Ole Christian Lingjærde

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Phone +47 22857964
Mobile phone +47 46636659
Room 4423
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Visiting address Gaustadalléen 23B Ole Johan Dahls hus 0373 Oslo
Postal address Postboks 1080 Blindern 0316 Oslo

I am a professor of computer science affiliated with the Biomedical Informatics Research Group (BMI) at the Department of Informatics (IFI) at University of Oslo (UiO). I am also head of the Biostatistics and Bioinformatics group in the KG Jebsen Centre for Breast Cancer Research, head of Bioinformatics in the MetAction project, senior investigator in the Centre for Cancer Biomedicine (a Norwegian Centre of Excellence), and affiliated with CELS (Centre for Computational Inference in Evolutionary Life Science, UiO).

Research interests

Mathematical and statistical modeling is the natural language to use for making precise statements about associations and structures in biology, and indeed such models form the backbone of countless analysis methods and bioinformatics tools. Equally important, however, modeling may be used highly interactively to explore properties of biological systems and to confront hypotheses with reality (through simulations). I find both these perspectives very fruitful in my own work. While some applications inevitably require sophisticated models and computational schemes, it is surprising and comforting to see that even the simplest models (if rightly chosen) can be very powerful in terms of revealing key properties of extremely complex systems. The recent explosion in massively parallel observations obtained with microarrays, high-throughput sequencing and other technologies, constitute a serious challenge in many applications. Lack of computational power and data storage are serious problems in this context, but equally important is the need for more research to understand the theoretical limitations on what can be learned from studies involving thousands or even millions of parallel observations on a few hundred or a few thousand individuals. 

From a biological point of view, I have a particular interest in the various manifestations and implications of molecular evolution. The tremendous success of introducing concepts such as cancer 'driver' and 'passenger' genes, and more lately notions such as cancer life histories and archaeology of cancer illustrates the power of alluding to evolutionary concepts. Still, evolution is a very elusive concept, even if it is well understood from a mathematical perspective. As Stephen Wolfram has pointed out, very simple programs (such as those written in the DNA) often result in very complex behavior (i.e. phenotype). So even though biological processes adhere to evolutionary principles and the latter are reasonably well understood, we may not be able to predict what comes out of an evolutionary process any more than we are able to predict the weather beyond a few weeks. There are definitely certain regularities in evolutionary processes, however; in a study of 2000 breast carcinomas (the METABRIC cohort) Curtis et al (2012) found 10 distinct classes of tumors each being characterized by a unique set of genes driving cancer development. Also in other types of cancer one typically finds a small number of distinct subgroups, indicating that nature (and evolution) is not behaving completely at random but following certains paths (often with many detours, though).

From a methodological point of view, I have a particular interest in large-scale inference on the basis of thousands or even millions of parallel data sets that may come from a single or several different measurement sources (the latter case often being referred to in the genomics literature as 'integrative analysis'). Apart from the more obvious problems arising in such settings (such as the need to adjust for multiple comparisons), the deeper challenges concerns how to take advantage of the parallelity of the data (e.g. through empirical Bayes approaches) and developing means to impose biologically reasonable (and justifiable) constraints on the models in order to ensure uniqueness and stability of estimates. Answering such questions requires deep knowledge of statistics as well as biology and is a truly interdisciplinary task.

Examples of recent work

Here are a few selected projects over the last years where I have played a major part in the methodological development (names in parentheses indicating others who have also played a particularly central role in the methodological development):

  • CARMA (Copy Aberration Regional Mapping Analysis) is a computational approach to analyze allele-specific copy number data from tumor DNA obtained with SNP arrays or by high-throughput sequencing. A series of distinct patterns of genomic aberrations are identified, each representing a particular mode of variation in individual copy number profiles. The purpose is to derive a compact, biologically and clinically relevant representation of the genomic architecture in a tumor (together with Gro Nilsen, Hans Kristian Moen Vollan, Arne Pladsen and Hege Russnes and others).
  • ASCAT (Allele-Specific Copy Aberrations in Tumors) is an algorithm for estimation of allele-specific copy numbers, genome ploidy and tumor cell percentage on the basis of SNP array data or HTS data (together with Peter Van Loo and Silje Nord)
  • CAAI (Complex Arm-wise Aberration Index) is a score of genomic complexity which has been shown to be an independent DNA-based prognostic marker in breast cancer (together with Hege Russnes and Hans Kristian Moen Vollan)
  • PART (Partitioning Algorithm using Recursive Thresholding) is an algorithm for identification of clusters in hierarchical clustering trees (together with Gro Nilsen, Knut Liestøl and Ørnulf Borgan).
  • PCF (Piecewise Constant Fitting) is an algorithm for segmentation of array CGH data or SNP array data (together with Gro Nilsen and Knut Liestøl)

