Ole Christian Lingjærde

Bilde av Ole Christian Lingjærde
English version of this page
Telefon +47 22857964
Mobiltelefon +47 46636659 46636659
Rom 4423
Besøksadresse Gaustadalléen 23B Ole Johan Dahls hus 0373 Oslo
Postadresse Postboks 1080 Blindern 0316 Oslo

I am a professor of computer science affiliated with the Biomedical Informatics Research Group (BMI) at the Department of Informatics (IFI) at University of Oslo (UiO). I am head of the Biostatistics and Bioinformatics group in the KG Jebsen Centre for Breast Cancer Research, senior investigator in the Centre for Cancer Biomedicine (a Norwegian Centre of Excellence), and affiliated with CELS (Centre for Computational Inference in Evolutionary Life Science, UiO).

Research interests

My research focuses on understanding aspects of biological systems through the use of mathematics and the development of computational tools. I have worked in particular on two types of biological systems: ecological systems (of interacting populations of individuals under external influences) and human cancers. Both types of systems involve processes on different time scales: changes in size and spatial distribution over shorter time spans and changes in genotype and phenotype over longer time spans. These processes are not independent of each other, and much of today's research in both ecology and cancer biology concerns the interlinkage between the two process levels. For example, how do the genotype and phenotype of individuals in a population affect the length and amplitude of population cycles? And can we determine from the genotype of tumor cells how likely they are to become metastatic (i.e. spread to distant organs)? Mathematical and statistical modeling is the language of choice to make precise statements about associations and structures in biology. Some applications inevitably require sophisticated models and computational schemes. However, often a complex system is best studied by focusing on understanding just one or a few properties at a time and applying simple and easily interpretable (and falsifiable) models. In fact, the more complex a model is and the more degrees of freedom it has, the more biological scenarios it will encompass and thus the less we can learn from it.

The recent explosion in massively parallel observations obtained with microarrays, high-throughput sequencing and other technologies, constitute a serious challenge in many applications. Lack of computational power and data storage are serious problems in this context, but equally important is the need for more research to understand the theoretical limitations on what can be learned from studies involving thousands or even millions of parallel observations on a few hundred or a few thousand individuals. 

From a biological point of view, I have a particular interest in the various manifestations and implications of molecular evolution. The tremendous success of introducing concepts such as cancer 'driver' and 'passenger' genes, and more lately notions such as cancer life histories and archaeology of cancer illustrates the power of alluding to evolutionary concepts. Still, evolution is a very elusive concept, even if it is well understood from a mathematical perspective. Part of the problem is that the map from genotype to phenotype can be very complicated. So even though biological processes adhere to evolutionary principles and the latter are reasonably well understood, we may not be able to predict what comes out of an evolutionary process any more than we are able to predict the weather beyond a few weeks (though for a different reason). There are definitely certain regularities in evolutionary processes, however; in a study of 2000 breast carcinomas (the METABRIC cohort) Curtis et al (2012) found 10 distinct classes of tumors each being characterized by a unique set of genes driving cancer development. Also in other types of cancer one typically finds a small number of distinct subgroups, indicating that nature (and evolution) is not behaving completely at random but following certains paths (often with many detours).

From a methodological point of view, I have a particular interest in large-scale inference on the basis of thousands or even millions of parallel data sets that may come from a single or several different measurement sources (the latter case often being referred to in the genomics literature as 'integrative analysis'). Apart from the more obvious problems arising in such settings (such as the need to adjust for multiple comparisons), the deeper challenges concerns how to take advantage of the parallelity of the data (e.g. through empirical Bayes approaches) and developing means to impose biologically reasonable (and justifiable) constraints on the models in order to ensure uniqueness and stability of estimates. Answering such questions requires deep knowledge of statistics as well as biology and is a truly interdisciplinary task.

Examples of recent work

Here are a few selected projects over the last years where I have been the PI or co-PI on the method development (names in parentheses indicating others who have also played a particularly central role in the methodological development):

  • CARMA (Copy Aberration Regional Mapping Analysis) is a computational approach to analyze allele-specific copy number data from tumor DNA obtained with SNP arrays or by high-throughput sequencing. A series of distinct patterns of genomic aberrations are identified, each representing a particular mode of variation in individual copy number profiles. The purpose is to derive a compact, biologically and clinically relevant representation of the genomic architecture in a tumor (together with Arne Pladsen, Gro Nilsen, Hege Russnes and others). 
  • ASCAT (Allele-Specific Copy Aberrations in Tumors) is an algorithm for estimation of allele-specific copy numbers, genome ploidy and tumor cell percentage on the basis of SNP array data or HTS data (together with Peter Van Loo and Silje Nord)
  • CAAI (Complex Arm-wise Aberration Index) is a score of genomic complexity which has been shown to be an independent DNA-based prognostic marker in breast cancer (together with Hege Russnes and Hans Kristian Moen Vollan)
  • PART (Partitioning Algorithm using Recursive Thresholding) is an algorithm for identification of clusters in hierarchical clustering trees (together with Gro Nilsen, Knut Liestøl and Ørnulf Borgan).
  • PCF (Piecewise Constant Fitting) is an algorithm for segmentation of array CGH data or SNP array data (together with Gro Nilsen and Knut Liestøl)

