokke, Trond; Sandvik, Joe Alexander; Ebbesen, Peter & Pettersen, Erik O (2009). Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming. International Journal of Radiation Biology.  ISSN 0955-3002.  85(12), s 1157- 1165 . doi: 10.3109/09553000903242107
• Edin, Nina Frederike J; Sandvik, Joe Alexander; Olsen, Dag Rune & Pettersen, Erik O (2009). The elimination of low dose hyper-radiosensitivity by transfer of irradiated-cell conditioned medium depends on dose rate. Radiation Research.  ISSN 0033-7587.  171(1), s 22- 32
• Edin, Nina Frederike J; Olsen, Dag Rune; Stokke, T & Pettersen, Erik O (2007). Recovery of low-dose hyper-radiosensitivity following a small priming dose depends on priming dose-rate. International Journal of Low Radiation.  ISSN 1477-6545.  4(1), s 69- 86 . doi: 10.1504/IJLR.2007.014491
• Pettersen, Erik O; Bjørhovde, Ingunn; Søvik, Åste; Edin, Nina Frederike J; Zachar, V; Hole, Eli Olaug; Sandvik, Joe Alexander & Ebbesen, P (2007). Response of chronic hypoxic cells to low dose-rate irradiation. International Journal of Radiation Biology.  ISSN 0955-3002.  83 . doi: 10.1080/09553000701287791

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• Hanson, Ingunn; Altanerova, Ursula; Thiede, Bernd & Edin, Nina Frederike J (2020). Radioprotector TGF-β3 is secreted in exosomes and activated by LDR priming. Vis sammendrag

  The biological effects of ionizing radiation in the low-dose region is important for diagnostic imaging, healthy tissue in radiation therapy and environmental radiation. For a majority of tested cell lines, the low dose hyper-radiosensitive (HRS) response has been shown to be default. We have previously shown that cells primed with a low dose-rate (⁓0.3 Gy/h) ionizing radiation permanently loses the HRS response. We have also shown that the transforming growth factor (TGF)-β3 is responsible for this effect. Here, we investigated the secretion mechanism of TGF-β3 from LDR primed cells, and theorize regarding the way it is activated. Exosomes were isolated from LDR primed cells, and were shown to remove HRS in reporter cells when co-cultured with these. Adding a TGF-β3 inhibitor to the medium restored the HRS response in reporter cells, confirming that TGF-β3 was the factor in the exosomes responsible for removing HRS. Mass spectrometry was performed on the content of exosomes from primed and control cells. Proteomic analysis confirmed the presence of exosome-specific proteins in exosomes from primed and control groups. TGF-β3 along with latency-associated protein (LAP), the protein that TGF-β3 is bound to in its inactive form, was present in similar amounts in both groups, indicating that TGF-β3 was secreted in its inactive form, regardless of LDR priming. Three proteins were significantly upregulated in the primed exosomes. These proteins will be investigated further in future experiments. We conclude that TGF-β3 is secreted in its inactive form in exosomes from LDR primed and unprimed cells, and that the priming is responsible for its activation. We will further investigate three significantly upregulated proteins with regards to their role in the activation of TGF-β3.