Over the last five years I have also been heavily involved in several genomics integration projects, including for example:

  • Prediction of histological transformation (most often to DLBCL) in follicular lymphoma, based on whole-genome copy number and gene expression data (together with Marianne Brodtkorb, Harald Holte, Erlend Smeland and others)
  • Identification of novel drivers of progression in breast cancer, based on whole-genome copy number and gene expression data (together with Miriam Ragle Aure, Lars Baumbusch, Israel Steinfeld, Anne-Lise Børresen-Dale, Zohar Yakhini and others)
  • Identification of genes for which the expression is deregulated in breast cancer both epigenetically (through methylation) and by copy number alteration (together with Miriam Ragle Aure and others)
  • Deriving a map of all direct and indirect interactions between whole-genome miRNA and a panel of 105 cancer related proteins (together with Miriam Ragle Aure, Sandra Jernstrøm, Marit Krohn and others)

PhD supervision

I am/has been involved in supervision of the following PhD students:

  • Maren Høland
  • Vandana Sandhu
  • Aliaksandr Hubin
  • Even Sannes Riiser
  • Hans Kristian Moen Vollan (2015)
  • Gro Nilsen (2015)
  • Miriam Ragle Aure (2013)
  • Eldrid Borgan (2012)
  • Xi Zhao (2011)

Master project supervision

I am/has been involved in supervision of the following master students:

  • Marius Bernklev
  • Anders Flisvang
  • Stian Lågstad
  • Jonas Meier Strømme
  • Kine Veronica Lund (2014)
  • Gro Nilsen (2009)
  • Espen Solberg (2007)
  • Stian Grenborgen (2007)
  • Olav Skjelkvåle Ligaarden (2007)
  • Daniel Løkken Rustad (2005)
  • Hege Leite Størvold (2004)
  • Kristin Robertsen (2003)
Tags: Bioinformatics