Over the last five years I have also been heavily involved in several genomics integration projects, including for example:

  • Prediction of histological transformation (most often to DLBCL) in follicular lymphoma, based on whole-genome copy number and gene expression data (together with Marianne Brodtkorb, Harald Holte, Erlend Smeland and others)
  • Identification of novel drivers of progression in breast cancer, based on whole-genome copy number and gene expression data (together with Miriam Ragle Aure, Lars Baumbusch, Israel Steinfeld, Anne-Lise Børresen-Dale, Zohar Yakhini and others)
  • Identification of genes for which the expression is deregulated in breast cancer both epigenetically (through methylation) and by copy number alteration (together with Miriam Ragle Aure and others)
  • Deriving a map of all direct and indirect interactions between whole-genome miRNA and a panel of 105 cancer related proteins (together with Miriam Ragle Aure, Sandra Jernstrøm, Marit Krohn and others)

PhD supervision

I am/have been involved in supervision of the following doctoral students:

  • Christian Fougner
  • Ståle Hårberg
  • Anand Khadse
  • Julian Hamfjord
  • Stina Stål
  • Chloé Steen
  • Maren Høland
  • Vandana Sandhu
  • Aliaksandr Hubin
  • Even Sannes Riiser
  • Arne Pladsen
  • Hans Kristian Moen Vollan (2015)
  • Gro Nilsen (2015)
  • Miriam Ragle Aure (2013)
  • Eldrid Borgan (2012)
  • Xi Zhao (2011)

Master project supervision

I am/have been involved in supervision of the following master students:

  • Marius Bernklev
  • Anders Flisvang
  • Stian Lågstad
  • Jonas Meier Strømme
  • Kine Veronica Lund (2014)
  • Gro Nilsen (2009)
  • Espen Solberg (2007)
  • Stian Grenborgen (2007)
  • Olav Skjelkvåle Ligaarden (2007)
  • Daniel Løkken Rustad (2005)
  • Hege Leite Størvold (2004)
  • Kristin Robertsen (2003)


Emneord: Life science, Genomics, Epigenomics, Integrated analyses, Big data, Data mining, Computational biology, Cancer biology, Personalized medicine, Biological markers, Ecology, Cancer evolution, Breast cancer, Lung cancer, Pancreatic cancer, Ovary cancer, Cancer metastasis, Biostatistics, Mathematical modeling, Bioinformatics


