Nina Frederike Jeppesen Edin

Førsteamanuensis - Biofysikk og medisinsk fysikk
Bilde av Nina Frederike Jeppesen Edin
English version of this page
Telefon +47 22855492
Mobiltelefon +47 92812070
Rom KV330
Brukernavn
Besøksadresse Kjemibygget
Postadresse Postboks 1048 Blindern 0316 Oslo

Faglige interesser

Det vitenskapelige hovedinteresse-området er cellulære effekter av stråling og hypoksi

Jeg er spesielt opptatt av følgende:

  • Mekanismer indusert av stråling med lave doserater, som kan beskytte mod senere bestråling og mod noen typer kjemoterapi
  • TGFbeta3 og stråling
  • Nye måter å gi protonbestråling og utnytte protoner fysiske egenskaper i kreftbehandling
  • Immunogene effekter av protonstråling
  • Stråling og hypoksi 
  • DNA-uavhengige strålinginduserte mekanismer
  • Beskytter små stråledoser ved lave doserater mot kreft?

Undervisning

FYS2150 Eksperimentalfysikk

FYS4720/9720 Cellulær radiobiologi

 

Emneord: Biomedisinsk fysikk, Biofysikk, Medisinsk fysikk, Strålingsfysikk, Strålingsbiofysikk, Kreft, Strålevern, Hypoxi, Lavdosestråling, Cellekinetikk, Celle- og molekylærbiologi, Livsvitenskap - life science