Publications

  • Castro-Mondragon, Jaime; Aure, Miriam Ragle; Lingjærde, Ole Christian; Langerød, Anita; Martens, John & Børresen-Dale, Anne-Lise [Show all 8 contributors for this article] (2022). Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of gene regulatory programs in cancers. Nucleic Acids Research (NAR). ISSN 0305-1048. doi: 10.1093/nar/gkac1143.
  • Khadse, Anand; Haakensen, Vilde Drageset; Silwal-Pandit, Laxmi; Hamfjord, Julian; Micke, Patrick & Botling, Johan [Show all 10 contributors for this article] (2022). Prognostic Significance of the Loss of Heterozygosity of KRAS in Early-Stage Lung Adenocarcinoma. Frontiers in Oncology. ISSN 2234-943X. 12. doi: 10.3389/fonc.2022.873532.
  • Silwat-Pandit, Laxmi; Stålberg, Stina Margrethe; Johansson, Henrik J.; Mermelekas, Georgios; Lothe, Inger Marie Bowitz & Skrede, Martina Landschoof [Show all 14 contributors for this article] (2022). Proteome Analysis of Pancreatic Tumors Implicates Extracellular Matrix in Patient Outcome. Cancer research communications. ISSN 2767-9764. 2(6), p. 434–446. doi: 10.1158/2767-9764.CRC-21-0100. Full text in Research Archive
  • Wolowczyk, Camilla; Neckmann, Ulrike; Aure, Miriam Ragle; Hall, Martina; Johannessen, Bjarne & Zhao, Sen [Show all 14 contributors for this article] (2022). NRF2 drives an oxidative stress response predictive of breast cancer. Free Radical Biology & Medicine. ISSN 0891-5849. 184, p. 170–184. doi: 10.1016/j.freeradbiomed.2022.03.029.
  • Rye, Inga Hansine; Huse, Kanutte; Josefsson, Sarah Elisabet; Kildal, Wanja; Danielsen, Håvard Emil Greger & Schlichting, Ellen [Show all 28 contributors for this article] (2021). Breast cancer metastasis: immune profiling of lymph nodes reveals exhaustion of effector T cells and immunosuppression. Molecular Oncology. ISSN 1574-7891. 16(1), p. 88–103. doi: 10.1002/1878-0261.13047. Full text in Research Archive
  • Haugen, Mads Haugland; Lingjærde, Ole Christian; Hedenfalk, Ingrid; Garred, Øystein; Borgen, Elin & Loman, Niklas [Show all 12 contributors for this article] (2021). Protein signature predicts response to neoadjuvant treatment with chemotherapy and bevacizumab in HER2-negative breast cancers. JCO Precision Oncology (JCO PO). 5, p. 286–306. doi: 10.1200/PO.20.00086. Full text in Research Archive
  • Hamfjord, Julian; Guren, Tormod Kyrre; Glimelius, Bengt; Sorbye, Halfdan; Pfeiffer, Per & Dajani, Olav [Show all 11 contributors for this article] (2021). Clinicopathological factors associated with tumour-specific mutation detection in plasma of patients with RAS-mutated or BRAF-mutated metastatic colorectal cancer. International Journal of Cancer. ISSN 0020-7136. 149(6), p. 1385–1397. doi: 10.1002/ijc.33672. Full text in Research Archive
  • Lien, Tonje Gulbrandsen; Ohnstad, Hege Oma; Lingjærde, Ole Christian; Vallon-Christersson, Johan; Aaserud, Marit & Sveli, My Anh Tu [Show all 12 contributors for this article] (2021). Sample preparation approach influences pam50 risk of recurrence score in early breast cancer. Cancers. ISSN 2072-6694. 13(23). doi: 10.3390/cancers13236118. Full text in Research Archive
  • Bjaanæs, Maria Moksnes; Nilsen, Gro; Halvorsen, Ann Rita; Russnes, Hege Elisabeth Giercksky; Solberg, Steinar & Jørgensen, Lars [Show all 9 contributors for this article] (2021). Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung adenocarcinoma tumors. BMC Cancer. ISSN 1471-2407. 21(1). doi: 10.1186/s12885-021-08811-7. Full text in Research Archive
  • Ben-Elazar, Shay; Aure, Miriam Ragle; Jonsdottir, Kristin; Leivonen, Suvi-Katri; Kristensen, Vessela N. & Janssen, Emiel [Show all 9 contributors for this article] (2021). miRNA normalization enables joint analysis of several datasets to increase sensitivity and to reveal novel miRNAs differentially expressed in breast cancer. PLoS Computational Biology. ISSN 1553-734X. 17(2). doi: 10.1371/JOURNAL.PCBI.1008608. Full text in Research Archive