  • Lien, Tonje Gulbrandsen; Ohnstad, Hege Oma; Lingjærde, Ole Christian; Vallon-Christersson, Johan; Aaserud, Marit & Sveli, My Anh Tu [Vis alle 12 forfattere av denne artikkelen] (2021). Sample preparation approach influences pam50 risk of recurrence score in early breast cancer. Cancers. ISSN 2072-6694. 13(23). doi: 10.3390/cancers13236118.
  • Bjaanæs, Maria Moksnes; Nilsen, Gro; Halvorsen, Ann Rita; Russnes, Hege Elisabeth Giercksky; Solberg, Steinar & Jørgensen, Lars [Vis alle 9 forfattere av denne artikkelen] (2021). Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung adenocarcinoma tumors. BMC Cancer. ISSN 1471-2407. 21(1). doi: 10.1186/s12885-021-08811-7.
  • Ben-Elazar, Shay; Aure, Miriam Ragle; Jonsdottir, Kristin; Leivonen, Suvi-Katri; Kristensen, Vessela N. & Janssen, Emiel [Vis alle 9 forfattere av denne artikkelen] (2021). miRNA normalization enables joint analysis of several datasets to increase sensitivity and to reveal novel miRNAs differentially expressed in breast cancer. PLoS Computational Biology. ISSN 1553-734X. 17(2). doi: 10.1371/JOURNAL.PCBI.1008608. Fulltekst i vitenarkiv
  • Ask, Eivind Heggernes; Tschan-Plessl, Astrid; Gjerdingen, Thea Johanne; Sætersmoen, Michelle Lu; Hoel, Hanna Julie & Wiiger, Merete Thune [Vis alle 16 forfattere av denne artikkelen] (2021). A Systemic Protein Deviation Score Linked to PD-1+ CD8+ T Cell Expansion That Predicts Overall Survival in Diffuse Large B Cell Lymphoma. Med. ISSN 2666-6340. 2(2), s. 180–195. doi: 10.1016/j.medj.2020.10.006.
  • Liu, Jingjing; van der Smissen, Wendy J. C. Prager; Collee, Margriet J.; Bolla, Manjeet K.; Wang, Qin & Kristensen, Vessela N. [Vis alle 82 forfattere av denne artikkelen] (2020). Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk. Scientific Reports. ISSN 2045-2322. 10:9688(1), s. 1–14. doi: 10.1038/s41598-020-65665-y. Fulltekst i vitenarkiv
  • Bailey, Matthew H.; Meyerson, William U.; Dursi, L. Jonathan; Wang, Liang-Bo; Dong, Guanlan & Aure, Miriam Ragle [Vis alle 51 forfattere av denne artikkelen] (2020). Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications. ISSN 2041-1723. 11:4748, s. 1–27. doi: 10.1038/s41467-020-18151-y. Fulltekst i vitenarkiv
  • Li, Constance H.; Prokopec, Stephenie D.; Sun, Ren X.; Yousif, Fouad; Schmitz, Nathaniel & Aure, Miriam Ragle [Vis alle 51 forfattere av denne artikkelen] (2020). Sex differences in oncogenic mutational processes. Nature Communications. ISSN 2041-1723. 11:4330, s. 1–24. doi: 10.1038/s41467-020-17359-2. Fulltekst i vitenarkiv
  • Wise, Jillian; Nakken, Sigve; Steen, Chloe Beate; Vodak, Daniel; Trøen, Gunhild & Johannessen, Bjarne [Vis alle 24 forfattere av denne artikkelen] (2020). Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. Blood Advances. ISSN 2473-9529. 4(9), s. 1859–1866. doi: 10.1182/bloodadvances.2019001325.
  • Hoff, Andreas Midbøe; Kraggerud, Sigrid M.; Alagaratnam, Sharmini; Berg, Kaja Christine Graue; Johannessen, Bjarne & Høland, Maren [Vis alle 11 forfattere av denne artikkelen] (2020). Frequent copy number gains of SLC2A3 and ETV1 in testicular embryonal carcinomas. Endocrine-Related Cancer. ISSN 1351-0088. 27(9), s. 457–468. doi: 10.1530/ERC-20-0064. Fulltekst i vitenarkiv
  • Kyte, Jon A; Andresen, Nikolai Kragøe; Russnes, Hege Elisabeth Giercksky; Fretland, Signe Øien; Falk, Ragnhild Sørum & Lingjærde, Ole Christian [Vis alle 7 forfattere av denne artikkelen] (2020). ICON: A randomized phase IIb study evaluating immunogenic chemotherapy combined with ipilimumab and nivolumab in patients with metastatic hormone receptor positive breast cancer. Journal of Translational Medicine. ISSN 1479-5876. 18(1). doi: 10.1186/s12967-020-02421-w. Fulltekst i vitenarkiv
  • ICGC/TCGA Pan-Cancer Analysis, of Whole Genomes Consortium; Campbell, Peter J.; Getz, Gad; Korbel, Jan O.; Stuart, Joshua M. & Jennings, Jennifer L. [Vis alle 54 forfattere av denne artikkelen] (2020). Pan-cancer analysis of whole genomes. Nature. ISSN 0028-0836. 578(7793), s. 82–93. doi: 10.1038/s41586-020-1969-6. Fulltekst i vitenarkiv
  • Pladsen, Arne Valebjørg; Nilsen, Gro; Rueda, Oscar M.; Aure, Miriam Ragle; Borgan, Ørnulf & Liestøl, Knut [Vis alle 18 forfattere av denne artikkelen] (2020). DNA copy number motifs are strong and independent predictors of survival in breast cancer. Communications Biology. ISSN 2399-3642. 3. doi: 10.1038/s42003-020-0884-6. Fulltekst i vitenarkiv