Publikasjoner

  • Asperud, Jonas; Arous, Delmon; Edin, Nina Frederike Jeppesen & Malinen, Eirik (2021). Spatially fractionated radiotherapy: Tumor response modelling including immunomodulation. Physics in Medicine and Biology. ISSN 0031-9155. 66(17). doi: 10.1088/1361-6560/ac176b.
  • Görgen, Andreas; Guttormsen, Magne Sveen; Larsen, Ann-Cecilie; Siem, Sunniva; Adli, Erik & Edin, Nina Frederike J [Vis alle 14 forfattere av denne artikkelen] (2021). The Oslo Cyclotron Laboratory. The European Physical Journal Plus. ISSN 2190-5444. 136, s. 1–13. doi: 10.1140/epjp/s13360-021-01150-3.
  • Grigalavicius, Mantas; Mastrangelopoulou, Maria; Berg, Kristian; Arous, Delmon; Ménard, Mathilde & Henriksen-Raabe, Tine Therese [Vis alle 12 forfattere av denne artikkelen] (2019). Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production. Nature Communications. ISSN 2041-1723. 10(1). doi: 10.1038/s41467-019-12042-7. Fulltekst i vitenarkiv
  • Printzell, Lisa; Reseland, Janne Elin; Edin, Nina Frederike J & Ellingsen, Jan Eirik (2019). Effects of ionizing irradiation and interface backscatter on human mesenchymal stem cells cultured on titanium surfaces. European Journal of Oral Sciences. ISSN 0909-8836. 127(6), s. 500–507. doi: 10.1111/eos.12654. Fulltekst i vitenarkiv
  • Mikalsen, Stine Gyland; Mikalsen, Lars Tore G; Sandvik, Joe Alexander; Aarnes, Eva-Katrine; Fenne, Siri & Flatmark, Kjersti [Vis alle 9 forfattere av denne artikkelen] (2018). Low dose-rate irradiation with [3H]-labelled valine to selectively target hypoxic cells in a human colorectal cancer xenograft model. Acta Oncologica. ISSN 0284-186X. 57(9), s. 1216–1224. doi: 10.1080/0284186X.2018.1457223.
  • Bousquet, Paula; Sandvik, Joe Alexander; Edin, Nina Frederike J & Krengel, Ute (2018). Hypothesis: Hypoxia induces de novo synthesis of NeuGc gangliosides in humans through CMAH domain substitute. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 495(1), s. 1562–1566. doi: 10.1016/j.bbrc.2017.11.183. Fulltekst i vitenarkiv
  • Mikalsen, Stine Gyland; Edin, Nina Frederike J; Sandvik, Joe Alexander & Pettersen, Erik O (2018). Separation of two sub-groups with different DNA content after treatment of T-47D breast cancer cells with low dose-rate irradiation and intermittent hypoxia. Acta Radiologica. ISSN 0284-1851. 59(1), s. 26–33. doi: 10.1177/0284185117699999.
  • Dahle, Tordis Johnsen; Rykkelid, Anne Marit; Stokkevåg, Camilla Hanquist; Mairani, Andrea; Görgen, Andreas & Edin, Nina Frederike J [Vis alle 10 forfattere av denne artikkelen] (2017). Monte Carlo simulations of a low energy proton beamline for radiobiological experiments. Acta Oncologica. ISSN 0284-186X. 56(6), s. 779–786. doi: 10.1080/0284186X.2017.1289239.
  • Edin, Nina Frederike J; Altaner, Čestmír; Altanerova, Veronica; Ebbesen, Peter & Pettersen, Erik O (2016). Low-Dose-Rate Irradiation for 1 Hour Induces Protection Against Lethal Radiation Doses but Does Not Affect Life Span of DBA/2 Mice. Dose-Response. ISSN 1559-3258. 14(4). doi: 10.1177/1559325816673901.
  • Bousquet, Paula; Sandvik, Joe Alexander; Arntzen, Magnus Øverlie; Edin, Nina Frederike J; Christoffersen, Stine & Krengel, Ute [Vis alle 8 forfattere av denne artikkelen] (2015). Hypoxia Strongly Affects Mitochondrial Ribosomal Proteins and Translocases, as Shown by Quantitative Proteomics of HeLa Cells. International Journal of Proteomics. ISSN 2090-2174. doi: 10.1155/2015/678527.