  • Ask, Eivind Heggernes; Tschan-Plessl, Astrid; Gjerdingen, Thea Johanne; Hoel, Hanna Julie; Sætersmoen, Michelle Lu & Wiiger, Merete Thune [Show all 16 contributors for this article] (2021). A Systemic Protein Deviation Score Linked to PD-1+ CD8+ T Cell Expansion That Predicts Overall Survival in Diffuse Large B Cell Lymphoma. Med. ISSN 2666-6359. 2(2), p. 180–195. doi: 10.1016/j.medj.2020.10.006.
  • Liu, Jingjing; van der Smissen, Wendy J. C. Prager; Collee, Margriet J.; Bolla, Manjeet K.; Wang, Qin & Kristensen, Vessela N. [Show all 82 contributors for this article] (2020). Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk. Scientific Reports. ISSN 2045-2322. 10:9688(1), p. 1–14. doi: 10.1038/s41598-020-65665-y. Full text in Research Archive
  • Bailey, Matthew H.; Meyerson, William U.; Dursi, L. Jonathan; Wang, Liang-Bo; Dong, Guanlan & Aure, Miriam Ragle [Show all 51 contributors for this article] (2020). Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications. ISSN 2041-1723. 11:4748, p. 1–27. doi: 10.1038/s41467-020-18151-y. Full text in Research Archive
  • Li, Constance H.; Prokopec, Stephenie D.; Sun, Ren X.; Yousif, Fouad; Schmitz, Nathaniel & Aure, Miriam Ragle [Show all 51 contributors for this article] (2020). Sex differences in oncogenic mutational processes. Nature Communications. ISSN 2041-1723. 11:4330, p. 1–24. doi: 10.1038/s41467-020-17359-2. Full text in Research Archive
  • Wise, Jillian; Nakken, Sigve; Steen, Chloe Beate; Vodak, Daniel; Trøen, Gunhild & Johannessen, Bjarne [Show all 24 contributors for this article] (2020). Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. Blood Advances. ISSN 2473-9529. 4(9), p. 1859–1866. doi: 10.1182/bloodadvances.2019001325.
  • Hoff, Andreas Midbøe; Kraggerud, Sigrid M.; Alagaratnam, Sharmini; Berg, Kaja Christine Graue; Johannessen, Bjarne & Høland, Maren [Show all 11 contributors for this article] (2020). Frequent copy number gains of SLC2A3 and ETV1 in testicular embryonal carcinomas. Endocrine-Related Cancer. ISSN 1351-0088. 27(9), p. 457–468. doi: 10.1530/ERC-20-0064. Full text in Research Archive
  • Kyte, Jon A; Andresen, Nikolai Kragøe; Russnes, Hege Elisabeth Giercksky; Fretland, Signe Øien; Falk, Ragnhild Sørum & Lingjærde, Ole Christian [Show all 7 contributors for this article] (2020). ICON: A randomized phase IIb study evaluating immunogenic chemotherapy combined with ipilimumab and nivolumab in patients with metastatic hormone receptor positive breast cancer. Journal of Translational Medicine. ISSN 1479-5876. 18(1). doi: 10.1186/s12967-020-02421-w. Full text in Research Archive
  • ICGC/TCGA Pan-Cancer Analysis, of Whole Genomes Consortium; Campbell, Peter J.; Getz, Gad; Korbel, Jan O.; Stuart, Joshua M. & Jennings, Jennifer L. [Show all 54 contributors for this article] (2020). Pan-cancer analysis of whole genomes. Nature. ISSN 0028-0836. 578(7793), p. 82–93. doi: 10.1038/s41586-020-1969-6. Full text in Research Archive
  • Pladsen, Arne Valebjørg; Nilsen, Gro; Rueda, Oscar M.; Aure, Miriam Ragle; Borgan, Ørnulf & Liestøl, Knut [Show all 18 contributors for this article] (2020). DNA copy number motifs are strong and independent predictors of survival in breast cancer. Communications Biology. ISSN 2399-3642. 3. doi: 10.1038/s42003-020-0884-6. Full text in Research Archive
  • Gythfeldt, Hedda von der Lippe; Lien, Tonje Gulbrandsen; Tekpli, Xavier; Silwal-Pandit, Laxmi; Borgen, Elin & Garred, Øystein [Show all 15 contributors for this article] (2020). Immune phenotype of tumor microenvironment predicts response to bevacizumab in neoadjuvant treatment of ER-positive breast cancer. International Journal of Cancer. ISSN 0020-7136. 147(9), p. 2515–2525. doi: 10.1002/ijc.33108. Full text in Research Archive