  • Gythfeldt, Hedda von der Lippe; Lien, Tonje Gulbrandsen; Tekpli, Xavier; Silwal-Pandit, Laxmi; Borgen, Elin & Garred, Øystein [Vis alle 15 forfattere av denne artikkelen] (2020). Immune phenotype of tumor microenvironment predicts response to bevacizumab in neoadjuvant treatment of ER-positive breast cancer. International Journal of Cancer. ISSN 0020-7136. 147(9), s. 2515–2525. doi: 10.1002/ijc.33108. Fulltekst i vitenarkiv
  • Ree, Anne Hansen; Nygaard, Vigdis; Pedersen, Kjetil Boye; Heinrich, Daniel; Dueland, Svein & Bergheim, Inger Riise [Vis alle 25 forfattere av denne artikkelen] (2020). Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer?the MetAction study. Acta Oncologica. ISSN 0284-186X. s. 1–10. doi: 10.1080/0284186X.2020.1742377. Fulltekst i vitenarkiv
  • Nygård, Ståle; Lingjærde, Ole Christian; Caldas, Carlos; Hovig, Eivind; Børresen-Dale, Anne-Lise & Helland, Åslaug [Vis alle 7 forfattere av denne artikkelen] (2019). PathTracer: High-sensitivity detection of differential pathway activity in tumours. Scientific Reports. ISSN 2045-2322. 9:16332, s. 1–8. doi: 10.1038/s41598-019-52529-3. Fulltekst i vitenarkiv
  • Hamfjord, Julian; Guren, Tormod Kyrre; Dajani, Olav; Johansen, Julia Sidenius; Glimelius, Bengt & Sorbye, Halfdan [Vis alle 12 forfattere av denne artikkelen] (2019). Total circulating cell-free DNA as a prognostic biomarker in metastatic colorectal cancer before first-line oxaliplatin-based chemotherapy. Annals of Oncology. ISSN 0923-7534. 30(7), s. 1088–1095. doi: 10.1093/annonc/mdz139. Fulltekst i vitenarkiv
  • Steen, Chloe Beate; Leich, Ellen; Myklebust, June Helen; Lockmer, Sandra; Wise, Jillian & Wahlin, Björn Engelbrekt [Vis alle 14 forfattere av denne artikkelen] (2019). A clinico-molecular predictor identifies follicular lymphoma patients at risk of early transformation after first-line immunotherapy. Haematologica. ISSN 0390-6078. 104(10), s. 460–464. doi: 10.3324/haematol.2018.209080. Fulltekst i vitenarkiv
  • Øjlert, Åsa Kristina; Halvorsen, Ann Rita; Nebdal, Daniel J.H.; Lund-Iversen, Marius; Solberg, Steinar & Brustugun, Odd Terje [Vis alle 8 forfattere av denne artikkelen] (2019). The immune microenvironment in non‐small cell lung cancer is predictive of prognosis after surgery. Molecular Oncology. ISSN 1574-7891. 13(5), s. 1166–1179. doi: 10.1002/1878-0261.12475. Fulltekst i vitenarkiv
  • Lindholm, Evita Maria; Aure, Miriam Ragle; Haugen, Mads Haugland; Sahlberg, Kristine Kleivi; Kristensen, Vessela N. & Nebdal, Daniel J.H. [Vis alle 9 forfattere av denne artikkelen] (2019). miRNA expression changes during the course of neoadjuvant bevacizumab and chemotherapy treatment in breast cancer. Molecular Oncology. ISSN 1574-7891. 13(10), s. 2278–2296. doi: 10.1002/1878-0261.12561. Fulltekst i vitenarkiv
  • Johansson, Henrik J.; Socciarelli, Fabio; Vacanti, Nathaniel M.; Haugen, Mads Haugland; Zhu, Yafeng & Siavelis, Ioannis [Vis alle 36 forfattere av denne artikkelen] (2019). Breast cancer quantitative proteome and proteogenomic landscape. Nature Communications. ISSN 2041-1723. 10:1600, s. 1–14. doi: 10.1038/s41467-019-09018-y. Fulltekst i vitenarkiv
  • Terkelsen, Thilde; Haakensen, Vilde Drageset; Saldova, Radka; Gromov, Pavel; Hansen, Merete Kjær & Stockmann, Henning [Vis alle 12 forfattere av denne artikkelen] (2018). N-glycan signatures identified in tumor interstitial fluid and serum of breast cancer patients: association with tumor biology and clinical outcome. Molecular Oncology. ISSN 1574-7891. 12(6), s. 972–990. doi: 10.1002/1878-0261.12312.
  • Møller, Elen Kristine; Nord, Silje; Wedge, David C; Lingjærde, Ole Christian; Silwal-Pandit, Laxmi & Gythfeldt, Hedda [Vis alle 19 forfattere av denne artikkelen] (2018). Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations. Genome Medicine. ISSN 1756-994X. 10:92. doi: 10.1186/s13073-018-0601-y. Fulltekst i vitenarkiv
  • Rye, Inga Hansine; Trinh, Anne; Sætersdal, Anna Barbro; Nebdal, Daniel J.H.; Lingjærde, Ole Christian & Almendro, Vanessa [Vis alle 11 forfattere av denne artikkelen] (2018). Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors. Molecular Oncology. ISSN 1574-7891. s. 1–18. doi: 10.1002/1878-0261.12375. Fulltekst i vitenarkiv
  • Holte, Harald; Beiske, Klaus; Boyle, Merrill; Trøen, Gunhild; Blaker, Yngvild Nuvin & Myklebust, June [Vis alle 13 forfattere av denne artikkelen] (2018). The MCL35 gene expression proliferation assay predicts high-risk MCL patients in a Norwegian cohort of younger patients given intensive first line therapy. British Journal of Haematology. ISSN 0007-1048. s. 1–10. doi: 10.1111/bjh.15518.