  • Edin, Nina Frederike J; Christoffersen, Stine; Fenne, Siri; Sandvik, Joe Alexander & Pettersen, Erik O (2015). Cell inactivation by combined low dose-rate irradiation and intermittent hypoxia. International Journal of Radiation Biology. ISSN 0955-3002. 91(4), s. 336–345. doi: 10.3109/09553002.2014.996262.
  • Edin, Nina Frederike J; Altaner, Čestmír; Altanerova, Veronica & Ebbesen, Peter (2015). TGF-Bdependent modification of radiosensitivity in reporter cells exposed to serum from whole-body low dose-rate irradiated mice. Dose-Response. ISSN 1559-3258. 13(1). doi: 10.2203/dose-response.14-015.Edin.
  • Edin, Nina Frederike J (2014). The role of interleukin-13 in the removal of hyper-radiosensitivity by priming irradiation. Journal of radiation research. ISSN 0449-3060. 55(6), s. 1066–1074. doi: 10.1093/jrr/rru053. Fulltekst i vitenarkiv
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Chang, Cheng; Bergersen, Linda Hildegard & Pettersen, Erik O (2014). The roles of TGF-β3 and peroxynitrite in removal of hyper-radiosensitivity by priming irradiation. International Journal of Radiation Biology. ISSN 0955-3002. 90(7), s. 527–537. doi: 10.3109/09553002.2014.906767.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Vollan, Hilde Synnøve; Reger, Katharina; Görlach, Agnes & Pettersen, Erik O (2013). The role of nitric oxide radicals in removal of hyper-radiosensitivity by priming irradiation. Journal of radiation research. ISSN 0449-3060. 54(6), s. 1015–1028. doi: 10.1093/jrr/rrt061.
  • Chang, Cheng; Edin, Nina Frederike J; Lauritzen, Knut Husø; Aspmodal, Ida; Christoffersen, Stine & Jian, Liu [Vis alle 10 forfattere av denne artikkelen] (2012). Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells. Cellular Oncology. ISSN 1570-5870. 35(3), s. 217–227. doi: 10.1007/s13402-012-0081-9.
  • Edin, Nina Frederike J; Olsen, Dag Rune; Sandvik, Joe Alexander; Malinen, Eirik & Pettersen, Erik O (2012). Low dose hyper-radiosensitivity is eliminated during exposure to cycling hypoxia but returns after reoxygenation. International Journal of Radiation Biology. ISSN 0955-3002. 88(4), s. 311–319. doi: 10.3109/09553002.2012.646046.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Olsen, Dag Rune & Pettersen, Erik O (2009). The elimination of low dose hyper-radiosensitivity by transfer of irradiated-cell conditioned medium depends on dose rate. Radiation Research. ISSN 0033-7587. 171(1), s. 22–32.
  • Edin, Nina Frederike J; Olsen, Dag Rune; Stokke, Trond; Sandvik, Joe Alexander; Ebbesen, Peter & Pettersen, Erik O (2009). Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming. International Journal of Radiation Biology. ISSN 0955-3002. 85(12), s. 1157–1165. doi: 10.3109/09553000903242107.
  • Edin, Nina Frederike J; Olsen, Dag Rune; Stokke, T & Pettersen, Erik O (2007). Recovery of low-dose hyper-radiosensitivity following a small priming dose depends on priming dose-rate. International Journal of Low Radiation. ISSN 1477-6545. 4(1), s. 69–86. doi: 10.1504/IJLR.2007.014491.
  • Pettersen, Erik O; Bjørhovde, Ingunn; Søvik, Åste; Edin, Nina Frederike J; Zachar, V & Hole, Eli Olaug [Vis alle 8 forfattere av denne artikkelen] (2007). Response of chronic hypoxic cells to low dose-rate irradiation. International Journal of Radiation Biology. ISSN 0955-3002. 83. doi: 10.1080/09553000701287791.