  • Ree, Anne Hansen; Nygaard, Vigdis; Pedersen, Kjetil Boye; Heinrich, Daniel; Dueland, Svein & Bergheim, Inger Riise [Show all 25 contributors for this article] (2020). Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer?the MetAction study. Acta Oncologica. ISSN 0284-186X. p. 1–10. doi: 10.1080/0284186X.2020.1742377. Full text in Research Archive
  • Nygård, Ståle; Lingjærde, Ole Christian; Caldas, Carlos; Hovig, Eivind; Børresen-Dale, Anne-Lise & Helland, Åslaug [Show all 7 contributors for this article] (2019). PathTracer: High-sensitivity detection of differential pathway activity in tumours. Scientific Reports. ISSN 2045-2322. 9:16332, p. 1–8. doi: 10.1038/s41598-019-52529-3. Full text in Research Archive
  • Hamfjord, Julian; Guren, Tormod Kyrre; Dajani, Olav; Johansen, Julia Sidenius; Glimelius, Bengt & Sorbye, Halfdan [Show all 12 contributors for this article] (2019). Total circulating cell-free DNA as a prognostic biomarker in metastatic colorectal cancer before first-line oxaliplatin-based chemotherapy. Annals of Oncology. ISSN 0923-7534. 30(7), p. 1088–1095. doi: 10.1093/annonc/mdz139. Full text in Research Archive
  • Steen, Chloe Beate; Leich, Ellen; Myklebust, June Helen; Lockmer, Sandra; Wise, Jillian & Wahlin, Björn Engelbrekt [Show all 14 contributors for this article] (2019). A clinico-molecular predictor identifies follicular lymphoma patients at risk of early transformation after first-line immunotherapy. Haematologica. ISSN 0390-6078. 104(10), p. 460–464. doi: 10.3324/haematol.2018.209080. Full text in Research Archive
  • Øjlert, Åsa Kristina; Halvorsen, Ann Rita; Nebdal, Daniel J.H.; Lund-Iversen, Marius; Solberg, Steinar & Brustugun, Odd Terje [Show all 8 contributors for this article] (2019). The immune microenvironment in non‐small cell lung cancer is predictive of prognosis after surgery. Molecular Oncology. ISSN 1574-7891. 13(5), p. 1166–1179. doi: 10.1002/1878-0261.12475. Full text in Research Archive
  • Lindholm, Evita Maria; Aure, Miriam Ragle; Haugen, Mads Haugland; Sahlberg, Kristine Kleivi; Kristensen, Vessela N. & Nebdal, Daniel J.H. [Show all 9 contributors for this article] (2019). miRNA expression changes during the course of neoadjuvant bevacizumab and chemotherapy treatment in breast cancer. Molecular Oncology. ISSN 1574-7891. 13(10), p. 2278–2296. doi: 10.1002/1878-0261.12561. Full text in Research Archive
  • Johansson, Henrik J.; Socciarelli, Fabio; Vacanti, Nathaniel M.; Haugen, Mads Haugland; Zhu, Yafeng & Siavelis, Ioannis [Show all 36 contributors for this article] (2019). Breast cancer quantitative proteome and proteogenomic landscape. Nature Communications. ISSN 2041-1723. 10:1600, p. 1–14. doi: 10.1038/s41467-019-09018-y. Full text in Research Archive
  • Terkelsen, Thilde; Haakensen, Vilde Drageset; Saldova, Radka; Gromov, Pavel; Hansen, Merete Kjær & Stockmann, Henning [Show all 12 contributors for this article] (2018). N-glycan signatures identified in tumor interstitial fluid and serum of breast cancer patients: association with tumor biology and clinical outcome. Molecular Oncology. ISSN 1574-7891. 12(6), p. 972–990. doi: 10.1002/1878-0261.12312.
  • Møller, Elen Kristine; Nord, Silje; Wedge, David C; Lingjærde, Ole Christian; Silwal-Pandit, Laxmi & Gythfeldt, Hedda [Show all 19 contributors for this article] (2018). Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations. Genome Medicine. ISSN 1756-994X. 10:92. doi: 10.1186/s13073-018-0601-y. Full text in Research Archive
  • Rye, Inga Hansine; Trinh, Anne; Sætersdal, Anna Barbro; Nebdal, Daniel J.H.; Lingjærde, Ole Christian & Almendro, Vanessa [Show all 11 contributors for this article] (2018). Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors. Molecular Oncology. ISSN 1574-7891. p. 1–18. doi: 10.1002/1878-0261.12375. Full text in Research Archive