  • Våtsveen, Thea Kristin; Myhre, Marit Renee; Steen, Chloe Beate; Wälchli, Sébastien; Lingjærde, Ole Christian & Bai, Baoyan [Vis alle 14 forfattere av denne artikkelen] (2018). Artesunate shows potent anti-tumor activity in B-cell lymphoma. Journal of Hematology & Oncology. ISSN 1756-8722. 11:23, s. 1–12. doi: 10.1186/s13045-018-0561-0. Fulltekst i vitenarkiv
  • Dean, Katharine Rose; Krauer, Fabienne; Walløe, Lars; Lingjærde, Ole Christian; Bramanti, Barbara & Stenseth, Nils Christian [Vis alle 7 forfattere av denne artikkelen] (2018). Human ectoparasites and the spread of plague in Europe during the Second Pandemic. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 115(6), s. 1304–1309. doi: 10.1073/pnas.1715640115.
  • Josefsson, Sarah Elisabet Göthberg; Huse, Kanutte; Kolstad, Arne; Beiske, Klaus; Pende, Daniela & Steen, Chloe Beate [Vis alle 13 forfattere av denne artikkelen] (2017). T cells expressing checkpoint receptor TIGIT are enriched in follicular lymphoma tumors and characterized by reversible suppression of T-cell receptor signaling. Clinical Cancer Research. ISSN 1078-0432. 24(4), s. 870–881. doi: 10.1158/1078-0432.CCR-17-2337. Fulltekst i vitenarkiv
  • Cheng, Jiqiu; Demeulemeester, Jonas; Wedge, David C.; Vollan, Hans Kristian Moen; Pitt, Jason & Russnes, Hege Elisabeth Giercksky [Vis alle 18 forfattere av denne artikkelen] (2017). Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors. Nature Communications. ISSN 2041-1723. 8:1221, s. 1–14. doi: 10.1038/s41467-017-01355-0. Fulltekst i vitenarkiv
  • Russnes, Hege Elisabeth Giercksky; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise & Caldas, Carlos (2017). Breast cancer molecular stratification– from intrinsic subtypes to integrative clusters. American Journal of Pathology. ISSN 0002-9440. doi: 10.1016/j.ajpath.2017.04.022.
  • Lågstad, Stian; Zhao, Sen; Hoff, Andreas Midbøe; Johannessen, Bjarne; Lingjærde, Ole Christian & Skotheim, Rolf I. (2017). Chimeraviz: A tool for visualizing chimeric RNA. Bioinformatics. ISSN 1367-4803. 33(18), s. 2954–2956. doi: 10.1093/bioinformatics/btx329.
  • Silwal-Pandit, Laxmi; Nord, Silje; Gythfeldt, Hedda; Møller, Elen Kristine; Fleischer, Thomas & Rødland, Einar Andreas [Vis alle 25 forfattere av denne artikkelen] (2017). The longitudinal transcriptional response to neoadjuvant chemotherapy with and without bevacizumab in breast cancer. Clinical Cancer Research. ISSN 1078-0432. 23(16), s. 4662–4670. doi: 10.1158/1078-0432.CCR-17-0160. Fulltekst i vitenarkiv
  • Ree, Anne Hansen; Russnes, Hege Elisabeth Giercksky; Heinrich, Daniel; Dueland, Svein; Pedersen, Kjetil Boye & Nygaard, Vigdis [Vis alle 33 forfattere av denne artikkelen] (2017). Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate. ESMO Open. ISSN 2059-7029. 2(2), s. 1–10. doi: 10.1136/esmoopen-2017-000158. Fulltekst i vitenarkiv
  • Aure, Miriam Ragle; Vitelli, Valeria; Jernström, Sandra Johanna; Kumar, Surendra; Krohn, Marit & Due, Eldri Undlien [Vis alle 34 forfattere av denne artikkelen] (2017). Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome. Breast Cancer Research. ISSN 1465-5411. 19. doi: 10.1186/s13058-017-0812-y. Fulltekst i vitenarkiv
  • Taraldsrud, Eli; Aukrust, Pål; Jørgensen, Silje Fjellgård; Lingjærde, Ole Christian; Olweus, Johanna & Myklebust, June [Vis alle 7 forfattere av denne artikkelen] (2017). Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency. Clinical Immunology. ISSN 1521-6616. 175, s. 69–74. doi: 10.1016/j.clim.2016.11.014.
  • Kaveh, Fatemeh; Baumbusch, Lars Oliver; Nebdal, Daniel J.H.; Børresen-Dale, Anne-Lise; Lingjærde, Ole Christian & Edvardsen, Hege [Vis alle 8 forfattere av denne artikkelen] (2016). A systematic comparison of copy number alterations in four types of female cancer. BMC Cancer. ISSN 1471-2407. 16(913). doi: 10.1186/s12885-016-2899-4.
  • Sas-Chen, Aldema; Aure, Miriam Ragle; Leibovich, Limor; Carvalho, Silvia; Enuka, Yehoshua & Körner, Cindy [Vis alle 38 forfattere av denne artikkelen] (2016). LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer. EMBO Molecular Medicine. ISSN 1757-4676. 8(9), s. 1052–1064. doi: 10.15252/emmm.201606198. Fulltekst i vitenarkiv
  • Sveen, Anita; Løes, Inger Marie; Alagaratnam, Sharmini; Nilsen, Gro; Høland, Maren & Lingjærde, Ole Christian [Vis alle 13 forfattere av denne artikkelen] (2016). Intra-patient inter-metastatic genetic heterogeneity in colorectal cancer as a key determinant of survival after curative liver resection. PLoS Genetics. ISSN 1553-7390. 12:e1006225(7). doi: 10.1371/journal.pgen.1006225.