Se alle arbeider i Cristin

  • Hanson, Ingunn; Pitman, Kathinka Elinor; Thiede, Bernd; Cai, Yiqing & Edin, Nina Frederike Jeppesen (2021). Proteomic Analysis of Low Dose-Rate Primed Cells and Extracellular Exosomes.
  • Nattudurai, Ravikumar; Arous, Delmon; Edin, Nina Frederike Jeppesen & Malinen, Eirik (2021). Estimating linear energy transfer in proton beams using alanine/EPR dosimetry.
  • Edin, Nina Frederike Jeppesen (2021). Proton radiobiology studies at Oslo Cyclotron Laboratory.
  • Nattudurai, Ravikumar; Arous, Delmon; Edin, Nina Frederike Jeppesen & Malinen, Eirik (2021). Alanine dosimeters for determining linear energy transfer in proton beams. Radiotherapy and Oncology. ISSN 0167-8140. 161, s. 229–229.
  • Zlygosteva, Olga; Malinen, Eirik & Edin, Nina Frederike J (2020). PROCCA: a new convergence environment.
  • Hanson, Ingunn; Edin, Nina Frederike J; Thiede, Bernd & Altanerova, Ursula (2020). Communication of radioprotective efects by TGF-β3.
  • Hanson, Ingunn; Altanerova, Ursula; Thiede, Bernd & Edin, Nina Frederike J (2020). Radioprotector TGF-β3 is secreted in exosomes and activated by LDR priming.
  • Edin, Nina Frederike J (2019). The role of TGF-beta3 in radioresistance.
  • Edin, Nina Frederike J; Rykkelid, Anne Marit; Görgen, Andreas; Baker, Agnes; Siem, Sunniva & Ytre-Hauge, Kristian [Vis alle 7 forfattere av denne artikkelen] (2019). Very high yield of double strand breaks found at the distal end of the proton Bragg peak. Radiotherapy and Oncology. ISSN 0167-8140. 133, s. 594–594.
  • Rykkelid, Anne Marit; Tormodsrud, Vera; Siem, Sunniva; Görgen, Andreas; Ytre-Hauge, Kristian & Malinen, Eirik [Vis alle 7 forfattere av denne artikkelen] (2019). Very high RBE values found at the distal end of the proton Bragg peak.
  • Rykkelid, Anne Marit; Siem, Sunniva; Ytre-Hauge, Kristian; Malinen, Eirik & Edin, Nina Frederike J (2018). Very high relative biological effectiveness found at the distal end of the proton Bragg peak. Radiotherapy and Oncology. ISSN 0167-8140. 127, s. 1259–1259.
  • Rykkelid, Anne Marit; Siem, Sunniva; Görgen, Andreas; Ytre-Hauge, Kristian; Brondz, Efim & Sandvik, Joe Alexander [Vis alle 9 forfattere av denne artikkelen] (2017). A high-resolution proton irradiator for in vitro studies of relative biological effectiveness.
  • Hole, Eli Olaug; Edin, Nina Frederike J; Malinen, Eirik; Pettersen, Erik O & Sagstuen, Einar (2017). Biophysics and medical physics at UiO: Research and education. An incomplete overview.
  • Dahle, Tordis Johnsen; Rykkelid, Anne Marit; Stokkevåg, Camilla Hanquist; Görgen, Andreas; Edin, Nina Frederike J & Malinen, Eirik [Vis alle 7 forfattere av denne artikkelen] (2017). Monte Carlo simulations of a low-energy proton beam and estimation of LET distributions. Radiotherapy and Oncology. ISSN 0167-8140. 123, s. 179–180.
  • Frettem, Åshild Kvammen; Edin, Nina Frederike J; Galtung, Hilde & Søland, Tine Merete (2016). Tumour associated Aquaporin-3 and hypoxia in an oral squamous cell carcinoma cell line .
  • Edin, Nina Frederike J; altaner, cestmir; Altanerova, Veronica & Ebbesen, Peter (2014). TGF-3 IN PROTECTION AGAINST RADIATION DAMAGE.
  • Edin, Nina Frederike J (2014). Induction of protection against radiation damage.
  • Christoffersen, Stine; Sandvik, Joe Alexander; Pettersen, Erik O & Edin, Nina Frederike J (2012). Cell respiration, hypoxia and low dose rate radiation.
  • Edin, Nina Frederike J (2012). Cycling hypoxia and inverse radiomodifying effects of oxygen at ultra-low radiation doses.
  • Edin, Nina Frederike J; Pettersen, Erik O; Sandvik, Joe Alexander; Bergersen, Linda Hildegard; Chang, Cheng & Vollan, Hilde Synnøve [Vis alle 9 forfattere av denne artikkelen] (2012). The role of TGFb3 and induced nitric oxide synthase activity in connection with induced resistance against low dose hyper-radiosensitivity.
  • Edin, Nina Frederike J (2012). Hvor farlig er radioaktiv stråling?
  • Edin, Nina Frederike J & Ebbesen, Peter (2012). Effect of small doses whole-body γ-radiation given at low dose-rate to mice with normal micro-flora.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Chang, Cheng; Vollan, Hilde Synnøve; Reger, Katharina & Görlach, Agnes [Vis alle 8 forfattere av denne artikkelen] (2011). Molecular mechanisms for induction of sustained elimination of low dose hyper-radiosensitivity.
  • Edin, Nina Frederike J (2011). The mechanism by which reoxygenation and low dose-rate radiation turn off hyper-radiosensitivity.
  • Edin, Nina Frederike J (2011). Low dose-rate gamma irradiation can protect against subsequent high dose-rate irradiation .
  • Edin, Nina Frederike J (2011). Molecular mechanisms for induction of sustained elimination of low dose hyper-radiosensitivity.
  • Edin, Nina Frederike J; Olsen, Dag Rune; Sandvik, Joe Alexander; Stokke, Trond & Pettersen, Erik O (2008). Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Olsen, Dag Rune & Pettersen, Erik O (2007). LOW DOSE HYPER-RADIOSENSITIVITY IN T-47D CELLS.
  • Edin, Nina Frederike J; Olsen, Dag Rune & Pettersen, Erik O (2006). Lav-dosis hypersensitivitet hos T-47D brystkræftceller.
  • Edin, Nina Frederike J; Sandvik, Joe Alexander; Olsen, Dag Rune & Pettersen, Erik O (2006). Intracellular signalling through medium transfer and low dose hyper-radiosensitivity.
  • Edin, Nina Frederike J; Olsen, Dag Rune & Pettersen, Erik O (2005). Recovery of low-dose HRS following a small priming dose depends on priming dose rate.
  • Edin, Nina Frederike J (2008). Elimination of low dose hyper-radiosensitivity in T-47D cells. Then significance of dose-rate and oxygen level. Det matematisk naturvitenskapelige fakultet.

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Publisert 4. nov. 2010 12:13 - Sist endret 30. jan. 2020 20:41

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