  • Holte, Harald; Beiske, Klaus; Boyle, Merrill; Trøen, Gunhild; Blaker, Yngvild Nuvin & Myklebust, June [Show all 13 contributors for this article] (2018). The MCL35 gene expression proliferation assay predicts high-risk MCL patients in a Norwegian cohort of younger patients given intensive first line therapy. British Journal of Haematology. ISSN 0007-1048. p. 1–10. doi: 10.1111/bjh.15518.
  • Våtsveen, Thea Kristin; Myhre, Marit Renee; Steen, Chloe Beate; Wälchli, Sébastien; Lingjærde, Ole Christian & Bai, Baoyan [Show all 14 contributors for this article] (2018). Artesunate shows potent anti-tumor activity in B-cell lymphoma. Journal of Hematology & Oncology. ISSN 1756-8722. 11:23, p. 1–12. doi: 10.1186/s13045-018-0561-0. Full text in Research Archive
  • Dean, Katharine Rose; Krauer, Fabienne; Walløe, Lars; Lingjærde, Ole Christian; Bramanti, Barbara & Stenseth, Nils Christian [Show all 7 contributors for this article] (2018). Human ectoparasites and the spread of plague in Europe during the Second Pandemic. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 115(6), p. 1304–1309. doi: 10.1073/pnas.1715640115.
  • Josefsson, Sarah Elisabet Göthberg; Huse, Kanutte; Kolstad, Arne; Beiske, Klaus; Pende, Daniela & Steen, Chloe Beate [Show all 13 contributors for this article] (2017). T cells expressing checkpoint receptor TIGIT are enriched in follicular lymphoma tumors and characterized by reversible suppression of T-cell receptor signaling. Clinical Cancer Research. ISSN 1078-0432. 24(4), p. 870–881. doi: 10.1158/1078-0432.CCR-17-2337. Full text in Research Archive
  • Cheng, Jiqiu; Demeulemeester, Jonas; Wedge, David C.; Vollan, Hans Kristian Moen; Pitt, Jason & Russnes, Hege Elisabeth Giercksky [Show all 18 contributors for this article] (2017). Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors. Nature Communications. ISSN 2041-1723. 8:1221, p. 1–14. doi: 10.1038/s41467-017-01355-0. Full text in Research Archive
  • Russnes, Hege Elisabeth Giercksky; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise & Caldas, Carlos (2017). Breast cancer molecular stratification– from intrinsic subtypes to integrative clusters. American Journal of Pathology. ISSN 0002-9440. doi: 10.1016/j.ajpath.2017.04.022.
  • Lågstad, Stian; Zhao, Sen; Hoff, Andreas Midbøe; Johannessen, Bjarne; Lingjærde, Ole Christian & Skotheim, Rolf I. (2017). Chimeraviz: A tool for visualizing chimeric RNA. Bioinformatics. ISSN 1367-4803. 33(18), p. 2954–2956. doi: 10.1093/bioinformatics/btx329.
  • Silwal-Pandit, Laxmi; Nord, Silje; Gythfeldt, Hedda; Møller, Elen Kristine; Fleischer, Thomas & Rødland, Einar Andreas [Show all 25 contributors for this article] (2017). The longitudinal transcriptional response to neoadjuvant chemotherapy with and without bevacizumab in breast cancer. Clinical Cancer Research. ISSN 1078-0432. 23(16), p. 4662–4670. doi: 10.1158/1078-0432.CCR-17-0160. Full text in Research Archive
  • Ree, Anne Hansen; Russnes, Hege Elisabeth Giercksky; Heinrich, Daniel; Dueland, Svein; Pedersen, Kjetil Boye & Nygaard, Vigdis [Show all 33 contributors for this article] (2017). Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate. ESMO Open. ISSN 2059-7029. 2(2), p. 1–10. doi: 10.1136/esmoopen-2017-000158. Full text in Research Archive
  • Aure, Miriam Ragle; Vitelli, Valeria; Jernström, Sandra Johanna; Kumar, Surendra; Krohn, Marit & Due, Eldri Undlien [Show all 34 contributors for this article] (2017). Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome. Breast Cancer Research. ISSN 1465-5411. 19. doi: 10.1186/s13058-017-0812-y. Full text in Research Archive
  • Taraldsrud, Eli; Aukrust, Pål; Jørgensen, Silje Fjellgård; Lingjærde, Ole Christian; Olweus, Johanna & Myklebust, June [Show all 7 contributors for this article] (2017). Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency. Clinical Immunology. ISSN 1521-6616. 175, p. 69–74. doi: 10.1016/j.clim.2016.11.014.