  • Blaker, Yngvild Nuvin; Spetalen, Signe; Eide, Marianne Brodtkorb; Lingjærde, Ole Christian; Beiske, Klaus & Østenstad, Bjørn [Vis alle 13 forfattere av denne artikkelen] (2016). The tumour microenvironment influences survival and time to transformation in follicular lymphoma in the rituximab era. British Journal of Haematology. ISSN 0007-1048. 175(1), s. 102–114. doi: 10.1111/bjh.14201.
  • Haukaas, Tonje Husby; Euceda, Leslie R.; Giskeødegård, Guro F.; Lamichhane, Santosh; Krohn, Marit & Jernström, Sandra Johanna [Vis alle 15 forfattere av denne artikkelen] (2016). Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes. Cancer & Metabolism. ISSN 2049-3002. 4. doi: 10.1186/s40170-016-0152-x. Fulltekst i vitenarkiv
  • Sandhu, Vandana; Wedge, David C.; Lothe, Inger Marie Bowitz; Labori, Knut Jørgen; Dentro, Stefan C. & Buanes, Trond [Vis alle 16 forfattere av denne artikkelen] (2016). The genomic landscape of pancreatic and periampullary adenocarcinoma. Cancer Research. ISSN 0008-5472. 76(17), s. 5092–5102. doi: 10.1158/0008-5472.CAN-16-0658.
  • Nik-Zainal, Serena; Davies, Helen; Staaf, Johan; Ramakrishna, Manasa; Glodzik, Dominik & Zou, Xueqing [Vis alle 88 forfattere av denne artikkelen] (2016). Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature. ISSN 0028-0836. 534(7605), s. 47–54. doi: 10.1038/nature17676.
  • Kjersem, Janne Beathe; Thomsen, Maria; Guren, Tormod Kyrre; Hamfjord, Julian; Carlsson, G & Gustavsson, B. [Vis alle 13 forfattere av denne artikkelen] (2016). AGXT and ERCC2 polymorphisms are associated with clinical outcome in metastatic colorectal cancer patients treated with 5-FU/oxaliplatin. The Pharmacogenomics Journal. ISSN 1470-269X. 16(3), s. 272–279. doi: 10.1038/tpj.2015.54.
  • Sandhu, Vandana; Lothe, Inger Marie Bowitz; Labori, Knut Jørgen; Skrede, Martina; Hamfjord, Julian & Larsen, Astrid Marie [Vis alle 14 forfattere av denne artikkelen] (2016). Differential expression of miRNAs in pancreatobiliary type of periampullary adenocarcinoma and its associated stroma. Molecular Oncology. ISSN 1574-7891. 10(2), s. 303–316. doi: 10.1016/j.molonc.2015.10.011.
  • Bjaanæs, Maria Moksnes; Nilsen, Gro; Solberg, Steinar; Brustugun, Odd Terje; Lingjærde, Ole Christian & Helland, Åslaug (2015). Whole-genome copy number analyses of NSCLC tumors reveal aberrations associated with EGFR mutations and may have prognostic impact. Journal of Thoracic Oncology. ISSN 1556-0864. 10(9), s. S581–S582.
  • Wise, Jillian Frances; Nakken, Sigve; Vodak, Daniel; Trøen, Gunhild; Lingjærde, Ole Christian & Meza-Zepeda, Leonardo A [Vis alle 12 forfattere av denne artikkelen] (2015). Discovery of recurrent mutations associated with chemo-immunotherapy relapse in diffuse large B-cell lymphoma. Blood. ISSN 0006-4971. 126(23), s. 110–110. doi: 10.1182/blood.v126.23.110.110.
  • Hamfjord, Julian; Saldova, Radka; Stockmann, Henning; Sandhu, Vandana; Lothe, Inger Marie Bowitz & Buanes, Trond [Vis alle 10 forfattere av denne artikkelen] (2015). Serum N-glycome characterization in patients with resectable periampullary adenocarcinoma. Journal of Proteome Research. ISSN 1535-3893. 14(12), s. 5144–5156. doi: 10.1021/acs.jproteome.5b00395.
  • Borge, Kaja Sverdrup; Nord, Silje H.; Van Loo, Peter; Lingjærde, Ole Christian; Gunnes, Gjermund & Grenaker, Grethe Irene [Vis alle 11 forfattere av denne artikkelen] (2015). Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN. PLOS ONE. ISSN 1932-6203. 10(5). doi: 10.1371/journal.pone.0126371. Fulltekst i vitenarkiv
  • Tinholt, Mari; Vollan, Hans Kristian Moen; Sahlberg, Kristine Kleivi; Jernström, Sandra Johanna; Kaveh, Fatemeh & Lingjærde, Ole Christian [Vis alle 12 forfattere av denne artikkelen] (2015). Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF. Breast Cancer Research. ISSN 1465-5411. 17(44), s. 1–15. doi: 10.1186/s13058-015-0548-5.
  • Potapenko, Ivan Olegovich; Luders, Torben; Russnes, Hege Elisabeth Giercksky; Helland, Åslaug; Sørlie, Therese & Kristensen, Vessela N. [Vis alle 10 forfattere av denne artikkelen] (2015). Glycan-related gene expression signatures in breast cancer subtypes; relation to survival. Molecular Oncology. ISSN 1574-7891. 9(4), s. 861–876. doi: 10.1016/j.molonc.2014.12.013.