• Edin, Nina Frederike J (2019). The role of TGF-beta3 in radioresistance.
• Edin, Nina Frederike J; Rykkelid, Anne Marit; Görgen, Andreas; Baker, Agnes; Siem, Sunniva; Ytre-Hauge, Kristian & Malinen, Eirik (2019). Very high yield of double strand breaks found at the distal end of the proton Bragg peak. Radiotherapy and Oncology.  ISSN 0167-8140.  133, s 594- 594
• Rykkelid, Anne Marit; Tormodsrud, Vera; Siem, Sunniva; Görgen, Andreas; Ytre-Hauge, Kristian; Malinen, Eirik & Edin, Nina Frederike J (2019). Very high RBE values found at the distal end of the proton Bragg peak.
• Rykkelid, Anne Marit; Siem, Sunniva; Ytre-Hauge, Kristian; Malinen, Eirik & Edin, Nina Frederike J (2018). Very high relative biological effectiveness found at the distal end of the proton Bragg peak. Radiotherapy and Oncology.  ISSN 0167-8140.  127, s 1259- 1259
• Dahle, Tordis Johnsen; Rykkelid, Anne Marit; Stokkevåg, Camilla Hanquist; Görgen, Andreas; Edin, Nina Frederike J; Malinen, Eirik & Ytre-Hauge, Kristian (2017). Monte Carlo simulations of a low-energy proton beam and estimation of LET distributions. Radiotherapy and Oncology.  ISSN 0167-8140.  123, s 179- 180
• Hole, Eli Olaug; Edin, Nina Frederike J; Malinen, Eirik; Pettersen, Erik O & Sagstuen, Einar (2017). Biophysics and medical physics at UiO: Research and education. An incomplete overview..
• Rykkelid, Anne Marit; Siem, Sunniva; Görgen, Andreas; Ytre-Hauge, Kristian; Brondz, Efim; Sandvik, Joe Alexander; Pettersen, Erik O; Malinen, Eirik & Edin, Nina Frederike J (2017). A high-resolution proton irradiator for in vitro studies of relative biological effectiveness.
• Frettem, Åshild Kvammen; Edin, Nina Frederike J; Galtung, Hilde & Søland, Tine Merete (2016). Tumour associated Aquaporin-3 and hypoxia in an oral squamous cell carcinoma cell line.
• Edin, Nina Frederike J (2014). Induction of protection against radiation damage.
• Edin, Nina Frederike J; altaner, cestmir; Altanerova, Veronica & Ebbesen, Peter (2014). TGF-3 IN PROTECTION AGAINST RADIATION DAMAGE.
• Christoffersen, Stine; Sandvik, Joe Alexander; Pettersen, Erik O & Edin, Nina Frederike J (2012). Cell respiration, hypoxia and low dose rate radiation.
• Edin, Nina Frederike J (2012). Cycling hypoxia and inverse radiomodifying effects of oxygen at ultra-low radiation doses.
• Edin, Nina Frederike J (2012). Hvor farlig er radioaktiv stråling?.
• Edin, Nina Frederike J & Ebbesen, Peter (2012). Effect of small doses whole-body γ-radiation given at low dose-rate to mice with normal micro-flora.
• Edin, Nina Frederike J; Pettersen, Erik O; Sandvik, Joe Alexander; Bergersen, Linda Hildegard; Chang, Cheng; Vollan, Hilde Synnøve; Görlach, Agnes; Reger, Katharina & Ebbesen, Peter (2012). The role of TGFb3 and induced nitric oxide synthase activity in connection with induced resistance against low dose hyper-radiosensitivity.
• Edin, Nina Frederike J (2011). Low dose-rate gamma irradiation can protect against subsequent high dose-rate irradiation .
• Edin, Nina Frederike J (2011). Molecular mechanisms for induction of sustained elimination of low dose hyper-radiosensitivity.
• Edin, Nina Frederike J (2011). The mechanism by which reoxygenation and low dose-rate radiation turn off hyper-radiosensitivity.
• Edin, Nina Frederike J; Sandvik, Joe Alexander; Chang, Cheng; Vollan, Hilde Synnøve; Reger, Katharina; Görlach, Agnes; Bergersen, Linda Hildegard & Pettersen, Erik O (2011). Molecular mechanisms for induction of sustained elimination of low dose hyper-radiosensitivity.
• Edin, Nina Frederike J (2008). Elimination of low dose hyper-radiosensitivity in T-47D cells. Then significance of dose-rate and oxygen level.
• Edin, Nina Frederike J; Olsen, Dag Rune; Sandvik, Joe Alexander; Stokke, Trond & Pettersen, Erik O (2008). Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming.
• Edin, Nina Frederike J; Sandvik, Joe Alexander; Olsen, Dag Rune & Pettersen, Erik O (2007). LOW DOSE HYPER-RADIOSENSITIVITY IN T-47D CELLS.
• Edin, Nina Frederike J; Olsen, Dag Rune & Pettersen, Erik O (2006). Lav-dosis hypersensitivitet hos T-47D brystkræftceller.
• Edin, Nina Frederike J; Sandvik, Joe Alexander; Olsen, Dag Rune & Pettersen, Erik O (2006). Intracellular signalling through medium transfer and low dose hyper-radiosensitivity.
• Edin, Nina Frederike J; Olsen, Dag Rune & Pettersen, Erik O (2005). Recovery of low-dose HRS following a small priming dose depends on priming dose rate.

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