  • Kaveh, Fatemeh; Baumbusch, Lars Oliver; Nebdal, Daniel J.H.; Børresen-Dale, Anne-Lise; Lingjærde, Ole Christian & Edvardsen, Hege [Show all 8 contributors for this article] (2016). A systematic comparison of copy number alterations in four types of female cancer. BMC Cancer. ISSN 1471-2407. 16(913). doi: 10.1186/s12885-016-2899-4.
  • Sas-Chen, Aldema; Aure, Miriam Ragle; Leibovich, Limor; Carvalho, Silvia; Enuka, Yehoshua & Körner, Cindy [Show all 38 contributors for this article] (2016). LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer. EMBO Molecular Medicine. ISSN 1757-4676. 8(9), p. 1052–1064. doi: 10.15252/emmm.201606198. Full text in Research Archive
  • Sveen, Anita; Løes, Inger Marie; Alagaratnam, Sharmini; Nilsen, Gro; Høland, Maren & Lingjærde, Ole Christian [Show all 13 contributors for this article] (2016). Intra-patient inter-metastatic genetic heterogeneity in colorectal cancer as a key determinant of survival after curative liver resection. PLoS Genetics. ISSN 1553-7390. 12:e1006225(7). doi: 10.1371/journal.pgen.1006225.
  • Blaker, Yngvild Nuvin; Spetalen, Signe; Eide, Marianne Brodtkorb; Lingjærde, Ole Christian; Beiske, Klaus & Østenstad, Bjørn [Show all 13 contributors for this article] (2016). The tumour microenvironment influences survival and time to transformation in follicular lymphoma in the rituximab era. British Journal of Haematology. ISSN 0007-1048. 175(1), p. 102–114. doi: 10.1111/bjh.14201.
  • Haukaas, Tonje Husby; Euceda, Leslie R.; Giskeødegård, Guro F.; Lamichhane, Santosh; Krohn, Marit & Jernström, Sandra Johanna [Show all 15 contributors for this article] (2016). Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes. Cancer & Metabolism. ISSN 2049-3002. 4. doi: 10.1186/s40170-016-0152-x. Full text in Research Archive
  • Sandhu, Vandana; Wedge, David C.; Lothe, Inger Marie Bowitz; Labori, Knut Jørgen; Dentro, Stefan C. & Buanes, Trond [Show all 16 contributors for this article] (2016). The genomic landscape of pancreatic and periampullary adenocarcinoma. Cancer Research. ISSN 0008-5472. 76(17), p. 5092–5102. doi: 10.1158/0008-5472.CAN-16-0658.
  • Nik-Zainal, Serena; Davies, Helen; Staaf, Johan; Ramakrishna, Manasa; Glodzik, Dominik & Zou, Xueqing [Show all 88 contributors for this article] (2016). Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature. ISSN 0028-0836. 534(7605), p. 47–54. doi: 10.1038/nature17676.
  • Kjersem, Janne Beathe; Thomsen, Maria; Guren, Tormod Kyrre; Hamfjord, Julian; Carlsson, G & Gustavsson, B. [Show all 13 contributors for this article] (2016). AGXT and ERCC2 polymorphisms are associated with clinical outcome in metastatic colorectal cancer patients treated with 5-FU/oxaliplatin. The Pharmacogenomics Journal. ISSN 1470-269X. 16(3), p. 272–279. doi: 10.1038/tpj.2015.54.
  • Sandhu, Vandana; Lothe, Inger Marie Bowitz; Labori, Knut Jørgen; Skrede, Martina; Hamfjord, Julian & Larsen, Astrid Marie [Show all 14 contributors for this article] (2016). Differential expression of miRNAs in pancreatobiliary type of periampullary adenocarcinoma and its associated stroma. Molecular Oncology. ISSN 1574-7891. 10(2), p. 303–316. doi: 10.1016/j.molonc.2015.10.011.
  • Bjaanæs, Maria Moksnes; Nilsen, Gro; Solberg, Steinar; Brustugun, Odd Terje; Lingjærde, Ole Christian & Helland, Åslaug (2015). Whole-genome copy number analyses of NSCLC tumors reveal aberrations associated with EGFR mutations and may have prognostic impact. Journal of Thoracic Oncology. ISSN 1556-0864. 10(9), p. S581–S582.
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  • Leoncio Netto, Waldir; Fagerland, Morten; Lydersen, Stian; Laake, Petter & Lingjærde, Ole Christian (2022). contingencytables: Statistical Analysis of Contingency Tables.
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Published Nov. 4, 2010 2:06 PM - Last modified Nov. 3, 2022 7:30 AM