  • Aure, Miriam Ragle; Jernström, Sandra Johanna; Krohn, Marit; Vollan, Hans Kristian Moen; Due, Eldri Undlien & Rødland, Einar Andreas [Vis alle 13 forfattere av denne artikkelen] (2015). Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer. Genome Medicine. ISSN 1756-994X. 7:21. doi: 10.1186/s13073-015-0135-5.
  • Sandhu, Vandana; Lothe, Inger Marie Bowitz; Labori, Knut Jørgen; Lingjærde, Ole Christian; Buanes, Trond & Dalsgaard, Astrid Marie [Vis alle 13 forfattere av denne artikkelen] (2015). Molecular signatures of mRNAs and miRNAs as prognostic biomarkers in pancreatobiliary and intestinal types of periampullary adenocarcinomas. Molecular Oncology. ISSN 1574-7891. 9(4), s. 758–771. doi: 10.1016/j.molonc.2014.12.002.
  • Vollan, Hans Kristian Moen; Rueda, Oscar M.; Chin, Suet-Feung; Curtis, Christina; Turashvili, Gulisa & Shah, Sohrab P. [Vis alle 25 forfattere av denne artikkelen] (2015). A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer. Molecular Oncology. ISSN 1574-7891. 9(1), s. 115–127. doi: 10.1016/j.molonc.2014.07.019.
  • Russnes, Hege Elisabeth Giercksky; Lønning, Per Eystein; Børresen-Dale, Anne-Lise & Lingjærde, Ole Christian (2014). The multitude of molecular analyses in cancer: the opening of Pandora’s box. Genome Biology. ISSN 1465-6906. 15:447. doi: 10.1186/s13059-014-0447-6. Fulltekst i vitenarkiv
  • Kjersem, Janne Beathe; Ikdahl, Tone; Lingjærde, Ole Christian; Guren, Tormod Kyrre; Tveit, Magne Kjell & Kure, Elin H. (2014). Plasma microRNAs predicting clinical outcome in metastatic colorectal cancer patients receiving first-line oxaliplatin-based treatment. Molecular Oncology. ISSN 1574-7891. 8(1), s. 59–67. doi: 10.1016/j.molonc.2013.09.001.
  • Zhao, Xi; Rødland, Einar Andreas; Sørlie, Therese; Vollan, Hans Kristian Moen; Russnes, Hege Elisabeth Giercksky & Kristensen, Vessela N. [Vis alle 7 forfattere av denne artikkelen] (2014). Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status. BMC Cancer. ISSN 1471-2407. 14(211). doi: 10.1186/1471-2407-14-211.
  • Kristensen, Vessela N.; Lingjærde, Ole Christian; Russnes, Hege Elisabeth Giercksky; Vollan, Hans Kristian Moen; Frigessi, Arnoldo & Børresen-Dale, Anne-Lise (2014). Principles and methods of integrative genomic analyses in cancer. Nature Reviews Cancer. ISSN 1474-175X. 14(5), s. 299–313. doi: 10.1038/nrc3721.
  • Brodtkorb, Marianne; Lingjærde, Ole Christian; Huse, Kanutte; Trøen, Gunhild; Hystad, Marit Elise & Hilden, Vera Irene [Vis alle 12 forfattere av denne artikkelen] (2014). Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma. Blood. ISSN 0006-4971. 123(7), s. 1051–1054. doi: 10.1182/blood-2013-07-512392.
  • Baumbusch, Lars Oliver; Helland, Åslaug; Wang, Yun; Liestøl, Knut; Schaner, M.E. & Holm, Ruth [Vis alle 16 forfattere av denne artikkelen] (2013). High Levels of Genomic Aberrations in Serous Ovarian Cancers Are Associated with Better Survival. PLOS ONE. ISSN 1932-6203. 8(1). doi: 10.1371/journal.pone.0054356.
  • Aure, Miriam Ragle; Steinfeld, I; Baumbusch, Lars Oliver; Liestøl, Knut; Lipson, Doron & Nyberg, Sandra Johanna [Vis alle 12 forfattere av denne artikkelen] (2013). Identifying In-Trans Process Associated Genes in Breast Cancer by Integrated Analysis of Copy Number and Expression Data. PLOS ONE. ISSN 1932-6203. 8(1). doi: 10.1371/journal.pone.0053014.
  • Borgan, Eldrid; Lindholm, Evita Maria; Moestue, Siver Andreas; Mælandsmo, Gunhild; Lingjærde, Ole Christian & Gribbestad, Ingrid S [Vis alle 9 forfattere av denne artikkelen] (2013). Subtype-specific response to bevacizumab is reflected in the metabolome and transcriptome of breast cancer xenografts. Molecular Oncology. ISSN 1574-7891. 7(1), s. 130–142. doi: 10.1016/j.molonc.2012.10.005. Fulltekst i vitenarkiv
  • Aure, Miriam Ragle; Leivonen, Suvi-Katri; Fleischer, Thomas; Zhu, Qian; Overgaard, Jens & Alsner, Jan [Vis alle 19 forfattere av denne artikkelen] (2013). Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors. Genome Biology. ISSN 1465-6906. doi: 10.1186/gb-2013-14-11-r126.
  • Nilsen, Gro; Borgan, Ørnulf; Liestøl, Knut & Lingjærde, Ole Christian (2013). Identifying clusters in genomics data by recursive partitioning. Statistical Applications in Genetics and Molecular Biology. ISSN 1544-6115. 12(5), s. 637–652. doi: 10.1515/sagmb-2013-0016.
  • Myhre, Simen; Lingjærde, Ole Christian; Hennessy, Bryan T; Aure, Miriam Ragle; Carey, Mark S & Alsner, Jan [Vis alle 11 forfattere av denne artikkelen] (2013). Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins. Molecular Oncology. ISSN 1574-7891. 7(3), s. 704–718. doi: 10.1016/j.molonc.2013.02.018.
  • Ruud Mathiesen, Randi Margit; Fjelldal, Renathe; Liestøl, Knut; Due, Eldri Undlien; Geigl, Jochen & Riethdorf, Sabine [Vis alle 18 forfattere av denne artikkelen] (2012). High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer. International Journal of Cancer. ISSN 0020-7136. 131(4), s. E405–E415. doi: 10.1002/ijc.26444.
  • van Loo, Peter; Nilsen, Gro; Nordgard, Silje H.; Vollan, Hans Kristian Moen; Børresen-Dale, Anne-Lise & Kristensen, Vessela N. [Vis alle 7 forfattere av denne artikkelen] (2012). Analyzing cancer samples with SNP arrays. I Wang, Junbai; Tian, Tianhai & Tan, Aik Choon (Red.), Next Generation Microarray Bioinformatics. Humana Press. ISSN 978-1-61779-399-8. s. 57–72. doi: 10.1007/978-1-61779-400-1_4.
  • Nilsen, Gro; Liestøl, Knut; Van Loo, P; Vollan, Hans Kristian Moen; Eide, Marianne Brodtkorb & Rueda, Oscar M. [Vis alle 12 forfattere av denne artikkelen] (2012). Copynumber: Efficient algorithms for single and multi-track copy number segmentation. BMC Genomics. ISSN 1471-2164. 13(591). doi: 10.1186/1471-2164-13-591.
  • Borgan, Eldrid; Navon, Roy; Vollan, Hans Kristian Moen; Schlichting, Ellen; Sauer, Torill & Yakhini, Zohar [Vis alle 9 forfattere av denne artikkelen] (2011). Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue. Molecular Oncology. ISSN 1574-7891. 5(6), s. 564–576. doi: 10.1016/j.molonc.2011.08.004.
  • Haakensen, Vilde Drageset; Lingjærde, Ole Christian; Luders, Torben; Riis, Margit; Prat, Aleix & Troester, Melissa A [Vis alle 17 forfattere av denne artikkelen] (2011). Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features. BMC Medical Genomics. ISSN 1755-8794. 4. doi: 10.1186/1755-8794-4-77.
  • Solvang, Hiroko Kato; Lingjærde, Ole Christian; Frigessi, Arnoldo; Børresen-Dale, Anne-Lise & Kristensen, Vessela N. (2011). Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer. BMC Bioinformatics. ISSN 1471-2105. 12. doi: 10.1186/1471-2105-12-197.
  • Zhao, Xi; Rødland, Einar Andreas; Sørlie, Therese; Naume, Bjørn; Langerød, Anita & Frigessi, Arnoldo [Vis alle 8 forfattere av denne artikkelen] (2011). Combining Gene Signatures Improves Prediction of Breast Cancer Survival. PLOS ONE. ISSN 1932-6203. 6(3). doi: 10.1371/journal.pone.0017845.
  • Russnes, Hege Elisabeth Giercksky; Vollan, Hans Kristian Moen; Lingjærde, Ole Christian; Krasnitz, Alexander; Lundin, Pär & Naume, Bjørn [Vis alle 23 forfattere av denne artikkelen] (2010). Genomic Architecture Characterizes Tumor Progression Paths and Fate in Breast Cancer Patients. Science Translational Medicine. ISSN 1946-6234. 2(38), s. 38–47. doi: 10.1126/scitranslmed.3000611.
  • Borgan, Eldrid; Sitter, Beathe; Lingjærde, Ole Christian; Johnsen, Hilde; Lundgren, Steinar & Bathen, Tone Frost [Vis alle 9 forfattere av denne artikkelen] (2010). Merging transcriptomics and metabolomics - advances in breast cancer profiling. BMC Cancer. ISSN 1471-2407. 10. doi: 10.1186/1471-2407-10-628.
  • Eide, Marianne Brodtkorb; Liestøl, Knut; Lingjærde, Ole Christian; Hystad, Marit Elise; Kresse, Stine Henrichson & Meza, Leonardo Zepeda [Vis alle 12 forfattere av denne artikkelen] (2010). Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones. Blood. ISSN 0006-4971. 116(9), s. 1489–1497. doi: 10.1182/blood-2010-03-272278.
  • Potapenko, Ivan Olegovich; Haakensen, Vilde Drageset; Luders, Torben; Helland, Åslaug; Bukholm, Ida Rashida Khan & Sørlie, Therese [Vis alle 9 forfattere av denne artikkelen] (2010). Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression. Molecular Oncology. ISSN 1574-7891. 4(2), s. 98–118. doi: 10.1016/j.molonc.2009.12.001.
  • van Loo, Pete; Nordgard, Silje H.; Lingjærde, Ole Christian; Russnes, Hege Elisabeth Giercksky; Rye, Inga Hansine & Wei, Sun [Vis alle 13 forfattere av denne artikkelen] (2010). Allele-specific copy number analysis of tumors. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 107(39), s. 16910–16915. doi: 10.1073/pnas.1009843107.
  • Haakensen, Vilde Drageset; Biong, Stine Margarethe; Lingjærde, Ole Christian; Holmen, Marit Muri; Frantzen, Jan Ole & Chen, Ying [Vis alle 15 forfattere av denne artikkelen] (2010). Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density. Breast Cancer Research. ISSN 1465-5411. 12(4). doi: 10.1186/bcr2632.

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Publisert 4. nov. 2010 14:06 - Sist endret 8. jan. 2020 09:13